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Inhibition of human recombinant T‐type calcium channels by phytocannabinoids in vitro

Authors :
Somayeh Mirlohi
Chris Bladen
Marina J. Santiago
Jonathon C. Arnold
Iain McGregor
Mark Connor
Source :
British Journal of Pharmacology. 179:4031-4043
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

T-type Ca channels (IA fluorometric (fluorescence imaging plate reader [FLIPR]) assay was used to investigate modulation of human T-type IIn the FLIPR assay, all 11 phytocannabinoids tested modulated T-type IModulation of T-type calcium channels is a common property of phytocannabinoids, which all increase steady-state inactivation at physiological membrane potentials, with some also affecting channel activation. Thus, T-type I

Details

ISSN :
14765381 and 00071188
Volume :
179
Database :
OpenAIRE
Journal :
British Journal of Pharmacology
Accession number :
edsair.doi.dedup.....89f0c595297c91ac03a721fa982f580f
Full Text :
https://doi.org/10.1111/bph.15842