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The article focuses on the research "Developmental trajectories of cerebrovascular reactivity in healthy children and young adults assessed with magnetic resonance imaging" by J. Leung and colleagues. It discusses the use of arterial spin labelling and blood-oxygen level-dependent magnetic resonance imaging to characterize the developmental trajectories of cerebral blood flow and cerebrovascular reactivity in brains of healthy children and young adults.

Causative factors of toxemia of pregnancy have not been completely resolved. This project examines rat placenta to determine which placental regions and cells become labeled with renin antibody. Renin is well known as hormone produced by juxtaglomerular cells of the distal renal afferent arteriole, as a response to low blood pressure. Renin is also an immediate downstream target of Class 1 Hox gene regulation. Mice express renin in embryonic renal, adrenal and gonadal arteries, adrenal glands, and tissue associated with the pro- and meso-nephric kidneys. Transgenic mice exhibit expression of a renin/GFP reporter in placental giant trophoblast cells and cells of the tunica adventitia of the uterine/ovarian artery. In RCS rats, renin antibody stain labels giant trophoblast cells and cells of the tunica adventitia of the uterine/ovarian artery. This project examines rat placental tissue labeled by indirect immuno-fluorescence with anti-mouse renin antibody and fluorescent conjugate. Mesometrial vessels, decidual cells, cells within the giant trophoblast layer, trophospongiosum and labyrinthine cells, and cells of the wails and within chorioallantoic vessels were renin positive. Only vasculature was stained in myometrium. Stained granules were more concentrated in regions corresponding to fetal contribution of placental tissue as compared to maternal parts. This suggests that renin is present in the placenta and could play a role in toxemia of pregnancy. Mouse renin antibody and lab space for stain procedures were generously donated by Dr. Kenneth Gross of Roswell Park Cancer Institute. [ABSTRACT FROM AUTHOR]