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There have been few studies on the effects of various FPCB manufacturing options on signal attenuation. This article represents the results of an effort to understand quantitatively the attenuation impact of commonly used manufacturing options, such as film/adhesive material, pretreatment, and FCCL process. Coupons from several different product FPCB constructions were measured and compared in terms of per‐unit‐length attenuation. While it is not a comprehensive compilation, it is more extensive than previously available. These results will be helpful to make a real trade‐off between electrical performance and manufacturing concerns. [ABSTRACT FROM AUTHOR]

The air‐cathode is investigated for the development and optimization of low‐cost, miniaturized, portable, quasi‐solid aluminum‐air batteries. The battery used aluminum as the anode and gelation sodium chloride as the electrolyte. The air‐cathode was activated carbon sheet made of carbon fiber, cellulose, and activated carbon powder. The air‐cathode requires a large surface area. Activated carbon (AC) has the property of porosity and large surface area. In this study, this property was utilized for enhancing the performance of the air‐cathode. The performance of AC sheets with AC ratio in the range of 0–75 wt% was compared. 60 wt% sample generated the highest maximum power density of 3.5 mW/cm−2 with an energy density of 1.0 kWh/kg. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Erlotinib (ERL), an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, shows notable efficacy against non-small cell lung cancer (NSCLC) harboring EGFR mutations. Bevacizumab (BEV), a humanized monoclonal antibody to vascular endothelial cell growth factor (VEGF), in combination with ERL (BEV1ERL) significantly extended progression-free survival in patients with EGFR-mutated NSCLC compared with ERL alone. However, the efficacy of BEV1ERL against EGFR-mutated NSCLC harboring T790M mutation or MET amplification, is unclear. Here, we examined the antitumor activity of BEV1ERL in four xenograft models of EGFR-mutated NSCLC (three harboring ERL resistance mutations). In the HCC827 models (exon 19 deletion: DEL), ERL significantly inhibited tumor growth by blocking EGFR signal transduction. Although there was no difference between ERL and BEV1ERL in maximum tumor growth inhibition, BEV1ERL significantly suppressed tumor regrowth during a drugcessation period. In the HCC827-EPR model (DEL+T790M) and HCC827-vTR model (DEL+MET amplification), ERL reduced EGFR signal transduction and showed less pronounced but still significant tumor growth inhibition than in the HCC827 model. In these models, tumor growth inhibition was significantly stronger with BEV+ERL than with each single agent. In the NCI-H1975 model (L858R+T790M), ERL did not inhibit growth or EGFR signal transduction, and BEV1ERL did not inhibit growth more than BEV. BEV alone significantly decreased microvessel density in each tumor. In conclusion, addition of BEV to ERL did not enhance antitumor activity in primarily ERL-resistant tumors with T790M mutation; however, BEV+ERL enhanced antitumor activity in T790M mutation- or MET amplification-positive tumors as long as their growth remained significantly suppressed by ERL. [ABSTRACT FROM AUTHOR]

The detection of an optical signal modulated at 15 GHz was demonstrated experimentally by using difference frequency generation based on a second-order nonlinear optical effect in a periodically poled LiTaO3 microwave rectangular waveguide. The measured frequency dependence of the generated microwave signal was in good agreement with the theoretically expected result. An interesting application of the proposed device is the detection of high-speed optical clock detection. [ABSTRACT FROM AUTHOR]