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A strategy for transition metal‐free cross‐coupling of alkyl nitroso‐carbamates and boronic acids is reported. The N‐nitroso carbamates are easily prepared from the corresponding amine in two simple steps. This method allows for the synthesis of a wide variety of secondary boronates, benzylic boronates and formal Csp3−Csp2 cross‐coupling products under operationally simple conditions. Functional group tolerance is also demonstrated and applied in the modification of lysine to make non‐canonical amino acids. [ABSTRACT FROM AUTHOR]

Increasing carbon dioxide concentrations in the mesosphere and lower thermosphere are increasing radiative cooling in the upper atmosphere, leading to thermospheric contraction and decreased neutral mass densities at fixed altitudes. Previous studies of the historic neutral density trend have shown a dependence upon solar activity, with larger F10.7 values resulting in lower neutral density reductions. To investigate the impact on the future thermosphere, the Whole Atmosphere Community Climate Model with ionosphere and thermosphere extension has been used to simulate the thermosphere under increasing carbon dioxide concentrations and varying solar activity conditions. These neutral density reductions have then been mapped onto the Shared Socioeconomic Pathways published by the Intergovernmental Panel on Climate Change. The neutral density reductions can also be used as a scaling factor, allowing commonly used empirical models to account for CO2 trends. Under the "best case" SSP1‐2.6 scenario, neutral densities reductions at 400 km altitude peak (when CO2 = 474 ppm) at a reduction of 13%–30% (under high and low solar activity respectively) compared to the year 2000. Higher CO2 concentrations lead to greater density reductions, with the largest modeled concentration of 890 ppm resulting in a 50%–77% reduction at 400 km, under high and low solar activity respectively. Plain Language Summary: Carbon dioxide (CO2) concentrations are increasing throughout the atmosphere, not just at ground level. While this results in global warming in the lower atmosphere, the much less dense upper atmosphere does not trap the radiated heat, resulting in cooling of the upper atmosphere. As the upper atmosphere cools, it contracts, reducing the atmospheric density at a fixed altitude. Satellites traveling in low Earth orbit, such as the International Space Station at 400 km altitude, experience atmospheric drag, slowly reducing their altitude until they "re‐enter" and burn up in the lower, denser atmosphere. Reducing neutral densities will increase satellite orbital lifetimes as they experience less drag. The upper atmosphere has been simulated under increasing CO2 concentrations and solar activity conditions. This has also been linked to potential future CO2 concentration scenarios. Scaling factors have been created allowing simpler, faster models to account for CO2 density reductions. Under a best‐case scenario (SSP1‐2.6) where CO2 concentrations peak in around the year 2065 and then decline, densities at 400 km are 13%–30% lower compared to the year 2000 at the CO2 peak concentration, and then recover as CO2 reduces. However, densities continue to reduce if CO2 concentrations keep rising. Key Points: Whole Atmosphere Community Climate Model with ionosphere and thermosphere extension has been used to model future thermospheric density reductions under increasing carbon dioxide concentrations and solar activityThe reductions in density have been mapped onto the Shared Socioeconomic Pathways to show future scenarios while accounting for solar cyclesDensities at 400 km are 13%–30% lower under high and low solar activity respectively in the SSP1‐2.6 scenario when CO2 peaks at 474 ppm [ABSTRACT FROM AUTHOR]

Ozone simulated in Mars Global Climate Models (MGCMs) is used to assess the underlying chemistry occurring in the atmosphere. Currently, ozone total column abundance (TCA) is under‐predicted in MGCMs by up to 120%, implying missing or inaccurate chemistry in models. Heterogeneous reactions of hydroxyl radicals (HOX) have been offered as an explanation for some of this bias, because they cause ozone to increase at locations where it's currently under‐predicted. We use four simulations to compare modeled ozone TCA with observations from the UVIS spectrometer aboard the ExoMars Trace Gas Orbiter to improve the representation of heterogeneous processes and their impact on ozone. We use a gas‐phase only run, a dissociative scheme, an adsorbed HOX retention scheme, and a hybrid scheme that combines the dissociative mechanism with the retention of HOX on water ice. We find retention of HOX is dependent on water ice sublimation, and ozone abundance increases when water ice persists for longer periods (1–20 sols). Over time, the loss of HOX causes a depletion in H2O2 concentration (HOX reservoir), and thus allows ozone concentration to increase. When adsorbed HOX are desorbed and dissociate into other by‐products, HOX are not immediately available to destroy ozone. This results in larger ozone concentrations than if desorbed HOX are released directly back into their gaseous states. When using the hybrid scheme, ozone TCA is increased up to 50% where the ozone deficit is greatest, demonstrating the best agreement with observations, and implying that HOX radicals are both retained when adsorbed and dissociate. Plain Language Summary: Ozone is a trace gas in the martian atmosphere, sensitive to chemical and light‐induced reactions. This makes it ideal for assessing the underlying reactions for chemical species called hydroxyl radicals, which destroy ozone and would otherwise be too reactive and shortlived to be measured directly. There has been an under‐prediction of ozone in global climate models which implies missing or inaccurate reactions. Heterogeneous reactions (a reaction which includes two or more phases) have been suggested to fill the deficit in modeled ozone. This involves hydroxyl radicals adsorbing onto water ice, which causes ozone to increase. We look at different simulations to understand hydroxyl radical chemistry on the surface of water ice by comparing to observations from the ExoMars Trace Gas Orbiter. We run four climate model simulations to test different theories as to what is occurring at the surface. There are two theories (a) reactions happen at the surface which alter hydroxyl radicals into other chemicals, and (b) hydroxyl radicals stay adsorbed onto water ice for as long as the ice persists. When we combine these theories, we have a more accurate prediction of ozone, which we can then use to infer what happens at the surface. Key Points: Heterogeneous reactions can have a major impact on martian ozone abundance at locations where water ice clouds persist for several solsLifetime of adsorbed hydroxyl radicals depends on water ice sublimation and longer lifetimes result in a greater abundance of ozoneA combination of longer lifetimes and dissociation of adsorbed HOX suppresses gaseous HOX and improves simulated ozone total column abundance [ABSTRACT FROM AUTHOR]

