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Abstract Large‐scale wildfires can significantly reduce the air gap insulation resistance of high‐voltage transmission lines and cause chain tripping incidents. To assess the resilience of the power transmission system during wildfire, this paper proposes a resilience assessment framework for transmission system that considers the entire process of wildfire disaster. Firstly, a wildfire spread model, considering multiple influencing factors, is developed based on the cellular automaton. Based on the air gap breakdown mechanism during wildfires, the trip‐out probability of transmission lines is calculated, and various failure scenarios are obtained by using the Monte Carlo sampling. Secondly, considering the geographical location of failures, maintenance personnel schedules and restoration time, a power transmission system restoration model is established. Thus, a resilience assessment method for power transmission system during wildfire disasters is proposed. Finally, IEEE RTS‐79 transmission system is taken as an example to demonstrate the effectiveness of the proposed resilience assessment method. The results show that the proposed method can effectively calculate the wildfire spread tendency and transmission line's trip‐out probability. Furthermore, three typical resilience improvement measures are quantitatively analysed, which provides a quantifiable reference for the power sector to formulate prevention and recovery strategies for extreme wildfire disasters.

Abstract The injection of supercritical CO2 (ScCO2) into the enhanced geothermal systems (EGS) is a highly intricate thermohydromechanical (THM) coupled process. To improve the realism and accuracy of simulating convective heat transfer characteristics in CO2‐EGS, a coupled model based on discrete fracture network (DFN) theory is established. In this model, the dynamic evolution laws of reservoir porosity and permeability, as well as the nonlinear variations of thermophysical parameters for ScCO2 under the influences of temperature and pressure are considered. The validity of the numerical results was confirmed through a comparative analysis with the analytical solution. The result shows that the ScCO2 can rapidly extracts heat from both the fractures and the adjacent rock matrix. The heat of the rock matrix far away from the fractures cannot be compensated to the fractures immediately, resulting in the high temperature peak effect of the local rock matrix. The injection of ScCO2 can increase the porosity and permeability of reservoir, which is induced by the weakened thermal expansion effect of rock. The alteration of reservoir porosity and permeability also leads to the change of the flow characteristics of ScCO2. Additionally, the thermal parameters of ScCO2 changes with the temperature and pressure conditions of the reservoir. The change of flow rate and heat extraction rate of ScCO2 in EGS is dominated by the decrease of density, specific heat capacity, porosity, permeability, and thermal conductivity.

Abstract Background Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, but the molecular mechanisms underlying IBD are incompletely understood. In this study, we explored the role and regulating mechanism of otubain 2 (OTUB2), a deubiquitinating enzyme, in IBD. Methods To study the function of OTUB2 in IBD, we generated Otub2–/– mice and treated them with dextran sulfate sodium (DSS) to induce experimental colitis. Bone marrow transplantation was performed to identify the cell populations that were affected by OTUB2 in colitis. The molecular mechanism of OTUB2 in signal transduction was studied by various biochemical methods. Results OTUB2 was highly expressed in colon‐infiltrating macrophages in both humans with IBD and mice with DSS‐induced experimental colitis. Colitis was significantly aggravated in Otub2–/– mice and bone marrow chimeric mice receiving Otub2–/– bone marrow. OTUB2‐deficiency impaired the production of cytokines and chemokines in macrophages in response to the NOD2 agonist muramyl dipeptide (MDP). Upon MDP stimulation, OTUB2 promoted NOD2 signaling by stabilizing RIPK2. Mechanistically, OTUB2 inhibited the proteasomal degradation of RIPK2 by removing K48‐linked polyubiquitination on RIPK2, which was mediated by the active C51 residue in OTUB2. In mice, OTUB2 ablation abolished the protective effects of MDP administration in colitis. Conclusion This study identified OTUB2 as a novel regulator of intestinal inflammation.

Abstract Ripretinib, a broad‐spectrum inhibitor of the KIT and PDGFRA receptor tyrosine kinases, is designated as a fourth‐line treatment for gastrointestinal stromal tumor (GIST). It is tailored for patients resistant to imatinib, sunitinib, and regorafenib. As its increasing use, instances of resistance to ripretinib are becoming more frequent. Unfortunately, there are currently no scientifically mature treatment options available for patients resistant to ripretinib. Posttranslational modifications (PTMs) such as ubiquitination, in conjunction with its interplay with other modifications, play a collective role in regulating tumor initiation and progression. However, the specific association between ubiquitination and ripretinib resistance is not reported. Through proteome–ubiquitinome sequencing, increased levels of the USP5 protein and decreased ubiquitination in ripretinib‐resistant GISTs are detected. Subsequent examination of the mass spectrometry findings validated the interaction through which TRIM21 governs USP5 expression via ubiquitination, and USP5 regulates MDH2 expression through deubiquitination, consequently fostering ripretinib resistance in GIST. Moreover, ZDHHC18 can palmitoylate MDH2, preventing its ubiquitination and further increasing its protein stability. The research underscores the correlation between posttranslational modifications, specifically ubiquitination, and drug resistance, emphasizing the potential of targeting the USP5‐MDH2 axis to counteract ripretinib resistance in GIST.

Abstract Three‐dimensional (3D) current collectors (CCs) have emerged as an effective strategy to inhibit dendrites and ensure the safety of lithium (Li) metal anodes. However, existing 3D CCs are generally too heavy (typically tens of mg cm−2) or too thick (tens to hundreds of micrometers), making large‐scale production and further application challenging. Additionally, the use of single‐component 3D CCs, whether electrically active or inert, only exhibits limited effects on stabilizing Li anodes. Here, we present a scalable screen‐printing technique for the synthesis of ultralight (~0.4 mg cm−2) and ultrathin (~0.54 μm) SiO2 grids on Cu foil to regulate both the vertical electric field and Li‐ion concentration by forming an electrically active/inert dual‐function architecture. This technology breaks the limitations of traditional 3D CCs in material/fabrication costs, weight, thickness and especially, scalability for large‐scale fabrication. By using this dual‐function architecture, our Cu@SiO2‐grid CCs (~8.31 mg cm−2), which are even lighter than the original Cu‐foil CCs (~8.85 mg cm−2), realize an ultra‐smooth anode surface without Li dendrites, and thus leads to an ultra‐long cyclic life of over 1500 h at 1 mA cm−2. The assembled Li metal batteries demonstrate excellent capacity retention of ~80% over 400 cycles at 1 C and ~ 76% over 250 cycles at 5 C, which highlight the promising 3D CCs for practical applications.

