474 results on '"In Kyung Lee"'
Search Results
2. Integrated factors affecting intention of <scp>COVID</scp> ‐19 preventive behaviours including vaccination in Korea
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Sung-rae Shin and WEE KYUNG LEE
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General Nursing - Abstract
The aim of the study was to determine the multiple potential contributing factors in preventive behaviours, including COVID-19 vaccination for an effective campaign strategy.This is a descriptive correlation study to examine the effects of the behavioural outcome, attitude, subjective norm, perceived behavioural control, optimistic bias and social stigma on the intention of preventive behaviour, based on Ajen's Theory of Planned Behaviour.The survey was performed by a professional research company online from 16-19 July 2021. Two hundred and thirty-three participants who had not been vaccinated against COVID-19 at the time of data collection completed the survey.Perceived benefit, perceived behavioural control and social stigma are significantly associated with intention of preventive behaviours. The factors engaging in preventive behaviour presents us that our society is strongly influenced by social groups. Social groups influence decision-making in intention of preventing behaviour. Public education using social networks can increase such desirable behaviour.
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- 2023
3. Virus detection of measles‐negative cases in Gyeonggi Province, South Korea, from 2017 to 2019
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Han‐Gil Cho, Su‐Kyoung Moon, Il‐Hyung Jeong, Yea‐Eun Lee, Hyun‐Kyung Lee, Baek‐Sang Han, Yujeong Kim, Yoon‐Seok Chung, Boksik Cha, and Wantae Kim
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Virology ,Immunology ,Microbiology - Abstract
To investigate viruses in measles-negative cases, 221 measles-suspected samples collected in Gyeonggi Province, South Korea were tested using a real-time PCR assay. Rubella virus was not detected. However, 11 cases of parvovirus B19 (5.0%), 47 cases of human herpesvirus 6 (21.3%), 25 cases of human herpesvirus 7 (11.3%), and one case of co-infection with parvovirus B19 and human herpesvirus 7 were confirmed, as were eight cases of co-infection with human herpesvirus 6 and human herpesvirus 7. This study showed that parvovirus B19, human herpesvirus 6, and human herpesvirus 7 should be considered by physicians for the diagnosis of measles-suspected patients.
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- 2022
4. Trust in <scp>COVID</scp> ‐19 public health information
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Nitin Verma, Kenneth R. Fleischmann, Le Zhou, Bo Xie, Min Kyung Lee, Kate Rich, Kristina Shiroma, Chenyan Jia, and Tara Zimmerman
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Information Systems and Management ,Computer Networks and Communications ,Library and Information Sciences ,Information Systems - Abstract
Understanding the factors that influence trust in public health information is critical for designing successful public health campaigns during pandemics such as COVID-19. We present findings from a cross-sectional survey of 454 US adults-243 older (65+) and 211 younger (18-64) adults-who responded to questionnaires on human values, trust in COVID-19 information sources, attention to information quality, self-efficacy, and factual knowledge about COVID-19. Path analysis showed that trust in direct personal contacts (
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- 2022
5. Generation of tandem alternative splice acceptor sites and <scp> CLTC </scp> haploinsufficiency: A cause of <scp> CLTC </scp> ‐related disorder
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Adam P. Sage, Hyun Kyung Lee, Joshua Dalmann, Susan Lin, Simran Samra, Areesha Salman, Kate L. Del Bel, Wenhui Laura Li, Anna Lehman, Stuart E. Turvey, Cornelius F. Boerkoel, and Phillip A. Richmond
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Genetics ,Genetics (clinical) - Published
- 2023
6. 2D Ni‐Naphthalene‐2,6‐Dicarboxylic Acid Metal‐Organic Framework as Electrocatalysts for Efficient Overall Water Splitting
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Min Kyung Lee, Sungkyun Choi, Hoonkee Park, Tae Hyung Lee, Sol A. Lee, Jin Wook Yang, Su Geun Ji, Woo Seok Cheon, Sang Hyun Ahn, Soo Young Kim, Mohammadreza Shokouhimehr, Jin Young Kim, and Ho Won Jang
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General Energy - Published
- 2023
7. Do <scp> PACS1 </scp> variants impeding adaptor protein binding predispose to syndromic intellectual disability?
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Ashley Moller‐Hansen, Duha Hejla, Hyun Kyung Lee, Jenea Barbara Lyles, Yunhan Yang, Kun Chen, Wenhui Laura Li, Gary Thomas, and Cornelius F. Boerkoel
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Genetics ,Genetics (clinical) - Published
- 2023
8. Randomized multicenter phase <scp>II</scp> trial of prophylactic irradiation of para‐aortic lymph nodes in advanced cervical cancer according to tumor hypoxia: Korean Radiation Oncology Group ( <scp>KROG</scp> 07‐01) study
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Meesun Yoon, Hyo Kyung Lee, Eun Young Park, Jin Hee Kim, Jong Hoon Lee, Young Seok Kim, Hak Jae Kim, Hunjung Kim, Chong Woo Yoo, Sun Lee, Eun Kyung Hong, Tae Hyun Kim, Tae‐Sung Kim, Sang‐soo Seo, Sokbom Kang, Suk‐Joon Chang, Hye Jin Shin, Tung Nguyen Thanh Uong, Semin Lee, and Joo‐Young Kim
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Cancer Research ,Oncology - Published
- 2022
9. Feasibility and acceptability of a digital tele‐guided intervention targeting components of the addictive appetite model for bulimia nervosa and binge‐eating disorder in Korea
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Kyung Hwa Kwag, Youl‐Ri Kim, You Kyung Lee, Hye Rin Lee, Ja Youn Lee, Jihye Lee, Jione Kim, Youngkeun Kim, and Janet Treasure
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Psychiatry and Mental health ,Republic of Korea ,Appetite ,Feasibility Studies ,Humans ,Female ,Bulimia Nervosa ,Binge-Eating Disorder - Abstract
We aimed to evaluate the feasibility, acceptability, and potential impact of a tele-guided digital-based intervention based on the addictive appetite model of recurrent binge eating.Female college students with bulimia nervosa (BN) or binge-eating disorder (BED) (n = 22) received a 6-week guided intervention targeting addictive processes and emotion regulation. The feasibility of the intervention was evaluated, and the outcomes were assessed at baseline, the end of the intervention, and 1-month follow-up.Of the participants, 86.4% (n = 19) completed the intervention. The self-help materials were viewed 6.03 ± 3.06 times per week, and the duration of using the self-help materials was 113.16 ± 160.19 min/week. The intervention group experienced a significant reduction with a moderate effect on binge eating at the end of the intervention (Hedges' g = 0.58), and the effects lasted through follow-up (Hedges' g = 0.82).The results suggest that the digital intervention targeting a maintenance mechanism of recurrent binge eating was feasible and acceptable for patients with BN and BED, proving the potential for symptom improvement.The addictive appetite model provides the framework for new interventions to improve treatments for BN and BED. This study found that the digital intervention based on the model was feasible and acceptable for patients with BN and BED.
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- 2022
10. Matched ligands for small, stable colloidal nanoparticles of copper, cuprous oxide and cuprous sulfide
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Bradley E. Cowie, Lisa Häfele, Andreas Phanopoulos, Said A. Said, Ja Kyung Lee, Anna Regoutz, Milo S. P. Shaffer, and Charlotte K. Williams
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Organic Chemistry ,General Chemistry ,Catalysis - Abstract
This work applies organometallic routes to copper(0/I) nanoparticles and describes how to match ligand chemistries with different material compositions. The syntheses involve reacting an organo-copper precursor, mesitylcopper(I) [CuMes]z (z=4, 5), at low temperatures and in organic solvents, with hydrogen, air or hydrogen sulfide to deliver Cu, Cu2 O or Cu2 S nanoparticles. Use of sub-stoichiometric quantities of protonated ligand (pro-ligand; 0.1-0.2 equivalents vs. [CuMes]z ) allows saturation of surface coordination sites but avoids excess pro-ligand contaminating the nanoparticle solutions. The pro-ligands are nonanoic acid (HO2 CR1 ), 2-[2-(2-methoxyethoxy)ethoxy]acetic acid (HO2 CR2 ) or di(thio)nonanoic acid, (HS2 CR1 ), and are matched to the metallic, oxide or sulfide nanoparticles. Ligand exchange reactions reveal that copper(0) nanoparticles may be coordinated by carboxylate or di(thio)carboxylate ligands, but Cu2 O is preferentially coordinated by carboxylate ligands and Cu2 S by di(thio)carboxylate ligands. This work highlights the opportunities for organometallic routes to well-defined nanoparticles and the need for appropriate ligand selection.