Background: In 2015 our centre introduced a nurse‐led renal cell cancer follow‐up protocol and clinic for patients who have undergone partial or radical nephrectomy for organ‐confined kidney tumours. The main aims of this clinic were to improve healthcare efficiency and standardize follow‐up processes. Objectives: The primary objective was to assess the effectiveness of a nurse‐led renal cell cancer follow up clinic in regard to surveillance protocol compliance and the timely identification and appropriate management of recurrences. A secondary objective was to evaluate this locally developed follow up protocol against the current European Association of Urology (EAU) guidelines surveillance protocol. Patient and Methods: All patients who underwent a partial or radical nephrectomy between 2015 and 2021 at a single Western Australia institution for a primary renal malignancy were included. Data was collected from local clinical information systems and protocol adherence, recurrence characteristics and management were assessed. The current EAU guidelines were applied to the cohort to assess differences in risk‐stratification and theoretical outcomes between the protocols. Results: After a mean follow up period of 31.2 months (range 0–77 months), 75.5% (185/245) of patients had all follow up imaging and reviews within 1 month of the timeframe scheduled on the protocol. 17.1% (42/245) had a delay in their follow up of more than a month at some stage, 5.7% (14/245) did not attend for follow up but had documented attempts to facilitate their compliance, and 0.4% (1/245) were lost to follow up with no evidence of attempted contact. 15.5% (38/245) of patients had recurrence of malignancy detected during follow up and these were all discussed in a multi‐disciplinary team (MDT) meeting. The recurrence rate was 2.5% (3/119) for low risk, 17.7% (14/79) for intermediate risk, and 44.7% (21/47) for high risk patients when they were re‐stratified according to EAU risk categories. No recurrences were detected through ultrasound (USS) or chest x‐ray (CXR) in this cohort and our protocol tended to place patients in higher risk‐stratification groups as compared to current EAU guidelines. Conclusion: Nurse‐led renal cell cancer follow up is a safe, reliable and effective clinical framework that has significant benefits in regard to resource utilization. USS and CXR are ineffective in detecting recurrence and Computerized tomography (CT) should be considered the imaging modality of choice for this purpose. The EAU surveillance protocol appears superior to our protocol, and we have therefore transitioned to the EAU guideline protocol going forward. [ABSTRACT FROM AUTHOR]

Objective: To elucidate the differences in auditory performance between auditory brainstem implant (ABI) patients with tumor or nontumor etiologies. Data Sources: PubMed, Embase, and Web of Science Core Collection from 1990 to 2021. Review Methods: We included published studies with 5 or more pediatric or adult ABI users. Auditory outcomes and side effects were analyzed with weighted means for closed‐set, open‐set speech, and categories of auditory performance (CAP) scores. Overall performance was compared using an Adult Pediatric Ranked Order Speech Perception (APROSPER) scale created for this study. Results: Thirty‐six studies were included and underwent full‐text review. Data were extracted for 662 tumor and 267 nontumor patients. 83% were postlingually deafened and 17% were prelingually deafened. Studies that included tumor ABI patients had a weighted mean speech recognition of 39.2% (range: 19.6%‐83.3%) for closed‐set words, 23.4% (range: 17.2%‐37.5%) for open‐set words, 21.5% (range: 2.7%‐48.4%) for open‐set sentences, and 3.1 (range: 1.0‐3.2) for CAP scores. Studies including nontumor ABI patients had a weighted mean speech recognition of 79.8% (range: 31.7%‐84.4%) for closed‐set words, 53.0% (range: 14.6%‐72.5%) for open‐set sentences, and 2.30 (range: 2.0‐4.7) for CAP scores. Mean APROSPER results indicate better auditory performance among nontumor versus tumor patients (3.5 vs 3.0, P =.04). Differences in most common side effects were also observed between tumor and nontumor ABI patients. Conclusion: Auditory performance is similar for tumor and nontumor patients for standardized auditory test scores. However, the APROSPER scale demonstrates better ABI performance for nontumor compared to tumor patients. [ABSTRACT FROM AUTHOR]

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The distribution of Mars ozone (O3) is well established; however, our knowledge on the dayside diurnal variation of O3 is limited. We present measurements of Mars O3 column abundances, spanning Mars Year (MY) 34 to the end of MY 36, by the Ultraviolet and VIsible Spectrometer (UVIS), part of the Nadir and Occultation for MArs Discovery (NOMAD) instrument, aboard the ExoMars Trace Gas Orbiter. UVIS provides the capability to measure dayside diurnal variations of O3 and for the first time, a characterization of the dayside diurnal variations of O3 is attempted. The observed O3 climatology for Mars Years (MY) 34–36 follows the established seasonal trends observed through previous O3 measurements. At aphelion, the equatorial O3 distribution is observed to be strongly correlated with the water ice distribution. We show that the early dust storm in MY 35 resulted in a near‐global reduction in O3 during northern spring and the O3 abundances remained 14% lower in northern summer compared to MY36. Strong latitudinal and longitudinal variation was observed in the diurnal behavior of O3 around the northern summer solstice. In areas with a weak O3 upper layer, O3 column abundance peaks in the mid‐morning, driven by changes in the near‐surface O3 layer. In regions with greater O3 column abundances, O3 is observed to gradually increase throughout the day. This is consistent with the expected diurnal trend of O3 above the hygropause and suggests that in these areas an upper O3 layer persists throughout the Martian day. Plain Language Summary: Ozone, a highly reactive gas, plays an important role in the chemical cycles of both carbon and hydrogen on Mars. As ozone is tightly correlated to the presence of the difficult to detect odd hydrogen species, measurement of the ozone distribution can provide vital insight into the Martian photochemistry. We present the ozone abundances measured by the UVIS spectrometer aboard the ExoMars Trace Gas Orbiter, spanning Mars years (MYs) 34–36 and attempt to characterize the daily variations in ozone. The ozone follows the expected seasonal trends, with the highest ozone abundances observed at polar regions in the spring, autumn and winter seasons of both hemispheres and very little ozone during southern summer, outside the northern polar latitudes. An enhancement in equatorial ozone during northern summer is observed, with MY 35 showing lower ozone abundances compared to MY 36, likely the effect of an early dust storm in MY 35 or the long‐term impact of the MY 34 global dust storm. In both years, the O3 distribution in northern summer appears to closely follow the water ice distribution and the observed daily cycle in ozone is shown to be highly sensitive to the presence of a high altitude ozone layer. Key Points: Dayside O3 column abundances on Mars between MY 34 (LS = 150°) and MY 36 have been obtained using the NOMAD‐UVIS instrumentOzone is strongly correlated with the presence of water ice clouds in the aphelion seasonDifferences between observed and modeled ozone diurnal variations points toward an under/overestimation of water ice condensation [ABSTRACT FROM AUTHOR]

Rigid bicycles are becoming more popular in the pharmaceutical industry because they allow for expansion to new and unique chemical spaces. This work describes a new strategy to construct 2‐azanorbornanes, which can act as rigid piperidine/pyrrolidine scaffolds with well‐defined exit vectors. To achieve the synthesis of 2‐azanorbornanes, new strain‐release reagent, azahousane, is introduced along with its photosensitized strain‐release formal cycloaddition with alkenes. Furthermore, new reactivity between a housane and an imine is disclosed. Both strategies lead to various substituted 2‐azanorbornanes with good selectivities. [ABSTRACT FROM AUTHOR]

Achieving visually consistent colors across multiple images is important when images are used in photo albums, websites, and brochures. Unfortunately, only a handful of methods address multi‐image color consistency compared to one‐to‐one color transfer techniques. Furthermore, existing methods do not incorporate high‐level features that can assist graphic designers in their work. To address these limitations, we introduce a framework that builds upon a previous palette‐based color consistency method and incorporates three high‐level features: white balance, saliency, and color naming. We show how these features overcome the limitations of the prior multi‐consistency workflow and showcase the user‐friendly nature of our framework. [ABSTRACT FROM AUTHOR]