Abstract MoS2 as a typical layered transition metal dichalcogenide (LTMD) has attracted considerable attention to work as sodium host materials for sodium‐ion batteries (SIBs). However, it suffers from low semiconducting behavior and high Na+ diffusion barriers. Herein, intercalation of N‐doped amorphous carbon (NAC) into each interlayer of the tiny MoS2 nanosheets embedded on rGO conductive network is achieved, resulting in formation of rGO@MoS2/NAC hierarchy with interoverlapped MoS2/NAC superlattices for high‐performance SIBs. Attributed to intercalation of NAC, the resulting MoS2/NAC superlattices with wide MoS2 interlayer of 1.02 nm facilitates rapid Na+ insertion/extraction and accelerates reaction kinetics. Theoretical calculations uncover that the MoS2/NAC superlattices are beneficial for enhanced electron transport, decreased Na+ diffusion barrier and improved Na+ adsorption energy. The rGO@MoS2/NAC anode presents significantly improved high‐rate capabilities of 228, 207, and 166 mAh g−1 at 20, 30, and 50 A g−1, respectively, compared with two control samples of pristine MoS2 and MoS2/NAC counterparts. Excellent long‐term cyclability over 10 000 cycles with extremely low capacity decay is demonstrated at high current densities of 20 and 50 A g−1. Sodium‐ion full cells based on the rGO@MoS2/NAC anode are also demonstrated, yielding decent cycling stability of 200 cycles at 5C. Our work provides a novel interlayer strategy to regulate electron/Na+ transport for fast‐charging SIBs.

Abstract The Carbon‐binder domain (CBD) plays a pivotal role in the performance of lithium‐ion battery electrodes. The heterogeneous distribution of CBD across the electrode has garnered significant attention. However, a thorough understanding of how this CBD inhomogeneity affects anode performance remains a crucial pursuit, especially when considering the inherent material variations present in the SiO/Graphite (SiO/Gr) composite anode. In this study, an electro‐chemo‐mechanical model is established that provides a detailed geometric description of the particles. This model allows to quantitatively uncover the effects of CBD inhomogeneity on the fundamental behaviors of the SiO/Gr composite anode. The findings indicate that reducing the proportion of CBD in the upper domain (near the anode surface) compared to the lower domain (near the current collector) positively influences electrochemical performance, particularly in terms of capacity and Li plating. However, such an arrangement introduces potential risks of mechanical failures, and it is recommended to incorporate a higher proportion of CBD alongside the SiO particles. Finally, an anode design with a lower CBD proportion in the upper domain exhibits superior rate performance. This study represents a pioneering modeling exploration of CBD inhomogeneity, offering a promising multiphysics model with significant potential for informing advanced battery design considerations.

Abstract Vasculogenic mimicry (VM) describes a process by which tumor cells formed a novel microcirculation pattern in an endothelial cell‐free manner. Clinically, VM is associated with aggressive phenotype and poor patient survival. However, the current models for investigating VM include 2D monolayer cultures, Matrigel‐based cultures, and animal models, each of which has limitations. Matrigel‐based models often exhibit batch‐to‐batch variations, while in vivo tumor models currently produce insufficient amounts of VM. There is currently no suitable tumor model to discover new therapeutic targets against VM. Herein, we establish an extracellular matrix (ECM)‐based engineered tumor model in vivo and in vitro. In this study, we demonstrate that matrix proteins enhanced the VM formation in the engineered xenograft model. Furthermore, we also investigated the role of collagen/fibronectin (FN) in melanoma progression and VM formation. Compared with cells cultured on TCPS plates, the B16F10 cells cultured on collagen/FN coated plates showed increased proliferation and stemness, and significantly enhanced invasion and formation of VM networks. Molecular mechanism analysis showed that Integrin/VE‐cadherin/EphA2/PI3K/MMP‐2 signaling pathways are responsible for VM formation. Our results indicate that collagen/FN matrix plays an important role in VM formation in melanoma, suggesting that ECM protein is a potential therapeutic target for anti‐VM therapy for melanoma.

Abstract To promote the widespread use of mobile robots in diverse fields, the performance of trajectory tracking must be ensured. To address the constraints and nonlinear features associated with mobile robot systems, nonlinear model predictive control (MPC) is applied to realize trajectory tracking of mobile robots. Specifically, to alleviate the online computational complexity of nonlinear MPC, this paper devises a lattice piecewise affine (PWA) approximation method that can approximate both the nonlinear system and control law of explicit nonlinear MPC. The kinematic model of the mobile robot is successively linearized along the trajectory to obtain a linear time‐varying description of the system, which is then expressed using a lattice PWA model. Subsequently, the nonlinear MPC problem can be transformed into a series of linear MPC problems. Furthermore, to reduce the complexity of online calculation of multiple linear MPC problems, the optimal solution of the linear MPCs is approximated by using the lattice PWA models. That is, for different sampling states, the optimal control inputs are obtained offline, and lattice PWA approximations are constructed for the state control pairs. Simulations are performed to evaluate the performance of the method in comparison with the state‐of‐the‐art methods, and the results show that the method has a higher online computing speed and can decrease the offline computing time without significantly increasing the tracking error.

Abstract To identify the mechanism underlying macrosteatosis (MaS)‐related graft failure (GF) in liver transplantation (LT) by multi‐omics network analysis. The transcriptome and metabolome were assayed in graft and recipient plasma in discovery (n = 68) and validation (n = 89) cohorts. Differentially expressed molecules were identified by MaS and GF status. Transcriptional regulatory networks were generated to explore the mechanism for MaS‐related inferior post‐transplant prognosis. The differentially expressed molecules associated with MaS and GF were enriched in ferroptosis and peroxisome‐related pathways. Core features of MaS‐related GF were presented on decreased transferrin and impaired anti‐oxidative capacity dependent upon dysregulation of transcription factors hepatocyte nuclear factor 4A (HNF4A) and hypoxia‐inducible factor 1A (HIF1A). Furthermore, miR‐362‐3p and miR‐299‐5p inhibited transferrin and HIF1A expression, respectively. Lower M2 macrophages but higher memory CD4 T cells were observed in MaS‐related GF cases. These results were validated in clinical specimens and cellular models. Systemic analysis of multi‐omics data depicted a panorama of biological pathways deregulated in MaS‐related GF. Transcriptional regulatory networks centered on transferrin and anti‐oxidant responses were associated with poor MaS graft quality, qualifying as potential targets to improve prognosis of patients after LT.

