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Rapid advances in digital hearing technologies, also known as hearables, are expected to disrupt the direct‐to‐consumer health market. For older adults with higher incidence of hearing loss, such disruption could reduce hearing problems, increase accessibility to hearing aids, and mitigate related stigmas. This paper delves into the intersection of disruptive innovation and hearables within the realm of biomedical ethics. Through a comprehensive exploration, we shed light on the ethical implications surrounding hearables. By critically evaluating the key ethical advantages and drawbacks, we find that no single concern presents an insurmountable a priori objection to hearables. We conclude with some ideas to maximize the benefits of hearables and further promote opportunities for equitable hearing health. [ABSTRACT FROM AUTHOR]

Objectives: Attention‐deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental condition and is characterized by inattention, hyperactivity, and impulsivity. Research suggests that some populations, such as females and individuals with high intelligence quotients may be a risk for late ADHD diagnosis and subsequent treatment. Our goal is to advance our understanding of ADHD diagnosis, by examining (1) how child sex and cognitive abilities together are related to the age of diagnosis and (2) whether symptom presentation, current internalizing and externalizing symptoms, and demographic factors are related to age of diagnosis. Methods: Our analyses contained children who completed the required tests (N = 568) from a pre‐existing dataset of 1380 children with ADHD from the Province of Ontario Neurodevelopmental Disorders (POND) Network (pond‐network.ca). First, we conducted a moderation analysis with sex as the predictor, cognitive abilities as the moderator, and age of diagnosis as the outcome. Second, we conducted correlation analyses examining how symptom presentation, current internalizing and externalizing symptoms, and demographic factors are related to age of diagnosis. Results: Higher IQ was related to a later age of diagnosis. Higher hyperactive–impulsive symptoms and externalizing symptoms were related to an earlier age of diagnosis. Internalizing symptoms were trend associated with a later age of diagnosis in girls. Higher socioeconomic status and non‐White maternal ethnicity were related to later age of diagnosis. Conclusions: IQ, sex, ADHD symptomology, internalizing symptoms, externalizing symptoms, and socio‐demographic factors affect the age of diagnosis. [ABSTRACT FROM AUTHOR]

The world's rich diversity of bats supports healthy ecosystems and important ecosystem services. Maintaining healthy biological systems requires prompt identification of threats to biodiversity and immediate action to protect species, which for wide‐ranging bat species that span geopolitical boundaries warrants international coordination. Anthropogenic forces drive the threats to bats throughout North America and the world. We conducted an international expert elicitation to assess the status of 153 bat species in Canada, the United States, and Mexico. We used expert assessment to determine the conservation status, highest impact threats, and recent population trends for these species. We found that 53% of North American bat species have moderate to very high risk of extinction in the next 15 years. The highest impact threats varied with species and country, and four IUCN threat categories had the greatest overall impacts: Climate Change, Problematic Species (including disease), Agriculture, and Energy Production. Experts estimated that 90% of species assessed had decreasing population trends over the past 15 years, demonstrating the need for conservation action. Although the state of North American bats is concerning, we identify threats that can be addressed through internationally collaborative, proactive, and protective actions to support the recovery and resilience of North American bat species. [ABSTRACT FROM AUTHOR]

Vascular corrosion casting is a method used to visualize the three dimensional (3D) anatomy and branching pattern of blood vessels. A polymer resin is injected in the vascular system and, after curing, the surrounding tissue is removed. The latter often deforms or even fractures the fragile cast. Here, a method is proposed that does not require corrosion, and is based on in situ micro computed tomography (micro‐CT) scans. To overcome the lack of CT contrast between the polymer cast and the animals' surrounding soft tissue, hafnium oxide nanocrystals (HfO2 NCs) are introduced as CT contrast agents into the resin. The NCs dramatically improve the overall CT contrast of the cast and allow for straightforward segmentation in the CT scans. Careful design of the NC surface chemistry ensures the colloidal stability of the NCs in the casting resin. Using only 5 m% of HfO2 NCs, high‐quality cardiovascular casts of both zebrafish and mice can be automatically segmented using CT imaging software. This allows to differentiate even μ$\umu$m‐scale details without having to alter the current resin injection methods. This new method of virtual dissection by visualizing casts in situ using contrast‐enhanced CT imaging greatly expands the application potential of the technique. [ABSTRACT FROM AUTHOR]

Multivariate extreme value distributions are a common choice for modeling multivariate extremes. In high dimensions, however, the construction of flexible and parsimonious models is challenging. We propose to combine bivariate max‐stable distributions into a Markov random field with respect to a tree. Although in general not max‐stable itself, this Markov tree is attracted by a multivariate max‐stable distribution. The latter serves as a tree‐based approximation to an unknown max‐stable distribution with the given bivariate distributions as margins. Given data, we learn an appropriate tree structure by Prim's algorithm with estimated pairwise upper tail dependence coefficients as edge weights. The distributions of pairs of connected variables can be fitted in various ways. The resulting tree‐structured max‐stable distribution allows for inference on rare event probabilities, as illustrated on river discharge data from the upper Danube basin. [ABSTRACT FROM AUTHOR]

Mobile health tools are often said to empower users by providing them with the information they need to exercise control over their health. We aim to bring clarity to this claim, and in doing so explore the relationship between empowerment and autonomy. We have identified three distinct models embedded in the empowerment rhetoric: empowerment as information, empowerment as control, and empowerment as values. Each distinct model of empowerment gives rise to an associated problem. These problems, the Problem of Interpretation, the Value Alignment Problem, and the Priority Problem, show that mobile health tools in their current form are either insufficient for empowerment or are self‐defeating. These digital health technologies encourage users to adopt an individualized conception of autonomy, one that may weaken the doctor–patient relationship and undermine practices in shared decision making, and ultimately may not deliver on improving the health outcomes for those that need it the most. [ABSTRACT FROM AUTHOR]