Space launches produce ionospheric disturbances which can be observed through measurements such as Global Navigation Satellite System signal delays. Here we report observations and numerical simulations of the ionospheric depletion due to a Small‐Lift Launch Vehicle. The case examined was the launch of a Rocket Lab Electron at 22:30 UTC on 22 March 2021. Despite the very small launch vehicle, ground stations in the Chatham Islands measured decreases in slant total electron content for navigation satellite signals following the launch. Global Ionosphere Thermosphere Model results indicated ionospheric depletions which were comparable with these measurements. Measurements indicated a maximum decrease of 2.7 TECU in vertical total electron content, compared with a simulated decrease of 2.6 TECU. Advection of the exhaust plume due to its initial velocity and subsequent effects of neutral winds are identified as some remaining challenges for this form of modeling. Plain Language Summary: The ionosphere is a region of the upper atmosphere containing a mixture of ions and electrons. Chemicals released when rockets pass through this region allow ions and electrons to recombine, reducing their concentrations. These reductions were measured for the launch of a Rocket Lab Electron rocket. The measurements were made based on the difference in time signals at different frequencies took to pass through the ionosphere, which indicated its concentration. Computer simulations were carried out for this case, which showed a similar decrease in the concentration of the ionosphere following launch to the measurements. Some potential improvements to the models are suggested based on this work. Key Points: The Rocket Lab Electron launch of 22 March 2021 produced measurable decreases in ionospheric total electron contentNumerical modeling using Global Ionosphere Thermosphere Model and navigation satellite signal observations showed comparable ionospheric depletionsThis study highlighted the importance of advection in determining the spatial distribution of ionospheric depletions [ABSTRACT FROM AUTHOR]

A randomized controlled trial was conducted to assess the effectiveness of an artificial intelligence (AI) tool in assisting with fetal anomaly screening ultrasound scans. The study found that the AI-assisted scans had a higher sensitivity and specificity in detecting congenital heart disease (CHD) compared to standard scans. Additionally, the AI-assisted scans were significantly shorter in duration and resulted in a lower cognitive load for sonographers. The study also found that the AI tool provided highly repeatable and reproducible biometric measurements. Further research is being conducted to integrate disease detection models into the AI tool. [Extracted from the article]

The synthesis of polycyclic compounds is of high interest due to the prevalence of these motifs in drugs and natural products. Herein, we report on the stereoselective construction of 3D bicyclic scaffolds and azetidine derivatives by modulation of N‐sulfonylimines to achieve either [4+2]‐ or [2+2]‐cycloaddition reactions. The utility of the method was established by further modulation of the product. Mechanistic studies are also included, which support reaction via Dexter energy transfer. [ABSTRACT FROM AUTHOR]

Multi‐model ensembles (MMEs) are used to improve the forecasts of thermospheric neutral densities. A variety of algorithms for constructing the model weights for the MMEs are described and have been implemented including: performance weighting, independence weighting, and non‐negative least squares. Using both empirical and physics‐based models, compared against in situ Challenging Minisatellite Payload (CHAMP) observations, the skill of each MME weighting approach has been tested in both solar minimum and maximum conditions. In both cases the MME performs better than any individual model. A non‐negative least squares weighting for the MME on a set of bias corrected models provides a 68% and 50% reduction in the mean square error compared to the best model (Jacchia‐Bowman 2008) in the solar minimum and maximum cases, respectively. Plain Language Summary: Combining multiple models of the neutral upper atmosphere (thermosphere) can lead to the cancellation of errors and improved short‐term forecasts of the environment. In this paper a number of different methods for creating these "multi‐model ensembles" (MMEs) are investigated, varying how the different models in the comparison are weighted and combined. Using both statistical and first‐principles models and compared to observations from the Challenging Minisatellite Payload (CHAMP) satellite, the skill of each MME approach has been tested in both solar minimum and maximum conditions. In both cases the MME performs better than any individual model. The best performing combination makes a 68% reduction in the mean square error compared to the best individual model at solar minimum and a 50% improvement at solar maximum. Key Points: Multi‐model ensembles (MMEs) are used to reduce the error in specifying the thermosphereThe MME performs better than any individual model in all test scenariosA non‐negative least squares weighting for the MME reduces the error by 68% at solar minimum and 50% at solar maximum [ABSTRACT FROM AUTHOR]

Two catalytic systems have been developed for the arylboration of endocyclic enecarbamates to deliver synthetically versatile borylated saturated N‐heterocycles in good regio‐ and diastereoselectivities. A Cu/Pd dual catalytic reaction enables the synthesis of borylated, α‐arylated azetidines, while a Ni‐catalysed arylboration reaction efficiently functionalizes 5‐, 6‐, and 7‐membered enecarbamates. In the case of the Cu/Pd‐system, a remarkable additive effect was identified that allowed for broader scope. The products are synthetically useful, as demonstrated by manipulations of the boronic ester to access biologically active compounds. [ABSTRACT FROM AUTHOR]

We show a positive vertical correlation between ozone and water ice using a vertical cross‐correlation analysis with observations from the ExoMars Trace Gas Orbiter's Nadir and Occultation for Mars Discovery instrument. This is particularly apparent during LS = 0°–180°, Mars Year 35 at high southern latitudes, when the water vapor abundance is low. Ozone and water vapor are anti‐correlated on Mars; Clancy et al. (2016, https://doi.org/10.1016/j.icarus.2015.11.016) also discuss the anti‐correlation between ozone and water ice. However, our simulations with gas‐phase‐only chemistry using a 1‐D model show that ozone concentration is not influenced by water ice. Heterogeneous chemistry has been proposed as a mechanism to explain the underprediction of ozone in global climate models (GCMs) through the removal of HOx. We find improving the heterogeneous chemical scheme by creating a separate tracer for the HOx adsorbed state, causes ozone abundance to increase when water ice is present (30–50 km), better matching observed trends. When water vapor abundance is high, there is no consistent vertical correlation between observed ozone and water ice and, in simulated scenarios, the heterogeneous chemistry has a minor influence on ozone. HOx, which are by‐products of water vapor, dominate ozone abundance, masking the effects of heterogeneous chemistry on ozone, and making adsorption of HOx have a negligible impact on ozone. This is consistent with gas‐phase‐only modeled ozone, showing good agreement with observations when water vapor is abundant. Overall, the inclusion of heterogeneous chemistry improves the ozone vertical structure in regions of low water vapor abundance, which may partially explain GCM ozone deficits. Plain Language Summary: Ozone gas is found in small quantities in the martian atmosphere, highly variable both in time and space. Ozone quantity is controlled by photochemical reactions involving other species too difficult to detect with remote sensing. Two main ways ozone is destroyed in the martian atmosphere are by: (a) absorbing ultraviolet sunlight; (b) reacting with hydroxyl radicals, highly reactive chemicals formed by water vapor absorbing ultraviolet sunlight. The latter leads to a well‐known anti‐correlation between ozone and water vapor. Ozone is underpredicted in climate models, implying chemical reactions are missing or incorrect in models. We investigate reactions between hydroxyl radicals and water ice as a potential explanation for the ozone underprediction by using a model and observed vertical profiles. We find observed ozone and water ice have a positive vertical correlation and, when simulating a model with improved chemistry, ozone abundance increases at altitudes where water ice is present due to the decrease in hydroxyl radicals. However, in areas where water vapor is abundant, no such correlation is seen and the chemistry has little impact on modeled ozone. This is due to large abundances of hydroxyl radicals which inhibit the increase in ozone caused by the addition of the improved chemistry. Key Points: Observed ozone and water ice profiles show a positive vertical correlation, contrary to global ozone and water vapor column anti‐correlationHeterogeneous chemistry increases ozone abundance at altitudes where water ice is present, matching locations where ozone is underpredictedHigh hydroxyl radical abundance, assumed proportional to high water vapor abundance, masks the effects of heterogeneous chemistry on ozone [ABSTRACT FROM AUTHOR]

