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The safety and efficacy of pharmacotherapy in children, particularly preterms, neonates and infants, is limited by a paucity of good-quality data from prospective clinical drug trials. A specific challenge is the establishment of valid biomarkers. OMICs technologies may support these efforts by complementary information about targeted and nontargeted molecules through systematic characterization and quantitation of biological samples. OMICs technologies comprise at least genomics, epigenomics, transcriptomics, proteomics, metabolomics and microbiomics in addition to the patient's phenotype. OMICs technologies are in part hypothesis-generating, allowing an in depth understanding of disease pathophysiology and pharmacological mechanisms. Application of OMICs technologies in paediatrics faces major challenges before routine adoption. First, developmental processes need to be considered, including a subdivision into specific age groups as developmental changes clearly impact OMICs data. Second, compared to the adult population, the number of patients is limited as are the type and amount of necessary biomaterial, especially in neonates and preterms. Thus, advanced trial designs and biostatistical methods, noninvasive biomarkers, innovative biobanking concepts including data and samples from healthy children, as well as analytical approaches (eg liquid biopsies) should be addressed to overcome these obstacles. The ultimate goal is to link OMICs technologies with innovative analysis tools, such as artificial intelligence at an early stage. The use of OMICs data based on a feasible approach will contribute to the identification complex phenotypes and subpopulations of patients to improve the development of medicines for children with potential economic advantages., (© 2022 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Big data refers to extremely large data generated at high volume, velocity, variety, and veracity. The nurse scientist is uniquely positioned to leverage big data to suggest novel hypotheses on patient care and the healthcare system. The purpose of this paper is to provide an introductory guide to understanding the use and capability of big data for nurse scientists. Herein, we discuss the practical, ethical, social, and educational implications of using big data in nursing research. Some practical challenges with the use of big data include data accessibility, data quality, missing data, variable data standards, fragmentation of health data, and software considerations. Opposing ethical positions arise with the use of big data, and arguments for and against the use of big data are underpinned by concerns about confidentiality, anonymity, and autonomy. The use of big data has health equity dimensions and addressing equity in data is an ethical imperative. There is a need to incorporate competencies needed to leverage big data for nursing research into advanced nursing educational curricula. Nursing science has a great opportunity to evolve and embrace the potential of big data. Nurse scientists should not be spectators but collaborators and drivers of policy change to better leverage and harness the potential of big data. [ABSTRACT FROM AUTHOR]

Avoiding financial losses requires preventing catastrophic oil‐filled power transformer breakdowns. Continuous online transformer monitoring is needed. The authors use paper insulation to evaluate transformer health for continuous online transformer monitoring. The study suggests a new artificial intelligence method for estimating paper insulation residual life in oil‐immersed power transformers. The four artificial intelligence models use backpropagation‐based neural networks to predict paper insulation lifespan. Four primary transformer insulating paper failure indices—degree of polymerisation, 2‐furfuraldehyde, carbon monoxide, and carbon dioxide—form the basis of these models. Each model, including the backpropagation‐based neural networks, estimates paper insulation life using one failure index, along with moisture and temperature data. Optimisation techniques enhance hidden layer neurons and epoch count for improved performance. Results are validated against literature‐based life models, establishing a precise input–output correlation. This method accurately predicts the remaining useable life of power transformer paper insulation, enabling utilities to take proactive measures for safe and efficient transformer operation. [ABSTRACT FROM AUTHOR]

In augmented reality (AR) headset devices, virtual image visibility and power consumption are major challenges. In this paper, we presented smart pixelated dimmer that locally enhance the ambient contrast ratio. The dimmer is integrated with image sensor and low‐power edge AI processor to control the dimming automatically. Adopting smart pixelated dimmer provides AR devices the possibility to operate in high brightness environment. [ABSTRACT FROM AUTHOR]

Reviews have long been recognized as among the most important forms of scientific communication. The rapid growth of the primary literature has further increased the need for reviews to distill and interpret the literature. This review on Reviews and Reviewing: Approaches to Research Synthesis encompasses the evolution of the review literature, taxonomy of review literature, uses and users of reviews, the process of preparing reviews, assessment of review quality and impact, the impact of information technology on the preparation of reviews, and research opportunities for information science related to reviews and reviewing. In addition to providing a synthesis of prior research, this review seeks to identify gaps in the published research and to suggest possible future research directions. [ABSTRACT FROM AUTHOR]