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- 2023
11. Suppression of Lung Cancer Malignancy by Micellized siRNA through Cell Cycle Arrest (Adv. Healthcare Mater. 11/2023)
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Haejoo Kim, In‐ho Jeong, Yeol Kyo Choi, Yeon Kyung Lee, Eunyoung Moon, Yang Hoon Huh, Wonpil Im, Jun‐O Jin, Minseok Kwak, and Peter Chang‐Whan Lee
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Biomaterials ,Biomedical Engineering ,Pharmaceutical Science - Published
- 2023
12. Mood management through metaverse enhancing life satisfaction
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Dooyoung Choi, Ha Kyung Lee, and Do Yuon Kim
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Marketing ,Economics and Econometrics ,Public Health, Environmental and Occupational Health ,Applied Psychology - Published
- 2023
13. Prenatal tobacco and cannabis co‐exposure and offspring obesity development from birth to mid‐childhood
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Kai Ling Kong, Jin‐kyung Lee, Shannon Shisler, Panayotis K. Thanos, Marilyn A. Huestis, Larry Hawk, and Rina D. Eiden
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Nutrition and Dietetics ,Health Policy ,Pediatrics, Perinatology and Child Health ,Public Health, Environmental and Occupational Health - Published
- 2023
14. Evaluation of Atopic Dermatitis Improvement Caused by Low‐Level, Low‐Frequency Pulsed Electromagnetic Fields
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Jun‐Young Kim, Ji‐Young Lee, Ja‐Woo Lee, Soo‐Kyung Lee, Chang‐Soon Park, Se‐Jung Yang, and Yong‐Heum Lee
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Mice ,Electromagnetic Fields ,Physiology ,Biophysics ,Animals ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Dermatitis, Atopic - Abstract
This study aimed to evaluate the effectiveness of using low-level, low-frequency pulsed electromagnetic field (LLLF_PEMF) stimulation to improve atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Twenty 6-week-old hairless mice were randomly divided into Normal (n = 5), PEMF 15 Hz (n = 5), PEMF 75 Hz (n = 5), and Sham (n = 5) groups. Following the onset of atopic dermatitis symptoms, PEMF groups (15 and 75 Hz) were stimulated with LLLF_PEMF (15 mT) for 8 h per day for 1 week. Sensory evaluation analysis revealed a significant difference between the PEMF 15 Hz group and Sham group (P 0.05), but these differences were not visually obvious. While both the PEMF and Sham groups had atopic dermatitis lesions, lesion size was significantly smaller in the two PEMF groups than in the Sham group (P 0.001). Additionally, changes in epithelial thickness because of skin inflammation significantly decreased for both PEMF groups, compared with the Sham group (P 0.001). In conclusion, these results suggest that PEMF stimulation in vivo triggers electro-chemical reactions that affect immune response. © 2022 Bioelectromagnetics Society.
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- 2022
15. Tubular dentin formation by TGF‐β/BMP signaling in dental epithelial cells
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Yoon Seon Lee, Yeoung‐Hyun Park, You‐Mi Seo, Hye‐Kyung Lee, and Joo‐Cheol Park
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Otorhinolaryngology ,General Dentistry - Abstract
This study aimed to identify formation of tubular dentin induced by transforming growth factor-β (TGF-β) and bone morphogenic protein (BMP) signaling pathway in dental epithelial cells.We collected conditioned medium (CM) of rTGF-β1/rBMP-2-treated HAT-7 and treated to MDPC-23 cells. The expression levels of odontoblast differentiation markers, KLF4, DMP1, and DSP were evaluated by real-time PCR and Western blot analysis. To evaluate whether CM of rTGF-β1/rBMP-2 induces tubular dentin formation, we made a beagle dog tooth defect model.Here, we show that Cpne7 is regulated by Smad4-dependent TGF-β1/BMP2 signaling pathway in dental epithelial cells. CM of rTGF-β1/rBMP-2 treated HAT-7 or rCPNE7 raises the expression levels of KLF4, DMP1, and DSP in MDPC-23 cells. When rTGF-β1 or rBMP-2 is directly treated to MDPC-23 cells, however, expression levels of Cpne7-regulated genes remain unchanged. In a beagle dog defect model, application of rTGF-β1/BMP2-treated CM resulted in tubular tertiary dentin mixed with osteodentin at cavity-prepared sites, while rTGF-β1 group exhibited homogenous osteodentin.Taken together, Smad4-dependent TGF-β1/BMP2 signaling regulates Cpne7 in dental epithelial cells, and CPNE7 protein secreted from pre-ameloblasts mediates odontoblast differentiation via epithelial-mesenchymal interaction.
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- 2022
16. The multiplicative function of expectancy and value in predicting engineering students' choice, persistence, and performance
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You‐kyung Lee, Emily Freer, Kristy A. Robinson, Tony Perez, Amalia K. Lira, Daina Briedis, S. Patrick Walton, and Lisa Linnenbrink‐Garcia
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General Engineering ,Education - Published
- 2022
17. MUL1‐RING recruits the substrate, p53‐TAD as a complex with UBE2D2–UB conjugate
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Min‐Sung Lee, Sang‐Ok Lee, Joonhyeok Choi, Minju Ryu, Mi‐Kyung Lee, Ji‐Hun Kim, Eunha Hwang, Chong‐Kil Lee, Seung‐Wook Chi, and Kyoung‐Seok Ryu
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Ubiquitin ,Ubiquitin-Protein Ligases ,Ubiquitin-Conjugating Enzymes ,Ubiquitination ,Cell Biology ,Tumor Suppressor Protein p53 ,Molecular Biology ,Biochemistry ,Protein Binding - Abstract
The RING domain of MUL1 (RING
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- 2022
18. International psychological research addressing the early phase of the <scp>COVID</scp> ‐19 pandemic: A rapid scoping review and implications for global psychology
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Martin Obschonka, Qiyue Cai, Athena C. Y. Chan, Scott Marsalis, Sydni A. J. Basha, Sun‐Kyung Lee, and Abigail H. Gewirtz
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Cross-Sectional Studies ,Mental Health ,Arts and Humanities (miscellaneous) ,SARS-CoV-2 ,COVID-19 ,Humans ,General Medicine ,Pandemics ,United States ,General Psychology - Abstract
In March 2020, the World Health Organization (WHO) declared COVID-19 a global pandemic. Given that keeping abreast of international perspectives and research results is of particular importance for such massive global emergencies, we employed a scoping review methodology to rapidly map the field of international psychological research addressing this important early phase of the pandemic. We included a total of 79 studies, with data mostly collected between March and June 2020. This review aimed to systematically identify and map the nature and scope of international studies examining psychological aspects of the unfolding COVID-19 pandemic. We mapped key research themes, subfields of psychology, the nature and extent of international research collaboration, data methods employed, and challenges and enablers faced by psychological researchers in the early stages of the pandemic. Among the wide range of themes covered, mental health and social behaviours were the key themes. Most studies were in clinical/health psychology and social psychology. Network analyses revealed how authors collaborated and to what extent the studies were international. Europe and the United States were often at the centre of international collaboration. The predominant study design was cross-sectional and online with quantitative analyses. We also summarised author reported critical challenges and enablers for international psychological research during the COVID pandemic, and conclude with implications for the field of psychology.
