Search

Your search keyword '"Kraume, Matthias"' showing total 106 results
Start Over Author "Kraume, Matthias" Publisher wiley
106 results on '"Kraume, Matthias"'

3. Improved Energy Efficiency of Power‐to‐X Processes Using Heat Pumps Towards Mobility Sector Defossilization

Author

Mantei, Franz, Kraume, Matthias, and Salem, Ouda

Subjects
power-to-X, hydrogen, General Chemical Engineering, oxymethylene ethers, defossilization, e-fuels, General Chemistry, 600 Technik, Medizin, angewandte Wissenschaften::660 Chemische Verfahrenstechnik::660 Chemische Verfahrenstechnik, Industrial and Manufacturing Engineering
Abstract

Combining Power-to-X (PtX) processes with high temperature heat pumps (HTHP) can significantly increase their energy efficiency. Evaluating the example of oxymethylene ethers (OME) production from H2 via H2O electrolysis and captured CO2 from air shows that by upgrading waste heat streams using HTHP, a process overall energy efficiency of higher than 61 % can be achieved compared to 30 % in conventional integrated processes. Thereby, the waste heat stream from H2O electrolysis already covers the low temperature heat demand for CO2 capture via direct air capture, not only for OME but also for various PtX products. Importantly, a significant lever for the energy efficiency enhancement is the consideration of other low temperature heat-demanding sectors. High overall process energy efficiencies and the electrification of the industry are key aspects towards a sustainable mobility sector.

Published
2022
Full Text
View/download PDF

9. Energie‐ und Ressourceneinsparung durch Innovative und CFD‐basierte Auslegung von Flüssig/Flüssig‐Schwerkraftabscheidern

Author

Steinhoff, Jan, primary, Charlafti, Evgenia, additional, Leleu, David, additional, Reinecke, Laura, additional, Franken, Heinz, additional, Becker, Karsten, additional, Kalem, Murat, additional, Sixt, Maximilian, additional, Braß, Manuel, additional, Borchardt, Daniel, additional, Bäcker, Werner, additional, Wegener, Mirco, additional, Maaß, Sebastian, additional, Weber, Manfred, additional, Acher, Thomas, additional, Matten, Christian, additional, Pfennig, Andreas, additional, Kraume, Matthias, additional, and Bart, Hans‐Jörg, additional

Published
2021
Full Text
View/download PDF

15. Development of a method for reliable power input measurements in conventional and single-use stirred bioreactors at laboratory scale

Author

Kaiser, Stephan C., Werner, Sören, Jossen, Valentin, Kraume, Matthias, Eibl, Dieter, Kaiser, Stephan C., Werner, Sören, Jossen, Valentin, Kraume, Matthias, and Eibl, Dieter

Abstract

Power input is an important engineering and scale-up/down criterion in stirred bioreactors. However, reliably measuring power input in laboratory-scale systems is still challenging. Even though torque measurements have proven to be suitable in pilot scale systems, sensor accuracy, resolution, and errors from relatively high levels of friction inside bearings can become limiting factors at smaller scales. An experimental setup for power input measurements was developed in this study by focusing on stainless steel and single-use bioreactors in the single-digit volume range. The friction losses inside the air bearings were effectively reduced to less than 0.5% of the measurement range of the torque meter. A comparison of dimensionless power numbers determined for a reference Rushton turbine stirrer (NP = 4.17 ± 0.14 for fully turbulent conditions) revealed good agreement with literature data. Hence, the power numbers of several reusable and single-use bioreactors could be determined over a wide range of Reynolds numbers between 100 and >104. Power numbers of between 0.3 and 4.5 (for Re = 104) were determined for the different systems. The rigid plastic vessels showed similar power characteristics to their reusable counterparts. Thus, it was demonstrated that the torque-based technique can be used to reliably measure power input in stirred reusable and single-use bioreactors at the laboratory scale.

