1. Observational study comparing the performance of first-trimester screening protocols for detecting trisomy 21 in a North Indian population.
- Author
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Kaul, Anita, Singh, Chanchal, Gupta, Rachna, Arora, Nidhi, and Gupta, Abha
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SCIENTIFIC observation , *FIRST trimester of pregnancy , *DOWN syndrome , *ULTRASONIC imaging , *NASAL bone , *DIAGNOSIS of Down syndrome , *CHORIONIC gonadotropins , *COMPARATIVE studies , *FETAL ultrasonic imaging , *LONGITUDINAL method , *MATERNAL age , *RESEARCH methodology , *MEDICAL cooperation , *MEDICAL screening , *NONPARAMETRIC statistics , *PREGNANCY proteins , *PRENATAL diagnosis , *RESEARCH , *EVALUATION research - Abstract
Objective: To evaluate first-trimester screening protocols for detecting trisomy 21 in an Indian population.Methods: The present prospective study collected data from women with singleton pregnancies and a crown-to-rump length of 45-84 mm who presented at the fetal medicine unit of a tertiary care center in North India between June 1, 2006, and December 31, 2015, for combined first-trimester screening. Maternal age, nuchal translucency, nasal bone, and maternal serum levels of free beta human chorionic gonadotropin and pregnancy-associated plasma protein A were assessed for calculating the risk of trisomy 21. Tricuspid regurgitation and qualitative analysis of ductus venosus data were available from June 2010, and were included where available. Trisomy-21 detection rates were calculated for various screening protocols and were compared.Results: There were 4523 women screened and 24 records of trisomy 21. Combined screening with maternal age, nuchal translucency, nasal bone, tricuspid regurgitation, and ductus venosus demonstrated optimal detection and false-positive rates of 93.8% and 1.9%, respectively. Screening using only maternal age yielded a detection rate of 37.5%; using fixed nuchal translucency cut-off values of 2.5 and 3 mm resulted in detection rates of 66.7% and 37.5%, respectively.Conclusion: Combined first-trimester screening performed well in an Indian population; combining maternal age, nuchal translucency, nasal bone, ductus venosus, and tricuspid regurgitation yielded the most accurate screening. [ABSTRACT FROM AUTHOR]- Published
- 2017
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