Background: Reading comprehension is an interactive process. Yet, instructional needs are usually identified with isolated componential tests. This study examined whether a dynamic approach, in which componential abilities are measured within the same text and global text comprehension is facilitated via feedback, can help in understanding variation in children's reading comprehension. Objectives: With a pretest‐posttest control group design, componential abilities before and after feedback were related to growth in global text comprehension within the same text. Methods: At pretest, third to fifth graders read 30 short texts, each followed by one global text comprehension question. This was repeated at posttest, but additional questions were asked with feedback prior to each global text comprehension question. The vocabulary group received two vocabulary questions with feedback (n = 97). The vocabulary plus integration group received two vocabulary questions and one sentence‐integration question with feedback (n = 98). The control group (n = 98) only answered the global text comprehension questions. Results and Conclusion: Participants in the experimental conditions who needed feedback (i.e., lower‐skilled) experienced a decrease in global text comprehension, whereas this was not found for the control group and participants in the experimental groups who did not need feedback (i.e., higher‐skilled). There was also less decrease among those lower‐skilled participants who had profited from the feedback. Implications: It is concluded from explorative analyses that not feedback but the overall design caused the decrease. Conceptually, the dynamic approach is worth further research. Lay Description: What is already known about this topic: Reading comprehension is a complex interaction of several componential abilities at word level, sentence level, and text level (e.g., vocabulary and sentence‐integration).Instruction should adapt to the profile of strengths and weaknesses in componential abilities.Assessing componential abilities with isolated tests does not align with the interactive processes in reading comprehension.Measuring learning ability can help to identify children with low responsiveness to instruction. What this paper adds: Reading comprehension is profiled by asking questions on vocabulary, sentence‐integration, and global text comprehension for the same text in third to fifth graders (8–11 years olds).Feedback is provided after a mistake in a vocabulary and sentence‐integration question, and the feedback effect on global text comprehension is measured with a pretest‐posttest design.Children who receive feedback decrease in global text comprehension but children with higher skills in componential abilities decrease less.Explorative analyses and previous research indicate that the assessment design had a negative impact on performance, for example, via cognitive load, attention, self‐esteem, and motivation. Implications for practice and/or policy: Global text comprehension cannot always be facilitated by providing feedback on vocabulary and sentence‐integration within the same text.The design of the assessment and its influence on performance should be carefully considered by instructional designers, educators, and researchers, especially in case of young learners.It remains unclear from this study if facilitating global text comprehension via feedback with a dynamic approach is useful to understand variation in children's reading comprehension.The dynamic approach with a proper design may potentially still provide a useful insight in individual differences. [ABSTRACT FROM AUTHOR]

The article explores the complex ethical implications of assisted reproductive technologies (ART) on family-making and reproductive autonomy. Topics discussed include the evolving motivations behind egg freezing, the moral and normative debates surrounding genetic relatedness and surrogacy, and the impact of traditional legal frameworks on Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ)+ reproductive rights.

Background: Word‐to‐text integration (WTI) can be challenging for second‐language (L2) learners, although it can positively contribute to reading comprehension. The present study examined the role of WTI, after controlling for decoding, vocabulary and morphosyntactic awareness, in predicting English as an L2 reading comprehension development in 441 Dutch seventh‐grade students. Methods: At the beginning (Time 1 [T1]) and the end (Time 2 [T2]) of the school year, students were tested on their English decoding, vocabulary, morphological and syntactic awareness and reading comprehension with paper‐and‐pencil tasks and on WTI with a self‐paced reading task with reading times being compared on passages with unknown versus known words and passages with and without anomalies. Results: Mediation analyses showed small indirect effects of processing argument overlap and anomalies on T2 reading comprehension, via T1 reading comprehension. Conclusions: WTI explained unique variance in reading comprehension at T2 via reading comprehension at T1, suggesting that it moderately impacts initial stages of reading comprehension in English as a second language (ESL). Highlights: What is already known about this topicWTI is important for reading comprehension but challenging for L2 learners.Lexical skills are also important for reading comprehension. What this paper addsNovice L2 learners can distinguish between passages with unknown and known words and with and without anomalies (WTI).These WTI skills have small effects on reading comprehension development. Implications for theory, policy or practiceWTI can provide unique insights into reading comprehension development of L2 learners.These insights can inform our understanding of why some students with sufficient lexical skills nevertheless show insufficient reading comprehension skills. [ABSTRACT FROM AUTHOR]

Bubble‐driven microsystems inspired by the therapeutic use of microbubbles under clinical ultrasound actuation offer innovative remote manipulation in biological settings. Ultrasound‐powered microrobots, benefiting from a distribution of vibrating microbubbles (1–100 μm in diameters), exhibit localized fluid flow for self‐propulsion. Microbubbles also contribute to the design of acoustic metamaterials, where distributed actuation of bubbles enables exotic material properties (e.g., negative refractive index). Herein, a metamaterial‐inspired microrobot design, which exploits the streaming induced by the collective oscillation of microbubble arrays (> 10), is reported. Such a large distribution of bubbles offers twofold advantages: a mesoscale microrobot allowing ease of handling and motion at a considerably low acoustic driving pressure of 50 kPa. In this work, the oscillatory amplitude of a single bubble that acts as a unit cell of the metamaterial‐based microrobot is first characterized. Thereon, this amplitude is related to the flow generated by the collective vibration of all the bubbles close to the theoretically predicted resonant frequency of the bubbles. Finally, the hovering motion of the microrobot induced by the streaming and flow‐assisted debris clearance is demonstrated. Such auxiliary functionalities of the microrobot can be useful for applications like contactless sample extraction in inaccessible biological environments. [ABSTRACT FROM AUTHOR]

Introduction: Introduction: Renal cell carcinoma (RCC) is a very rare pediatric renal tumor. Robust evidence to guide treatment is lacking and knowledge on targeted therapies and immunotherapy is mainly based on adult studies. Currently, the International Society of Pediatric Oncology–Renal Tumor Study Group (SIOP-RTSG) 2016 UMBRELLA protocol recommends sunitinib for metastatic or unresectable RCC. Methods: This retrospective study describes the effects of tyrosine kinase inhibitors (TKI), anti-programmed cell death 1 (PD-(L)1) monoclonal antibodies, and immunotherapeutic regimens in advanced-stage and relapsed pediatric RCC. Results: Of the 31 identified patients (0–18 years) with histologically proven RCC, 3/31 presented with TNM stage I/II, 8/31 with TNM stage III, and 20/31 with TNM stage IV at diagnosis. The majority were diagnosed with translocation type RCC (MiT-RCC) (21/31) and the remaining patients mainly presented with papillary or clear-cell RCC. Treatment in a neoadjuvant or adjuvant setting, or upon relapse or progression, included mono- or combination therapy with a large variety of drugs, illustrating center specific choices in most patients. Sunitinib was often administered as first choice and predominantly resulted in stable disease (53%). Other frequently used drugs included axitinib, cabozantinib, sorafenib, and nivolumab; however, no treatment seemed more promising than sunitinib. Overall, 15/31 patients died of disease, 12/31 are alive with active disease, and only four patients had a complete response. The sample size and heterogeneity of this cohort only allowed descriptive statistical analysis. Conclusion: This study provides an overview of a unique series of clinical and treatment characteristics of pediatric patients with RCC treated with targeted therapies. [ABSTRACT FROM AUTHOR]