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- 2021
19. Why did (some) consumers buy toilet papers? A cross‐cultural examination of panic buying as a maladaptive coping response to <scp>COVID</scp> ‐19
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Hyunjoo Im, Ha Kyung Lee, and Naeun Lauren Kim
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Toilet ,Social support ,Sociology and Political Science ,Coronavirus disease 2019 (COVID-19) ,Maladaptive coping ,Cross-cultural ,Panic buying ,Psychology ,General Economics, Econometrics and Finance ,Social psychology - Published
- 2021
20. Real‐time multi‐GPU‐based 8KVR stitching and streaming on 5G MEC/Cloud environments
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Seong Yong Lim, Moonsung Gwak, Jeongil Seo, Hee-Kyung Lee, and Gi-Mun Um
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Image stitching ,General Computer Science ,business.industry ,Computer science ,Cloud computing ,Multi gpu ,Electrical and Electronic Engineering ,business ,5G ,Electronic, Optical and Magnetic Materials ,Computational science - Published
- 2021
21. Diffusion Kurtosis <scp>MR</scp> Imaging of Invasive Breast Cancer: Correlations With Prognostic Factors and Molecular Subtypes
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Yohan Son, Hie Bum Suh, Robert Grimm, Han Sol Kang, Jin Joo Kim, Suk Kim, Nam Kyung Lee, Jin You Kim, Ji Won Lee, and Lee Hwangbo
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Oncology ,medicine.medical_specialty ,Population ,Breast Neoplasms ,Sensitivity and Specificity ,Breast cancer ,Internal medicine ,medicine ,Humans ,Breast MRI ,Effective diffusion coefficient ,Radiology, Nuclear Medicine and imaging ,education ,Diffusion Kurtosis Imaging ,Retrospective Studies ,education.field_of_study ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,Mann–Whitney U test ,Kurtosis ,Female ,business - Abstract
BACKGROUND The associations between diffusion kurtosis imaging (DKI)-derived parameters and clinical prognostic factors of breast cancer have not been fully evaluated; this knowledge may have implications for outcome prediction and treatment strategies. PURPOSE To determine associations between quantitative diffusion parameters derived from DKI and diffusion-weighted imaging (DWI) and the prognostic factors and molecular subtypes of breast cancer. STUDY TYPE Retrospective. POPULATION A total of 383 women (mean age, 53.8 years; range, 31-82 years) with breast cancer who underwent preoperative breast MRI including DKI and DWI. FIELD STRENGTH/SEQUENCE A 3.0 T; DKI using a spin-echo echo-planar imaging (EPI) sequence (b values: 200, 500, 1000, 1500, and 2000 sec/mm2 ), DWI using a readout-segmented EPI sequence (b values: 0 and 1000 sec/mm2 ) and dynamic contrast-enhanced breast MRI. ASSESSMENT Two radiologists (J.Y.K. and H.S.K. with 9 years and 1 year of experience in MRI, respectively) independently measured kurtosis, diffusivity, and apparent diffusion coefficient (ADC) values of breast cancer by manually placing a regions of interest within the lesion. Diffusion measures were compared according to nodal status, grade, and molecular subtypes. STATISTICAL TESTS Kruskal-Wallis test, Mann-Whitney U test with Bonferroni correction, receiver operating characteristic (ROC) analysis, and multivariate logistic regression analysis. (Statistical significance level of P
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- 2021
22. Molecular epidemiological study of the G protein of human respiratory syncytial virus detected in patients with acute respiratory infections in Gyeonggi Province, South Korea
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Joo-Hyoung Cho, Sun-Hwa Lee, Baek-Sang Han, Ok-Kyung Choi, Joo-Won Suh, Han-Gil Cho, Hyun-Kyung Lee, Yea-Eun Lee, Jinhua Cheng, and Seon-Jae Bang
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Genotype ,Respiratory Syncytial Virus Infections ,Real-Time Polymerase Chain Reaction ,Virus ,Disease Outbreaks ,Evolution, Molecular ,Young Adult ,GTP-Binding Proteins ,Virology ,Republic of Korea ,Epidemiology ,Sore throat ,Humans ,Medicine ,In patient ,Respiratory system ,Child ,Phylogeny ,Aged ,Aged, 80 and over ,business.industry ,Infant, Newborn ,Infant ,Outbreak ,Middle Aged ,Reverse transcription polymerase chain reaction ,Infectious Diseases ,Child, Preschool ,Respiratory Syncytial Virus, Human ,Female ,Seasons ,medicine.symptom ,business - Abstract
To investigate the molecular characteristics of human respiratory syncytial virus (HRSV) detected in Gyeonggi Province from 2015/16 to 2017/18, 2331 specimens from patients with sporadic acute respiratory illness and 85 specimens from four HRSV outbreaks in the postpartum care center were analyzed by real-time reverse transcription PCR. HRSVs were detected in 97 of the 2416 (4.0%) specimens, and among the positive specimens, 38 (39.2%) were identified as HRSV-A and 59 (60.8%) as HRSV-B. During the study periods, HRSV-B predominated in all seasons, except in 2016/17 during which HRSV-A predominated. Depending on the age groups, HRSV prevalence was the highest in 0- to 2-year-old patients. Comparison of noninfected subjects with HRSV-infected subjects revealed that HRSV infection more frequently resulted in fever, nasal obstruction, and wheezing, although the frequency of sore throat was low; however, comparison of the symptoms between HRSV-A- and HRSV-B-infected patients revealed no significant differences in symptoms. Phylogenetic analysis showed that all HRSV-A patients had an ON1 genotype, and all HRSV-B patients had an BA9 genotype. These results provide a valuable reference regarding the circulating pattern and molecular characterization of HRSV. Continuous monitoring will be essential to detect newly emerging HRSV genotypes.
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- 2021
23. Successful treatment of induced oligometastasis and repeated oligoprogression of advanced lung adenocarcinoma with immunotherapy and radiotherapy
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Ho Young Lee, Sung Hyun Kim, Hong Yeul Lee, Young‐Min Lee, Ji Yeon Han, Heunglae Cho, and Hyun‐Kyung Lee
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Pulmonary and Respiratory Medicine ,Oncology ,General Medicine - Published
- 2022
24. Prognostic significance of surgery‐induced sarcopenia in the survival of gastric cancer patients: a sex‐specific analysis
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Sang Hoon Ahn, Sa Hong Min, Do Joong Park, Young Suk Park, Ja Kyung Lee, Kanghaeng Lee, Sang Il Youn, Yongjoon Won, and Hyung Ho Kim
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Male ,Stomach neoplasm ,Sarcopenia ,medicine.medical_specialty ,Survival ,medicine.medical_treatment ,Skeletal muscle ,Diseases of the musculoskeletal system ,Gastrectomy ,Stomach Neoplasms ,Physiology (medical) ,medicine ,Humans ,Orthopedics and Sports Medicine ,Risk factor ,Aged ,Retrospective Studies ,business.industry ,QM1-695 ,Hazard ratio ,Retrospective cohort study ,Original Articles ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,Surgery ,RC925-935 ,Human anatomy ,Cohort ,Female ,Original Article ,business - Abstract
Background Preoperative sarcopenia is associated with a poor long‐term prognosis in patients with gastric cancer (GC). Most GC patients rapidly lose muscle mass after gastrectomy. This retrospective cohort study analysed the effect of postoperative muscle loss and surgery‐induced sarcopenia on the long‐term outcomes of patients with GC. Methods Preoperative and postoperative 1 year abdominal computed tomography scans were available for 1801 GC patients who underwent curative gastrectomy between January 2009 and December 2013 at Seoul National University Bundang Hospital. The patients were categorized into normal, presarcopenia, and sarcopenia groups according to the skeletal muscle index (SMI) measured on computed tomography scans. Patients who were not sarcopenic prior to gastrectomy but became sarcopenic after surgery were defined as the surgery‐induced sarcopenia group. Results There were 1227 men and 574 women included in the study. The mean age of the patients was 59.5 ± 12.3 years. Multivariable Cox‐regression analyses showed that preoperative SMI was not associated with overall survival (OS). However, postoperative sarcopenia was associated with significantly worse OS only in men [hazard ratio (HR), 1.75; 95% confidence interval (CI), 1.08–2.85]. SMI loss was an independent risk factor for OS in the entire cohort and in men (HR, 1.01; 95% CI, 1.00–1.02, for the entire cohort; HR, 1.02; 95% CI, 1.01–1.04, for men). The surgery‐induced sarcopenia group was associated with significantly higher mortality (HR, 1.84; 95% CI, 1.16–2.90, for the cohort; HR, 2.73; 95% CI, 1.54–4.82, for men), although SMI loss and surgery‐induced sarcopenia were not risk factors in women. Similar results were obtained for relapse‐free survival. Conclusions Postoperative muscle mass loss and surgery‐induced sarcopenia are prognostic factors for survival in patients with GC. Impact of postoperative muscle mass loss and surgery‐induced sarcopenia on survival outcomes is dependent on the sex.
