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EDTA treatment of intermittent claudication - a doubleblind, placebo-controlled study
- Source :
- Journal of Internal Medicine. 231:261-267
- Publication Year :
- 1992
- Publisher :
- Wiley, 1992.
-
Abstract
- A double-blind, randomized multicentre study was undertaken to evaluate the possible effect of chelation treatment with ethylenediamine-tetraacetic acid (EDTA) in patients with severe intermittent claudication. A total of 153 patients received 20 intravenous infusions of either 3 g Na2EDTA or placebo during a period of 5-9 weeks. Vitamin, mineral and trace element supplements were administered orally. The changes observed in the pain-free and maximal walking distances, measured on a treadmill, were similar in the two groups. During the 3-month (n = 149) and 6-month (n = 123) follow-up period, no long-term therapeutic effect of EDTA could be demonstrated. The ankle-brachial blood pressure index remained unchanged throughout the study period. This study failed to demonstrate any effect of EDTA chelation treatment in intermittent claudication.
- Subjects :
- Male
Vitamin
medicine.medical_specialty
Placebo-controlled study
Walking
Placebo
law.invention
chemistry.chemical_compound
Double-Blind Method
Randomized controlled trial
law
Internal Medicine
medicine
Humans
Chelation therapy
Infusions, Intravenous
Edetic Acid
Aged
Analysis of Variance
business.industry
Therapeutic effect
Intermittent Claudication
Middle Aged
Intermittent claudication
Surgery
chemistry
Anesthesia
Exercise Test
Female
medicine.symptom
business
Claudication
Follow-Up Studies
Subjects
Details
- ISSN :
- 13652796 and 09546820
- Volume :
- 231
- Database :
- OpenAIRE
- Journal :
- Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....41309d1d7e66f6aa6de49d7a7f72778c