The present study aims to develop, validate, and cross‐validate an instrument measuring three proactive social informal learning activities, namely feedback seeking, help seeking and information seeking. Prior research mainly focused on detecting or measuring the frequency of these seeking behaviours and did not consider whether the information, help or feedback that has been sought was also used. Furthermore, although these seeking behaviours were studied extensively in different research fields, the current study takes a learning perspective and interprets feedback, help and information seeking as learning activities. The questionnaire was completed by a convenient sample of 650 professionals working in higher education, consultancy, retail and food production. We performed an exploratory factor analysis (N = 230 educators) to explore the structure of the questionnaire. This was followed by a confirmatory factor analysis (N = 230 educators) to confirm the structure. Finally, we cross‐validated the questionnaire in a sample of business professionals (N = 190) by testing for measurement invariance. The final questionnaire resulted in a five‐factor structure measuring the (1) Use of Feedback Seeking, (2) Frequency of Help and Information Seeking, (3) Use of Help seeking, (4) Use of Information Seeking and (5) Frequency of Feedback Seeking. The current study presents a preliminary, yet promising instrument that taps into proactive social informal learning. [ABSTRACT FROM AUTHOR]

Background and Objective: Patellar tendinopathy (PT) is a highly prevalent overuse injury in volleyball and is often linked with overloading of the patellar tendon. Little is known, however, about whether and how patellar tendon loading is affected by fatigue during the most challenging jump activity in volleyball. Therefore, this study investigates the effect of a high‐intensity, intermittent fatigue protocol on movement alterations in terms of patellar tendon loading during a volleyball spike jump. Methods: Forty‐three male volleyball players participated in this study. Three‐dimensional full‐body kinematics and kinetics were collected when performing a spike jump before and after the fatigue protocol. Sagittal plane joint angles, joint work and patellar tendon loading were calculated and analyzed with curve analyses using paired sample t‐tests to investigate fatigue effects (p < 0.05). Results: Fatigue induced a stiffer lower extremity landing strategy together with prolonged pelvis‐trunk flexion compared to baseline (p = 0.001–0.005). Decreased patellar tendon forces (p = 0.001–0.010) and less eccentric knee joint work (−5%, p < 0.001) were observed after the fatigue protocol compared to baseline. Conclusion: Protective strategies seem to be utilized in a fatigued state to avoid additional tensile forces acting on the patellar tendon, including proximal compensations and stiff lower extremity landings. We hypothesize that players might be more prone for developing PT if eccentric patellar tendon loads are high in the non‐fatigued state and/or these loads are somehow not decreased after fatigue. [ABSTRACT FROM AUTHOR]

In the present study, we aimed to clarify variation in prospective poor decoders by studying the development of their word decoding skills during the first 1½ years of formal reading education and their unique pre‐reading profiles before the onset of formal reading education. Using structural equation modelling and a factorial mixed model analysis of variance (ANOVA), we found autoregression and growth in the word decoding efficiency of prospective poor decoders (n = 90) and matched prospective adequate decoders (n = 90) in first and second grade. However, the gap between the two groups widened over time. Next, we zoomed in on the group of poor decoders by retrospectively studying their individual variation regarding cognitive and linguistic pre‐reading skills. Using latent profile analysis, we found three distinct pre‐reading profiles: (1) Poor PA, Letter Knowledge, RAN, and Verbal STM; (2) Poor PA and Letter Knowledge; and (3) Poor RAN. Together, these findings suggest that reading difficulties emerge at the intersection of multiple risk factors which can be detected in kindergarten, and that these reading problems persist throughout early reading education. [ABSTRACT FROM AUTHOR]

Introduction: Vincristine is an integral component of treatment for children with cancer. Its main dose‐limiting side effect is vincristine‐induced peripheral neuropathy (VIPN). The VINCA trial was a randomized controlled trial that explored the effect of 1‐hour infusion compared with push injection of vincristine on the development of VIPN in children with cancer. The short‐term outcomes (median follow‐up 9 months) showed that there was no difference in VIPN between the randomization groups. However, 1‐hour infusion was less toxic in children who also received azoles. We now report the results of the final analyses (median follow‐up 20 months), which includes treatment outcome as a secondary objective (follow‐up 3 years). Methods: VIPN was measured 1–7 times per participant using the Common Terminology Criteria for Adverse Events (CTCAE) and the pediatric‐modified total neuropathy score. Poisson mixed model and logistic generalized estimating equation analysis for repeated measures were performed. Results: Forty‐five participants per randomization group were included. There was no significant effect of 1‐hour infusion compared with push injection on VIPN. In participants receiving concurrent azoles, the total CTCAE score was significantly lower in the one‐hour group (rate ratio 0.52, 95% confidence interval 0.33–0.80, p = 0.003). Four patients in the one‐hour group and one patient in the push group relapsed. Two patients in the one‐hour group died. Conclusion: 1‐hour infusion of vincristine is not protective against VIPN. However, in patients receiving concurrent azoles, 1‐hour infusion may be less toxic. The difference in treatment outcome is most likely the result of differences in risk profile. Vincristine is an integral component of treatment for children with cancer. Its main dose‐limiting side effect is vincristine‐induced peripheral neuropathy (VIPN). The VINCA trial was a randomized controlled trial that explored the effect of one‐hour infusion compared with push injection of vincristine on the development of VIPN in children with cancer. We found that in patients receiving concurrent azoles, one‐hour infusion may be less toxic. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the performance of different probabilistic classifiers to predict posterior capsule rupture (PCR) prior to cataract surgery. Methods: Three probabilistic classifiers were constructed to estimate the probability of PCR: a Bayesian network (BN), logistic regression (LR) model, and multi‐layer perceptron (MLP) network. The classifiers were trained on a sample of 2 853 376 surgeries reported to the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO) between 2008 and 2018. The performance of the classifiers was evaluated based on the area under the precision‐recall curve (AUPRC) and compared to existing scoring models in the literature. Furthermore, direct risk factors for PCR were identified by analysing the independence structure of the BN. Results: The MLP network predicted PCR overall the best (AUPRC 13.1 ± 0.41%), followed by the BN (AUPRC 8.05 ± 0.39%) and the LR model (AUPRC 7.31 ± 0.15%). Direct risk factors for PCR include preoperative best‐corrected visual acuity (BCVA), year of surgery, operation type, anaesthesia, target refraction, other ocular comorbidities, white cataract, and corneal opacities. Conclusions: Our results suggest that the MLP network performs better than existing scoring models in the literature, despite a relatively low precision at high recall. Consequently, implementing the MLP network in clinical practice can potentially decrease the PCR rate. [ABSTRACT FROM AUTHOR]