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- 2021
25. Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus
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Dong Hyeon Lee, Bo Kyung Koo, Geum-Sook Hwang, Min Kyung Lee, Seo Young Jang, Mee Soo Chang, Taekyeong Yoo, Sae Kyung Joo, Murim Choi, Youngae Jung, Yong Jin Jung, Heeyeon Lee, Dain Kim, Jeong Hwan Park, Sang Won Kang, and Won Kim
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medicine.medical_specialty ,medicine.drug_class ,digestive system ,Bile Acids and Salts ,Non-alcoholic Fatty Liver Disease ,Diabetes mellitus ,Internal medicine ,Nonalcoholic fatty liver disease ,Diabetes Mellitus ,medicine ,Metabolome ,Humans ,Obesity ,Hepatology ,Bile acid ,business.industry ,Fatty liver ,nutritional and metabolic diseases ,medicine.disease ,digestive system diseases ,Endocrinology ,Liver ,CYP8B1 ,business ,Body mass index - Abstract
Background and aims Bile acid (BA) dysregulation is related to not only metabolic diseases but also nonalcoholic fatty liver disease (NAFLD). We investigated whether circulating BA levels are altered according to the histological severity of NAFLD independent of metabolic derangements. Methods Global metabolic profiling and targeted BA analysis using sera collected from biopsy-proven no-NAFLD (n = 67), nonalcoholic fatty liver (NAFL) (n = 99), and nonalcoholic steatohepatitis (NASH, n = 75) subjects were performed sequentially. Circulating metabolome analysis integrated with the hepatic transcriptome was performed to elucidate the mechanistic basis of altered circulating BA profiles after stratification by obesity (body mass index ≤ 25 kg/m2 ). Circulating BA alterations were also validated in an independent validation cohort (29 no-NAFLD, 70 NAFL and 37 NASH). Results Global profiling analysis showed that BA was the metabolite significantly altered in NASH compared to NAFL. Targeted BA analysis demonstrated that glyco-/tauro-conjugated primary BAs were commonly increased in nonobese and obese NASH, while unconjugated primary BAs increased only in nonobese NASH. These characteristic primary BA level changes were maintained even after stratification according to diabetes status and were replicated in the independent validation cohort. Compared to nonobese NAFL patients, nonobese NASH patients exhibited upregulated hepatic expression of CYP8B1. Conclusions BA metabolism is dysregulated as the histological severity of NAFLD worsens, independent of obesity and diabetes status; dysregulation is more prominent in nonobese NAFLD patients. Metabolome-driven omics approach provides new insight into our understanding of altered BA metabolism associated with individual phenotypes of NAFLD.
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- 2021
26. Politically connected companies are less likely to shutdown due to COVID‐19 restrictions
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Haillie Na Kyung Lee, Andrey Tomashevskiy, and Robert Kubinec
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Government ,Coronavirus disease 2019 (COVID-19) ,Inequality ,media_common.quotation_subject ,General Social Sciences ,Original Articles ,Preferential treatment ,Rule of law ,Politics ,Market economy ,Original Article ,Business ,Shut down ,Potential mechanism ,media_common - Abstract
Objective While the aim of COVID‐19 policies is to suppress the pandemic, many fear that the burden of the restrictions will fall more heavily on less privileged groups. We show one potential mechanism for COVID‐19 responses to increase inequality by examining the intersection of business restrictions and business political connections. Methods We fielded an online survey of 2735 business employees and managers in Ukraine, Egypt, and Venezuela over the summer of 2020 to collect data on companies' closures due to COVID‐19 and nuanced information about their political connections. Findings We show that businesses with political connections to government officials were significantly less likely to shut down as a result of COVID‐19 policies. This finding suggests that measures designed to mitigate COVID‐19 are ineffective in countries with a weak rule of law if politically connected firms are able to circumvent restrictions by leveraging political connections to receive preferential treatment. In addition, politically connected firms are no more likely—and sometimes even less likely—to engage in social‐distancing policies to mitigate the pandemic despite the fact that they are more likely to remain open.
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- 2021
27. A feeling for the data: How government and nonprofit stakeholders negotiate value conflicts in data science approaches to ending homelessness
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Stephen C. Slota, Kenneth R. Fleischmann, Min Kyung Lee, Sherri R. Greenberg, Ishan Nigam, Tara Zimmerman, Sarah Rodriguez, and James Snow
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Information Systems and Management ,Computer Networks and Communications ,Library and Information Sciences ,Information Systems - Published
- 2022
28. Front Cover: Application of Nanopore Sensors for Biomolecular Interactions and Drug Discovery (Chem. Asian J. 19/2022)
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Ki‐Baek Jeong, Jin‐Sik Kim, Naresh Niranjan Dhanasekar, Mi‐Kyung Lee, and Seung‐Wook Chi
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Organic Chemistry ,General Chemistry ,Biochemistry - Published
- 2022
29. Application of Nanopore Sensors for Biomolecular Interactions and Drug Discovery
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Ki‐Baek Jeong, Jin‐Sik Kim, Naresh Niranjan Dhanasekar, Mi‐Kyung Lee, and Seung‐Wook Chi
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Nanopores ,Nucleic Acids ,Drug Discovery ,Organic Chemistry ,Humans ,Nanotechnology ,General Chemistry ,Ligands ,Biochemistry - Abstract
Biomolecular interactions, such as protein-protein, protein-nucleic acid, and protein/nucleic acid-ligand interactions, play crucial roles in various cellular signaling and biological processes, and offer attractive therapeutic targets in numerous human diseases. Currently, drug discovery is limited by the low efficiency and high cost of conventional ensemble-averaging-based techniques for biomolecular interaction analysis and high-throughput drug screening. Nanopores are an emerging technology for single-molecule sensing of biomolecules. Owing to the notable merits of single-molecule sensing, nanopore sensors have contributed tremendously to nucleic acid sequencing and disease diagnostics. In this minireview, we summarize the recent developments and outlooks in single-molecule sensing of various biomolecular interactions for drug discovery applications using biological and solid-state nanopore sensors.
