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1. Inhibition of human recombinant T‐type calcium channels by phytocannabinoids in vitro

Author

Somayeh Mirlohi, Chris Bladen, Marina J. Santiago, Jonathon C. Arnold, Iain McGregor, and Mark Connor

Subjects
Pharmacology, Calcium Channels, T-Type, HEK293 Cells, Patch-Clamp Techniques, Cannabidiol, Humans, Calcium, Membrane Potentials
Abstract

T-type Ca channels (IA fluorometric (fluorescence imaging plate reader [FLIPR]) assay was used to investigate modulation of human T-type IIn the FLIPR assay, all 11 phytocannabinoids tested modulated T-type IModulation of T-type calcium channels is a common property of phytocannabinoids, which all increase steady-state inactivation at physiological membrane potentials, with some also affecting channel activation. Thus, T-type I

Published
2022
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