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A copper-catalyzed one-pot synthesis of functionalized benzimidazoles has been developed. The procedure combines the copper-catalyzed three-component cascade reaction of sulfonyl azides, alkynes and 2-bromoaniline and the copper-catalyzed intramolecular N-arylation of sulfonamides in one sequence, which afforded the products in moderate to good yields.

Objective OPC-28326 is a selective α-adrenergic antagonist with preferential binding to the α2C-adrenergic receptor (α2C-AR) subtype. This study observed the effect of OPC-28326 on skin temperature and digital blood flow following an acute cold challenge in patients with Raynaud's phenomenon secondary to scleroderma. Methods The study was designed as a single-center, double-blind, placebo-controlled, randomized, 3-period crossover study of OPC-28326 (oral doses of 10 mg or 40 mg) or placebo. The primary outcome measures were the time to recover 50% and 70% of the fall (induced by cold challenge) in baseline digital skin temperature. Results Twelve of 13 enrolled patients completed the study. The mean time to achieve 50% and 70% recovery of the change in prechallenge digital skin temperature was shorter after the OPC-28326 40-mg dose than after placebo (50% recovery at 5.8 minutes versus 10.0 minutes [P = 0.02]; 70% recovery at 13.8 minutes versus 19.5 minutes [P = 0.01]). These recovery times tended to be shorter in the 10 mg OPC-28326 group as well, but the difference versus placebo was not significant (50% recovery at 9.0 minutes versus 10.0 minutes [P = 0.65]; 70% recovery at 15.3 minutes versus 19.5 minutes [P = 0.07]). Total digital blood flow tended to be lower prior to the cold challenge and after administration of 40 mg OPC-28326, as compared with that after placebo, but the difference was not significant. Symptoms that were potentially drug-related were reported more frequently with 40 mg OPC-28326 than with 10 mg OPC-28326 or with placebo, but none were serious or sustained. Conclusion OPC-28326 at doses of 10 mg and 40 mg was well tolerated during this study. The shorter time to skin temperature recovery after 40 mg OPC-28326 suggests that selective α2C-AR blockade improves digital skin perfusion during recovery from cooling in patients with Raynaud's phenomenon secondary to scleroderma.

Influences of nitrile rubber (NBR, acrylonitrile content 33.5 – 36.5 wt.-%) on the structure and mechanical properties of poly(vinyl chloride) (PVC)/low density polyethylene (LDPE) blends and its synergism with crosslinking agent have been studied. The addition of NBR to the blend is accompanied by a decrease in domain size and improvements in mechanical properties of the blend. When dicumyl peroxide (DCP) is added to the blend together with NBR, good synergism is caused and mechanical properties will improve dramatically. It is concluded that NBR can promote the phase dispersion of PVC and LDPE and their interfacial adhesion. Then, the probability of DCP existing at the interface will increase and more co-crosslinked products will form. Therefore, compatibilization and crosslinking are both exerted sufficiently. Der Einflus von Nitrilkautschuk (NBR, 33,5 – 36,5 Gew.-% Acrylnitril) auf Struktur und mechanische Eigenschaften von Blends aus Polyvinylchlorid (PVC) und Polyethylen niedriger Dichte (LDPE) und der synergistische Effekt von NBR mit einem Vernetzer wurden untersucht. Die NBR-Zugabe fuhrt zu einer Domanenverkleinerung und Verbesserung der mechanischen Eigenschaften der Blends. Dieser Effekt wird durch gleichzeitige Zugabe von Dicumylperoxid (DCP) synergistisch verstarkt. Daraus wird geschlossen, das NBR die Phasendispersion und die Grenzflachenadhasion von PVC und LDPE verbessert, wodurch der DCP-Anteil an den Grenzflachen erhoht wird, was zur Vernetzung der PVC- mit den LDPE-Domanen fuhrt. Insgesamt werden die Kompatibilitat und die Vernetzung dadurch gefordert.

Highly ordered porous Ni3P films are electrodeposited through a self-assembled monodisperse polystyrene sphere template on a Cu substrate followed by heating the as-prepared films at 500 °C for 1 h under Ar flow.

A copper-catalyzed one-pot synthesis of functionalized benzimidazoles has been developed. The procedure combines the copper-catalyzed three-component cascade reaction of sulfonyl azides, alkynes and 2-bromoaniline and the copper-catalyzed intramolecular N-arylation of sulfonamides in one sequence, which afforded the products in moderate to good yields.