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Advanced multifunctional hydrogels for diabetic foot ulcer healing: Active substances and biological functions
- Source :
- Journal of Diabetes, Vol 16, Iss 4, Pp n/a-n/a (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley, 2024.
-
Abstract
- Abstract Aim Hydrogels with excellent biocompatibility and biodegradability can be used as the desirable dressings for the therapy of diabetic foot ulcer (DFU). This review aimed to summarize the biological functions of hydrogels, combining with the pathogenesis of DFU. Methods The studies in the last 10 years were searched and summarized from the online database PubMed using a combination of keywords such as hydrogel and diabetes. The biological functions of hydrogels and their healing mechanism on DFU were elaborated. Results In this review, hydrogels were classified by their active substances such as drugs, cytokines, photosensitizers, and biomimetic peptide. Based on this, the biological functions of hydrogels were summarized by associating the pathogenesis of DFU, including oxidative stress, chronic inflammation, cell phenotype change, vasculopathy, and infection. This review also pointed out some of the shortcomings of hydrogels in present researches. Conclusions Hydrogels were classified into carrier hydrogels and selfâfunctioning hydrogels in this review. Besides, the functions and components of existing hydrogels were clarified to provide assistance for future researches and clinical applications.
Details
- Language :
- English
- ISSN :
- 17530407 and 17530393
- Volume :
- 16
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0f5cd52cbc44e09a1ae4ddebf81c57
- Document Type :
- article
- Full Text :
- https://doi.org/10.1111/1753-0407.13537