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Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.
- Source :
-
EMBO Journal . 10/1/2002, Vol. 21 Issue 19, p5235-5244. 10p. - Publication Year :
- 2002
-
Abstract
- Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucteotide treatment of embryonic mouse lung explants suggests that Rcd1 also plays a role in retinoic acid-controlled lung development. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRETINOIN
*TRANSCRIPTION factors
*YEAST
*RETINOIDS
*PROTEINS
*DERMATOLOGIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 02614189
- Volume :
- 21
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- EMBO Journal
- Publication Type :
- Academic Journal
- Accession number :
- 12956120
- Full Text :
- https://doi.org/10.1093/emboj/cdf521