The authors investigated left–right turning preferences of n = 260 juvenile European sea bass (Dicentrarchus labrax) reared in ambient conditions and ocean acidification (OA) conditions or in ambient conditions but tested in OA water. Groups of 10 individuals were observed alone in a circular tank, and individuals' left and right turning during free‐swimming was quantified using trajectory data from the video. The authors showed that near‐future OA levels do not affect the number of turns made, or behavioural lateralization (turning preference), in juvenile D. labrax tested in groups. [ABSTRACT FROM AUTHOR]

Bird pollination systems are diverse, ranging from narrow‐tubed flowers pollinated by specialist nectarivores such as hummingbirds and sunbirds, to relatively open flowers pollinated by opportunistic (i.e. generalist) nectarivores. The role of opportunistic avian nectarivores as pollinators has historically been under‐appreciated. A key aspect to understanding the importance of opportunistic birds as pollinators is to investigate how efficiently they transfer pollen among flowers. Here, we document the pollination and breeding systems of Schotia brachypetala, a southern African tree known as the 'weeping boer‐bean' on account of its prolific production of dilute hexose‐dominated nectar. The cup‐shaped flowers of this tree attract a large number of bird species, including both opportunistic and specialist nectarivores.We identified floral visitors using observations and camera traps and quantified the floral traits responsible for animal attraction. We documented the breeding system, used selective pollinator exclusion to test the contribution of birds to fecundity, and performed supplemental pollination to test for pollen limitation. Single‐visit pollen deposition trials were undertaken to determine the efficacy of bird pollinators.Controlled hand‐pollination experiments showed that S. brachypetala is genetically self‐incompatible and therefore dependent on pollinators for seed production. Supplemental hand‐pollination experiments showed that natural fecundity is limited by either the amount and/or the quality of pollen on stigmas. Flowers from which birds but not insects were experimentally excluded set fewer seeds than open control flowers. Opportunistic birds deposited more pollen per visit than did specialist sunbirds.We conclude that S. brachypetala has a generalized bird pollination system that mainly involves opportunistic nectarivores. [ABSTRACT FROM AUTHOR]

A new strategy for the synthesis of highly versatile cyclobutylboronates via the photosensitized [2+2]‐cycloaddition of alkenylboronates and alkenes is presented. The process is mechanistically different from other processes in that energy transfer occurs with the alkenylboronate as opposed to the other alkene. This strategy allows for the synthesis of an array of diverse cyclobutylboronates. The conversion of these adducts to other compounds as well as their utility in the synthesis of melicodenine C is demonstrated. [ABSTRACT FROM AUTHOR]

The crystal structures of three β‐halolactic acids have been determined, namely, β‐chlorolactic acid (systematic name: 3‐chloro‐2‐hydroxypropanoic acid, C3H5ClO3) (I), β‐bromolactic acid (systematic name: 3‐bromo‐2‐hydroxypropanoic acid, C3H5BrO3) (II), and β‐iodolactic acid (systematic name: 2‐hydroxy‐3‐iodopropanoic acid, C3H5IO3) (III). The number of molecules in the asymmetric unit of each crystal structure (Z′) was found to be two for I and II, and one for III, making I and II isostructural and III unique. The difference between the molecules in the asymmetric units of I and II is due to the direction of the hydrogen bond of the alcohol group to a neighboring molecule. Molecular packing shows that each structure has alternating layers of intermolecular hydrogen bonding and halogen–halogen interactions. Hirshfeld surfaces and two‐dimensional fingerprint plots were analyzed to further explore the intermolecular interactions of these structures. In I and II, energy minimization is achieved by lowering of the symmetry to adopt two independent molecular conformations in the asymmetric unit. [ABSTRACT FROM AUTHOR]

Head trauma in early childhood has been hypothesized as a potential risk factor for childhood brain tumours (CBTs). However, head trauma has not been extensively studied in the context of CBTs and existing studies have yielded conflicting results. A population‐based and hospital‐based case‐control study of children 0 to 15 years with newly diagnosed CBTs from 1997 to 2003 recruited across Ontario through paediatric oncology centres was conducted. Controls were frequency‐matched with cases by age, sex and geographical region. The association was assessed based on multivariable logistic regressions, accounting for child's age, sex, ethnicity, highest level of maternal education and maternal pack‐years of smoking during the pregnancy. Analyses were conducted separately based on age of first head trauma, sex and histology. A latency period analysis was conducted. Overall, based on 280 cases and 919 controls, CBTs were not significantly associated with previous history of head trauma (OR 1.34, 95% CI 0.96, 1.86), head trauma severity, number of head injuries, or head or neck X‐rays or computed tomography (CT) examinations. Results were consistent across sexes and histological subtypes. However, head trauma within the first year of life was significantly associated with CBTs (OR 2.00, 95% CI 1.01, 3.98), but the association diminished when adjusted for X‐ray or CT occurring during the same time period (OR 1.62, 95% CI 0.75, 3.49), albeit limited sample size. Overall, no association was observed between head trauma and CBTs among all children, while head trauma occurring within first year of life may warrant further investigation in future research. What' s new? : Head trauma in early childhood has been hypothesised as a potential risk factor for childhood brain tumours (CBTs). However, existing studies have yielded conflicting results. In this case‐control study of children aged 0–15 years with newly diagnosed brain tumours in Ontario, Canada, no overall association was observed between head trauma and CBTs among the total population of 280 cases and 919 controls. There was an association between head trauma within the first year of life and CBTs, which became non‐significant after adjusting for X‐ray and CT exposures to the head and neck in the same time period. [ABSTRACT FROM AUTHOR]

