1. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.
- Author
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Hiroi, Noriko, Ito, Takaaki, Vamamoto, Hanako, Ochiya, Takahiro, Jinno, Shigeki, and Okayama, Hiroto
- Subjects
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TRETINOIN , *TRANSCRIPTION factors , *YEAST , *RETINOIDS , *PROTEINS , *DERMATOLOGIC agents - Abstract
Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucteotide treatment of embryonic mouse lung explants suggests that Rcd1 also plays a role in retinoic acid-controlled lung development. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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