The importance of allergen immunotherapy (AIT) is multifaceted, encompassing both clinical and quality-of-life improvements and cost-effectiveness in the long term. Key mechanisms of allergen tolerance induced by AIT include changes in memory type allergen-specific T- and B-cell responses towards a regulatory phenotype with decreased Type 2 responses, suppression of allergen-specific IgE and increased IgG 1 and IgG 4 , decreased mast cell and eosinophil numbers in allergic tissues and increased activation thresholds. The potential of novel patient enrolment strategies for AIT is taking into account recent advances in biomarkers discoveries, molecular allergy diagnostics and mobile health applications contributing to a personalized approach enhancement that can increase AIT efficacy and compliance. Artificial intelligence can help manage and interpret complex and heterogeneous data, including big data from omics and non-omics research, potentially predict disease subtypes, identify biomarkers and monitor patient responses to AIT. Novel AIT preparations, such as synthetic compounds, innovative carrier systems and adjuvants, are also of great promise. Advances in clinical trial models, including adaptive, complex and hybrid designs as well as real-world evidence, allow more flexibility and cost reduction. The analyses of AIT cost-effectiveness show a clear long-term advantage compared to pharmacotherapy. Important research questions, such as defining clinical endpoints, biomarkers of patient selection and efficacy, mechanisms and the modulation of the placebo effect and alternatives to conventional field trials, including allergen exposure chamber studies are still to be elucidated. This review demonstrates that AIT is still in its growth phase and shows immense development prospects., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Integrated personalized diabetes management (IPDM) has emerged as a promising approach to improving outcomes in patients with diabetes mellitus (DM). This care approach emphasizes the integration and coordination of different providers, including physicians, nurses, dietitians, social workers and pharmacists. The goal of IPDM is to provide patients with personalized care that is tailored to their needs. This review addresses the concept of integrated care and the use of technology (including data, software applications and artificial intelligence) as well as managerial, regulatory and financial aspects. The implementation and upscaling of digitally enabled IPDM are discussed, with elaboration of successful practices and related evidence. Finally, recommendations are made. It is concluded that the adoption of digitally enabled IPDM on a global level is inevitable, considering the challenges created by an increasing prevalence of patients with DM and the need for better outcomes and improvement of health system sustainability., (© 2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.)

Metabolic dysfunction-associated fatty liver disease (MAFLD) has reached epidemic proportions worldwide and is the most frequent cause of chronic liver disease in developed countries. Within the spectrum of liver disease in MAFLD, steatohepatitis is a progressive form of liver disease and hepatocyte ballooning (HB) is a cardinal pathological feature of steatohepatitis. The accurate and reproducible diagnosis of HB is therefore critical for the early detection and treatment of steatohepatitis. Currently, a diagnosis of HB relies on pathological examination by expert pathologists, which may be a time-consuming and subjective process. Hence, there has been interest in developing automated methods for diagnosing HB. This narrative review briefly discusses the development of artificial intelligence (AI) technology for diagnosing fatty liver disease pathology over the last 30 years and provides an overview of the current research status of AI algorithms for the identification of HB, including published articles on traditional machine learning algorithms and deep learning algorithms. This narrative review also provides a summary of object detection algorithms, including the principles, historical developments, and applications in the medical image analysis. The potential benefits of object detection algorithms for HB diagnosis (specifically those combined with a transformer architecture) are discussed, along with the future directions of object detection algorithms in HB diagnosis and the potential applications of generative AI on transformer architecture in this field. In conclusion, object detection algorithms have huge potential for the identification of HB and could make the diagnosis of MAFLD more accurate and efficient in the near future., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The meaning of most words in language depends on their context. Understanding how the human brain extracts contextualized meaning, and identifying where in the brain this takes place, remain important scientific challenges. But technological and computational advances in neuroscience and artificial intelligence now provide unprecedented opportunities to study the human brain in action as language is read and understood. Recent contextualized language models seem to be able to capture homonymic meaning variation ("bat", in a baseball vs. a vampire context), as well as more nuanced differences of meaning-for example, polysemous words such as "book", which can be interpreted in distinct but related senses ("explain a book", information, vs. "open a book", object) whose differences are fine-grained. We study these subtle differences in lexical meaning along the concrete/abstract dimension, as they are triggered by verb-noun semantic composition. We analyze functional magnetic resonance imaging (fMRI) activations elicited by Italian verb phrases containing nouns whose interpretation is affected by the verb to different degrees. By using a contextualized language model and human concreteness ratings, we shed light on where in the brain such fine-grained meaning variation takes place and how it is coded. Our results show that phrase concreteness judgments and the contextualized model can predict BOLD activation associated with semantic composition within the language network. Importantly, representations derived from a complex, nonlinear composition process consistently outperform simpler composition approaches. This is compatible with a holistic view of semantic composition in the brain, where semantic representations are modified by the process of composition itself. When looking at individual brain areas, we find that encoding performance is statistically significant, although with differing patterns of results, suggesting differential involvement, in the posterior superior temporal sulcus, inferior frontal gyrus and anterior temporal lobe, and in motor areas previously associated with processing of concreteness/abstractness., (© 2023 The Authors. Cognitive Science published by Wiley Periodicals LLC on behalf of Cognitive Science Society (CSS).)