Abstract Objective The aim of this study is to investigate the clinical characteristics and pathogens involved in persistent or recurrent pneumonia combined with airway malacia in children. Methods We retrospectively reviewed the information of children hospitalised with persistent or recurrent pneumonia, including clinical presentations, laboratory examination results and pathogens. Results A total of 554 patients were admitted, 285 (51.44%) of whom were found to have airway malacia. There were 78 (27.37%), 166 (58.25%) and 41 (14.39%) patients with mild, moderate and severe malacia, respectively. Patients with airway malacia were younger than those without malacia (6.0 vs. 12.0 months, p

Abstract Aims We aimed to investigate the independent associations between growth differentiation factor 15 (GDF‐15) level at admission and cardiovascular (CV) death, thrombotic events, heart failure (HF), and bleeding outcomes in patients with coronary artery disease (CAD). Methods and results We measured the plasma concentrations of GDF‐15 centrally in patients from the BIomarker‐based Prognostic Assessment for patients with Stable angina and acute coronary Syndrome (BIPass) registry, which consecutively enrolled patients with CAD from November 2017 to September 2019 at five tertiary hospitals in China. The outcomes included CV death, thrombotic events [myocardial infarction (MI) and ischaemic stroke], HF events [acute HF during hospitalization and hospitalization for HF post‐discharge (A/H HF) and cardiogenic shock], and bleeding outcomes [non‐coronary artery bypass grafting‐related major bleeding and clinically significant bleeding (CSB)] during the 12 month follow‐up period after hospitalization. Among 6322 patients with CAD {65.4% male, median age 63.7 [inter‐quartile range (IQR)] 56.0–70.1 years}, the median concentration of plasma GDF‐15 at admission was 1091 (IQR 790.5–1635.0) ng/L. Higher concentrations of GDF‐15 were associated with an increased risk of CV death [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.35–2.88, P

Abstract Recurrence is the key factor affecting the prognosis of osteosarcoma. Currently, there is a lack of clinically useful tools to predict osteosarcoma recurrence. The application of pathological images for artificial intelligence‐assisted accurate prediction of tumour outcomes is increasing. Thus, the present study constructed a quantitative histological image classifier with tumour nuclear features to predict osteosarcoma outcomes using haematoxylin and eosin (H&E)‐stained whole‐slide images (WSIs) from 150 osteosarcoma patients. We first segmented eight distinct tissues in osteosarcoma H&E‐stained WSIs, with an average accuracy of 90.63% on the testing set. The tumour areas were automatically and accurately acquired, facilitating the tumour cell nuclear feature extraction process. Based on six selected tumour nuclear features, we developed an osteosarcoma histological image classifier (OSHIC) to predict the recurrence and survival of osteosarcoma following standard treatment. The quantitative OSHIC derived from tumour nuclear features independently predicted the recurrence and survival of osteosarcoma patients, thereby contributing to precision oncology. Moreover, we developed a fully automated workflow to extract quantitative image features, evaluate the diagnostic values of feature sets and build classifiers to predict osteosarcoma outcomes. Thus, the present study provides a novel tool for predicting osteosarcoma outcomes, which has a broad application prospect in clinical practice.

Abstract Intervention of the gut microbiome is a promising adjuvant strategy in cancer immunotherapy. Chemotherapeutic agents are recognized for their substantial impacts on the gut microbiome, yet their therapeutic potential as microbiome modulators remains uncertain, due to the complexity of microbiome‐host‐drug interactions. Here, it is showed that low‐dose chemotherapy preferentially shapes the ileal microbiome to augment the extraintestinal immune response to anti‐programmed death‐1 (anti‐PD‐1) therapy without causing intestinal toxicity. Mechanistically, low‐dose chemotherapy causes DNA damage restricted to highly‐proliferative ileal epithelial cells, resulting in the accumulation of cytosolic dsDNA and the activation of the absent in melanoma 2 (AIM2) inflammasome. AIM2‐dependent IL‐18 secretion triggers the interplay between proximal Th1 cells and Paneth cells in ileal crypts, impairing the local antimicrobial host defense and resulting in ileal microbiome change. Intestinal epithelium‐specific knockout of AIM2 in mice significantly attenuates CPT‐11‐caused IL‐18 secretion, Paneth cell dysfunction, and ileal microbiome alteration. Moreover, AIM2 deficiency in mice or antibiotic microbial depletion attenuates chemotherapy‐augmented antitumor responses to anti‐PD1 therapy. Collectively, these findings provide mechanistic insights into how chemotherapy‐induced genomic stress is transduced to gut microbiome change and support the rationale of applying low‐dose chemotherapy as a promising adjuvant strategy in cancer immunotherapy with minimal toxicity.

Abstract Background The post‐remission therapy (PRT) choices for adult t(8;21) acute myeloid leukemia (AML) in first complete remission (CR1) need to be further explored. Aims We aimed to investigate the impact of measurable residual disease (MRD) combined with CD19 on PRT choices for adult t(8;21) AML in CR1. Methods A total of 150 t(8;21) AML patients were enrolled, including 67 underwent chemotherapy (CMT) and 83 allogeneic hematopoietic stem cell transplantation (allo‐SCT) as PRT in CR1. Subgroup analyses were performed according to MRD level after three cycles of chemotherapy combined with CD19 expression. Results Multivariate analysis indicated MRDhigh after three courses of treatment (HR, 0.14 [95% CI, 0.03–0.66]; p = 0.013) and CD19 negativity (HR, 0.14 [95% CI, 0.02–0.96]; p = 0.045) were risk factors for relapse, while allo‐SCT was protective factor for relapse (HR, 0.34 [95% CI, 0.15–0.75]; p = 0.008). Grouped by MRD after three courses of chemotherapy, allo‐SCT had lower CIR (p