Published
2020

32. Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods

Author

Löffelholz, Christian, Husemann, Ute, Greller, Gerhard, Meusel, Wolfram, Kauling, Jörg, Ay, Peter, Kraume, Matthias, Eibl-Schindler, Regine, Eibl, Dieter, Löffelholz, Christian, Husemann, Ute, Greller, Gerhard, Meusel, Wolfram, Kauling, Jörg, Ay, Peter, Kraume, Matthias, Eibl-Schindler, Regine, and Eibl, Dieter

Abstract

During the past five years, the number of single-use bioreactors used in biopharmaceutical research and production has increased tremendously. This increase has been particularly associated with mammalian cell culture processes from small- to medium-scale volumes. Even though nowadays customers can choose from a multitude of 2nd and 3rd generation single-use bioreactors, ranging from mL- up to m3-scale, there is a lack of knowledge of their engineering parameters. Different approaches have been applied to characterization investigations, resulting in an inability to compare different single-use bioreactors with each other and their reusable counterparts, creating an obstacle to a systematic approach to scaling-up the process. This article describes parametric, experimental and computer-based numeric methods for biochemical engineering characterization of single-use bioreactors, which have already been used successfully for the characterization of their reusable counterparts. For the first time, these methods have been evaluated in terms of their practical application.

Published
2018

33. Bag mixing system for single-use

Author

Werner, Sören, Kraume, Matthias, Eibl, Dieter, Werner, Sören, Kraume, Matthias, and Eibl, Dieter

Published
2018

34. Development of the travelling wave bioreactor. Part II : engineering characteristics and cultivation results

Author

Kaiser, Stephan, Perepelitsa, Nadja, Kraume, Matthias, Eibl, Dieter, Kaiser, Stephan, Perepelitsa, Nadja, Kraume, Matthias, and Eibl, Dieter

Abstract

The innovative travelling wave bioreactor (TWB), an orbitally shaken system, developed specifically for cell culture applications, is investigated. In this study, engineering parameters covering power input, mixing time and oxygen mass transfer obtained in two TWB prototypes are presented for the first time. Based on the results, cultivation parameters for CHO suspension cell cultivations were defined. Cell growth and substrate consumption were comparable with a wave-mixed reference bioreactor, which demonstrates the bioreactor's applicability for cultivations of mammalian cell cultures for the first time.

Published
2018

35. Development of the travelling wave bioreactor. Part I : design studies based on numerical models

Author

Kaiser, Stephan, Kraume, Matthias, Eibl, Dieter, Kaiser, Stephan, Kraume, Matthias, and Eibl, Dieter

Abstract

In the travelling wave bioreactor (TWB) an orbital movement is used to set up a quasi-periodic wave motion in the partially filled, toroidal shaped vessel. Based on computational fluid dynamics (CFD) models, this study presents detailed analyses of the fluid flow in the TWB for a wide range of operational conditions. Even though the wave propagation is shown to be greatly influenced by the rotation, it was found that the regular vessel shape facilitates a predominantly tangential flow with low back mixing, irrespective of the operational conditions. Hence, the influence of different bioreactor geometries without and with baffles is examined. The study indicates that CFD models can be used as a valuable tool for bioreactor development, because it provides a deep insight into the bioreactor's hydrodynamics and can help to reduce the number of prototypes.

Published
2018

36. A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps

Author

Dittler, Ina, Kaiser, Stephan, Blaschczok, Katharina, Löffelholz, Christian, Bösch, Pascal, Dornfeld, Wolfgang, Schöb, Reto, Rojahn, Jürgen, Kraume, Matthias, Eibl, Dieter, Dittler, Ina, Kaiser, Stephan, Blaschczok, Katharina, Löffelholz, Christian, Bösch, Pascal, Dornfeld, Wolfgang, Schöb, Reto, Rojahn, Jürgen, Kraume, Matthias, and Eibl, Dieter

Abstract

The suitability of oil-water emulsions to predict shear forces in stirred bioreactors under cost-effective and time-saving conditions has been demonstrated several times, but no application to pumps has been described so far. In this report, the drop sizes in a model oil-water system were determined for the Levitronix PuraLev® MU series (PuraLev® 200MU and PuraLev® 600MU), a peristaltic pump (Masterflex® I/P Easy Load), and a 4-piston diaphragm pump (Quattroflow 1200-SU) using inline endoscopy. It was determined that the Sauter mean diameter could be used as a comparison criterion to estimate mechanical stress in pumps. The investigation showed that PuraLev® MU pumps are characterized by up to 59 % larger Sauter mean diameters than their counterparts at comparable operational conditions. This indicates lower hydrodynamic stress in the PuraLev® MU pumps. Using computational fluid dynamics (CFD), a well-streamlined fluid flow and low turbulent energy dissipation rates (TEDR) were found in the PuraLev® MU pumps, which correlated well with experimental results. A calculation model was used to predict the Sauter mean diameter by combining both experimental and CFD data. Good agreement with deviations below 13% was determined between model predictions and experimental data.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results