Health monitoring using wearable artificial intelligence (AI) sensors with sensing and cognitive capabilities has garnered significant attention. The development of self‐contained AI sensors that can operate with low power consumption, akin to the human brain, is necessary. Physical reservoir computing (PRC), which mimics the human brain using physical phenomena, offers a low‐power consumption architecture. Nevertheless, creating a flexible and easily disposable sensors using PRC capable of processing optical signals with sub‐second response times suitable for biological signals presents a challenge. In this study, a disposable and flexible paper‐based optoelectronic synaptic devices are designed, which are composed of nanocellulose and ZnO nanoparticles, for PRC. This device exhibits synaptic photocurrent in response to optical input. To assess its performance, a classification and time‐series forecasting tasks are conducted. The memory capacity of short‐term memory task, indicating the device's ability to store past information, is 1.8. The device can recognize handwritten digits with an accuracy of 88%. These results highlight the potential of the device for PRC. In addition, subjecting the device to 1000 rounds of bending do not affect its accuracy. Furthermore, the device burn in a few seconds, much like regular office paper, demonstrating its disposability. [ABSTRACT FROM AUTHOR]

The labor market is undergoing a rapid artificial intelligence (AI) revolution. There is currently limited empirical scholarship that focuses on how AI adoption affects employment opportunities and work environments in ways that shape worker health, safety, well-being and equity. In this article, we present an agenda to guide research examining the implications of AI on the intersection between work and health. To build the agenda, a full day meeting was organized and attended by 50 participants including researchers from diverse disciplines and applied stakeholders. Facilitated meeting discussions aimed to set research priorities related to workplace AI applications and its impact on the health of workers, including critical research questions, methodological approaches, data needs, and resource requirements. Discussions also aimed to identify groups of workers and working contexts that may benefit from AI adoption as well as those that may be disadvantaged by AI. Discussions were synthesized into four research agenda areas: (1) examining the impact of stronger AI on human workers; (2) advancing responsible and healthy AI; (3) informing AI policy for worker health, safety, well-being, and equitable employment; and (4) understanding and addressing worker and employer knowledge needs regarding AI applications. The agenda provides a roadmap for researchers to build a critical evidence base on the impact of AI on workers and workplaces, and will ensure that worker health, safety, well-being, and equity are at the forefront of workplace AI system design and adoption., (© 2023 The Authors. American Journal of Industrial Medicine published by Wiley Periodicals LLC.)

Purpose: The purpose of this study was to compare student performance in removable partial denture (RPD) design during a pre-clinical RPD course with and without using a recently developed computer software named AiDental. Additionally, student perceptions associated with the use of this software were assessed., Methods: The AiDental software consists of a learning environment containing an RPD design system that automatically designs RPDs based on the user's input. The software also contains an RPD game component that compares the user's RPD Design to an automatically generated RPD ideal design. The study was conducted in two phases. In phase one, pre-clinical second-year dental students who participated in the study were randomly divided into two groups: The AiDental group with AiDental software access (n = 36), and the conventional group without software access (n = 37). Both groups received conventional RPD instruction and practice, however, the AiDental group had additional access to the AiDental software. After 2 weeks, both groups took a mock practical test, which was collected and graded by the principal investigator (PI). The PI was blinded from group assignment and no identifying information was used in the mock practical. In phase two, all students were granted access to the AiDental software for the remainder of the pre-clinical course duration. At the conclusion of the course, all students were given a survey to evaluate their perceptions of the AiDental software. Descriptive statistics were calculated and analyzed. Variables related to perceptions of both the AiDental designer and game were assessed using Spearman's rank correlation test, the chi-square test, Fisher's exact test, and the non-parametric Wilcoxon rank-sum test as appropriate. In addition, a thematic analysis of the responses to the optional comments section was conducted using the Braun and Clarke method., Results: Phase one results showed that subjects in the AiDental group were more likely than subjects in the conventional group to receive a final grade of A or B. Phase two results showed generally favorable student perceptions towards the software, and additionally, the results showed that age was significantly negatively correlated with ease of use of the software, improving decision-making, and critical thinking relative to RPD design choices. However, no correlation between age and using the software as a reference were noted., Conclusions: The use of AiDental's automated feedback and gamification techniques in RPD education had a positive effect on student grades and it was well-liked by students. Thus, the results suggest that AiDental has the potential to be a useful adjunct to pre-clinical teaching., (© 2023 The Authors. Journal of Dental Education published by Wiley Periodicals LLC on behalf of American Dental Education Association.)

The article discusses the need for improvement in the peer review system for evaluating submitted manuscripts. The authors propose a new system to track the outcomes of rejected manuscripts, allowing for a better understanding of their "fates." They suggest that authors should report to the journal that finally accepted their manuscript where it was previously rejected. This system aims to increase transparency in the academic publication world and improve the evaluation skills of reviewers, editors, and journals. [Extracted from the article]

This article discusses OpenAI's ChatGPT, a generative pre‐trained transformer, which uses natural language processing to fulfill text‐based user requests (i.e., a "chatbot"). The history and principles behind ChatGPT and similar models are discussed. This technology is then discussed in relation to its potential impact on academia and scholarly research and publishing. ChatGPT is seen as a potential model for the automated preparation of essays and other types of scholarly manuscripts. Potential ethical issues that could arise with the emergence of large language models like GPT‐3, the underlying technology behind ChatGPT, and its usage by academics and researchers, are discussed and situated within the context of broader advancements in artificial intelligence, machine learning, and natural language processing for research and scholarly publishing. [ABSTRACT FROM AUTHOR]