Abstract Introduction Small cell lung cancer (SCLC) is a highly aggressive lung cancer variant known for its elevated risk of brain metastases (BM). While earlier meta‐analyses supported the use of prophylactic cranial irradiation (PCI) to reduce BM incidence and enhance overall survival, modern MRI capabilities raise questions about PCI's universal benefit for limited‐stage SCLC (LS‐SCLC) patients. As a response, we have created a predictive model for BM, aiming to identify low‐risk individuals who may not require PCI. Methods A total of 194 LS‐SCLC patients without PCI treated between 2009 and 2021 were included. We conducted both univariate and multivariate analyses to pinpoint the factors associated with the development of BM. A nomogram for predicting the 2‐ and 3‐year probabilities of BM was then constructed. Results Univariate and multivariate analyses revealed several significant independent risk factors for the development of BM. These factors include TNM stage, the number of chemotherapy (ChT) cycles, Ki‐67 expression level, pretreatment serum lactate dehydrogenase (LDH) levels, and haemoglobin (HGB) levels. These findings underscore their respective roles as independent predictors of BM. Based on the results of the final multivariable analysis, a nomogram model was created. In the training cohort, the nomogram yielded an area under the receiver operating characteristic curve (AUC) of 0.870 at 2 years and 0.828 at 3 years. In the validation cohort, the AUC values were 0.897 at 2 years and 0.789 at 3 years. The calibration curve demonstrated good agreement between the predicted and observed probabilities of BM. Conclusions A novel nomogram has been developed to forecast the likelihood of BM in patients diagnosed with LS‐SCLC. This tool holds the potential to assist healthcare professionals in formulating more informed and tailored treatment plans.

Abstract Silicon monoxide (SiO) (silicon [Si] mixed with silicon dioxide [SiO2])/graphite (Gr) composite material is one of the most commercially promising anode materials for the next generation of high‐energy‐density lithium‐ion batteries. The major bottleneck for SiO/Gr composite anode is the poor cyclability arising from the stress/strain behaviors due to the mismatch between two heterogenous materials during the lithiation/delithiation process. To date, a meticulous and quantitative understanding of the highly nonlinear coupling behaviors of such materials is still lacking. Herein, an electro–chemo–mechanics‐coupled detailed model containing particle geometries is established. The underlying mechanism of the regulation between SiO and Gr components during electrochemical cycling is quantitatively revealed. We discover that increasing the SiO weight percentage (wt%) reduces the utilization efficiency of the active materials at the same 1 C rate charging and enhances the hindering effects of stress‐driven flux on diffusion. In addition, the mechanical constraint demonstrates a balanced effect on the overall performance of cells and the local behaviors of particles. This study provides new insights into the fundamental interactions between SiO and Gr materials and advances the investigation methodology for the design and evaluation of next‐generation high‐energy‐density batteries.

Abstract Monitoring and alarm play an important role in preventing trip‐out caused by wildfires for high‐voltage transmission lines. This paper proposes a multi‐Doppler weather radar‐based method for monitoring and alerting of wildfires near transmission lines. Firstly, characteristic parameters are mathematically proposed to distinguish wildfire's radar echoes. Then, the four‐site neighbourhood algorithm and the multithreading method are used to extract all possible wildfire echo units detected by various Doppler weather radars, and a cumulative probability is calculated to identify the wildfire. Finally, a regional block search method is used to quickly locate wildfire‐affected transmission towers. The membership function of spread time in the fuzzy set is proposed to determine the alarm level, which takes into account the influences of environment, topography, and vegetation on wildfire spread rate. The application to a provincial power grid demonstrates that the proposed method has an accuracy of 82.4%, a missing alarm rate of 27.4%, and a delay of fewer than 15 min. In addition, the joint observation of wildfires by multi‐Doppler weather radars and satellites indicates a promising application prospect for transmission line wildfire fighting.

Abstract The characteristics of internal short circuits (ISC) play a critical role in determining the thermal runaway behaviors and associated hazards of lithium‐ion batteries (LIBs). However, due to safety concerns and limitations in operando characterization at high state‐of‐charges (SoCs), the fundamental understanding of stress‐driven ISCs under high SOC situations (above 30%) is still lacking. In this study, combined post‐mortem characterization and multiphysics modeling is employed to clarify the evolution of ISC modes in LIBs with high SOCs. These findings reveal that the triggered ISC mode is SOC‐dependent, with the Al current collector (Al)‐Anode coating (An) mode dominant in high SOC situations. Experimentally obtained ISC resistance for the specified ISC mode is then assigned to the corresponding ISC region in the established multiphysics model, allowing for accurate coupling of the electromechanical relationship and prediction of mechanical‐electrical‐thermal responses of the LIB. Finally, a simple yet effective approach is proposed for avoiding the Al‐An mode after battery fractures, achieved through surface notches on electrodes. Results discover novel phenomena for ISC in high SOC cells and reveal the underlying mechanisms, highlighting the importance and potential of battery structural design for developing next‐generation robust batteries.

Abstract Recent studies have shown a decoupling in the way community composition and functions respond to environmental changes. A common pattern observed is that aggregated functions at the community level are more stable than community composition, which is likely the result of functional compensatory dynamics driven by interspecific differences in response to environmental change. However, the mechanisms by which these patterns emerge remain largely unexplored. Here we investigated in a mesocosm experiment for four weeks the compositional and functional responses of edible phytoplankton (