SUMMARY: Reductions in red to far‐red ratio (R:FR) provide plants with an unambiguous signal of vegetational shade and are monitored by phytochrome photoreceptors. Plants integrate this information with other environmental cues to determine the proximity and density of encroaching vegetation. Shade‐sensitive species respond to reductions in R:FR by initiating a suite of developmental adaptations termed shade avoidance. These include the elongation of stems to facilitate light foraging. Hypocotyl elongation is driven by increased auxin biosynthesis promoted by PHYTOCHROME INTERACTING FACTORs (PIF) 4, 5 and 7. UV‐B perceived by the UV RESISTANCE LOCUS 8 (UVR8) photoreceptor rapidly inhibits shade avoidance, in part by suppressing PIF4/5 transcript accumulation and destabilising PIF4/5 protein. Here, we show that longer‐term inhibition of shade avoidance is sustained by ELONGATED HYPOCOTYL 5 (HY5) and HY5 HOMOLOGUE (HYH), which regulate transcriptional reprogramming of genes involved in hormone signalling and cell wall modification. HY5 and HYH are elevated in UV‐B and suppress the expression of XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE (XTH) genes involved in cell wall loosening. They additionally increase expression GA2‐OXIDASE1 (GA2ox1) and GA2ox2, encoding gibberellin catabolism enzymes that act redundantly to stabilise the PIF‐inhibiting DELLA proteins. UVR8 therefore regulates temporally distinct signalling pathways to first rapidly inhibit and subsequently maintain suppression of shade avoidance following UV‐B exposure. Significance Statement: UV‐B perceived by the photoreceptor UVR8 provides a strong brake on plant shade avoidance responses. Following the rapid depletion of PHYTOCHROME INTERACTING FACTORS (PIFs), UV‐B‐mediated suppression of shade avoidance is maintained by the transcription factors HY5 and HYH, which regulate wide‐scale transcriptional reprogramming of genes involved in hormone signalling and cell wall loosening, stabilising PIF‐inhibiting DELLA proteins. [ABSTRACT FROM AUTHOR]

Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramural friction in‐between two parts of a vessel wall influence the longitudinal displacement. We therefore studied the interaction between pressure, vessel geometry and intramural friction, tapered and straight ultrasound phantoms in a paralleled hydraulic bench study and corresponding numerical models. Profound antegrade longitudinal motion was induced in the innermost part of both tapered phantoms and the numerical models, but to a lesser extent when intramural friction was increased in the simulations. Strong correlations (R = 0.82–0.96; p < 1e‐3; k = 9.3–14 μm/mmHg) between longitudinal displacement and pulse pressure were found in six of seven regions of interest in tapered phantoms. The motion of the straight phantom and the corresponding numerical model was smaller, on average zero or close to zero. This study demonstrates that tapering of the lumen, low intramural friction, and pressure might be important conducive features to the antegrade longitudinal motion of the arterial wall in vivo. [ABSTRACT FROM AUTHOR]

We present a thin‐film piezoelectric micromachined ultrasonic transducer (PMUT) technology compatible with flat‐panel manufacturing methods. Using the developed flow which is based on a low temperature AlScN piezoelectric layer, we fabricate large area 48x48 element PMUT arrays on glass. Beam steering and ultrasound medical imaging are demonstrated. The developed transducer technology can be combined with a TFT backplane and has the potential of direct integration on top of display size glass sheets, expanding the boundaries of ultrasound application domains. [ABSTRACT FROM AUTHOR]

Objective: This meta‐analysis assesses cognitive functioning in children with acute lymphoblastic leukemia post‐treatment who were treated with either chemotherapy‐only (CT‐only) or in combination with radiation therapy (CTRT). Methods: The databases Pubmed and PsychInfo were searched between 1‐1‐2000 and 31‐12‐2021. Data were analyzed using Comprehensive Meta‐Analysis (version 2). Results: Mean weighted intelligence after treatment was 100.2 (number of studies n = 51, 95% CI: 98.8–101.5). For CT‐only, it was 100.8 (95% CI: 99.5–102.2) and for CTRT 97.8 (95% CI: 95.9–100.2). Compared to recruited healthy controls, treated children had on average lower IQ scores (n = 23, mean difference −7.8, 95% CI: −10.7 to −5.0, p < 0.001). When looking only at studies using controls recruited from the patient's family, results remained significant (n = 5, mean difference −6.0, 95% CI: −8.6 to −3.5, p = 0.001). Meta‐regressions aimed at identifying predictors of IQ after treatment failed to find an effect for sex or age. We could demonstrate an effect of time between diagnosis and IQ measurement for the CTRT treated patient (B = −0.26, 95% CI: −0.40 to −0.1, p = 0.002). Conclusions: IQ scores of patients treated with CT‐only or CTRT treatment regimens did not differ from the normative population. However, compared to recruited control groups, patients showed lower mean IQ scores. The Flynn effect and/or selection effects may play a role in this discrepancy. Considering time since diagnosis may have a significant impact on IQ, at least in CTRT treated patients, long‐term clinical follow‐up of neurocognitive development may be prudent to detect possible (late) neurocognitive effects. [ABSTRACT FROM AUTHOR]

The chemical transport model LOTOS‐EUROS uses a volatility basis set (VBS) approach to represent the formation of secondary organic aerosol (SOA) in the atmosphere. Inclusion of the VBS approximately doubles the dimensionality of LOTOS‐EUROS and slows computation of the advection operator by a factor of two. This complexity limits SOA representation in operational forecasts. We develop a mass‐conserving dimensionality reduction method based on matrix factorization to find latent patterns in the VBS tracers that correspond to a smaller set of superspecies. Tracers are reversibly compressed to superspecies before transport, and the superspecies are subsequently decompressed to tracers for process‐based SOA modeling. This physically interpretable data‐driven method conserves the total concentration and phase of the tracers throughout the process. The superspecies approach is implemented in LOTOS‐EUROS and found to accelerate the advection operator by a factor of 1.5–1.8. Concentrations remain numerically stable over model simulation times of 2 weeks, including simulations at higher spatial resolutions than the data‐driven models were trained on. The reversible compression of VBS tracers enables detailed, process‐based SOA representation in LOTOS‐EUROS operational forecasts in a computationally efficient manner. Beyond this case study, the physically consistent data‐driven approach developed in this work enforces conservation laws that are essential to other Earth system modeling applications, and generalizes to other processes where computational benefit can be gained from a two‐way mapping between detailed process variables and their representation in a reduced‐dimensional space. Plain Language Summary: The chemical composition of the atmosphere is a complex system involving many physical processes. Computer models can be used to improve our understanding of how these processes interact, as well as simulate hypothetical scenarios to support scientifically‐informed climate and air quality policies. However, complicated models with many variables can take a lot of time to run. The LOTOS‐EUROS model spends a large fraction of time and computational resources on simulating the transport of chemical species, like particulate matter, by wind. We combine data‐driven approaches with domain knowledge to reduce the number of variables while ensuring essential properties are conserved: we model representative combinations of chemical species that are transported all at once, rather than transport each species individually. This leads to faster and cheaper simulations without loss of scientific detail or internal consistency. Key Points: We develop a data‐driven method to find a reduced‐dimension set of superspecies representing tracers in a chemical transport modelThis method is designed to be physically consistent, preserving information on phase and conserving mass to machine precisionAdvecting the superspecies accelerates the advection operator by a factor of 1.5–1.8 [ABSTRACT FROM AUTHOR]

