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In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial.
- Source :
- NMR in Biomedicine; Jun2006, Vol. 19 Issue 4, p504-512, 9p
- Publication Year :
- 2006
-
Abstract
- The standardization and reproducibility of techniques required to acquire anatomically localized <superscript>31</superscript>P MR spectra non-invasively while studying tumors in cancer patients in a multi-institutional group at 1.5 T are reported. This initial group of patients was studied from 1995 to 2000 to test the feasibility of acquiring in vivo localized <superscript>31</superscript>P MRS in clinical MR spectrometers. The cancers tested were non-Hodgkin's lymphomas, sarcomas of soft tissue and bone, breast carcinomas and head and neck carcinomas. The best accrual and spectral quality were achieved with the non-Hodgkin's lymphomas. The initial analysis of the spectral values of the sum of phosphoethanolamine plus phosphocholine normalized by the content of nucleotide triphosphates in a homogeneous sample of 32 NHL patients studied by in vivo <superscript>31</superscript>P MRS showed good reproducibility among different institutions. No statistical differences were found between the institution with the largest number of cases accrued and the rest of the multi-institutional NHL data (2.28 ± 0.64, mean ± standard error; n = 17, vs 2.08 ± 0.14, n = 15). The preliminary data reported demonstrate that the institutions involved in this trial are obtaining reproducible <superscript>31</superscript>P MR spectroscopic data non-invasively from human tumors. This is a fundamental prerequisite for the international cooperative group to be able to demonstrate the clinical value of the normalized determination of phosphoethanolamine plus phosphocholine by <superscript>31</superscript>P MRS as predictor for treatment response in cancer patients. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09523480
- Volume :
- 19
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- NMR in Biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 64208609
- Full Text :
- https://doi.org/10.1002/nbm.1057