Objective To investigate the correlation between melatonin and osteoarthritis (OA) in rats. To explore the relevant mechanisms in the occurrence and development of osteoarthritis in rats, and to further understand the disease of osteoarthritis. Methods Forty healthy 6‐month‐old male SD rats were randomly divided into two groups: sham and drug intervention groups. Pre‐OA modeling, enzyme‐linked immunosorbent assay was employed to detect the levels of IL‐1β, IL‐6, COX‐2, and melatonin in the serum of the rats in each group. For OA modeling, we administered an injection of papain into the knee cavity of all rats. The levels of IL‐1β, IL‐6, and COX‐2 in the serum of rats in each group were detected 2 weeks after the modeling. Additionally, 2 weeks after the modeling, the rats in the drug intervention group were intraperitoneally injected with melatonin antagonists. The rats in the sham group were intraperitoneally injected with normal saline for 2 weeks. The levels of IL‐1β, IL‐6, and COX‐2 in the serum of each group were measured at the second, third, and fourth weeks after the drug intervention, and the levels of melatonin in the serum were measured at the second week after the drug intervention. Finally, the rats were euthanized by cervical dislocation, and pathological sections were collected from the knee joint to observe the pathological tissue changes under a microscope, and Mankin score was determined. The independent samples t‐test method was used for analysis. Results The imaging examination after the drug intervention showed that the modeling of knee osteoarthritis in rats was successful. In the pathological findings, HE staining showed a legible cartilage structure of each layer, with cartilage proliferation and partial cartilage tearing to the radial layer. The tide line was intact; toluidine blue staining revealed more obvious changes. The differences among the mean values of IL‐6, IL‐1β, and COX‐2 measured in each period were statistically significant (t = 5.50, p

Abstract An advanced electrocatalyst to accelerate the sluggish kinetics of multistep redox reactions and suppress the severe shuttle effects is desirable in Li‐S batteries (LSBs). Phase engineering can provide a fascinating way to modulate electronic structures and boost catalytic activity of electrocatalysts. In this study, few‐layered 1T‐MoSe2 nanosheets grown on carbon cloth (1T‐MoSe2/CC) are synthesized and employed as a multifunctional interlayer as well as a catalytic 3D current collector in LSBs to promote both physiochemical confinement and catalytic conversion toward lithium polysulfides (LiPSs). Density functional theory (DFT) calculations reveal that 1T‐MoSe2 has metallic properties beneficial for rapid electronic transport and exhibits a superior catalytic activity to reduce the Gibbs free energy barriers toward LiPS conversion. Significant improvements in chemisorption toward LiPSs, diffusion coefficients of Li ions, and Li2S deposition/decomposition reaction kinetics are realized by the 1T‐MoSe2/CC film. Consequently, the Al@S/AB@1T‐MoSe2/CC LSB, where 1T‐MoSe2/CC is used an interlayer, presents high rate capability of 1253 (1C), 1052 (2C) and 882 (4C) mAh g−1 and excellent long‐term cycling stability at a high rate (2000 cycles at 4C) with a low capacity fading rate (0.017% per cycle). Moreover, with a sandwiched cathode of 1T‐MoSe2/CC@S/AB@1T‐MoSe2/CC, where 1T‐MoSe2/CC works as both a catalytic 3D current collector and a multifunctional interlayer, the LSB at high S loading of 5.7 mg cm−2 and low electrolyte/sulfur ratio of 7.8 μL mg−1 exhibits a high initial areal capacity of 5.43 mAh cm−2 and remarkable rate‐cycling performance (200 cycles).

Abstract Introduction To investigate the role of the long‐chain noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) in the process of angiogenesis in human umbilical vein endothelial cells (HUVECs) and illustrate its potential role in burn sepsis (BS) pathogenesis. Methods HUVECs were treated with BS patient serum or healthy control serum. NEAT1 shRNA, miR‐495‐3p mimics, and miR‐495‐3p inhibitor were transfected into HUVECs. NEAT1 and miR‐495‐3 levels in serum or HUVECs were detected using quantitative reverse transcription‐polymerase chain reaction. Cell counting kit‐8 and flow cytometry assays were used to explore the proliferation and apoptosis of HUVECs. The expression of vascular endothelial growth factor (VEGF) in the supernatant was detected using enzyme‐linked immunosorbent assay. Tube formation of HUVECs was also analyzed. Western blot analysis was used to analyze signaling pathway proteins. Results In HUVECs stimulated with BS patient serum, NEAT1 expression was increased, while miR‐495‐3p expression was decreased. In addition, NEAT1 silencing by specific shRNA inhibited cell proliferation, VEGF production, and tube formation under burn patient serum treatment, which decreased the TGFβ1/SMAD signaling pathway activation. Moreover, miR‐495‐3p minics inhibited angiogenesis and the activation of signaling pathways induced by NEAT1 shRNA. Furthermore, miR‐495‐3p inhobitor promoted angiogenesis in HUVECs and activated the TGFβ1/SMAD signaling pathway. In patients with BS, NEAT1 expression was significantly increased and miR‐495‐3p expression was decreased compared to healthy controls, and NEAT1 and miR‐495‐3p expression was associated with the clinical features of patients. Conclusions Our results indicate that lncRNA NEAT1 regulates angiogenesis and activates the TGFβ1/SMAD signaling pathway during the occurrence of BS.

Abstract In this letter, the authors present a novel compact waveguide filtering twist that can be readily fabricated from metal using the computer numerical control (CNC) machining process. This filtering twist comprises four coupled resonators that are rotationally deformed to provide the desired 90° twist. Such resonator structures eliminate the use of curved features and therefore are ideally suitable for conventional CNC machining. The proposed design offers appealing advantages, including great compactness, easy fabrication, and good scalability to millimetre‐wave and terahertz frequencies. The design is demonstrated at X‐band and has a fourth‐order Chebyshev filter response (bandwidth 0.4 GHz, centred at 10 GHz). The good agreement between simulation and measurement results validates the proposed concept.

Abstract Background Secondary poor graft function (sPGF) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) related to poor outcome. We aimed to retrospectively evaluate the morbidity and hazard elements of sPGF after allo‐HSCT. Methods Eight hundred and sixty‐three patients who achieved initial engraftment of both neutrophils and platelets were retrospectively reviewed in this study. Results Fifty‐two patients developed sPGF within 180 days post‐transplants, with the median onset time was 62 days (range, 34–121 days) post‐transplants. The overall cumulative incidence of sPGF within 180 days post‐transplantation was 6.0%, with 3.4%, 3.4%, and 10.1%, respectively, in matched sibling donor (MSD), matched unrelated donor (MUD), and haploidentical donor (HID) transplant (p