Mercury (Hg) is a heavy metal that enters the environment through natural and anthropogenic means. Once in the environment, Hg can biomagnify in food webs and is known to cause immunotoxic effects to wildlife. Compared with other vertebrates, knowledge of the reptilian immune system is lacking, especially in snakes. Further, even less is known about the impact of environmental contaminants on snake immunity. This gap in knowledge is largely due to an absence of established immune‐based assays or specific reagents for these species. In this study, brown watersnakes (Nerodia taxispilota; n = 23) were captured on the Savannah River (Augusta, Georgia, USA), weighed, measured, bled, and released. Peripheral blood leukocytes (24 h old) were enriched and evaluated with an established mammalian in vitro lymphocyte proliferation assay. Enriched leukocytes were then exposed to mercury chloride (HgCl2) at 3.75, 37.5, and 75 μM. Total mercury (THg) in whole blood was also quantified. Snake peripheral blood leukocyte enrichment yielded >90% lymphocytes with viabilities averaging >70%. Exposure to HgCl2 resulted in significant dose‐dependent suppression of proliferative responses relative to spontaneous proliferation at 37.5 and 75 μM (both p ≤ 0.01) but not 3.75 μM (p = 0.99). Mean ± 1 SE concentration of THg in whole blood was 0.127 ± 0.027 mg/kg (wet weight). Based on the in vitro findings with HgCl2, snakes in systems with heavy Hg pollution may be at risk of immunosuppression, but N. taxispilota at the site in this study appear to be at low risk. Mercury biomagnifies in food webs and causes immunotoxic effects in wildlife. In this study, leukocytes from wild brown watersnakes were exposed in vitro to mercury chloride (HgCl2) at 3.75, 37.5, and 75 μM. Exposure to HgCl2 resulted in suppression of proliferation at 37.5 and 75 μM (both p ≤ 0.01) but not 3.75 μM. Snakes exposed to heavy mercury pollution may be at risk of immunosuppression, but snakes at the site in this study appear to be at low risk. [ABSTRACT FROM AUTHOR]

Accurate fire emissions inventories are crucial to predict the impacts of wildland fires on air quality and atmospheric composition. Two traditional approaches are widely used to calculate fire emissions: a satellite‐based top‐down approach and a fuels‐based bottom‐up approach. However, these methods often considerably disagree on the amount of particulate mass emitted from fires. Previously available observational datasets tended to be sparse, and lacked the statistics needed to resolve these methodological discrepancies. Here, we leverage the extensive and comprehensive airborne in situ and remote sensing measurements of smoke plumes from the recent Fire Influence on Regional to Global Environments and Air Quality (FIREX‐AQ) campaign to statistically assess the skill of the two traditional approaches. We use detailed campaign observations to calculate and compare emission rates at an exceptionally high‐resolution using three separate approaches: top‐down, bottom‐up, and a novel approach based entirely on integrated airborne in situ measurements. We then compute the daily average of these high‐resolution estimates and compare with estimates from lower resolution, global top‐down and bottom‐up inventories. We uncover strong, linear relationships between all of the high‐resolution emission rate estimates in aggregate, however no single approach is capable of capturing the emission characteristics of every fire. Global inventory emission rate estimates exhibited weaker correlations with the high‐resolution approaches and displayed evidence of systematic bias. The disparity between the low‐resolution global inventories and the high‐resolution approaches is likely caused by high levels of uncertainty in essential variables used in bottom‐up inventories and imperfect assumptions in top‐down inventories. Plain Language Summary: Smoke emitted by wildland fires is dangerous to human health and contributes to climate change. To predict and evaluate the impacts of fires, we need to know how much smoke is emitted into the atmosphere. There are two state‐of‐the‐art methods used to estimate the mass of smoke emitted by fires, but they often disagree. In this study, we use unusually detailed measurements collected using an aircraft that flew within wildland fire smoke plumes to calculate the amount of smoke emitted from fires in the Western United States. We compare emission rates derived from the exceptionally high spatial and temporal resolution approach to the two traditional, lower resolution approaches to understand why they sometimes diverge. Key Points: In situ measurements of wildland fire smoke plumes provide emission rates for evaluating emissions inventories at unprecedented resolutionFire emissions inventories struggle to capture the emissions rate characteristics of individual fires but may perform well in the aggregateBottom‐up inventories suffer from major uncertainty in key variables, while top‐down inventories may have bias from imperfect assumptions [ABSTRACT FROM AUTHOR]

We present ∼1.5 Mars Years (MY) of ozone vertical profiles, covering LS = 163° in MY34 to LS = 320° in MY35, a period which includes the 2018 global dust storm. Since April 2018, the Ultraviolet and Visible Spectrometer channel of the Nadir and Occultation for Mars Discovery (NOMAD) instrument aboard the ExoMars Trace Gas Orbiter has observed the vertical, latitudinal and seasonal distributions of ozone. Around perihelion, the relative abundance of both ozone and water (from coincident NOMAD measurements) increases with decreasing altitude below ∼40 km. Around aphelion, localized decreases in ozone abundance exist between 25 and 35 km coincident with the location of modeled peak water abundances. High‐latitude (>±55°), high altitude (40–55 km) equinoctial ozone enhancements are observed in both hemispheres (LS ∼350°–40°) and discussed in the companion article to this work (Khayat et al., 2021). The descending branch of the main Hadley cell shapes the observed ozone distribution at LS = 40°–60°, with the possible signature of a northern hemisphere thermally indirect cell identifiable from LS = 40°–80°. Morning terminator observations show elevated ozone abundances with respect to evening observations, with average ozone abundances between 20 and 40 km an order of magnitude higher at sunrise compared to sunset, attributed to diurnal photochemical partitioning along the line of sight between ozone and O or fluctuations in water abundance. The ozone retrievals presented here provide the most complete global description of Mars ozone vertical distributions to date as a function of season and latitude. Plain Language Summary: We present over two years of new observations of the vertical distribution of ozone in the atmosphere of Mars. The ExoMars Trace Gas Orbiter spacecraft has been recording observations of the Martian atmosphere since 2018 to map the presence and changes in abundance of gases such as ozone by using the "Nadir and Occultation for Mars Discovery (NOMAD)" instrument. NOMAD continually observes the change in ozone abundance (among other gases) at different heights across much of the planet. These abundance profiles have revealed the presence of distinct layers of ozone enhancement at high altitudes in the atmosphere of Mars toward the polar regions and between spring and autumn in the southern hemisphere of Mars, discussed in detail in the companion article. We observe broad periods where often the abundance of ozone follows the abundance of water from ∼10 km altitude up to ∼50 km altitude, and other times when the two appear to be opposite in their variation with height. Our retrievals of ozone from NOMAD data provide the first coincident observations of ozone and water and provide previously unavailable information on the photochemistry of Mars. Key Points: The annual Martian O3 distribution has been measured at a vertical resolution up to 0.2 km and for the first time alongside H2O profilesO3 and H2O show strong vertical anti‐correlation around aphelion as expected, contrasted with vertical correlation toward perihelionO3 abundances between altitudes of 20–40 km are an order of magnitude higher at sunrise than at sunset between LS = 40°–50° [ABSTRACT FROM AUTHOR]