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- 2022
30. Comparison between tube test and automated column agglutination technology on <scp>VISION</scp> Max for anti‐A/B isoagglutinin titres: A multidimensional analysis
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Hee-Won Moon, Mikyoung Park, Minjeong Nam, Mina Hur, Yeo-Min Yun, Hanah Kim, and Hyun Kyung Lee
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Blood type ,Agglutination ,Technology ,business.industry ,Hematology ,General Medicine ,Antibodies ,ABO Blood-Group System ,Agglutination (biology) ,Hemagglutinins ,Us dollar ,Nuclear medicine ,business ,Blood bank ,Mathematics - Abstract
Background and objectives VISION Max (Ortho Clinical Diagnostics, Raritan, NJ) measures anti-A/B isoagglutinin titres using automated column agglutination technology (CAT). We compared tube test (TT) and CAT of VISION Max comprehensively, including failure mode and effect analysis (FMEA), turnaround time (TAT) and cost, and suggested modified CAT (MCAT). Materials and methods For 100 samples (each 25 for blood type A, B and O with anti-A and anti-B), anti-A/B isoagglutinin titres were measured by TT and CAT (1:2-1:1024 dilution), as well as by MCAT (with agglutination at 1:32 dilution, then perform additional testing from 1:64 to 1:1024). We assessed the agreement and correlation between TT and CAT and compared FMEA (risk priority number [RPN] score), TAT (h:min:sec) and cost (US dollar, US $) among TT, CAT and MCAT. Results TT and CAT showed overall substantial agreement (k = 0.73) and high correlation (ρ ≥ 0.75) except blood type O with anti-A (ρ = 0.68). Compared with TT, CAT showed lower RPN scores in FMEA and similar TAT and cost (FMEA, 33,700 vs. 184,300; TAT, 15:23:00 vs. 14:26:40; cost, 1377.4 vs. 1312.4, respectively). Regarding FMEA, TAT and cost, MCAT was superior to CAT or TT (43,810; 13:28:00; 899.2, respectively). Conclusion This is the first multidimensional analysis on VISION Max CAT for measuring anti-A/B isoagglutinin titres. The results of anti-A/B isoagglutinin titres by CAT were comparable with those of TT. MCAT would be a safe, time-saving and cost-effective alternative to TT and CAT in high-volume blood bank laboratories.
- Published
- 2021
31. Isoniazid Population Pharmacokinetics and Dose Recommendation for Korean Patients With Tuberculosis Based on Target Attainment Analysis
- Author
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Jae-Gook Shin, Young-Kyung Choi, Hyun Kyung Lee, Yumi Park, Jong-Lyul Ghim, Hyo-Jung Kim, Jee Youn Oh, Nguyen Thi Thu Phuong, Yong-Soon Cho, Hye Kyeong Park, Nguyen Phuoc Long, and Tae-Won Jang
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Tuberculosis ,Genotype ,Arylamine N-Acetyltransferase ,Memory, Episodic ,Population ,Antitubercular Agents ,Drug resistance ,Models, Biological ,Asian People ,Pharmacokinetics ,Internal medicine ,Republic of Korea ,Isoniazid ,medicine ,Humans ,Body Weights and Measures ,Pharmacology (medical) ,Prospective Studies ,Dosing ,education ,Prospective cohort study ,Aged ,Pharmacology ,education.field_of_study ,Dose-Response Relationship, Drug ,business.industry ,Middle Aged ,medicine.disease ,Phenotype ,Pharmacodynamics ,Female ,business ,medicine.drug - Abstract
The wide variability of isoniazid (INH) pharmacokinetics is mainly attributed to the trimodal N-acetyltransferase 2 (NAT2) acetylator phenotype, i.e., rapid, intermediate, and slow. Consequently, a uniform INH dose in the current clinical practice may lead to treatment failure and drug resistance emergence. There is a lack of studies on specific doses of INH for different NAT2 acetylator phenotypes among tuberculosis patients. Therefore, we aimed to provide insight into the optimal dosing of INH for each NAT2 acetylator phenotype with respect to the probability of achieving a pharmacokinetic (PK)/pharmacodynamic target. PK, NAT2 genotype, and clinical data were collected in a multicenter prospective cohort study conducted at 13 clinical centers in Korea. Population PK modeling and simulation were carried out. Data from 454 TB patients were divided into a training dataset and a test dataset with a ratio of 4 to 1. The PK of the training data were best described by a two-compartment model with allometric scaling for the body size effect. Importantly, NAT2 acetylator phenotypes significantly affected the apparent clearance. Our model provided better predictive performance compared to previously published models, which was evaluated by external validation using the test set. The simulation for assessing the target efficacy and toxicity indicated that the best INH dosing regimens for Korean tuberculosis patients were once-daily doses of 400, 300, and 200 mg for rapid, intermediate, and slow acetylators, respectively. In conclusion, our study provides a step forward in precision dosing for anti-tuberculosis management. This article is protected by copyright. All rights reserved.
- Published
- 2021
32. Disproportionate microbial responses to decadal drainage on a Siberian floodplain
- Author
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Mathias Göckede, Yoo Kyung Lee, Binu M. Tripathi, Min Jung Kwon, Nu Ri Myeong, Seung Chul Shin, and Mincheol Kim
- Subjects
Population ,Permafrost ,Carbon Cycle ,Carbon cycle ,Soil ,Environmental Chemistry ,Ecosystem ,education ,General Environmental Science ,Global and Planetary Change ,education.field_of_study ,Ecology ,Methanoregula ,biology ,Microbiota ,Carbon Dioxide ,15. Life on land ,biology.organism_classification ,Arctic ,13. Climate action ,Metagenomics ,Environmental science ,Terrestrial ecosystem ,Methane - Abstract
Permafrost thaw induces soil hydrological changes which in turn affects carbon cycle processes in the Arctic terrestrial ecosystems. However, hydrological impacts of thawing permafrost on microbial processes and greenhouse gas (GHG) dynamics are poorly understood. This study examined changes in microbial communities using gene and genome-centric metagenomics on an Arctic floodplain subject to decadal drainage, and linked them to CO2 and CH4 flux and soil chemistry. Decadal drainage led to significant changes in the abundance, taxonomy, and functional potential of microbial communities, and these modifications well explained the changes in CO2 and CH4 fluxes between ecosystem and atmosphere-increased fungal abundances potentially increased net CO2 emission rates and highly reduced CH4 emissions in drained sites corroborated the marked decrease in the abundance of methanogens and methanotrophs. Interestingly, various microbial taxa disproportionately responded to drainage: Methanoregula, one of the key players in methanogenesis under saturated conditions, almost disappeared, and also Methylococcales methanotrophs were markedly reduced in response to drainage. Seven novel methanogen population genomes were recovered, and the metabolic reconstruction of highly correlated population genomes revealed novel syntrophic relationships between methanogenic archaea and syntrophic partners. These results provide a mechanistic view of microbial processes regulating GHG dynamics in the terrestrial carbon cycle, and disproportionate microbial responses to long-term drainage provide key information for understanding the effects of warming-induced soil drying on microbial processes in Arctic wetland ecosystems.
- Published
- 2021
33. Video‐assisted thoracoscopic surgical wedge resection using multiplanar computed tomography reconstruction‐fluoroscopy after <scp>CT</scp> guided microcoil localization
- Author
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Sang-Won Hwang, Moon Ok Lee, Sung Yup Jin, Sang Kyung Lee, Yun Gyu Song, and Tae Gyu Kim
- Subjects
Adult ,Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,wedge resection ,medicine.medical_treatment ,Microcoil ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Fluoroscopy ,Robotic surgery ,video‐assisted thoracoscopic surgery ,Lung cancer ,RC254-282 ,Aged ,Aged, 80 and over ,computed tomography multiplanar reconstruction ,medicine.diagnostic_test ,Thoracic Surgery, Video-Assisted ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Postoperative complication ,pulmonary nodule ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,fluoroscopy ,030104 developmental biology ,Oncology ,Cardiothoracic surgery ,030220 oncology & carcinogenesis ,Video-assisted thoracoscopic surgery ,Original Article ,Female ,Radiology ,Tomography, X-Ray Computed ,business ,Wedge resection (lung) - Abstract
Background When early‐stage lung cancer is diagnosed, the recommended treatment is anatomical resection using video‐assisted thoracoscopic surgery (VATS) or robotic lobectomy. However, nonanatomical resection, known as wedge resection (WR), which is performed to diagnose pulmonary nodules, can be problematic for clinicians performing VATS or robotic‐assisted thoracic surgery (RATS). The purpose of this study was to evaluate the safety and effectiveness of VATS WR using multiplanar computed tomography reconstruction (CT MPR)‐fluoroscopy after CT guided microcoil localization to achieve complete pulmonary nodule resection. Methods Between January 2016 to December 2020, the medical records of patients who underwent CT‐guided microcoil localization for suspicious malignant pulmonary nodules and VATS WR with CT MPR and intraoperative fluoroscopy were retrospectively reviewed. Results All 130 patients successfully underwent CT‐guided localization. The success rate of VATS WR with CT MPR‐intraoperative fluoroscopy was 98.5%. Mean operation time was 58 min (range 50–84 min). The postoperative complication rate was 3.1%, and no major postoperative complications were reported. The mean postoperative length of hospital stay was 4.7 days (range 4–8 days). Conclusions VATS WR using CT MPR‐fluoroscopy after CT guided microcoil localization is a safe and highly effective approach for complete pulmonary nodule resection. However, even in uniport VATS or recently performed robotic surgery, localization and resection of nonvisible, nonpalpable pulmonary nodules is a challenging problem. Consequently, satisfactory outcomes can be expected if this technique is used for suspicious malignant pulmonary nodule resection., VATS wedge resection with CT multiplanar reconstruction‐fluoroscopy is a safe and highly effective approach for complete pulmonary nodule resection. It will help clinicians perform uniportal VATS or robotic surgery for the localization and resection of nonvisible, nonpalpable pulmonary nodules.
