1. Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging
- Author
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Ivonne Suridjan, Mark Dias, Sjoerd J. Finnema, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Kyle C. Wilcox, Takuya Toyonaga, Richard E. Carson, Jim Ropchan, Brian Pittman, Shannan Henry, Mika Naganawa, Sule Tinaz, and Robert A. Comley
- Subjects
Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Pyrrolidines ,Pyridines ,Red nucleus ,Nerve Tissue Proteins ,Substantia nigra ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Dopamine ,Humans ,Medicine ,Research Articles ,Red Nucleus ,SV2A ,Membrane Glycoproteins ,business.industry ,Functional Neuroimaging ,Putamen ,Parkinson Disease ,Middle Aged ,3. Good health ,Substantia Nigra ,Early Diagnosis ,030104 developmental biology ,nervous system ,Neurology ,Case-Control Studies ,Positron-Emission Tomography ,Synapses ,Autoradiography ,Locus coeruleus ,Female ,Locus Coeruleus ,Neurology (clinical) ,Brainstem ,business ,030217 neurology & neurosurgery ,Research Article ,medicine.drug - Abstract
Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system. Methods This study examined the density of all synapses with synaptic vesicle glycoprotein 2A (SV2A) in Parkinson disease subjects with mild bilateral disease (n = 12) and matched normal controls (n = 12) using in vivo high‐resolution positron emission tomographic imaging as well as postmortem autoradiography in an independent sample with Parkinson disease (n = 15) and normal controls (n = 13) in the substantia nigra and putamen. Results A group‐by‐brain region interaction effect (F 10, 22 = 3.52, p = 0.007) was observed in the primary brain areas with in vivo SV2A binding. Post hoc analyses revealed that the Parkinson disease group exhibited lower SV2A in the substantia nigra (−45%; p
- Published
- 2020