Background/objectives: Artificial intelligence (AI) holds remarkable potential to improve care delivery in dermatology. End users (health professionals and general public) of AI-based Software as Medical Devices (SaMD) require relevant labelling information to ensure that these devices can be used appropriately. Currently, there are no clear minimum labelling requirements for dermatology AI-based SaMDs., Methods: Common labelling recommendations for AI-based SaMD identified in a recent literature review were evaluated by an Australian expert panel in digital health and dermatology via a modified Delphi consensus process. A nine-point Likert scale was used to indicate importance of 10 items, and voting was conducted to determine the specific characteristics to include for some items. Consensus was achieved when more than 75% of the experts agreed that inclusion of information was necessary., Results: There was robust consensus supporting inclusion of all proposed items as minimum labelling requirements; indication for use, intended user, training and test data sets, algorithm design, image processing techniques, clinical validation, performance metrics, limitations, updates and adverse events. Nearly all suggested characteristics of the labelling items received endorsement, except for some characteristics related to performance metrics. Moreover, there was consensus that uniform labelling criteria should apply across all AI categories and risk classes set out by the Therapeutic Goods Administration., Conclusions: This study provides critical evidence for setting labelling standards by the Therapeutic Goods Administration to safeguard patients, health professionals, consumers, industry, and regulatory bodies from AI-based dermatology SaMDs that do not currently provide adequate information about how they were developed and tested., (© 2024 The Authors. Australasian Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Australasian College of Dermatologists.)

Artificial intelligence (AI) and natural language processing technologies have fuelled the growth of Pedagogical Conversational Agents (PCAs) with empathic conversational capabilities. However, no systematic literature review has explored the intersection between conversational agents, education and emotion. Therefore, this study aimed to outline the key aspects of designing, implementing and evaluating these agents. The data sources were empirical studies, including peer‐reviewed conference papers and journal articles, and the most recent publications, from the ACM Digital Library, IEEE Xplore, ProQuest, ScienceDirect, Scopus, SpringerLink, Taylor & Francis Online, Web of Science and Wiley Online Library. The remaining papers underwent a rigorous quality assessment. A filter study meeting the objective was based on keywords. Comparative analysis and synthesis of results were used to handle data and combine study outcomes. Out of 1162 search results, 13 studies were selected. The results indicate that agents promote dialogic learning, proficiency in knowledge domains, personalized feedback and empathic abilities as essential design principles. Most implementations employ a quantitative approach, and two variables are used for evaluation. Feedback types play a vital role in achieving positive results in learning performance and student perceptions. The main limitations and gaps are the time range for literature selection, the level of integration of the empathic field and the lack of a detailed development stage report. Moreover, future directions are the ethical implications of agents operating beyond scheduled learning times and the adoption of Responsible AI principles. In conclusion, this review provides a comprehensive framework of empathic PCAs, mostly in their evaluation. The systematic review registration number is osf.io/3xk6a.Practitioner notesWhat is already known about this topicEmotions play a pivotal role in shaping the interaction process, making it essential to consider them when designing methodological strategies or learning tools.Empathic Pedagogical Conversational Agents (PCAs) have emerged as a crucial approach for enhancing and personalizing the learning experience (24/7) for pupils and supporting human teachers in their teaching process.Despite the creation of numerous empathic PCAs, there is a scarcity of Systematic Literature Reviews (SLRs) on their application in the educational field, particularly concerning the integration of emotional abilities in combination with the competencies of each subject.What this paper addsIt offers new insights into the design principles underlying the integration of the empathic field.It reviews different approaches for incorporating students' prior knowledge in real time.It provides a comprehensive and up‐to‐date overview of the research designs used for implementation, including quantitative, qualitative and mixed methods.It examines the factors that influence the effectiveness of empathic PCA in teaching and learning.It evaluates the types of feedback that enhance the impact of the empathic field on learning outcomes.Implications for practice and/or policyIt is crucial to grasp the topics that this paper introduces in order to effectively integrate new learning tools into any context.Techno‐pedagogical designers seeking to gain insights into empathic PCAs will find immense value in this SLR, as it comprehensively covers each stage of the process.For future research endeavours, this study offers a wealth of ideas to draw upon, enabling researchers to address the challenges outlined and explore new avenues of investigation. [ABSTRACT FROM AUTHOR]

Recently, artificial intelligence (AI) techniques have been increasingly used to overcome the challenges in drug discovery. Although traditional AI techniques generally have high accuracy rates, there may be difficulties in explaining the decision process and patterns. This can create difficulties in understanding and making sense of the outputs of algorithms used in drug discovery. Therefore, using explainable AI (XAI) techniques, the causes and consequences of the decision process are better understood. This can help further improve the drug discovery process and make the right decisions. To address this issue, Explainable Artificial Intelligence (XAI) emerged as a process and method that securely captures the results and outputs of machine learning (ML) and deep learning (DL) algorithms. Using techniques such as SHAP (SHApley Additive ExPlanations) and LIME (Locally Interpretable Model-Independent Explanations) has made the drug targeting phase clearer and more understandable. XAI methods are expected to reduce time and cost in future computational drug discovery studies. This review provides a comprehensive overview of XAI-based drug discovery and development prediction. XAI mechanisms to increase confidence in AI and modeling methods. The limitations and future directions of XAI in drug discovery are also discussed., (© 2023 John Wiley & Sons Ltd.)