Background: Secondary bile acids entrain peripheral circadian clocks and inhibit colonic motility via the bile acid receptor GPBAR1. We aimed to investigate whether chronodisruption affected the rhythm in serum bile acid levels and whether this was associated with alterations in clock gene and Gpbar1 mRNA expression in the colonic smooth muscle layer. We hypothesized that this in turn may affect the rhythm in the inhibitory effect of secondary bile acids on colonic contractility. Methods: Mice were exposed to 4 weeks of chronic jetlag induction. The expression of Gpbar1 and clock genes was measured in colonic smooth muscle tissue using RT‐qPCR over 24 h (4 h time interval). The effect of secondary bile acids on electrical field‐induced neural contractions was measured isometrically in colonic smooth muscle strips. Key Results: Chronic jetlag abolished the rhythmicity in serum bile acid levels. This was associated with a phase‐shift in diurnal clock gene mRNA fluctuations in smooth muscle tissue. Chronic jetlag induced a rhythm in Gpbar1 expression in the colonic smooth muscle layer. In parallel, a rhythm was induced in the inhibitory effect of taurodeoxycholic acid (TDCA), but not deoxycholic acid, on neural colonic contractions that peaked together with Gpbar1 expression. Conclusions & Inferences: Chronodisruption abolished the rhythm in bile acid levels which might contribute to a shift in smooth muscle clock gene expression. Our findings suggest that chronodisruption caused a transcriptional reprogramming in the colonic smooth layer thereby inducing a rhythm in the expression of Gpbar1 and in the inhibitory effect of TDCA on colonic contractility. [ABSTRACT FROM AUTHOR]

Congenital melanocytic nevus syndrome (CMNS) is a rare condition characterized by pigmented skin lesions that are usually present at birth and are associated with an increased risk of neurological abnormalities and malignant melanoma. It mostly results from a post‐zygotic NRAS mutation of neural‐derived crest cells, leading to uncontrolled cell growth. Because of the increased knowledge of the genetics underlying CMNS, targeted therapy becomes a promising treatment option. We present a case of CMNS in a newborn. Physical examination at birth showed a giant congenital melanocytic nevus, extending from the occipital to the lower lumbar region. A magnetic resonance imaging scan revealed multiple cerebral and cerebellar parenchymal lesions. Genetic analysis of the cutaneous lesions showed the presence of an NRAS Q61R mutation. The patient was treated with dermabrasion to reduce the color intensity of the nevus. However, this was complicated by recurrent wound infections and laborious wound healing. At the age of 1 year, the patient had an age‐appropriate psychomotor development, without neurological deficits. [ABSTRACT FROM AUTHOR]

Background: Up to 15% of all visits to the Emergency Department (ED) are alcohol related. Identification of problematic alcohol use is important in this setting because it allows for intervention and prevention efforts. This study investigated the correlation between the objective phosphatidylethanol (PEth) marker and the subjective Alcohol Use Disorders Identification Test (AUDIT) and Timeline Followback Questionnaire (TLFB) as screening methods for hazardous alcohol use in the general ED population. Methods: This prospective cohort study included 301 ED patients (57% male) who were seen in the ED and required to give a blood sample. The correlation between the values of PEth (PEth 16:0/18:1 and PEth 16:0/18:2) and the scores on the AUDIT and TLFB were analyzed using Spearman's rank correlation coefficient. Differences between risk categories of PEth and AUDIT were also examined. Results: The Spearman correlation coefficients between PEth 16:0/18:1|PEth 16:0/18:2 values and the AUDIT scores were moderate (PEth 16:0/18:1: 0.67, p < 0.001; PEth 16:0/18:2: 0.67, p < 0.001). Of the patients who scored 'low risk drinking/abstinence' according to the AUDIT questionnaire, respectively 1% and 4% had PEth 16:0/18:1|PEth 16:0/18:2 values indicating excessive alcohol use, and another 10% and 12% had PEth 16:0/18:1|PEth 16:0/18:2 values indicating moderate alcohol consumption. Of the 12 (PEth 16:0/18:1) and 25 (PEth 16:0/18:2) patients with high‐risk values, respectively 25% and 40% scored in the lowest risk category on the AUDIT questionnaire. Spearman correlation coefficients between PEth 16:0/18:1|PEth 16:0/18:2 values and TLFB two‐week scores were high (PEth 16:0/18:1: 0.74, p < 0.001; PEth 16:0/18:2: 0.82, p < 0.001). Conclusions: AUDIT scores were moderately correlated with PEth values in the general ED population. In almost all cases where there was not a good correlation, patients had high PEth values with low AUDIT scores. We conclude that PEth identifies patients with problematic alcohol use who are missed by the AUDIT questionnaire and therefore PEth could be used as an additional screening method for hazardous alcohol use in this population. [ABSTRACT FROM AUTHOR]

The centrality of trust in traditional doctor–patient relationships has been criticized as inordinately paternalistic, yet in today's discussions about medical ethics—mostly in response to disruptive innovation in healthcare—trust reappears as an asset to enable empowerment. To turn away from paternalistic trust‐based doctor–patient relationships and to arrive at an empowerment‐based medical model, increasing reference is made to the importance of nurturing trust in technologies that are supposed to bring that empowerment. In this article we stimulate discussion about why the move towards patient empowerment may not be able to keep clear of the criticism of trust in traditional patient–doctor relationships. First, we explore how such a shift in trust dynamics might corrode patient empowerment in the name of patient empowerment. Second, we examine how a translocation of trust may at best push the "trust issue" elsewhere and at worst make it harder to evaluate trustworthiness. [ABSTRACT FROM AUTHOR]

People have various desires, but it is a contested moral issue when a desire becomes of such importance that it legitimizes a moral claim on others. This paper explores how the normative significance of desire satisfaction can be assessed and argues that a normatively significant desire can constitute a pro tanto obligation to help satisfy it. The paper presents a framework that relates the normative significance of a given desire to the general goal of living a reasonably valuable life and inquires how the latter can be given determinate content without excluding a heterogeneity of the personal good. The paper contends that the set of possibly normatively significant desires is thus restricted by considerations about intelligibility, adequacy, and replaceability, which are mediated by societal background theories. [ABSTRACT FROM AUTHOR]

