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Background: In contrast to adults, only limited data are available on the human papillomavirus (HPV)‐type spectrum in anogenital warts (AGW) of children. Objective: This study aimed to evaluate the HPV‐type spectrum in AGW of prepubertal children. Materials & methods: In a retrospective German multicentre study, HPV genotyping was performed in AGW biopsies of 55 1‐ to 12‐year‐old children using HPV group‐specific PCRs followed by hybridization with type‐specific probes or sequence analysis. Results: Human papillomavirus‐DNA was found in 53 of the 55 AGW. In 58.5% (31/53) of the HPV‐positive AGW, mucosal HPV types were detected. HPV6 (27/53, 50.9%) was the predominant type. 43.4% (23/53) of the lesions were induced by cutaneous HPV types (HPV2, HPV27, HPV57). Mucosal HPV types were significantly more common in children under 5 years of age than in children 5 years of age and older (22/25, 88.0% [95% CI: 70.0–95.8] vs. 9/28, 32.1% [95% CI: 17.9–50.7], P < 0.001). In contrast, cutaneous HPV types were significantly more prevalent in the 5‐ to 12‐year age group (4/25, 16.0% [95% CI 6.4–34.7] vs. 19/28, 67.9% [95% CI 49.3–82.1], P < 0.001). Conclusion: Anogenital warts in 5‐ to 12‐year‐old children are frequently associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can potentially help in the assessment of these cases. [ABSTRACT FROM AUTHOR]

We report a case of subacute cutaneous lupus erythematosus (SCLE) that transitioned into systemic lupus erythematosus (SLE) following AdV-vaccination with AZD1222. These findings indicate a transition of SCLE into SLE, fulfilling the current SLE classification criteria.2 Under tapered glucocorticosteroid therapy with prednisolone 250 mg/day, the skin lesions and systemic symptoms significantly improved within 7 days. Transition of cutaneous into systemic lupus erythematosus following adenoviral vector-based SARS-CoV-2 vaccination. [Extracted from the article]

Moreover, we evaluated the prevalence of HPV67 in cutaneous and mucosal lesions of HIV-positive men who have sex with men (HIV + MSM), a high-risk group for HPV-induced dysplasia and cancer.4 A 68-year-old man presented with a verrucous hyperkeratotic plaque located on the left little finger (Fig. In order to detect HPV-associated pathogenesis, HPV typing should include possibly carcinogenic HPV types in unusual clinical presentations, especially in immunosuppressed patients. So far, limited data are available on HPV67 prevalence in HPV-associated dysplasias and cancers.6 In a large retrospective cross-sectional worldwide study, 26 (0.3%) of 8799 HPV-positive cervical cancers were HPV67-positive.7 In a Danish population-based study, HPV67 was found in 0.2% of 432 HPV-positive oropharyngeal SCC.8 Similar to our data, HPV67 monoinfection was found in 1.6% (1/62) of high-grade AIN from HIV + MSM in Canada.9 Yoneta I et al i .10 reported on a 35-year-old immunocompetent man with multiple HPV31- or HPV67-positive perianal, penile and inguinal dysplasias who developed invasive perianal and inguinal SCCs. [Extracted from the article]

2 Medical record review revealed a total of 12 patients with GC but four patients were excluded (insufficient clinical information and lack of histological confirmation in three patients, one patient had concomitant Crohn disease). This is in line with another report showing short-term improvement in only one of five patients treated with azithromycin.4 We achieved the best response with methotrexate, but only one patient had a durable remission (Fig. Of the remaining eight patients (six women and two men; mean age at first presentation of 43.6 years [range, 24-81 years]), four had GC of the upper lip, three of the lower lip, and one patient had both lips affected. [Extracted from the article]