There is a widely held view that visual representations (images) do not depict negation, for example, as expressed by the sentence, "the train is not coming." The present study focuses on the real-world visual representations of photographs and comic (manga) illustrations and empirically challenges the question of whether humans and machines, that is, modern deep neural networks, can recognize visual representations as expressing negation. By collecting data on the captions humans gave to images and analyzing the occurrences of negation phrases, we show some evidence that humans recognize certain images as expressing negation. Furthermore, based on this finding, we examined whether or not humans and machines can classify novel images as expressing negation. The humans were able to correctly classify images to some extent, as expected from the analysis of the image captions. On the other hand, the machine learning model of image processing was only able to perform this classification at about the chance level, not at the same level of performance as the human. Based on these results, we discuss what makes humans capable of recognizing negation in visual representations, highlighting the role of the background commonsense knowledge that humans can exploit. Comparing human and machine learning performances suggests new ways to understand human cognitive abilities and to build artificial intelligence systems with more human-like abilities to understand logical concepts., (© 2023 The Authors. Cognitive Science published by Wiley Periodicals LLC on behalf of Cognitive Science Society (CSS).)

Introduction: Artificial intelligence models and networks can learn and process dense information in a short time, leading to an efficient, objective, and accurate clinical and histopathological analysis, which can be useful to improve treatment modalities and prognostic outcomes. This paper targets oral pathologists, oral medicinists, and head and neck surgeons to provide them with a theoretical and conceptual foundation of artificial intelligence-based diagnostic approaches, with a special focus on convolutional neural networks, the state-of-the-art in artificial intelligence and deep learning., Methods: The authors conducted a literature review, and the convolutional neural network's conceptual foundations and functionality were illustrated based on a unique interdisciplinary point of view., Conclusion: The development of artificial intelligence-based models and computer vision methods for pattern recognition in clinical and histopathological image analysis of head and neck cancer has the potential to aid diagnosis and prognostic prediction., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Drug information specialists (DIS) bring unique, specialized expertise and provide services in diverse settings including health systems, academia, pharmaceutical industry, compendia, medical writing, and other areas. With widespread access to drug information (DI) resources through user‐friendly, online platforms, the role of DIS has shifted. Core skill sets once confined to DIS are now distributed across various non‐DIS clinical specialties. DIS have transformed the application of their specialized skill set and adapted it to a variety of traditional and nontraditional areas, providing and applying advanced expertise to solve a variety of contemporary challenges. The training of students and residents has evolved to include evidence‐based practical contemporary methods that promote critical thinking and reasoning. Effective DI evaluation and communication necessitates customizing content for stakeholders to ensure understanding and contribute to optimal patient care, all while addressing misinformation and disinformation. The future of DI as a specialty is bright, with ever‐increasing recognition of the importance of DI skills in non‐DIS practitioners. DIS will likely continue to guide best practices in the education/training of new practitioners and continue to provide advanced services and formulary analytics. This update to our 2009 DI PRN Opinion paper will focus on: (1) DI education and training needed for all students, residents, and pharmacists; (2) career opportunities, roles, and responsibilities specifically tailored for DIS in health systems, managed care organizations, academia, pharmaceutical/biotechnology industry, and medical writing services; and (3) the future direction of DI, including the potential impact of artificial intelligence. [ABSTRACT FROM AUTHOR]

Introduction: Accuracy and validity of voice AI algorithms rely on substantial quality voice data. Although commensurable amounts of voice data are captured daily in voice centers across North America, there is no standardized protocol for acoustic data management, which limits the usability of these datasets for voice artificial intelligence (AI) research., Objective: The aim was to capture current practices of voice data collection, storage, analysis, and perceived limitations to collaborative voice research., Methods: A 30-question online survey was developed with expert guidance from the voicecollab.ai members, an international collaborative of voice AI researchers. The survey was disseminated via REDCap to an estimated 200 practitioners at North American voice centers. Survey questions assessed respondents' current practices in terms of acoustic data collection, storage, and retrieval as well as limitations to collaborative voice research., Results: Seventy-two respondents completed the survey of which 81.7% were laryngologists and 18.3% were speech language pathologists (SLPs). Eighteen percent of respondents reported seeing 40%-60% and 55% reported seeing >60 patients with voice disorders weekly (conservative estimate of over 4000 patients/week). Only 28% of respondents reported utilizing standardized protocols for collection and storage of acoustic data. Although, 87% of respondents conduct voice research, only 38% of respondents report doing so on a multi-institutional level. Perceived limitations to conducting collaborative voice research include lack of standardized methodology for collection (30%) and lack of human resources to prepare and label voice data adequately (55%)., Conclusion: To conduct large-scale multi-institutional voice research with AI, there is a pertinent need for standardization of acoustic data management, as well as an infrastructure for secure and efficient data sharing., Level of Evidence: 5 Laryngoscope, 134:1333-1339, 2024., (© 2023 The American Laryngological, Rhinological and Otological Society, Inc.)