Purpose: The present study aimed to determine whether runners can reduce impact measures after a six‐session in‐the‐field gait retraining program with real‐time musical biofeedback on axial peak tibial acceleration (PTAa) and identify the associated biomechanical adaptations. Methods: Twenty trained high‐impact runners were assigned to either the biofeedback or the music‐only condition. The biofeedback group received real‐time feedback on the PTAa during the gait retraining program, whereas the music‐only condition received a sham treatment. Three‐dimensional gait analysis was conducted in the laboratory before (PRE) and within one week after completing the gait retraining program (POST). Subjects were instructed to replicate the running style from the last gait retraining session without receiving feedback while running overground at a constant speed of 2.9 m∙s−1. Results: Only the biofeedback group showed significant reductions in both PTAa (∆x̅ = −26.9%, p = 0.006) and vertical instantaneous loading rate (∆x̅ = −29.2%, p = 0.003) from PRE to POST. In terms of biomechanical adaptations, two strategies were identified. Two subjects transitioned toward a more forefoot strike. The remaining eight subjects used a pronounced rearfoot strike and posteriorly inclined shank at initial contact combined with less knee extension at toe‐off while reducing vertical excursion of the center of mass. Conclusions: After completing a music‐based biofeedback gait retraining program, runners can reduce impact while running overground in a laboratory. We identified two distinct self‐selected strategies used by the participants to achieve reductions in impact. [ABSTRACT FROM AUTHOR]

Ectopic liver tissue represents a rare entity and is mostly attributed to events occurring during embryogenesis. Previous case reports documented the presence of fetal liver parenchyma within temporarily developed organs during pregnancy, such as the placenta or the umbilical cord. Moreover, the terminology of these benign findings varies from "ectopic liver" to "hepatocellular adenoma-like neoplasm" or "hepatocellular adenoma". Ancillary tests performed on these lesions have shown positive immunohistochemical staining for hepatocellular origin marker HepPar-1. Only one recent case report comprising molecular analysis showed no beta-catenin gain-of-function mutation. We report a case of ectopic liver in one placenta of a twin pregnancy, with an updated review of literature. [ABSTRACT FROM AUTHOR]

Innate lymphoid cells (ILCs) are important for tissue immune homeostasis, and are thoroughly characterized in mice and humans. Here, we have performed in‐depth characterization of rat ILCs. Rat ILCs were identified based on differential expression of transcription factors and lack of lineage markers. ILC3s represented the major ILC population of the small intestine, while ILC2s were infrequent but most prominent in liver and adipose tissue. Two major subsets of group 1 ILCs were defined. Lineage–T‐bet+Eomes+ cells were identified as conventional NK cells, while lineage–T‐bet+Eomes– cells were identified as the probable rat counterpart of ILC1s based on their selective expression of the ILC marker CD200R. Rat ILC1s were particularly abundant in liver and intestinal tissues, and were functionally similar to NK cells. Single‐cell transcriptomics of spleen and liver cells confirmed the main division of NK cells and ILC1‐like cells, and demonstrated Granzyme A as an additional ILC1 marker. We further report differential distributions of NK cells and ILCs along the small and large intestines, and the association of certain bacterial taxa to frequencies of ILCs. In conclusion, we provide a framework for future studies of ILCs in diverse rat experimental models, and novel data on the potential interplay between commensals and intestinal ILCs. [ABSTRACT FROM AUTHOR]

Summary: In active infrared thermographic inspection of materials, heat wave is stimulated by activation of heat sources, e.g., through optical heat radiation or vibration‐induced heat dissipation. Therefore, the monopolar (i.e., heating only) nature of excitation introduces an inevitable ascending trend in the measured thermal response. To obtain an improved thermal wave imaging quality, it is crucial to remove this ascending trend and to analyze the decoupled bipolar (i.e., AC) component of the thermal response. This study introduces the concept of phase inversion in thermographic inspection, as a deterministic method for (i) decoupling the AC component and (ii) filtering the prominent second‐order nonlinearities from the thermal response. First, this "phase inversion thermography (PIT)" is theoretically substantiated by analysis of heat diffusion through the thickness of a solid material subjected to dissipative boundary conditions. Then, the performance of PIT in accurately decoupling the AC response from various excitation waveforms is verified by finite element simulation of optical infrared thermography on an anisotropic composite coupon. It is shown that by proper selection of the signal's initial phase and waveform duration, PIT yields the AC response with a zero‐mean amplitude. At last, the experimental applicability of PIT is evaluated for two different test cases: (1) optical thermography on a backside‐stiffened carbon fiber‐reinforced polymer (CFRP) aircraft panel with a complex cluster of production defects and (2) low‐power vibrothermography on an impacted CFRP coupon. It is shown that PIT, as a physics‐based signal processing technique, robustly resolves the strongly transient onset of the excitation and systematically decouples an AC response which is equivalent to the thermal response to an ideally linear and bipolar excitation. The recorded thermal responses are post‐processed through Fourier transform, and the enhanced thermal imaging quality and improved defect detectability of the decoupled AC component are demonstrated. [ABSTRACT FROM AUTHOR]

Background: Running retraining with the use of biofeedback on an impact measure has been executed or evaluated in the biomechanics laboratory. Here, the execution and evaluation of feedback-driven retraining are taken out of the laboratory. Purpose: To determine whether biofeedback can reduce the peak tibial acceleration with or without affecting the running cadence in a 3-week retraining protocol. Study Design: Quasi-randomized controlled trial. Methods: Twenty runners with high peak tibial acceleration were allocated to either the retraining (n = 10, 32.1 ± 7.8 years, 10.9 ± 2.8 g) or control (n = 10, 39.1 ± 10.4 years, 13.0 ± 3.9 g) groups. They performed six running sessions in an athletic training environment. A body-worn system collected axial tibial acceleration and provided real-time feedback. The retraining group received music-based biofeedback in a faded feedback scheme. Pink noise was superimposed on tempo-synchronized music when the peak tibial acceleration was ≥70% of the runner's baseline. The control group received tempo-synchronized music, which acted as a placebo for blinding purposes. Speed feedback was provided to obtain a stable running speed of ~2.9 m·s−1. Peak tibial acceleration and running cadence were evaluated. Results: A significant group-by- feedback interaction effect was detected for peak tibial acceleration. The experimental group had a decrease in peak tibial acceleration by 25.5% (mean: 10.9 ± 2.8 g versus 8.1 ± 3.9 g, p = 0.008, d = 1.08, mean difference = 2.77 [0.94, 4.61]) without changing the running cadence. The control group had no statistically significant change in peak tibial acceleration nor in running cadence. Conclusion: The retraining protocol was effective at reducing the peak tibial acceleration in high-impact runners by reacting to music-based biofeedback that was provided in real time per wearable technology in a training environment. This reduction magnitude may have meaningful influences on injury risk. [ABSTRACT FROM AUTHOR]