Objective To better understand the risks of bisphosphonates in order to develop guidance for appropriate clinical usage, to compared femoral fracture healing at different time points and to explore the effects of Residronate on fracture healing. Methods Osteoporosis model was achieved by ovariectomy surgery, followed by surgical incision of left femoral shaft 4 weeks after ovariectomy surgery. Three days after fracture surgery, risedronateor saline was fed by intragastric administration. X ray examination was used to check the callus formation, Bone Mineral Density (BMD), Bone Mineral Content (BMC), biomechanical, imaging and micromorphological of bone tissue as well as the trabecular bone parameters were all examined. The femoral pathology tissue of each rat was used to analyze trabecular bone parameters, including trabecular bone volume/tissue volume (Tb. BV/TV), bone surface to tissue volume ratio (BS/TV), trabecular bone mineral density (Tb. BMD), trabecular bone number (Tb. N), trabecular bone thickness (Tb. Th) and small bone Trabecular bone space (Tb. Sp). Results Via X‐ray and pathologically, risedronate treatment promoted the callus forming at the fracture site during the following 6 weeks after osteoporotic fracture by X‐ray (P

Abstract This paper proposes a new assessment method for lightning trip‐out of transmission lines that includes an improved analytic hierarchy process (IAHP) algorithm based on a lift in association rules. First, the k‐means clustering algorithm is used to discretize the geomorphic information along transmission lines, and ten feature factors are obtained. Next, by analysing the correlation between each feature factor and a lightning trip‐out event using the lift algorithm, the strong correlation factors are extracted. On this basis, an IAHP algorithm optimized by lift is proposed to establish an objective judgment matrix. Then, multiple indexes are combined as a criterion layer of the IAHP, and a lightning risk assessment model of transmission lines is established. Finally, the proposed method is validated by simulations using 28 transmission lines with 220 kV voltage grade of a provincial power grid of China. An assessment model is established using the lightning trip‐out data in the period 2010–2014, and then this model is employed to estimate the lightning trip‐out risk in the period 2015–2018. Based on the number of phase faults, the agreement between the estimation results and the actual values is 76%. The proposed model provides a new method for the lightning risk assessment of transmission lines.

Abstract The deterioration of tissue structure and decline in physiological function during aging are accompanied by alterations to the gut microbiota. The elderly has higher risks of various diseases and chronic diseases. However, inter‐individual differences are more apparent in elderly than younger, and a proportion of individuals have a delayed onset or even avoid developing chronic diseases. This difference in health status is influenced by both heredity and Lifestyle and environmental factors. During the process of aging, the gut microbiota is also affected by the external environment, and provides a buffer to external challenge, and thus the gut microbiota reflects an individual's personal experience. Moreover, the immune system undergoes a series of changes with age, which are related to chronic inflammation in the elderly. The formation, maturation and senescence of the intestinal immune system is closely related to the gut microbiota. Additionally, changes in the gut microbiota of elderly individuals may modulate the immune system, which may in turn affect health status. Herein, we summarize the correlations between the gut microbiota with individual health status in the elderly and explore the related mechanisms, which may provide a basis to maintain or enhance the health of the elderly though interventions targeting the gut microbiota.

Abstract Submerged macrophytes play a key role in maintaining a clear‐water phase and promoting biodiversity in shallow aquatic ecosystems. Since their abundance has declined globally due to anthropogenic activities, it is important to include them in aquatic ecosystem restoration programs. Macrophytes establishment in early spring is crucial for the subsequent growth of other warm‐adapted macrophytes. However, factors affecting this early establishment of submerged macrophytes have not been fully explored yet. Here, we conducted an outdoor experiment from winter to early spring using the submerged macrophytes Potamogeton crispus and Vallisneria spinulosa to study the effects of shading, nutrient loading, snail herbivory (Radix swinhoei), and their interactions on the early growth and stoichiometric characteristics of macrophytes. The results show that the effects strongly depend on macrophyte species. Biomass and number of shoots of P. crispus decreased, and internode length increased during low light conditions, but were not affected by nutrient loading. P. crispus shoot biomass and number showed hump‐shaped responses to increased snail biomass under full light. In contrast, the biomass of the plant linearly decreased with snail biomass under low light. This indicates an interaction of light with snail herbivory. Since snails prefer grazing on periphyton over macrophytes, a low density of snails promoted growth of P. crispus by removing periphyton competition, while herbivory on the macrophyte increased during a high density of snails. The growth of V. spinulosa was not affected by any of the factors, probably because of growth limitation by low temperature. Our study demonstrates that the interaction of light with snail herbivory may affect establishment and growth of submerged macrophytes in early spring. Macrophyte restoration projects may thus benefit from lowering water levels to increase light availability and making smart use of cold‐adapted herbivores to reduce light competition with periphyton.

Abstract This study presents a microwave oscillator in which an innovative hybrid microstrip and substrate integrated waveguide filter is proposed for phase noise reduction. By virtue of equivalent circuit, the specific topology of this filter is clearly revealed and verified by both the simulation and the experiment. It can realize a third‐order elliptic bandpass response with two transmission zeros near the passband. Specific phase response can be formed, in which a high group delay can be achieved within a narrow frequency range around the centre frequency. This feature makes the filter performance very flexible for its application in microwave oscillator, and then reduces its phase noise. For demonstration, an oscillator example at 9.0 GHz was deigned, fabricated and measured. The measured phase noise at 100 kHz away from the oscillation frequency is as low as −120.06 dBc/Hz. Furthermore, the proposed oscillator is featured by greater than 60 dB second‐harmonic suppression and at least the third harmonic is suppressed.

Abstract Quasi‐1D silicon nanowires (SiNWs) field effect transistors (FETs) integrated upon large‐area elastomers are advantageous candidates for developing various high‐performance stretchable electronics and displays. In this work, it is demonstrated that an orderly array of slim SiNW channels, with a diameter of 105 and 134 ‐ 277 mV decade−1, respectively, working stably in an ambient environment over 270 days without any passivation protection. These results indicate a promising new routine to batch‐manufacture and integrate high‐performance, scalable and stretchable SiNW‐FET electronics that can work stably in harsh and large‐strain environments, which is a key capability for future practical flexible display and wearable electronic applications.

