1. EDTA treatment of intermittent claudication - a doubleblind, placebo-controlled study
- Author
-
Jelnes R, K Mogensen, A Klaerke, Guldager B, Jørgensen Sj, Ottesen S, J S Nielsen, E Reimer, Holm J, and K E Larsen
- Subjects
Male ,Vitamin ,medicine.medical_specialty ,Placebo-controlled study ,Walking ,Placebo ,law.invention ,chemistry.chemical_compound ,Double-Blind Method ,Randomized controlled trial ,law ,Internal Medicine ,medicine ,Humans ,Chelation therapy ,Infusions, Intravenous ,Edetic Acid ,Aged ,Analysis of Variance ,business.industry ,Therapeutic effect ,Intermittent Claudication ,Middle Aged ,Intermittent claudication ,Surgery ,chemistry ,Anesthesia ,Exercise Test ,Female ,medicine.symptom ,business ,Claudication ,Follow-Up Studies - Abstract
A double-blind, randomized multicentre study was undertaken to evaluate the possible effect of chelation treatment with ethylenediamine-tetraacetic acid (EDTA) in patients with severe intermittent claudication. A total of 153 patients received 20 intravenous infusions of either 3 g Na2EDTA or placebo during a period of 5-9 weeks. Vitamin, mineral and trace element supplements were administered orally. The changes observed in the pain-free and maximal walking distances, measured on a treadmill, were similar in the two groups. During the 3-month (n = 149) and 6-month (n = 123) follow-up period, no long-term therapeutic effect of EDTA could be demonstrated. The ankle-brachial blood pressure index remained unchanged throughout the study period. This study failed to demonstrate any effect of EDTA chelation treatment in intermittent claudication.
- Published
- 1992