1. Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years
- Author
-
Aristides M. Machado-Rodrigues, Cristina Padez, Licínio Manco, Simão Pinho, and David Albuquerque
- Subjects
Male ,Pediatric Obesity ,medicine.medical_specialty ,Waist ,Alpha-Ketoglutarate-Dependent Dioxygenase FTO ,030209 endocrinology & metabolism ,Standard score ,Overweight ,Logistic regression ,Polymorphism, Single Nucleotide ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Polymorphism (computer science) ,Internal medicine ,Genetics ,medicine ,Humans ,0601 history and archaeology ,Child ,Exercise ,Ecology, Evolution, Behavior and Systematics ,Waist-Height Ratio ,060101 anthropology ,Portugal ,business.industry ,nutritional and metabolic diseases ,06 humanities and the arts ,Odds ratio ,medicine.disease ,Obesity ,Child, Preschool ,Anthropology ,Female ,Waist Circumference ,Anatomy ,medicine.symptom ,business ,Body mass index - Abstract
OBJECTIVES To investigate whether objectively measured physical activity (PA) modulates the association between the FTO rs9939609 polymorphism and obesity variables in a sample of Portuguese children. METHODS A total of 440 children (213 girls and 227 boys) aged 3 to 11 years were observed. Genotyping was performed using TaqMan assay. Body mass index (BMI), BMI Z scores, waist circumference (WC), and waist-to-height ratio (WHtR) were calculated. PA was estimated in 399 children by accelerometry. RESULTS Linear regression, in the additive model, showed that the rs9939609 minor A-allele significantly associated with BMI (P = .029), BMI Z score (P = .017), WC (P = .016), and WHtR (P = .019). Logistic regression, in the additive model, showed a marginally significant association between the A-allele and overweight/obesity (odds ratio [OR]: 1.372; P = .049). When stratified by sex, rs9939609 showed marginal or significant associations with BMI (P = .08), BMI Z score (P = .07), WC (P = .005), WHtR (P = .02), and overweight/obesity (OR: 1.529; P = .064) in girls but not in boys (P > .05). Significant interactions were not found between the FTO polymorphism and PA (inactive vs active groups of children) for BMI (P = .461), BMI Z score (P = .387), WC (P = .757), or WHtR (P = .621). CONCLUSIONS Findings of the present study highlight the association between FTO rs9939609 and obesity or body fat indices in girls but not in boys. PA was not found to mediate the impact of FTO genetic variation on risk of obesity.
- Published
- 2019