Abstract Background Recreational N2O abuse is an important etiology of neurological impairment in young patients, which may easily be ignored clinically. Few current studies have investigated the characteristics or the effects experienced by its users. We aimed to explore any correlation between the clinical severity and biomarkers and spinal magnetic resonance imaging (MRI) abnormalities, identify independent factors associated with spinal MRI abnormalities, and ascertain factors affecting depression/anxiety in patients with N2O‐related neurological disorders. Methods Patients with N2O‐related neurological disorders were enrolled retrospectively between February 2017 and July 2020. Their demographic, clinical, laboratory, neuroimaging, electrophysiological, and neuropsychological findings were analyzed. Correlation analyses were conducted using Spearman's or Pearson's correlation and linear regression analysis. Independent factors associated with spinal MRI abnormalities were identified using univariate and multivariate analyses. Results The principal clinical manifestations of N2O‐related neurological disorders (n = 63; 38 men, 25 women; mean age ± SD: 22.60 ± 4.46 years) were sensory disturbance, followed by gait disturbance and pyramidal tract damage. A significant negative correlation existed between serum vitamin B12 levels and clinical severity (r = −0.309, p = .014), which disappeared after linear regression. An interval of less than 6 months between initial N2O abuse and hospitalization was independently associated with spinal MRI abnormalities (39.47% vs. 72.00%, respectively; χ2 = 6.40, p = .01). Thirty‐eight (60.32%) and 40 (63.49%) patients experienced anxiety and depression, respectively. Moreover, the higher the clinical scores/serum homocysteine levels, the greater the severity of anxiety/depression (r = 0.442, p

Abstract Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of FGFR2 signaling initiates tumor formation. In an attempt to answer this question, a mouse model berrying an activation mutation of FGFR2 (FGFR2‐S252W) in the mammary gland is generated. It is found that FGF/FGFR2 signaling drives the development of triple‐negative breast cancer accompanied by epithelial‐mesenchymal transition that is regulated by FGFR2‐STAT3 signaling. It is demonstrated that FGFR2 suppresses BRCA1 via the ERK‐YY1 axis and promotes tumor progression. BRCA1 knockout in the mammary gland of the FGFR2‐S252W mice significantly accelerated tumorigenesis. It is also shown that FGFR2 positively regulates PD‐L1 and that a combination of FGFR2 inhibition and immune checkpoint blockade kills cancer cells. These data suggest that the mouse models mimic human breast cancers and can be used to identify actionable therapeutic targets.

Abstract This letter reports a highly compact microstrip quad‐band bandpass filter based on two folded λ/4 stepped impedance resonators and three folded dual‐mode short stub‐loaded resonators. The two stepped impedance resonators not only form the first passband but also serve as the feed structure and provide the source‐load coupling path for the three higher passbands created by the short stub‐loaded resonators. Thus, a compact size can be obtained, and three pairs of transmission zeros can be realised near the three higher passbands to improve the frequency selectivity. It has been shown that the centre frequencies and bandwidths of the four passbands can be controlled independently. A microstrip quad‐band bandpass filter centred at 1.1/2.05/3/3.55 GHz is implemented and tested achieving an extremely small size of 0.07λg × 0.14λg, where λg is the guided wavelength at 1.1 GHz. This presents one of the smallest quad‐band bandpass filter ever demonstrated in the literature.

Abstract A compact four‐order fully‐canonical dual‐band bandpass filter (DBBPF) with independently controllable bandwidths is reported in this letter. The filter comprises of a pair of identical electrically end‐coupled dual‐mode open stub‐loaded resonators (OSLRs) and two different pairs of magnetically coupled λ/4 short‐circuit resonators (SCRs) that are embedded within the OSLRs for compactness. Specifically, the fundamental odd‐ and even‐mode of the OSLRs are coupled with the upper and lower pairs of λ/4 SCRs to generate the first and second passbands, respectively. In addition, the input and output ports feed the two OSLRs and provide a magnetic source‐load coupling for the filter. Owing to the special layout arrangement, the proposed filter can achieve compact size and fully‐canonical frequency response with independently controllable bandwidths, simultaneously. A four‐pole DBBPF protype centred at 2 and 3.5 GHz is designed and implemented. The measurements and the simulated ones are in good consistency.

Abstract Structural design of advanced cathodes is a promising strategy to suppress the shuttle effect for lithium‐sulfur batteries (LSBs). In this work, the carbon cloth covered with CoS2 nanoparticles (CC‐CoS2) is prepared to function as both three‐dimensional (3D) current collector and physicochemical barrier to retard migration of soluble lithium polysulfides. On the one hand, the CC‐CoS2 film works as a robust 3D current collector and host with high conductivity, high sulfur loading, and high capability of capturing polysulfides. On the other hand, the 3D porous CC‐CoS2 film serves as a multifunctional interlayer that exhibits efficient physical blocking, strong chemisorption, and fast catalytic redox reaction kinetics toward soluble polysulfides. Consequently, the Al@S/AB@CC‐CoS2 cell with a sulfur loading of 1.2 mg cm−2 exhibits a high rate capability (≈823 mAh g−1 at 4 C) and delivers excellent capacity retention (a decay of ≈0.021% per cycle for 1000 cycles at 4 C). Moreover, the sandwiched cathode of CC‐CoS2@S/AB@CC‐CoS2 is designed for high sulfur loading LSBs. The CC‐CoS2@S/AB@CC‐CoS2 cells with sulfur loadings of 4.2 and 6.1 mg cm−2 deliver high reversible capacities of 1106 and 885 mAh g−1, respectively, after 100 cycles at 0.2 C. The outstanding electrochemical performance is attributed to the sandwiched structure with active catalytic component.

Abstract The past decade has seen the materialization of immune checkpoint blockade as an emerging approach to cancer treatment. However, the overall response and patient survival are still modest. Various efforts to study the “cancer immunogram” have highlighted complex biology that necessitates a multipronged approach. This includes increasing the antigenicity of the tumor, strengthening the immune infiltration in the tumor microenvironment, removing the immunosuppressive mechanisms, and reducing immune cell exhaustion. The coordination of these approaches, as well as the ability to enhance them through delivery, is evaluated. Due to their success in multiple preclinical models, external‐stimuli‐responsive nanoparticles have received tremendous attention. Several studies report success in distantly located tumor regression, metastases, and reoccurrence in preclinical mouse models. However, clinical translation in this space remains low. Herein, the recent advancement in external‐stimuli‐responsive nanoconstruct‐synergized immune checkpoint blockade is summarized, offering an industry perspective on the limitations of current academic innovations and discussing challenges in translation from a technical, manufacturing, and regulatory perspective. These limitations and challenges will need to be addressed to establish external‐stimuli‐based therapeutic strategies for patients.