- Published
- 2021
34. Impact of the COVID‐19 Pandemic on Parent, Child, and Family Functioning
- Author
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Emily Hotez, Jacqueline Mogle, Sunhye Bai, Mark E. Feinberg, Jin kyung Lee, Samantha L. Tornello, Michelle L. Hostetler, and Joseph A. Cifelli
- Subjects
Parents ,Coparenting ,Social Psychology ,Family support ,Mothers ,Family income ,Intervention (counseling) ,Pandemic ,medicine ,Humans ,0501 psychology and cognitive sciences ,Child ,Pandemics ,Covid‐19 ,Parenting ,05 social sciences ,COVID-19 ,Original Articles ,Moderation ,Mental health ,Clinical Psychology ,Mental Health ,050902 family studies ,Anxiety ,Female ,Original Article ,0509 other social sciences ,medicine.symptom ,Psychology ,Family Relationships ,Social Sciences (miscellaneous) ,050104 developmental & child psychology ,Clinical psychology - Abstract
To quantify the impact of the COVID-19 pandemic and public health interventions on parent and child mental health and family relationships, we examined change in individual and family functioning in a sample of parents enrolled in a prevention trial; we examined change before the pandemic (2017-2019) when children were an average of 7 years old to the first months after the imposition of widespread public health interventions in the United States (2020) with paired t tests and HLM models. We examined moderation by parent gender, education, family income, and coparenting conflict. We found large deteriorations from before the pandemic to the first months of the pandemic in child internalizing and externalizing problems and parent depression, and a moderate decline in coparenting quality. Smaller changes were found for parent anxiety and parenting quality. Mothers and families with lower levels of income were at particular risk for deterioration in well-being. Results indicate a need for widespread family support and intervention to prevent potential family "scarring," that is, prolonged, intertwined individual mental health and family relationship problems.Para cuantificar el efecto de la pandemia de la COVID-19 y de las intervenciones de salud pública en la salud mental de los padres y los niños y en las relaciones familiares, analizamos los cambios en el funcionamiento individual y familiar en una muestra de padres inscriptos en un ensayo de prevención; estudiamos el cambio antes de la pandemia (2017-2019) cuando los niños tenían un promedio de 7 años hasta los primeros meses después de la imposición de las intervenciones generalizadas de salud pública en los Estados Unidos (2020) con pruebas t apareadas y modelos lineales jerárquicos. Analizamos la moderación por género, educación, ingresos familiares y conflicto de cocrianza de los padres. Hallamos grandes deterioros desde antes de la pandemia hasta los primeros meses de la pandemia en problemas de interiorización y exteriorización de los niños y depresión de los padres, y una disminución moderada de la calidad de la cocrianza. También encontramos cambios más pequeños en la ansiedad de los padres y la calidad de la crianza. Las madres y las familias con niveles más bajos de ingresos estuvieron en riesgo particular de deterioro del bienestar. Los resultados indican la necesidad de apoyo familiar generalizado y de intervenciones para prevenir posibles «secuelas» familiares, p. ej.: salud mental individual interconectada y prolongada y problemas en las relaciones familiares.本文把COVID-19和公共健康干预措施对父母和儿童的心理健康以及对家庭关系的影响进行量化,对参加一项预防试验的人群样本进行了研究,主要关于这些受试父母的个体功能和家庭功能产生了哪些变化; 我们采用配对t检验和HLM模型,研究了新冠肺炎(2017-2019年)前的变化,即平均年龄为7岁的儿童至美国实施广泛公共健康干预措施(2020年)后的第一个月。我们通过父母性别、教育程度、家庭收入和养育子女的冲突来考察这些因素的调适作用。我们发现,儿童对很多问题以及父母的抑郁表现都进行内化和外化,从新冠肺炎流行发生前到新冠大流行的头几个月出现了严重恶化倾向,亲子教育的质量略有下降。父母的焦虑和培养孩子方面的质量也有较小的变化。收入水平较低的母亲和家庭的福祉尤其有恶化的风险。结果表明,需要给予广泛的家庭支持和干预,以防止潜在的家庭"伤疤",即长期错综搅合在一起的个人心理健康和家庭关系问题。.
- Published
- 2021
35. Developing Museum Education Content: AR Blended Learning
- Author
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TaeRyun Kim, Ji Eun Lee, Hyun-Kyung Lee, JiHyon Lee, Dabin Jeong, and Ji-Hye Lee
- Subjects
Blended learning ,Arts and Humanities (miscellaneous) ,Visual Arts and Performing Arts ,Teaching method ,Cultural education ,Computer software ,Museum education ,Mathematics education ,Augmented reality ,Sociology ,Content (Freudian dream analysis) ,Experiential learning ,Education - Published
- 2021
36. Designing a New Empathy‐Oriented Prototyping Toolkit for the Design Thinking Process: Creativity and Design Sensibility
- Author
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Hyun-Kyung Lee and Joo Eun Park
- Subjects
Cognitive science ,Arts and Humanities (miscellaneous) ,Visual Arts and Performing Arts ,media_common.quotation_subject ,Sensibility ,Empathy ,Design thinking ,Sociology ,Creativity ,Education ,media_common - Published
- 2021
37. Excess mortality persists in patients with rheumatoid arthritis
- Author
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Mi Kyung Kim, Ji Young Lee, Jung Min Shin, Dae Jin Park, Ga Young Ahn, Sang Cheol Bae, Tae Han Lee, Yeo Jin Song, and Yeon Kyung Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Population ,Comorbidity ,Arthritis, Rheumatoid ,Rheumatology ,Cause of Death ,Internal medicine ,Republic of Korea ,Epidemiology ,Humans ,Rheumatoid factor ,Medicine ,Prospective Studies ,education ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Mortality rate ,Middle Aged ,Prognosis ,Survival Rate ,Standardized mortality ratio ,Erythrocyte sedimentation rate ,Cohort ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Objectives To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA). Methods Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 patients were enrolled from October 2001 to December 2015. Mortality data were derived by linking with data from the Korean National Statistical Office. Standardized mortality ratio was estimated by dividing observed deaths by expected number of deaths in the general population. Results Over the observation period, 225 deaths were reported. Total age- and sex-adjusted standardized mortality ratio was 1.65 (95% confidence interval 1.44-1.87). The most common cause of death was malignancy (40 cases; 17.8%), followed by respiratory disease (38 cases; 16.9%) and cardiovascular disease (32 cases; 14.2%). Mortality rate and causes of death differed according to year and age of RA onset. Compared with survivors, individuals who died were more likely to be male, smokers, diagnosed with RA at an older age, and to have long disease duration, higher erythrocyte sedimentation rate and C-reactive protein, higher rheumatoid factor positivity rate, more severe radiographic damage, and more comorbidities. Conclusion The mortality rate of patients with RA remains higher than that of the general population. Therefore, to improve the survival of patients with RA, attention should be paid to the management of comorbidities as well as to the RA itself.
