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Lessons in Strain and Stability: Enantioselective Synthesis of (+)‐[5]‐Ladderanoic Acid.
- Source :
- Angewandte Chemie International Edition; 1/2/2020, Vol. 59 Issue 1, p436-441, 6p
- Publication Year :
- 2020
-
Abstract
- The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)‐[5]‐ladderanoic acid is reported. En route to the target, unusual and unexpected strain release driven transformations were uncovered. This occurrence required a drastic revision of the synthetic design that ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweifel olefination sequence. [ABSTRACT FROM AUTHOR]
- Subjects :
- NATURAL products
ALLYLBORATION
CYCLOBUTANE
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 140845874
- Full Text :
- https://doi.org/10.1002/anie.201910901