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Background: Magnetic resonance imaging (MRI) has become important in the diagnostic work‐up of neurodegenerative diseases. icobrain dm, a CE‐labeled and FDA‐cleared automatic tool for brain volumetry using clinical MRI scans, has shown great potential in differentiating cognitively healthy controls (HC) from Alzheimer’s disease (AD) dementia (ADD) patients in selected research cohorts (Struyfs H, et al. (2020)).This study examined the diagnostic value of icobrain dm for AD in routine clinical practice, and compared it to FreeSurfer, one of the standard tools in neuroimaging research. Method: The Belgian Dementia Council (BeDeCo) initiated a retrospective, multi‐center Belgian study (REMEMBER). Through automated volumetric analyses of whole brain, gray matter, cortical gray matter, frontal, parietal, occipital and temporal cortices, hippocampal volumes and lateral ventricles on real‐world clinical brain MRI T1w (n=820) images across the AD continuum, icobrain dm’s (v.4.4.0) ability to differentiate diagnostic groups in the AD continuum vs. HC was compared to FreeSurfer (v.6.0). Using icobrain dm’s automated volumetric output, we also investigated which combined brain volumes contributed most to establish an AD diagnosis and could differentiate between different stages of the disease. Result: The final study population consisted of subjects from eight Belgian memory clinics, with HC (n=89), subjective cognitive decline (SCD, n=89), mild cognitive impairment (MCI, n=350), and ADD (n=250) (Table 1). icobrain dm outperformed FreeSurfer in processing time (15‐30 minutes vs. 9‐32 hours), robustness (0 failures vs. 67 failures due to complete abortion of analysis during topology corrections) and diagnostic performance (AUC, sensitivity and specificity) in univariate differentiation between HC and ADD patients (Figure 1, Table 2). Stepwise backward regression models showed improved diagnostic accuracy for pairwise group differentiations when combining multiple brain volumes computed by icobrain dm, with highest performance obtained for distinguishing HC from ADD patients (AUC=0.914; Specificity 83.0%; Sensitivity 86.3%) (Table 3). Conclusion: Automated volumetry has a diagnostic value for ADD diagnosis in routine clinical practice. Our findings indicate that icobrain dm’s automated volumetry can improve diagnostic certainty in a real‐world clinical setting with a significantly reduced processing time, robustness and diagnostic performance, as compared to FreeSurfer. [ABSTRACT FROM AUTHOR]

Aim: Chronodisruption desynchronizes peripheral clocks and leads to metabolic diseases. Feeding cues are important synchronizers of peripheral clocks and influence rhythmic oscillations in intestinal microbiota and their metabolites. We investigated whether chronic jetlag, mimicking frequent time zone travelling, affected the diurnal fluctuations in faecal short‐chain fatty acid (SCFA) levels, that feed back to the gut clock to regulate rhythmicity in gut function. Methods: Rhythms in faecal SCFAs levels and in the expression of clock genes and epithelial markers were measured in the colonic mucosa of control and jetlagged mice. The entraining effect of SCFAs on the rhythm in clock gene mRNA expression was studied in primary colonic crypts. The role of the circadian clock in epithelial marker expression was studied in Arntl−/− mice. Results: Chronic jetlag increased body weight gain and abolished the day/night food intake pattern which resulted in a phase‐delay in the rhythm of faecal SCFAs that paralleled the shift in the expression of mucosal clock genes. This effect was mimicked by stimulation of primary colonic crypts from control mice with SCFAs. Jetlag abolished the rhythm in Tnfα, proglucagon and ghrelin expression but not in the expression of tight junction markers. Only a dampening in plasma glucagon‐like peptide‐1 but not in ghrelin levels was observed. Rhythms in ghrelin but not proglucagon mRNA expression were abolished in Arntl−/− mice. Conclusion: The altered food intake pattern during chronodisruption corresponds with the changes in rhythmicity of SCFA levels that entrain clock genes to affect rhythms in mRNA expression of gut epithelial markers. [ABSTRACT FROM AUTHOR]

This research examines the social side of learning among professionals in the fast evolving and knowledge intense field of consultancy. Its first aim is to unravel social informal learning by proposing a new, integrated framework of workplace learning. Its second aim is to explore the role of learning climate for social informal learning behavior among consultants. Our qualitative inquiry using interviews based on the critical incident technique illustrates that consultants engaged in deliberative and reactive learning, thereby indicating a clear intention to learn. The source of learning was often the direct colleagues and direct supervisor, which highlights the relevance of close proximity of other individuals. The consultants mainly learned from others in a passive manner, followed by proactive and collaborative learning. Finally, this study shows that granting professionals responsibility and autonomy in their learning process as well as having a leader who facilitates learning are important elements of a learning climate that enhances social informal learning. We conclude with recommendations for organizations and directions for future research. [ABSTRACT FROM AUTHOR]

Purpose: Vincristine (VCR) is a chemotherapeutic agent used in the treatment of pediatric oncology patients, but its main toxicity is VCR‐induced peripheral neuropathy (VIPN). However, whether VIPN has an effect on health‐related quality of life (HR‐QoL) in children during treatment is unknown. Therefore, the aim of our study was to investigate the association between VIPN and HR‐QoL in children starting treatment for cancer. Methods: Measurements of VIPN were performed using two tools: Common Terminology Criteria for Adverse Events (CTCAE) and pediatric‐modified Total Neuropathy Score (ped‐mTNS). Assessment of HR‐QoL was done with self‐ and proxy assessment of the Cancer and Generic module of the Pediatric Cancer Quality of Life Inventory™ (PedsQL). Results: In total, N = 86 children were included. HR‐QoL of children with VIPN (n = 67%, 76%) was significantly lower in comparison with children without VIPN: estimated Total score of PedsQL Generic (proxy) 84.57; β = −8.96 and 95% confidence interval (CI) −14.48 to −3.43; p = 0.002, estimated PedsQL Generic Total score (self‐reported): 85.16, β = −8.38 (95% CI: −13.76 to −3.00); p = 0.003. Similar results were found in the Pain and Hurt domain of the PedsQL Cancer (pain: estimated score [proxy]: 85.28, β = −9.94 [95%CI: −16.44 to −3.45], p = 0.003; hurt: estimated score [self‐report] 97.57, β = −19.15 [95%CI: −26.82 to −11.48], p < 0.001). Conclusion: VIPN results in a significant reduction of HR‐QoL in children under treatment for a malignancy, which means that VIPN is important for the well‐being of pediatric oncology patients. Therefore, this study underlines the importance of optimizing treatment with VCR, thereby aiming to reduce VIPN while maintaining efficacy. [ABSTRACT FROM AUTHOR]