- Published
- 2021
38. A Fluorinated <scp>Metal</scp> ‐ <scp>Organic</scp> Framework, <scp>FMOF</scp> ‐2, for Preferential Adsorption of Ethane over Ethylene
- Author
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Su-Kyung Lee, Kanghee Cho, Yeo Jin Lee, Jong-San Chang, and U-Hwang Lee
- Subjects
chemistry.chemical_compound ,Ethylene ,Preferential adsorption ,Adsorption ,chemistry ,Chemical engineering ,Metal-organic framework ,General Chemistry ,Gas separation - Published
- 2021
39. Design and Synthesis of <scp>5‐Aryl</scp> ‐substituted Phenylpyrimidine‐2,4‐diamine Derivatives as Novel Mer and Tyro3 Kinase Inhibitors
- Author
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Jong Yeon Hwang, Kyungwon Lee, Yeon Kyung Lee, Y. J. Kim, Sung Yun Cho, Hyesu Yeom, Mi-Ok Kim, Do Hyun Ryu, Chang-Hoon Lee, Youngki Min, and Joo-Youn Lee
- Subjects
chemistry.chemical_compound ,chemistry ,Stereochemistry ,Kinase ,Diamine ,Aryl ,General Chemistry ,TYRO3 - Published
- 2020
40. Author response for 'Tubular dentin formation by TGF‐β/BMP signaling in dental epithelial cells'
- Author
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null Yoon Seon Lee, null Yeoung‐Hyun Park, null You‐Mi Seo, null Hye‐Kyung Lee, and null Joo‐Cheol Park
- Published
- 2022
41. The Swedish Brief Coparenting Relationship Scale: Psychometrics and Concurrent Validity Among Primiparous and Multiparous Fathers
- Author
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Jin kyung Lee, Mark E. Feinberg, and Michael B. Wells
- Subjects
Coparenting ,Scale (ratio) ,Psychometrics ,Concurrent validity ,Developmental and Educational Psychology ,Psychology ,Social Sciences (miscellaneous) ,Education ,Developmental psychology - Published
- 2020
42. In vivo quantitative analysis of advanced glycation end products in atopic dermatitis—Possible culprit for the comorbidities?
- Author
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Ji Yeon Hong, Seong Jun Seo, Mi-Kyung Lee, Kui Young Park, MinJeong Kim, Hyun Noh, and Jun Ki Hong
- Subjects
Adult ,Glycation End Products, Advanced ,Keratinocytes ,0301 basic medicine ,medicine.medical_specialty ,Receptor for Advanced Glycation End Products ,Inflammation ,Dermatology ,Severity of Illness Index ,Biochemistry ,Culprit ,Dermatitis, Atopic ,RAGE (receptor) ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Glycation ,Internal medicine ,medicine ,Humans ,Receptor ,Molecular Biology ,Skin ,business.industry ,Atopic dermatitis ,medicine.disease ,030104 developmental biology ,Endocrinology ,Case-Control Studies ,Biomarker (medicine) ,medicine.symptom ,business - Abstract
Advanced glycation end products (AGEs) interact with the membrane-bound receptor for AGEs (RAGE), consequently amplifying the inflammatory response. Soluble receptor for AGE (sRAGE) and endogenous secretory RAGE (esRAGE) act as decoys for AGE and competitively sequester RAGE ligands, thereby serving a cytoprotective role. Our objective was to investigate AGE expression and their receptors in the serum and skin of patients with atopic dermatitis (AD). In this case-control study, the levels of AGE, sRAGE and esRAGE were measured in the blood samples and corneocytes of 29 adult patients with AD and 12 healthy controls by ELISA. Corneocyte AGE levels increased in the AD group (P = .002). Higher corneocyte AGE levels were observed in the severe AD than in the milder form of AD. No significant difference in serum AGE level was observed in patients with AD and healthy controls. Serum sRAGE markedly decreased in patients with AD (P = .007) and serum esRAGE followed a similar trend. In conclusion, dermal accumulation of AGE in AD may have a role in fuelling skin inflammation. The potential after-effects of reduced neutralizer on systemic risk need further evaluation.
- Published
- 2020
43. A structural model for quality of life of alcoholics
- Author
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Sohyune R. Sok, Hye Kyung Lee, and Min Kyung Gu
- Subjects
Adult ,media_common.quotation_subject ,Social issues ,Structural equation modeling ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Quality of life ,Republic of Korea ,Humans ,030212 general & internal medicine ,Alcoholics ,General Nursing ,Depression (differential diagnoses) ,media_common ,Self-efficacy ,030504 nursing ,Social Support ,Abstinence ,Models, Structural ,Alcoholism ,Quality of Life ,0305 other medical science ,Psychology ,Alcohol Abstinence ,Clinical psychology - Abstract
To investigate the factors affecting the quality of life of alcoholics and to identify the relationships between these factors to establish and verify a hypothetical model for the quality of life of alcoholics.Covariance structure analysis using structural equation model.Participants were 223 adults who were hospitalized at alcohol addiction treatment centre after being diagnosed with alcoholism in Gyunggi-do, South Korea. Data included the general characteristics of study participants, depression, abstinence self-efficacy, stress level, stress coping strategy, social support and quality of life. Data were collected from March - 28 May 2016 and were analysed using SPSS 22.0 and AMOS 22.0.The factors affecting the quality of life of alcoholics included alcohol abstinence self-efficacy (β = 0.37, t = 4.56), stress copying strategy (β = 0.23, t = 2.37), stress level (β = -0.20, t = -2.08) and social support (β = 0.14, t = 2.52). Factor analysis and statistical significance level was used for model coefficients and t-value estimation.This study suggested that to improve the quality of life of alcoholics, their alcohol abstinence self-efficacy should be increased, measures to improve their stress coping strategy and ability should be prepared, their stress level should be lowered and the social support system perceived by them should be strengthened. Health professionals need to pay attention to the affecting factors to improve the quality of life of alcoholics.Alcoholism is emerging as a social problem, not just an individual problem. Alcohol abstinence self-efficacy had the greatest direct effect on the quality of life of alcoholics, followed by stress coping strategy, stress level and social support, which had significant direct effects. Depression had significant indirect effect on the quality of life of alcoholics. Health professionals need to pay attention to the affecting factors to improve the quality of life of alcoholics in clinical practice or community fields.目的: 探讨酗酒者生活质量的影响因素,找出这些因素之间的关系,建立并验证酗酒者生活质量的假设模型。 设计: 采用结构方程模型进行协方差结构分析。 方法: 受访者是223名被诊断为酗酒中毒而在韩国京畿道酒瘾治疗中心接受治疗的成年人。数据包括研究对象的一般特征、抑郁、戒酒的自我效能、应激水平、应激应对策略、社会支持和生活质量。数据收集自2016年3月至5月28日,使用社会科学统计软件包(SPSS)版本22和AMOS 22.0进行分析。 结果: 影响酗酒者生活质量的因素有戒酒的自我效能(β = 0.37,t = 4.56)、应激应对策略(β = 0.23,t = 2.37)、应激水平(β = −0.20,t = −2.08)和社会支持(β = 0.14,t = 2.52)。采用因子分析和统计意义水平用于模型系数和t值估计。 结论: 为提高酗酒者的生活质量,本研究建议应提高其戒酒的自我效能,制定改善其应激应对策略和能力的措施,降低其应激水平,强化其感知的社会支持系统。卫生医护人员需要关注影响酗酒者生活质量的因素。 影响: 酗酒正成为社会的一大问题,而不仅仅是一个个人的问题。戒酒的自我效能对酗酒者生活质量的直接影响最大,其次是应激应对策略、应激水平和社会支持,都有显著的直接影响作用。抑郁对酗酒者的生活质量有着显著的间接影响作用。在临床实践或社区工作中,卫生医护人员需要关注影响酗酒者生活质量的因素。.
