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Observational study comparing the performance of first-trimester screening protocols for detecting trisomy 21 in a North Indian population.
- Source :
-
International Journal of Gynecology & Obstetrics . Apr2017, Vol. 137 Issue 1, p14-19. 6p. - Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>To evaluate first-trimester screening protocols for detecting trisomy 21 in an Indian population.<bold>Methods: </bold>The present prospective study collected data from women with singleton pregnancies and a crown-to-rump length of 45-84 mm who presented at the fetal medicine unit of a tertiary care center in North India between June 1, 2006, and December 31, 2015, for combined first-trimester screening. Maternal age, nuchal translucency, nasal bone, and maternal serum levels of free beta human chorionic gonadotropin and pregnancy-associated plasma protein A were assessed for calculating the risk of trisomy 21. Tricuspid regurgitation and qualitative analysis of ductus venosus data were available from June 2010, and were included where available. Trisomy-21 detection rates were calculated for various screening protocols and were compared.<bold>Results: </bold>There were 4523 women screened and 24 records of trisomy 21. Combined screening with maternal age, nuchal translucency, nasal bone, tricuspid regurgitation, and ductus venosus demonstrated optimal detection and false-positive rates of 93.8% and 1.9%, respectively. Screening using only maternal age yielded a detection rate of 37.5%; using fixed nuchal translucency cut-off values of 2.5 and 3 mm resulted in detection rates of 66.7% and 37.5%, respectively.<bold>Conclusion: </bold>Combined first-trimester screening performed well in an Indian population; combining maternal age, nuchal translucency, nasal bone, ductus venosus, and tricuspid regurgitation yielded the most accurate screening. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SCIENTIFIC observation
*FIRST trimester of pregnancy
*DOWN syndrome
*ULTRASONIC imaging
*NASAL bone
*DIAGNOSIS of Down syndrome
*CHORIONIC gonadotropins
*COMPARATIVE studies
*FETAL ultrasonic imaging
*LONGITUDINAL method
*MATERNAL age
*RESEARCH methodology
*MEDICAL cooperation
*MEDICAL screening
*NONPARAMETRIC statistics
*PREGNANCY proteins
*PRENATAL diagnosis
*RESEARCH
*EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 137
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 121698584
- Full Text :
- https://doi.org/10.1002/ijgo.12087