1. Longitudinal displacement of the carotid wall and cardiovascular risk factors: associations with aging, adiposity, blood pressure and periodontal disease independent of cross-sectional distensibility and intima-media thickness
- Author
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Mark Bartold, David S. Celermajer, Lisa Jamieson, Kostas Kapellas, André Sérusclat, Michael R. Skilton, Guillaume Zahnd, Djhianne Alibay, Philippe Moulin, Kerin O'Dea, Didier Vray, Louise J. Maple-Brown, Marion Durand, Alex Brown, Zahnd, Guillaume, Vray, Didier, Serusclat, Andre, Alibay, Djhianne, Bartold, Mark, Brown, Alex, Durand, Marion, Jamieson, Lisa M, Kapellas, Kostas, Maple-Brown, Louise J, O'Dea, Kerin, Moulin, Philippe, Celermajer, David S, Skilton, Michael R, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hopital Cardio-Thoracique et Vasculaire Louis Pradel, Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Université Henri Poincaré - Nancy 1 (UHP), Australian Research Centre for Population Oral Health, School of Dentistry, University of Adelaide, Menzies School of Health Research [Australia], Charles Darwin University, Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), The University of Sydney, Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Technology Sydney (UTS), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Adelaide, Charles Darwin University [Australia], and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,cardiovascular risk factors ,Aging ,Longitudinal study ,Acoustics and Ultrasonics ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Labex CELYA ,periodontal disease ,Blood Pressure ,Comorbidity ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,Labex PRIMES ,030218 nuclear medicine & medical imaging ,motion estimation ,0302 clinical medicine ,Risk Factors ,Carotid artery disease ,Prevalence ,Common carotid artery ,Pulse wave velocity ,ComputingMilieux_MISCELLANEOUS ,Adiposity ,education.field_of_study ,Radiological and Ultrasound Technology ,Middle Aged ,3. Good health ,Imagerie Ultrasonore ,reseau_international ,Carotid Arteries ,arterial stiffness ,speckle tracking ,Cardiovascular Diseases ,Female ,categₘixte ,Radiology ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Adult ,medicine.medical_specialty ,Population ,Biophysics ,imagerie_ultrasonore ,Risk Assessment ,03 medical and health sciences ,Age Distribution ,Elastic Modulus ,medicine.artery ,reseau_internationnal ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,education ,Periodontal Diseases ,longitudinal displacement ,[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,business.industry ,carotid artery ,segmentation ,Australia ,Australie ,medicine.disease ,Blood pressure ,Intima-media thickness ,b-mode ultrasound ,Arterial stiffness ,Vascular Resistance ,atherosclerosis ,business - Abstract
The recently discovered longitudinal displacement of the common carotid arterial wall (i.e., the motion along the same plane as the blood flow), may be associated with incident cardiovascular events and represents a novel and relevant clinical information. At present, there have only been a few studies that have been conducted to investigate this longitudinal movement. We propose here a method to assess noninvasively the wall bi-dimensional (two-dimensional [2-D], cross-sectional and longitudinal) motion and present an original approach that combines a robust speckle tracking scheme to guidance by minimal path contours segmentation. Our method is well suited to large clinical population studies as it does not necessitate strong imaging prerequisites. The aim of this study is to describe the association between the longitudinal displacement of the carotid arterial wall and cardiovascular risk factors, among which periodontal disease. Some 126 Indigenous Australians with periodontal disease, an emerging risk factor, and 27 healthy age- and sex-matched non-indigenous control subjects had high-resolution ultrasound scans of the common carotid artery. Carotid intima-media thickness and arterial wall 2-D motion were then assessed using our method in ultrasound B-mode sequences. Carotid longitudinal displacement was markedly lower in the periodontal disease group than the control group (geometric mean (IQR): 0.15 mm (0.13) vs. 0.42 mm (0.30), respectively; p < 0.0001), independent of cardiovascular risk factors, cross-sectional distensibility and carotid intima-media thickness (p < 0.0001). A multivariable model indicated that the strongest correlates of carotid longitudinal displacement in adults with periodontal disease were age (β-coefficient = -.235, p = .03), waist (β-coefficient = -.357, p = 0.001), and pulse pressure (β-coefficient = .175, p = 0.07), independent of other cardiovascular risk factors, cross-sectional distensibility and pulse wave velocity. Carotid longitudinal displacement, estimated with our approach, is impaired in the periodontal disease group, independent of established cardiovascular risk factors and other noninvasive measures of arterial stiffness, and may represent an important marker of cardiovascular risk. Refereed/Peer-reviewed
- Published
- 2012