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This article discusses the successful treatment of epidermal nevus (EN) in a patient with phacomatosis spilosebacea (PSS) using topical sirolimus. EN is a type of birthmark, while PSS is a rare disorder characterized by the presence of EN along with other organ system involvement. Treatment of EN can be challenging, but topical sirolimus has shown promising results in managing difficult-to-treat dermatological disorders. In this case, a patient with PSS experienced a marked decrease in thickness of the EN lesions after 5 weeks of treatment with topical sirolimus, with no adverse effects reported. Further follow-up is needed to confirm the long-term improvement. [Extracted from the article]

Primary TMAU is a rare metabolic disorder that results from the failure of hepatic FMO3 to oxidize TMA due to a mutation in the I FMO3 i gene. Trimethylaminuria (TMAU) is a rare metabolic disorder characterized by an unpleasant body odor resembling decaying fish.[1] Biochemically, all affected patients present with an increased amount of trimethylamine (TMA) due to a mutation in the I FMO3 i gene, leading to the inability to oxidize this amine to the non-odorous metabolite, trimethylamine N-oxide (TMAO).[2] Patients with TMAU may experience serious psychosocial phenomena that limit their quality of life and also several systemic diseases.[3] Many therapeutic regimens have been proposed, and TMAU symptoms can be temporarily alleviated with certain drugs. Our patient exhibited a substantial and sustained improvement after a deprivation diet, underlining the importance of avoiding food containing elevated amounts of TMA in patients with mutations affecting the I FMO3 i gene. [Extracted from the article]

Immunofluorescence of the patient affected skin with monoclonal antibodies against high molecular weight keratins (34 E12), OSMR and caspase-3 was also performed (Supplementary Data). Keywords: amyloidosis; apoptosis; caspases EN amyloidosis apoptosis caspases 1638 1640 3 10/06/22 20221001 NES 221001 Primary localized cutaneous amyloidosis (PLCA) is a rare form of cutaneous amyloidosis, characterized by the presence of flat-topped papules and macules with amyloid deposits in the superficial dermis. [Extracted from the article]

Hailey-Hailey disease (HHD) is a rare genodermatosis caused by a mutation in the ATP2C1 gene, which codes for a calcium channel. Therefore, we suggest the combined use of apremilast with BoNT infiltrations as rescue treatment for lesions located in skin folds with excessive sweating activity. Here we present a case of refractory HHD who experienced an excellent response after treatment with apremilast and botulinum toxin-A (BoNT) infiltrations. [Extracted from the article]

Unilateral linear capillaritis is a rare variant of the pigmented purpuric dermatoses that can be misdiagnosed due to confusion with other cutaneous diseases that follow a linear distribution. We present the case of an 8‐year‐old boy with hyperpigmented patches linearly distributed on the right arm, initially diagnosed with segmental neurofibromatosis. [ABSTRACT FROM AUTHOR]

The appearance of morphea after vaccination has been reported to date as single and deep lesions that appear exactly at the site of the skin puncture. It was therefore postulated that the origin could be the trauma related to the injection. The aim of this article is to review the various hypotheses offered in the published literature about generalized morphea following vaccination. We present two cases of generalized morphea after COVID-19 vaccination and review the published literature on immune-related cutaneous reactions. As previously reported, antigenic cross-reactivity between vaccine spike proteins and human tissues could cause certain immune-mediated diseases, including generalized morphea. Herein we report two cases of generalized morphea probably induced by the COVID-19 vaccine, given the temporal relationship with its administration. In summary, environmental factors such as vaccination against SARS-COV-2 could induce an immune system dysregulation, which would have an important role in the pathogenesis of morphea. We present two cases of generalized morphea probably induced by the COVID-19 vaccine, given the time elapsed between vaccination and the onset of the skin lesions., (© 2022 The Authors. Dermatologic Therapy published by Wiley Periodicals LLC.)