The time that animals spend travelling at various speeds and the tortuosity of their movement paths are two of the many things that affect space‐use by animals. In this, high turn rates are predicted to be energetically costly, especially at high travel speeds, which implies that animals should modulate their speed according to path characteristics. When animals move so as to maximize distance and minimize metabolic energy expenditure, they travel most efficiently at the speed that gives them a minimum cost of transport (COTmin), a well‐defined point for animals that move entirely in fluid media. Theoretical considerations show though, that land animals should travel at their maximum speed to minimize COT, which they do not, instead travelling at walking pace. So, to what extent does COTmin depend on speed and turn rate and how might this relate to movement paths? We measured oxygen consumption in humans walking along paths with varied tortuosity at defined speeds to demonstrate that the energetic costs of negotiating these paths increase disproportionately with both speed and angular velocity. This resulted in the COTmin occurring at very low speeds, and these COTmin speeds reduced with increased path tortuosity and angular velocity. Logged movement data from six free‐ranging terrestrial species underpinned this because all individuals turned with greater angular velocity the slower their travel speeds across their full speed range. It seems, therefore, that land animals may strive to achieve minimum movement costs by reducing speed with increasing path variability, providing one of many possible explanations as to why speed is much lower than currently predicted based on lab measurements of mammalian locomotor performance. [ABSTRACT FROM AUTHOR]

This article explores the phenomenon of the call to professional public service in Canada. It draws on the testimonials of exemplars in Canada and elsewhere, and research findings from the fields of prosocial behaviour and public service motivation (PSM), and especially from motivational psychology, with its concepts of "flow" and "element," to shed light on the dynamics of the call and steps professional public services can take to best mobilize individuals responding to it. The conclusion suggests there should be greater acknowledgement of the reality of the call, embeds the call in PSM theory, and sets out an agenda for research. [ABSTRACT FROM AUTHOR]

Double‐allylation reagents allow for the construction of highly complex molecules in an expedient fashion. We have developed an efficient, modular, and enantioselective approach towards accessing novel variants of these reagents through Cu/Pd‐catalyzed alkenylboration of alkenylboron derivatives. Importantly, we demonstrate novel use of an allylBdan reagent directly in a stereocontrolled allylation without initial deprotection to the boronic ester. These allylation products are employed in a second intermolecular allylation to access complex diol motifs, which has yet to be shown with these types of double‐allylation reagents. Overall, the modularity of this approach and the ease in which complex structural motifs can be accessed in a rapid manner signify the importance and utility of this method. [ABSTRACT FROM AUTHOR]

A process to achieve 1,2‐metalate rearrangements of indole boronate as a way to access substituted indolines in high diastereoselectivities is presented. The reaction involves the generation of a Cu–allenylidene, which is sufficiently electrophilic to induce the 1,2‐metalate rearrangement. The scope of the reaction is evaluated as well as further transformations of the product. [ABSTRACT FROM AUTHOR]

Increasing carbon dioxide causes cooling in the upper atmosphere and a secular decrease in atmospheric density over time. With the use of the Whole Atmospheric Community Climate Model with thermosphere and ionosphere extension (WACCM‐X), neutral thermospheric densities up to 500 km have been modeled under increasing carbon dioxide concentrations. Only carbon dioxide and carbon monoxide concentrations are changed between simulations, and solar activity is held low at F10.7 = 70 throughout. Neutral density decreases through to the year 2100 have been modeled using four carbon dioxide emission scenarios produced by the Intergovernmental Panel on Climate Change (IPCC). The years 1975 and 2005 have also been simulated, which indicated a historic trend of −5.8% change in neutral density per decade. Decreases in the neutral density relative to the year 2000 have been given for increasing ground‐level carbon dioxide concentrations. WACCM‐X shows there has already been a 17% decrease in neutral densities at 400 km relative to the density in the year 2000. This becomes a 30% reduction at the 50:50 probability threshold of limiting warming to 1.5°C, as set out in the Paris Agreement. A simple orbital propagator has been used to show the impact the decrease in density has on the orbital lifetime of objects traveling through the thermosphere. If the 1.5°C target is met, objects in Low Earth Orbit (LEO) will have orbital lifetimes around 30% longer than comparable objects from the year 2000. Plain Language Summary: The atmosphere extends upwards into the lower regions of space. Here, carbon dioxide causes cooling of the atmosphere and a decrease in atmospheric density. These density reductions have been simulated for increasing CO2 concentrations up to an altitude of 500 km by computationally modeling the Earth's atmosphere. For reference, the International Space Station orbits at around 400 km. Density reductions up to the year 2100 have been given for the four CO2 concentration scenarios published by the Intergovernmental Panel on Climate Change (IPCC). The model has shown there has already been a 17% decrease in atmospheric density at an altitude of 400 km since the year 2000. This will reach a maximum of 30% if the Paris Agreement target to limit global warming to 1.5°C is met. Objects in low Earth orbit travel through the thin, upper atmosphere. A reduction in density at these altitudes means a decrease in the amount of atmospheric drag that orbiting objects experience. This increases the amount of time it takes for their orbit to decay. If the 1.5°C target is met, orbital lifetimes will be 30% longer than those in the year 2000. Key Points: Thermospheric neutral density at 500 km altitude lowers by over 80% with a high ground‐level carbon dioxide concentration of 890 ppmMeeting the 1.5°C Paris Agreement target limits the reduction in neutral density at 400 km since the year 2000 to around 28%Objects in Low Earth Orbit (LEO) will have orbital lifetimes around 30% longer at the 1.5°C target than comparable objects from the year 2000 [ABSTRACT FROM AUTHOR]

The ladderane family of natural products are well known for their linearly concatenated cyclobutane skeletal structure. Owing to their unique carbocyclic framework, several chemical syntheses have been reported since their discovery in 2002. The focus of this review is to showcase the novel tactics that have been used to generate the ladderane core and the challenges that are associated with the synthesis of these unusual and complex natural products. [ABSTRACT FROM AUTHOR]

Aim: To compare the frequency and factors associated with diabetes medication‐taking (depression, perceived side effects, self‐efficacy and social support) in people with mild to moderate intellectual disability and those without intellectual disability. Methods: In stage 1 of this study, we collated information on diabetes medication‐taking and associated factors in 111 people with diabetes: 33 adults with mild to moderate intellectual disability and 78 adults without intellectual disability. Validated instruments measuring medicine‐taking, self efficacy, depressive symptoms, perceived level of social support and perceived side effects were administered in both groups. In stage 2, we used an abductive qualitative approach to triangulate stage 1 findings with carers responses (n = 12). Results: The instruments showed good internal reliability (Cronbach's α = 0.7–0.9). Comparisons between people with intellectual disabilities and those without revealed similar frequency of medication‐taking (70% vs 62%; P = 0.41). People with intellectual disabilities and diabetes had significantly higher depressive symptoms, as measured by the Glasgow Depression Scale for people with a Learning Disability (P = 0.04), higher levels of perceived side effects (P = 0.01), and lower confidence levels, as measured by the Perceived Confidence Scale (P = 0.01). The results of stage 2 showed how carers of people with intellectual disabilities and diabetes optimized medication‐taking yet infrequently discussed the side effects of medicines. Conclusions: Further investigation of medication‐taking and side effects may result in the development of an evidence‐informed intervention to improve medicines safety in people with intellectual disabilities. What's new?: Approximately 30–50% of medicines are not taken as prescribed, with a paucity of research on medication‐taking specific to people with intellectual disability.The frequency of medication‐taking in adults with diabetes with and without intellectual disabilities is similar. People with intellectual disabilities and diabetes had perceived side effects to be greater compared to people without intellectual disabilities and diabetes.People with intellectual disabilities and diabetes may benefit from increased pharmacovigilance and screening for side effects by family, paid carers and healthcare professionals. [ABSTRACT FROM AUTHOR]