Artificial intelligence (AI) will impact many aspects of clinical pharmacology, including drug discovery and development, clinical trials, personalized medicine, pharmacogenomics, pharmacovigilance and clinical toxicology. The rapid progress of AI in healthcare means clinical pharmacologists should have an understanding of AI and its implementation in clinical practice. As with any new therapy or health technology, it is imperative that AI tools are subject to robust and stringent evaluation to ensure that they enhance clinical practice in a safe and equitable manner. This review serves as an introduction to AI for the clinical pharmacologist, highlighting current applications, aspects of model development and issues surrounding evaluation and deployment. The aim of this article is to empower clinical pharmacologists to embrace and lead on the safe and effective use of AI within healthcare., (© 2023 British Pharmacological Society.)

An algorithm refers to a series of stepwise instructions used by a machine to perform a mathematical operation. In 1955, the term artificial intelligence (AI) was coined to indicate that a machine could be programmed to duplicate human intelligence. Even though that goal has not yet been reached, the use of sophisticated machine learning algorithms has moved us closer to that goal. While algorithm-enabled systems and devices will bring many benefits to occupational safety and health, this Commentary focuses on new sources of worker risk that algorithms present in the use of worker management systems, advanced sensor technologies, and robotic devices. A new "digital Taylorism" may erode worker autonomy, and lead to work intensification and psychosocial stress. The presence of large amounts of information on workers within algorithmic-enabled systems presents security and privacy risks. Reliance on indiscriminate data mining may reproduce forms of discrimination and lead to inequalities in hiring, retention, and termination. Workers interfacing with robots may face work intensification and job displacement, while injury in the course of employment by a robotic device is also possible. Algorithm governance strategies are discussed such as risk management practices, national and international laws and regulations, and emerging legal accountability proposals. Determining if an algorithm is safe for workplace use is rapidly becoming a challenge for manufacturers, programmers, employers, workers, and occupational safety and health practitioners. To achieve the benefits that algorithm-enabled systems and devices promise in the future of work, now is the time to study how to effectively manage their risks., (© 2022 Wiley Periodicals LLC.)

This Editorial introduces a Special Issue of papers from the SEE International Conference RADAR 2019, which took place in Toulon, France, 23–27 September 2019. The papers are expanded versions of ones that were judged in the reviewing process to be of the highest quality and relevance. Benefitting from the unique location of the conference centre on the French Riviera, the conference was given the theme 'Sensing from sea to space', attracting nearly 400 attendees from 26 countries from all over the world (Figure 1). Engineers and researchers coming from private or public sector (universities and laboratories) shared their knowledge and experience on radar topics of common interests from physics to signal processing, from sensor validation to system design, and also on emerging technologies based on artificial intelligence; all topics being supported by 200 papers presented either in oral (150 papers in 36 sessions), or poster sessions (50 papers). Figure 2 shows the range of topics of the papers. 1 FIGURE: Conference attendees by country 2 FIGURE: Conference paper topics [ABSTRACT FROM AUTHOR]

This paper presented intelligent display technologies integrated in the 55‐inch 4K LCD cell based on a‐Si process. Adaptive adjustment of backlight brightness and optimization of LC response time were achieved utilizing the ALS and TS integration. By using the novel GOA architecture and TCON IC, dynamic local refresh at any position and with different refresh rate at different area on panel were achieved. The power consumption of GOA and data drivers can be reduced by up to 50% respectively. This technology provides hardware foundation for the realization of AI intelligent display. [ABSTRACT FROM AUTHOR]

Artificial intelligence is more present than ever, both in our society in general and in science. At the center of this development has been the concept of deep learning, the use of artificial neural networks that are many layers deep and can often reproduce human‐like behavior much better than other machine‐learning techniques. The articles in this collection are some recent examples of its application for X‐ray photon science and crystallography that have been published in Journal of Applied Crystallography. [ABSTRACT FROM AUTHOR]

We investigate partner effects on spatial perspective taking behavior in listeners, comparing behavior with a human versus a computer partner (Experiments 1 and 2), and with computer partners of different perceived capabilities (Experiment 3). Participants responded to spoken instructions from their partner which could be interpreted egocentrically (from their own perspective) or othercentrically (from their partner's perspective). In contrast to earlier work, we found that participants were more egocentric with a computer than a human partner. Participants were also more egocentric with a computer partner that appeared more modern and capable, compared to one that appeared outdated and limited in ability. Our results show that perspective taking behavior is sensitive to information about one's partner; in particular, listeners consider their partner's potential ability to collaborate, adjusting their egocentric tendencies accordingly. Moreover, we highlight what appears to be a shift in listeners' expectations regarding computers' collaborative capabilities, leading to greater willingness to push the burden of perspective taking onto a computer partner., (© 2023 The Authors. Cognitive Science published by Wiley Periodicals LLC on behalf of Cognitive Science Society (CSS).)

