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Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years
- Source :
- American Journal of Human Biology. 31
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- OBJECTIVES To investigate whether objectively measured physical activity (PA) modulates the association between the FTO rs9939609 polymorphism and obesity variables in a sample of Portuguese children. METHODS A total of 440 children (213 girls and 227 boys) aged 3 to 11 years were observed. Genotyping was performed using TaqMan assay. Body mass index (BMI), BMI Z scores, waist circumference (WC), and waist-to-height ratio (WHtR) were calculated. PA was estimated in 399 children by accelerometry. RESULTS Linear regression, in the additive model, showed that the rs9939609 minor A-allele significantly associated with BMI (P = .029), BMI Z score (P = .017), WC (P = .016), and WHtR (P = .019). Logistic regression, in the additive model, showed a marginally significant association between the A-allele and overweight/obesity (odds ratio [OR]: 1.372; P = .049). When stratified by sex, rs9939609 showed marginal or significant associations with BMI (P = .08), BMI Z score (P = .07), WC (P = .005), WHtR (P = .02), and overweight/obesity (OR: 1.529; P = .064) in girls but not in boys (P > .05). Significant interactions were not found between the FTO polymorphism and PA (inactive vs active groups of children) for BMI (P = .461), BMI Z score (P = .387), WC (P = .757), or WHtR (P = .621). CONCLUSIONS Findings of the present study highlight the association between FTO rs9939609 and obesity or body fat indices in girls but not in boys. PA was not found to mediate the impact of FTO genetic variation on risk of obesity.
- Subjects :
- Male
Pediatric Obesity
medicine.medical_specialty
Waist
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
030209 endocrinology & metabolism
Standard score
Overweight
Logistic regression
Polymorphism, Single Nucleotide
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Polymorphism (computer science)
Internal medicine
Genetics
medicine
Humans
0601 history and archaeology
Child
Exercise
Ecology, Evolution, Behavior and Systematics
Waist-Height Ratio
060101 anthropology
Portugal
business.industry
nutritional and metabolic diseases
06 humanities and the arts
Odds ratio
medicine.disease
Obesity
Child, Preschool
Anthropology
Female
Waist Circumference
Anatomy
medicine.symptom
business
Body mass index
Subjects
Details
- ISSN :
- 15206300 and 10420533
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- American Journal of Human Biology
- Accession number :
- edsair.doi.dedup.....d37ebbb49d31832a26ef7e6889d587bf