A copper‐based complex that contains a sulfonate N‐heterocyclic carbene ligand was first reported 15 years ago. Since then, these organometallic entities have proven to be uniquely effective in catalyzing an assortment of enantioselective transformations, including allylic substitutions, conjugate additions, proto‐boryl additions to alkenes, boryl and silyl substitutions, hydride‐allyl additions to alkenyl boronates, and additions of boron‐containing allyl moieties to N‐H ketimines. In this review article, we detail the shortcomings in the state‐of‐the‐art that fueled the development of this air stable ligand class, members of which can be prepared on multigram scale. For each reaction type, when relevant, the prior art at the time of the advance involving sulfonate NHC‐Cu catalysts and/or subsequent key developments are briefly analyzed, and the relevance of the advance to efficient and enantioselective total or formal synthesis of biologically active molecules is underscored. Mechanistic analysis of the structural attributes of sulfonate NHC‐Cu catalysts that are responsible for their ability to facilitate transformations with high efficiency as well as regio‐ and enantioselectivity are detailed. This review contains several formerly undisclosed methodological advances and mechanistic analyses, the latter of which constitute a revision of previously reported proposals. [ABSTRACT FROM AUTHOR]

Objective: To develop a core outcome set for pre-eclampsia.Design: Consensus development study.Setting: International.Population: Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.Methods: Modified Delphi method and Modified Nominal Group Technique.Results: A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.Conclusions: The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies.Tweetable Abstract: 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.]. [ABSTRACT FROM AUTHOR]

A method for the stereoselective [4+2]‐cycloaddition of alkenylboranes and dienes is presented. This transformation was accomplished through the introduction of a new strategy that involves the use of chiral N‐protonated alkenyl oxazaborolidines as dieneophiles. The reaction leads to the formation of products that can be readily derivatized to more complex structural motifs through stereospecific transformations of the C−B bond such as oxidation and homologation. Detailed computation evaluation of the reaction has uncovered a surprising role of the counterion on stereoselectivity. [ABSTRACT FROM AUTHOR]

Background and purpose: The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors. Methods: This was a secondary analysis of the multicentre prospective observational CROMIS‐2 ICH study. Death was defined as 'early' if occurring within 6 months of study entry and 'late' if occurring after this time point. Results: In our cohort (n = 1094), there were 306 deaths (per 100 patient‐years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were 'early' and 150 'late'. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre‐event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre‐event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time. Conclusions: We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH. [ABSTRACT FROM AUTHOR]

Aim: To investigate the use of magnification in undergraduate endodontic teaching in dental schools within the UK and Ireland and identify factors that may impact on levels of adoption. Methodology: An electronic questionnaire was distributed to teaching leads in undergraduate endodontics in all UK and Ireland dental schools. Results: Completed questionnaires were received from 15 of 18 course leads. The study revealed magnification is not universally embedded within the undergraduate curricula, and the majority of schools had no expectation for students to use magnification, although it was encouraged. The study provided insight into teaching staff factors, student factors and institutional factors that impact upon the adoption of magnification in undergraduate endodontic teaching. Although course leads utilized magnification in their own practice, this did not translate into institutional expectation for students to use magnification. Barriers to adoption of such an institutional expectation included cost and lack of staff training. Conclusions: Magnification has become viewed as an essential part of endodontic practice. The dental operating microscope has the most significant impact on endodontic visualization; however, the use of dental loupes in nonsurgical endodontics could be considered the minimum standard. The pedagogical dilemma faced by dental educators training undergraduates to behave in a manner that they themselves would not, cannot be rationalized on the basis of cost and lack of staff training. It is proposed that although significant, these barriers are not insurmountable and the use of dental loupe should become an expectation in undergraduate training in the UK and Ireland. [ABSTRACT FROM AUTHOR]

Parasitism can result in dramatic changes in host phenotype, which are themselves underpinned by genes and their expression. Understanding how hosts respond at the molecular level to parasites can therefore reveal the molecular architecture of an altered host phenotype. The entomoparasitic nematode Sphaerularia bombi is a parasite of bumblebee (Bombus) hosts where it induces complex behavioural changes and host castration. To examine this interaction at the molecular level, we performed genome‐wide transcriptional profiling using RNA‐Sequencing (RNA‐Seq) of S. bombi‐infected Bombus terrestris queens at two critical time‐points: during and just after overwintering diapause. We found that infection by S. bombi affects the transcription of genes underlying host biological processes associated with energy usage, translation, and circadian rhythm. We also found that the parasite affects the expression of immune genes, including members of the Toll signalling pathway providing evidence for a novel interaction between the parasite and the host immune response. Taken together, our results identify host biological processes and genes affected by an entomoparasitic nematode providing the first steps towards a molecular understanding of this ecologically important host–parasite interaction. [ABSTRACT FROM AUTHOR]

A method for the regioselective 1,2‐arylboration of 1,3‐butadiene, a feedstock chemical, is reported. The reactions result in the formation of products that can be easily elaborated to other structures. The mechanistic details of this process are also discussed. [ABSTRACT FROM AUTHOR]

Objective: Electrically evoked auditory brainstem responses (EABR) guide placement of the multichannel auditory brainstem implant (ABI) array during surgery. EABRs are also recorded under anesthesia in nontumor pediatric ABI recipients prior to device activation to confirm placement and guide device programming. We examine the influence of anesthesia on evoked response morphology in pediatric ABI users by comparing intraoperative with postoperative EABR recordings.Study Design: Retrospective review.Methods: Seven children underwent ABI surgery by way of retrosigmoid craniotomy. General anesthesia included inhaled sevoflurane induction and propofol maintenance during which EABRs were recorded to confirm accurate positioning of the ABI. A mean of 7.7 ± 2.8 weeks following surgery, the ABI was activated under general anesthesia or sedation (dexmedetomidine) and EABR recordings were made. A qualitative analysis of intraoperative and postoperative waveform morphology was performed.Results: Seven subjects (mean age 20.6 months) underwent nine ABI surgeries (seven primary, two revisions) and nine activations. EABRs were observed in eight of nine postoperative recordings. In three cases, intraoperative EABRs during general anesthesia were similar to postoperative EABRs with sedation. In one case, sevoflurane and propofol were used for intra- and postoperative recordings, and waveforms were also similar. In four cases, amplitude and latency changes were observed for intraoperative versus postoperative EABRs.Conclusion: Similarity of EABR morphology in the anesthetized versus sedated condition suggests that anesthesia does not have a large effect on far-field evoked potentials. Changes in EABR waveform morphology observed postoperatively may be influenced by other factors such as movements of the surface array.Level Of Evidence: 4 Laryngoscope, 130:507-513, 2020. [ABSTRACT FROM AUTHOR]