The use of artificial intelligence (AI) is deeply embedded in all aspects of our daily lives, promoting efficiency and safety in routine tasks at home and work. Likewise, dentistry is rapidly exploring new uses of AI for image analysis, electronic health records, and clinical decision-making. The accelerating advancement of AI and its application in dentistry demands dental education conscientiously integrate AI into curricula and equip graduates to use it ethically and responsibly in practice. The approach must be threefold: instill knowledge of the basic algorithms and appropriate application of AI, discuss its limitations/biases, and examine current and potential ethical challenges in practice. Furthermore, dental education must protect the public from intentional and unintentional harm introduced by AI. Therefore, the purpose of this perspective paper is to discuss various considerations for integrating AI into the dental curriculum, prioritizing patient safety by ensuring knowledgeable, safe, and ethical application by future providers., (© 2023 The Authors. Journal of Dental Education published by Wiley Periodicals LLC on behalf of American Dental Education Association.)

The letter to the editor discusses the use of ChatGPT, an AI language model, in medical writing. The author argues that while ChatGPT can be helpful for non-native English speakers, it is important to be cautious of relying too heavily on it. Doctors who heavily rely on ChatGPT may struggle to accurately convey their intended nuances and may not fully understand the details of referenced articles. The author suggests that doctors should write a rough draft themselves and seek linguistic help from experienced mentors or commercial services. The author expresses concern that the emergence of ChatGPT may undermine the opportunity for younger doctors to develop their writing skills. [Extracted from the article]

Holographic near‐eye displays promise unprecedented capabilities for virtual and augmented reality (VR/AR) systems; they can accurately reproduce focus cues, improve power efficiency, and correct for optical aberrations. However, the image quality achieved by traditional holographic displays is limited, and algorithms for computer‐generated holography (CGH) are slow. In this paper, we review emerging artificial intelligence‐enabled holographic near‐eye displays that promise to solve these long‐standing challenges. [ABSTRACT FROM AUTHOR]

3D display technology can bring users 3D stereoscopic and realistic visual experience. At present, many types of 3D display technologies have been developed in this field. Among them, naked eye 3D is a more advanced 3D display technology. Compared with traditional polarized 3D display technology, it allows people to directly observe the stereo vision effect without polarized glasses. The naked-eye 3D technology discussed in this paper is based on micro-lens array, which is an important branch in the field of naked-eye 3D display. In this paper, the real-time human eye tracking technology is used to capture the user's human eye coordinates, and the pixel layout on the display module is adjusted in real time according to the human eye coordinate position, so as to ensure that the images taken into the human eye within any visual angle range have a three- dimensional effect. BOE has accumulated many advanced technologies in the field of display and artificial intelligence, especially in the fields of high-resolution display, new display and human eye tracking. This paper focuses on the naked eye 3D display system independently developed by BOE. [ABSTRACT FROM AUTHOR]

The article provides a preview of forthcoming papers accepted for publication in the Health Information and Libraries Journal. Topics include the effectiveness of citation searching in urgent and emergency care configuration studies, an alternative screening approach for Google Search in systematic reviews, and the analysis of health information seeking behavior among adolescents.

The explosive growth in medical devices, imaging and diagnostics, computing, and communication and information technologies in drug development and healthcare has created an ever-expanding data landscape that the pharmacometrics (PMX) research community must now traverse. The tools of machine learning (ML) have emerged as a powerful computational approach in other data-rich disciplines but its effective utilization in the pharmaceutical sciences and PMX modelling is in its infancy. ML-based methods can complement PMX modelling by enabling the information in diverse sources of big data, e.g. population-based public databases and disease-specific clinical registries, to be harnessed because they are capable of efficiently identifying salient variables associated with outcomes and delineating their interdependencies. ML algorithms are computationally efficient, have strong predictive capabilities and can enable learning in the big data setting. ML algorithms can be viewed as providing a computational bridge from big data to complement PMX modelling. This review provides an overview of the strengths and weaknesses of ML approaches vis-à-vis population methods, assesses current research into ML applications in the pharmaceutical sciences and provides perspective for potential opportunities and strategies for the successful integration and utilization of ML in PMX., (© 2021 British Pharmacological Society.)

Objectives/hypothesis: Create an autonomous computational system to classify endoscopy findings., Study Design: Computational analysis of vocal fold images at an academic, tertiary-care laryngology practice., Methods: A series of normal and abnormal vocal fold images were obtained from the image database of an academic tertiary care laryngology practice. The benign images included normals, nodules, papilloma, polyps, and webs. A separate set of carcinoma and leukoplakia images comprised a single malignant-premalignant class. All images were classified with their existing labels. Images were randomly withheld from each class for testing. The remaining images were used to train and validate a neural network for classifying vocal fold lesions. Two classifiers were developed. A multiclass system classified the five categories of benign lesions. A separate analysis was performed using a binary classifier trained to distinguish malignant-premalignant from benign lesions., Results: Precision ranged from 71.7% (polyps) to 89.7% (papilloma), and recall ranged from 70.0% (papilloma) to 88.0% (nodules) for the benign classifier. Overall accuracy for the benign classifier was 80.8%. The binary classifier correctly identified 92.0% of the malignant-premalignant lesions with an overall accuracy of 93.0%., Conclusions: Autonomous classification of endoscopic images with artificial intelligence technology is possible. Better network implementations and larger datasets will continue to improve classifier accuracy. A clinically useful optical cancer screening system may require a multimodality approach that incorporates nonvisual spectra., Level of Evidence: NA Laryngoscope, 132:S1-S8, 2022., (© 2020 The American Laryngological, Rhinological and Otological Society, Inc.)

