Apremilast in combination with botulinum toxin‐A injection for recalcitrant Hailey‐Hailey disease.

Hailey-Hailey disease (HHD) is a rare genodermatosis caused by a mutation in the ATP2C1 gene, which codes for a calcium channel. Therefore, we suggest the combined use of apremilast with BoNT infiltrations as rescue treatment for lesions located in skin folds with excessive sweating activity. Here we present a case of refractory HHD who experienced an excellent response after treatment with apremilast and botulinum toxin-A (BoNT) infiltrations. [Extracted from the article]