The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)‐[5]‐ladderanoic acid is reported. En route to the target, unusual and unexpected strain release driven transformations were uncovered. This occurrence required a drastic revision of the synthetic design that ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweifel olefination sequence. [ABSTRACT FROM AUTHOR]

Toxin handlers are organizational members who help colleagues manage negative emotions in the workplace. Although toxin handling activities help distressed employees remain productive, they put the toxin handler at risk of emotional exhaustion. In this research, more than 400 HR managers described their experience managing emotionally charged employee problems. We found that formalizing toxin handling responsibilities provided a buffering effect: HR managers whose organizations had made handling emotionally charged employee problems a formal part of HR responsibilities experienced lower levels of emotional exhaustion and perceived HR as more effective, even when they engaged in high levels of toxin handling. Formalizing toxin handling responsibilities may protect HR managers from harm and ensure that they maintain the toxin handling function in their organizations. © 2009 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

A method for the construction of boron‐substituted quaternary carbons or diarylquaternary carbons by arylboration of highly substituted alkenylarenes is presented. A wide range of alkenes and arylbromides can participate in this reaction thus allowing for a diverse assortment of products to be prepared. In addition, a solvent dependent regiodivergent arylboration of 1,2‐disubstituted alkenylarenes is presented, thus greatly increasing the scope of products that can be accessed. [ABSTRACT FROM AUTHOR]

Background: Health behaviors including smoking cessation, physical activity (PA), and alcohol moderation are key aspects of cancer survivorship. Immigrants may have unique survivorship needs. We evaluated whether immigrant cancer survivors had health behaviors and perceptions that were distinct from native‐born cancer survivors. Methods: Adult cancer patients from Princess Margaret Cancer Centre were surveyed on their smoking, PA, and alcohol habits and perceptions of the effects of these behaviors on quality of life (QoL), 5‐year survival, and fatigue. Multivariable models evaluated the association of immigration status and region‐of‐origin on behaviors and perceptions. Results: Of the 784 patients, 39% self‐identified as immigrants. Median time of survey was 24 months after histological diagnosis. At baseline, immigrants had trends toward not meeting Canadian PA guidelines or being ever‐drinkers; patients from non‐Western countries were less likely to smoke (aORcurrent = 0.46, aORex‐smoker = 0.47, P = 0.02), drink alcohol (aORcurrent = 0.22, aORex‐drinker = 0.52, P < 0.001), or meet PA guidelines (aOR = 0.44, P = 0.006). Among immigrants, remote immigrants (migrated ≥40 years ago) were more likely to be consuming alcohol at diagnosis (aOR = 5.70, P < 0.001) compared to recent immigrants. Compared to nonimmigrants, immigrants were less likely to perceive smoking as harmful on QoL (aOR = 0.58, P = 0.008) and survival (aOR = 0.56, P = 0.002), and less likely to perceive that PA improved fatigue (aOR = 0.62, P = 0.04) and survival (aOR = 0.64, P = 0.08). Conclusions: Immigrants had different patterns of health behaviors than nonimmigrants. Immigrants were less likely to perceive continued smoking as harmful and were less likely to be aware of PA benefits. Culturally tailored counselling may be required for immigrants who smoke or are physically sedentary at diagnosis. [ABSTRACT FROM AUTHOR]

The development of pyridylidene‐Cu‐complexes and their application in Cu/Pd‐catalyzed heteroarylboration of alkenylheteroarenes is reported. The significance of 1,1′‐heteroarylalkanes as building blocks for drug discovery, as well as the straightforward and modular sequence to prepare the pyridylidene‐Cu‐complexes, makes this catalyst and it applications attractive for chemical synthesis. Furthermore, chiral variants of the pyridylidene‐Cu‐complexes have been prepared and utilized in the enantioselective arylboration of E‐alkenes, further demonstrating the value and potential of this class of catalysts. [ABSTRACT FROM AUTHOR]

Two methods are reported for the 1,2‐ and 1,1‐arylboration of α‐methyl vinyl arenes. In the case of 1,2‐arylboration, the formation of a quaternary center occurred through a rare cross‐coupling reaction of a tertiary organometallic complex. 1,1‐Arylboration was enabled by catalyst optimization and occurred through a β‐hydride elimination/reinsertion cascade. Enantioselective variants of both processes are presented as well as mechanistic investigations. Keep your options open: Methods were developed for both the 1,2‐ and 1,1‐arylboration of α‐alkyl alkenyl arenes, including enantioselective variants. The formation of quaternary centers by 1,2‐arylboration occurred through a rare cross‐coupling of a tertiary organometallic complex (see scheme). 1,1‐Arylboration was enabled by catalyst optimization and occurred through a β‐hydride elimination/reinsertion cascade. [ABSTRACT FROM AUTHOR]

Summary: An 8‐year‐old Appaloosa mare with rectal paralysis due to a cosmetic ethanol ‘tail block’ was treated with traditional Chinese veterinary medicine treatments including acupuncture and herbal medicine. Her rectal and tail tone gradually improved after the treatment. At 4 months after initial presentation, the mare was able to produce faecal piles on a regular basis, and manual evacuations were no longer needed. Significant improvement was within 30 days of beginning treatment. At 8 months, the owner indicated that the mare had normal defaecation, was able to swish the tail from side to side and lift the tail to urinate, and had no evidence of straining to defaecate or colic. [ABSTRACT FROM AUTHOR]

Abstract: Background: Individuals with intellectual disability (ID) are at greater risk of exposure to traumatic life events compared with the non‐ID population. Yet no study to date has examined the role of multiple traumatisation and subsequent psychopathology in people with ID. The aim of this study was to explore the association between multiple traumatisation and subsequent mental health. Methods: A preliminary cross‐sectional study involving 33 participants with DSM‐5 post‐traumatic stress disorder completed self‐report questionnaires on exposure to traumatic life events and post‐traumatic stress disorder symptoms, anxiety, depression and general distress. Results: A proportion of 42.4% of the sample reported multiple traumatisation, including exposure to life events in both childhood and adulthood. Those who reported exposure to life events in childhood and adulthood reported significantly higher risk of harm, depression and general psychological distress compared with those who reported exposure to life events only in adulthood. Conclusions: Preliminary results indicate that more severe psychopathology is associated with multiple traumatisation in childhood and adulthood compared with trauma experienced solely in adulthood. [ABSTRACT FROM AUTHOR]