In this white paper, experts from the Digital Pathology Association (DPA) define terminology and concepts in the emerging field of computational pathology, with a focus on its application to histology images analyzed together with their associated patient data to extract information. This review offers a historical perspective and describes the potential clinical benefits from research and applications in this field, as well as significant obstacles to adoption. Best practices for implementing computational pathology workflows are presented. These include infrastructure considerations, acquisition of training data, quality assessments, as well as regulatory, ethical, and cyber‐security concerns. Recommendations are provided for regulators, vendors, and computational pathology practitioners in order to facilitate progress in the field. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

The article discusses the use of chatbot technology in the field of microscopy. The authors, Filip Braet and David Poger, highlight the potential benefits of chatbots in providing access to academic information and datasets. However, they also acknowledge the challenges and ethical considerations associated with using this technology in research. The authors share their experiences working with chatbots and express curiosity about the future role of AI in microscopy. They emphasize the importance of responsible and ethical use of AI in research and education. [Extracted from the article]

Objective: To perform a comprehensive review of the use of artificial intelligence (AI) and machine learning (ML) in dentistry, providing the community with a broad insight on the different advances that these technologies and tools have produced, paying special attention to the area of esthetic dentistry and color research., Materials and Methods: The comprehensive review was conducted in MEDLINE/PubMed, Web of Science, and Scopus databases, for papers published in English language in the last 20 years., Results: Out of 3871 eligible papers, 120 were included for final appraisal. Study methodologies included deep learning (DL; n = 76), fuzzy logic (FL; n = 12), and other ML techniques (n = 32), which were mainly applied to disease identification, image segmentation, image correction, and biomimetic color analysis and modeling., Conclusions: The insight provided by the present work has reported outstanding results in the design of high-performance decision support systems for the aforementioned areas. The future of digital dentistry goes through the design of integrated approaches providing personalized treatments to patients. In addition, esthetic dentistry can benefit from those advances by developing models allowing a complete characterization of tooth color, enhancing the accuracy of dental restorations., Clinical Significance: The use of AI and ML has an increasing impact on the dental profession and is complementing the development of digital technologies and tools, with a wide application in treatment planning and esthetic dentistry procedures., (© 2021 The Authors. Journal of Esthetic and Restorative Dentistry published by Wiley Periodicals LLC.)

The field of medicine is witnessing an exponential growth of interest in artificial intelligence (AI), which enables new research questions and the analysis of larger and new types of data. Nevertheless, applications that go beyond proof of concepts and deliver clinical value remain rare, especially in the field of allergy. This narrative review provides a fundamental understanding of the core concepts of AI and critically discusses its limitations and open challenges, such as data availability and bias, along with potential directions to surmount them. We provide a conceptual framework to structure AI applications within this field and discuss forefront case examples. Most of these applications of AI and machine learning in allergy concern supervised learning and unsupervised clustering, with a strong emphasis on diagnosis and subtyping. A perspective is shared on guidelines for good AI practice to guide readers in applying it effectively and safely, along with prospects of field advancement and initiatives to increase clinical impact. We anticipate that AI can further deepen our knowledge of disease mechanisms and contribute to precision medicine in allergy., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Objective: This article provides an overview of the implications of ChatGPT and other large language models (LLMs) for dental medicine., Overview: ChatGPT, a LLM trained on massive amounts of textual data, is adept at fulfilling various language-related tasks. Despite its impressive capabilities, ChatGPT has serious limitations, such as occasionally giving incorrect answers, producing nonsensical content, and presenting misinformation as fact. Dental practitioners, assistants, and hygienists are not likely to be significantly impacted by LLMs. However, LLMs could affect the work of administrative personnel and the provision of dental telemedicine. LLMs offer potential for clinical decision support, text summarization, efficient writing, and multilingual communication. As more people seek health information from LLMs, it is crucial to safeguard against inaccurate, outdated, and biased responses to health-related queries. LLMs pose challenges for patient data confidentiality and cybersecurity that must be tackled. In dental education, LLMs present fewer challenges than in other academic fields. LLMs can enhance academic writing fluency, but acceptable usage boundaries in science need to be established., Conclusions: While LLMs such as ChatGPT may have various useful applications in dental medicine, they come with risks of malicious use and serious limitations, including the potential for misinformation., Clinical Significance: Along with the potential benefits of using LLMs as an additional tool in dental medicine, it is crucial to carefully consider the limitations and potential risks inherent in such artificial intelligence technologies., (© 2023 The Authors. Journal of Esthetic and Restorative Dentistry published by Wiley Periodicals LLC.)