Abstract The breast cancer susceptibility gene 1 (BRCA1) is a major tumor suppressor gene and is most frequently mutated in hereditary breast cancer. BRCA1 plays a critical role in many biological processes, especially maintaining genomic stability in the nucleus, yet its role in the cytoplasm remains elusive. Here, it is revealed that BRCA1 maintains a healthy mitochondrial network through regulating mitochondrial dynamics, including fission and fusion. BRCA1 deficiency causes dysfunctional mitochondrial dynamics through increased expression of mitofusin1/2. With mitochondrial stress, BRCA1 is recruited to the mitochondrial outer membrane, where it plays an essential role in maintaining a healthy mitochondrial network. Consequently, BRCA1 deficiency impairs stress‐induced mitophagy through blocking ataxia‐telangiectasia mutated (ATM)‐AMP‐activated protein kinase (AMPK)‐Dynamin‐related protein 1 (DRP1)‐mediated mitochondrial fission and triggers NLRP3 inflammasome activation, which creates a tumor‐associated microenvironment, thereby facilitating tumor proliferation and metastasis. It is further shown that inflammasome inhibition can prevent tumor recurrence and metastasis. This study uncovers an important role of BRCA1 in regulating mitophagy and suggests a therapeutic approach for fighting this deadly disease.

Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a âdormantâ disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer. Keywords: Anti-angiogenesis, Angiogenesis, Vascular endothelial growth factor, Cancer

Abstract Few‐layer black phosphorus (FL‐BP) has been intensively studied due to its attractive properties and great potential in electronic and optoelectronic applications. However, the intrinsic instability of FL‐BP greatly limits its practical application. In this study, the amphiphobic FL‐BP is achieved by functionalization of 1H,1H,2H,2H‐perfluorooctyltrichlorosilane (PFDTS) on the surface of FL‐BP. The obtained PFDTS coated FL‐BP (FL‐BP/PFDTS) demonstrates enhanced stability, which is not observed during significant degradation for 2 months in high moisture content environment (95% humidity). Particularly, attributing to the surface amphiphobicity, FL‐BP/PFDTS exhibits strong surface water repellency in the presence of oleic acid (as the contaminant), while other passivation coating layers (such as hydrophilic or hydrophobic coating) become hydrophilicity under such conditions. Owing to this advantage, the obtained FL‐BP/PFDTS demonstrates enhanced stability in high moisture content environment for 2 months, even though the surface is contaminated by oil liquid or other organic solvents (such as oleic acid, CH2Cl2, and N‐methyl‐2‐pyrrolidone). The passivation of FL‐BP by amphiphobic coating provides an effective approach for FL‐BP stabilization toward future applications.

Abstract Fibronectin‐binding protein A (FnBPA) is a key adhesin of Staphylococcus aureus, and the protein binding to fibrinogen and elastin is mediated by its N‐terminal A domain. Thus, FnBPA‐A has been considered a potential vaccine candidate, but the relevant epitopes are not fully understood. Here, purified rabbit anti‐FnBPA‐A antibodies were produced and used to screen for peptides corresponding to or mimicking the epitope of native FnBPA‐A protein by using a phage random 12‐mer peptide library. After four rounds of panning, 25 randomly selected phage clones were detected by phage‐ELISA and competition‐inhibition ELISA. Then, eight anti‐rFnBPA‐A antibody‐binding phage clones were selected for sequencing, and six different 12‐mer peptides were displayed by these phages. Although these displayed peptides shared no more than three consecutive amino acid residues identical to the sequence of FnBPA‐A, they could be recognized by the FnBPA‐A‐specific antibodies in vitro and could induce specific antibodies against FnBPA‐A in vivo, suggesting that these displayed peptides were mimotopes of FnBPA‐A. Finally, the protective efficiencies of these mimotopes were investigated by mouse vaccination and challenge experiments. Compared with that of control group mice, the relative percent survival of mice immunized with phage clones displaying a mimotope was 13.33% (C2 or C15), 0% (C8), 6.67% (C10), 26.67% (C19 or 1:2 mixture of C23 and C19), 53.33% (C23), 33.33% (1:1 mixture of C23 and C19), and 66.67% (2:1 mixture of C23 and C19). Overall, five peptides mimicking FnBPA‐A protein epitopes were obtained, and a partially protective immunity against S. aureus infection could be stimulated by these mimotope peptides in mice.

Aiming at meeting the requirement of balancing the fluctuating wind power, this study proposed an optimal control strategy for wind power hybrid energy storage system considering output power amendment. Firstly, fluctuant wind power is decomposed into low-frequency, sub-high frequency and high-frequency components. Low-frequency part is used as the expected value of wind power integration. Sub-high frequency and high-frequency components are used as the target value of output power of storage batteries and ultra-capacitor energy storage system. Secondly, a double power amendment is proposed. In the first-time power amendment, the amendment coefficient is calculated by fuzzy controller whose inputs are the target value of power and state of charge (SOC) of the energy storage system. On the other hand, complement of batteries and super-capacitors are utilised in the second amendment. Through simulation analysis, it can be indicated that the configuration of the hybrid energy storage system and the control system design are feasible. This system can be widely used in wind farm, undertaking the task of balancing the fluctuating wind power.

An improved scheme of a dual-switch forward converter is proposed in this paper. Compared with the original converter, the new one can provide higher resetting voltage during the hold-up time interval under the action of an additional reset capacitor. Namely, it allows the converter's duty cycle to be larger than 50%. As a result, the proposed method can transfer more energy stored in the bulk capacitor to the load side during the hold-up interval. Therefore, a smaller bulk capacitor can be used for the converter's hold-up time requirement. Since the additional reset capacitor acts only as a compensation, it would not affect other performance of the converter. The additional circuit can be applied for the dual-switch forward converter when small-volume and high power density are required. The working principle and the performance of the converter are analysed, and the relevant theory formulas are deduced. Then the parameters of key components are given. Finally, the theoretical analysis is validated through a 200 W experimental prototype.