- Published
- 2020
44. Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis
- Author
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Hwa Jin Cho and Hyun Kyung Lee
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,pulmonary ,Vimentin ,Case Reports ,Malignancy ,lcsh:RC254-282 ,03 medical and health sciences ,Cytokeratin ,0302 clinical medicine ,Case report ,Biopsy ,medicine ,Carcinoma ,Basaloid Squamous Cell Carcinoma ,Sarcomatoid carcinoma ,biology ,medicine.diagnostic_test ,business.industry ,immunohistochemical analysis ,digestive, oral, and skin physiology ,food and beverages ,NUT carcinoma ,General Medicine ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,biology.protein ,Differential diagnosis ,business - Abstract
Nuclear protein in testis (NUT) carcinoma is a rare, aggressive carcinoma that is a diagnostic challenge for pathologists. Here, we report a case of NUT carcinoma in a 63-year-old woman with uncommon immunohistochemical results. The initial bronchoscopic biopsy revealed a poorly differentiated carcinoma with p63 immunohistochemical stain positivity. However, the cytomorphological features of the pleural fluid were unusual. Immunohistochemical staining of the pleural fluid revealed diffuse positivity for vimentin and focal positivity for cytokeratin and neuroendocrine markers. Because of chemoresistance, other malignancies, including sarcomatoid carcinoma, combined small cell carcinoma, and an unusual form of NUT carcinoma, were considered as differential diagnoses. The diagnosis of NUT carcinoma was confirmed using NUT-specific antibodies and fluorescence in situ hybridization. The current case was a diagnostic challenge because of the poorly differentiated cytomorphology and uncommon immunohistochemical results. Pathologists and clinicians should consider NUT carcinoma in the differential diagnosis, as this malignancy has a dismal prognosis and needs to be diagnosed accurately for the most effective treatment. KEY POINTS: Metastatic NUT carcinoma can show diffuse vimentin positivity and focal neuroendocrine marker positivity. NUT carcinoma can be misdiagnosed as basaloid squamous cell carcinoma in routine diagnosis, especially in older-aged patients. This study was a diagnostic challenge because of the poorly differentiated cytomorphology and uncommon immunohistochemical results for NUT carcinoma. Pathologists should differentially diagnose NUT carcinoma when rare cytohistological features are observed at any age.
- Published
- 2020
45. Image Processing in Spark
- Author
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Pierre Mesler Lazennec, Hyeyoung Kwoon, Lennart Nilsen, Thomas Baldaquin, Ji Young Jung, Yannick Le Nir, Yoo Kyung Lee, Dominique Laffly, Florent Devin, and Se-eun Kim
- Subjects
Computer science ,Computer graphics (images) ,Spark (mathematics) ,Image processing - Published
- 2020
46. Method of operating a GIS‐based autopilot drone to inspect ultrahigh voltage power lines and its field tests
- Author
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Ji Wan Ham, Seok Tae Kim, Jae-Kyung Lee, Ki Yong Oh, and Joon-Young Park
- Subjects
Operation method ,business.industry ,Computer science ,Electrical engineering ,Field tests ,Drone ,Computer Science Applications ,law.invention ,Electric power transmission ,Control and Systems Engineering ,law ,Autopilot ,business ,Voltage - Published
- 2020
47. Weighted spatial dynamic shift‐share model as a forecasting tool for a regional economy: The case of South Korea
- Author
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Hong-bae Kim and Hyun-Kyung Lee
- Subjects
Global and Planetary Change ,Mean absolute percentage error ,Computer science ,Contiguity ,05 social sciences ,0211 other engineering and technologies ,0507 social and economic geography ,Econometrics ,021107 urban & regional planning ,02 engineering and technology ,Spatial dependence ,050703 geography ,Economic change - Abstract
This study proposes a weighted spatial dynamic shift‐share model that considers two regional attributes, namely, interregional interactions and regional receptive capabilities for domestic and international economic change, to improve the forecasting capability of the traditional shift‐share model. In particular, the spatial dependence among regions is embodied by a spatial weight matrix based on contiguity. Additionally, regional receptive capabilities are represented by weights imposed on regional industries. Forecasts over the period of 2014–2016 are made for 14 regions in South Korea using the proposed model. The results are compared with actual data from the same period and evaluated in terms of the mean absolute percentage error. The results indicate that the proposed model is more reliable and accurate than the traditional model and other dynamic extensions.
- Published
- 2020
48. Crystallinity in quasi‐alternating cycloolefin copolymers: Overcoming brittleness
- Author
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Kyung Lee Park, Yeonju Lee, Ji‐Hwan Choi, Jun Won Baek, Seung Hyun Moon, Bun Yeoul Lee, and Hyun Ju Lee
- Subjects
Crystallinity ,Brittleness ,Materials science ,Differential scanning calorimetry ,Polymers and Plastics ,Materials Chemistry ,Copolymer ,Physical and Theoretical Chemistry ,Composite material - Published
- 2020
49. The yeast community of Conotelus sp. (Coleoptera: Nitidulidae) in Brazilian passionfruit flowers ( <scp> Passiflora edulis </scp> ) and description of Metschnikowia amazonensis sp. nov., a large‐spored clade yeast
- Author
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Carlos A. Rosa, Dong Kyung Lee, Tom Hsiang, Katharina O. Barros, Andressa Graebin Ferreira, Vando Miossi Rondelli, Ana Raquel O. Santos, Marc-André Lachance, and Marina Carmo
- Subjects
0106 biological sciences ,0303 health sciences ,Mating type ,food.ingredient ,biology ,Phylogenetic tree ,Rare species ,Bioengineering ,15. Life on land ,biology.organism_classification ,01 natural sciences ,Applied Microbiology and Biotechnology ,Biochemistry ,Yeast ,Kodamaea ohmeri ,Passiflora ,03 medical and health sciences ,food ,010608 biotechnology ,Botany ,Genetics ,Metschnikowia ,Convolvulaceae ,030304 developmental biology ,Biotechnology - Abstract
Species of the nitidulid beetle Conotelus found in flowers of Convolvulaceae and other plants across the New World and in Hawaii consistently harbour a yeast community dominated by one or more large-spored Metschnikowia species. We investigated the yeasts found in beetles and flowers of cultivated passionfruit in Rondonia state, in the Amazon biome of Brazil, where a Conotelus species damages the flowers and hinders fruit production. A sample of 46 beetles and 49 flowers yielded 86 and 83 yeast isolates, respectively. Whereas the flower community was dominated by Kodamaea ohmeri and Kurtzmaniella quercitrusa, the major yeasts recovered from beetles were Wickerhamiella occidentalis, which is commonly isolated from this community, and a novel species of large-spored Metschnikowia in the arizonensis subclade, which we describe here as Metschnikowia amazonensis sp. nov. Phylogenetic analyses based on barcode sequences (ITS-D1/D2) and a multigene alignment of 11,917 positions (genes ura2, msh6, and pmt2) agreed to place the new species as a sister to Metschnikowia arizonensis, a rare species known only from one locality in Arizona. The two form sterile asci when mated, which is typical of related members of the clade. The α pheromone of the new species is unique but typical of the subclade. The type of M. amazonensis sp. nov. is UFMG-CM-Y6309T (ex-type CBS 16156T , mating type a), and the designated allotype (mating type α) is UFMG-CM-Y6307A (CBS 16155A ). MycoBank MB 833560.
- Published
- 2020
50. Controlling Families’ Risk Allocation in a Business Group
- Author
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Eun Jung Lee, Yu Kyung Lee, Hyung Cheol Kang, and Joon Chae
- Subjects
Actuarial science ,Corporate group ,Risk allocation ,Business ,Risk taking ,Finance - Published
- 2020
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