1. In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial.
- Author
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Arias-Mendoza, F., Payne, G. S., Zakian, K. L., Schwarz, A. J., Stubbs, M., Stoyanova, R., Ballon, D., Howe, F. A., Koutcher, J. A., Leach, M. O., Griffiths, J. R., Heerschap, A., Glickson, J. D., Nelson, S. J., Evelhoch, J. L., Charles, H. C., and Brown, T. R.
- Abstract
The standardization and reproducibility of techniques required to acquire anatomically localized
31 P MR spectra non-invasively while studying tumors in cancer patients in a multi-institutional group at 1.5 T are reported. This initial group of patients was studied from 1995 to 2000 to test the feasibility of acquiring in vivo localized31 P MRS in clinical MR spectrometers. The cancers tested were non-Hodgkin's lymphomas, sarcomas of soft tissue and bone, breast carcinomas and head and neck carcinomas. The best accrual and spectral quality were achieved with the non-Hodgkin's lymphomas. The initial analysis of the spectral values of the sum of phosphoethanolamine plus phosphocholine normalized by the content of nucleotide triphosphates in a homogeneous sample of 32 NHL patients studied by in vivo31 P MRS showed good reproducibility among different institutions. No statistical differences were found between the institution with the largest number of cases accrued and the rest of the multi-institutional NHL data (2.28 ± 0.64, mean ± standard error; n = 17, vs 2.08 ± 0.14, n = 15). The preliminary data reported demonstrate that the institutions involved in this trial are obtaining reproducible31 P MR spectroscopic data non-invasively from human tumors. This is a fundamental prerequisite for the international cooperative group to be able to demonstrate the clinical value of the normalized determination of phosphoethanolamine plus phosphocholine by31 P MRS as predictor for treatment response in cancer patients. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2006
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