Dracocephalum moldavica L. is a significant component in the Iranian food basket. This study aimed to investigate the bioactive compounds and biological activities of different extracts obtained from D. moldavica aerial parts. From the aerial parts, a crude methanolic (MeOH) extract and its four sub‐fractions, that is, petroleum ether (Pet), ethyl acetate (EtOAc), n‐butanol (n‐BuOH), and aqueous (water) extracts were obtained. The total phenolic and flavonoid contents as well as the antioxidant and cytotoxic activities of the extracts were determined. Moreover, the phytochemical profiles of the essential oil (EO) and of those extracts with the highest antioxidant activity measured by GC/MS and UPLC–PDA‐ESI–QTOF–MS/MS. Results showed that the highest concentrations of phenols and flavonoids as well as the most potent antioxidant potential according to the DPPH method were determined in the EtOAc and MeOH extracts with IC50 values of 22.0 and 34.4 µg.ml‐1, respectively. Quantitative analysis of these extracts was subsequently performed by UPLC–PDA‐ESI–QTOF–MS/MS. Both extracts contained mainly rosmarinic acid, caffeic acid, and 2‐hydroxycinnamic acid, which may be responsible for their high antioxidant activity. Moreover, none of the extracts showed cytotoxic effects against MCF7, SW48, and a normal cell line of mouse embryonic fibroblast cells (NIH/3T3) in the tested concentrations (up to 400 μg.ml‐1). Additionally, GC‐MS analysis showed that oxygenated monoterpenes (55.4%) were the main constituents of the EO of D. moldavica. [ABSTRACT FROM AUTHOR]

The opaque English orthography complicates learning to read, as irregular words, such as the word pint, cannot be Addread accurately by decoding. Studies with first language (L1) English children show that vocabulary facilitates word reading, especially in the case of irregular words. It is unclear whether this influence of vocabulary extends to children learning to read English as a foreign language (EFL). When learning EFL, words are often encountered in print first, potentially making orthographic knowledge especially important. Orthographic knowledge might partially account for the effect of vocabulary on irregular word reading. In this study, 455 Dutch students in their first year of formal English education (11–13 years, Grade 7) were followed. Their English vocabulary, orthographic knowledge, and irregular, regular and pseudoword reading skills were assessed in fall and spring. Commonality analyses showed that vocabulary contributed more to irregular than to regular or pseudoword reading, even when controlling for orthographic knowledge. Additionally, orthographic knowledge was related to irregular word reading concurrently, independent of vocabulary. Longitudinal analyses showed that vocabulary and orthographic knowledge also had independent effects on the development of irregular word reading, but not on regular or pseudoword reading. Overall, the predictors for EFL word reading were in line with previous L1 findings. Both EFL and L1 learners use vocabulary and orthographic knowledge to read irregular words. This suggests that the relationship between vocabulary and word reading is related to aspects of the English orthography itself. To enable EFL learners to read irregular words, it is important to teach the other constituents of word knowledge, that is, vocabulary and orthography. Highlights: What is already known about this topicFor L1 English learners, vocabulary facilitates reading of words that cannot be read accurately by decoding (irregular words).Orthographic knowledge is also important for word reading, but its relative contribution compared with vocabulary is unknown.For L1 learners of more transparent languages, reading is less dependent on vocabulary. What this paper addsWe investigated whether effects of vocabulary and orthographic knowledge on reading extend to reading in English as a foreign language for students with a semi‐transparent L1.For the first time, effects of vocabulary on irregular word reading were investigated longitudinally in a large sample.Shared and unique contributions of vocabulary and orthographic knowledge to both irregular and regular word reading were compared. Implications for theory, policy or practicePredictors for word reading are similar in EFL as in L1 English.Both vocabulary and orthographic knowledge make independent contributions to irregular word reading, including its development.To enable EFL learners to read irregular words, it is important to also train the other constituents of word knowledge, that is, vocabulary and orthography. [ABSTRACT FROM AUTHOR]

Aim: To explore parents' experiences of parenting a child hospitalised with congenital heart disease (CHD) and undergoing surgery.Methods: Five electronic databases were systematically searched for articles describing the experiences of parents with a child with a CHD. A thematic analysis approach was used to identify the most common themes.Results: A total of 188 articles were identified. Eight studies were included in the review. Four themes emerged, including balancing the parental role, experiencing anticipatory grief, decreasing parental stress using coping strategies and professional support.Conclusion: Having a child with CHD undergoing heart surgery is a stressful experience due to, among other things, the different situation-related parenting role during the hospital stay and feelings of anticipatory grief. Healthcare professionals in the PICU have an essential role in supporting parents and understanding the needs that are crucial for the parents in order to provide better support and reduce stress and anxiety. More qualitative research regarding the pathway from the prenatal diagnosis through the early childhood period is warranted. [ABSTRACT FROM AUTHOR]

Background: The present study examined patterns and predictors of reading comprehension growth in first language (L1) and second language (L2) readers in the upper grades of primary school. Previous research suggests that L1 and L2 readers differ in their growth trajectories and that differences in language proficiency play a role in this. However, how predictors at different levels of processing influence growth has not been investigated. In particular, the role of unification skills such as syntactic integration and the ability to form a situation model of a text is under‐investigated. Method: In a longitudinal study, 63 L1 Dutch and 109 L2 Dutch readers were followed from fourth to sixth grade (mean ages 10 to 13 years). L2 children had a variety of language backgrounds. In Grades 4–6, reading comprehension was assessed. In Grade 4, participants were also assessed on cognitive ability (nonverbal reasoning and working memory), decoding, vocabulary, and unification skills (syntax and situation model building ability). Patterns and predictors of growth were investigated by means of mixed‐effects modelling. Results: Reading comprehension growth was predicted by vocabulary and decoding, such that participants with lower decoding or vocabulary scores made more reading comprehension gains. L1 and L2 readers with high vocabulary scores did not differ in their reading comprehension growth. L2 readers with low vocabulary made less reading comprehension gains than L1 readers with low vocabulary. Unification skills predicted initial reading comprehension but not growth. Conclusions: Findings suggest that linguistic skills above the word level predict initial reading comprehension but not growth. Children with lower initial literacy skills caught up on reading comprehension, but this was less true for L2 children. L2 children with high vocabulary, however, did not differ from their L1 peers. [ABSTRACT FROM AUTHOR]