1. Cardiac factors affecting the success of vardenafil in erectile dysfunction
- Author
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Serhat Tanik, Kursad Zengin, Hüseyin Ede, Ali Riza Erbay, Mesut Gurdal, Muhammet Abdurrahim Imamoğlu, Sebahattin Albayrak, and Savaş Sarıkaya
- Subjects
Male ,medicine.medical_specialty ,Phosphodiesterase Inhibitors ,Statistics as Topic ,Biological Availability ,Significant negative correlation ,Doppler echocardiography ,Doppler imaging ,Cardiovascular System ,Piperazines ,Erectile Dysfunction ,Vardenafil Dihydrochloride ,Heart Rate ,Predictive Value of Tests ,Internal medicine ,Heart rate ,medicine ,Humans ,In patient ,Sulfones ,medicine.diagnostic_test ,business.industry ,Triazines ,Penile Erection ,Imidazoles ,General Medicine ,Middle Aged ,Erectile dysfunction,phosphodiesterase type 5 inhibitor,diastolic dysfunction ,medicine.disease ,Echocardiography, Doppler ,Surgery ,Erectile dysfunction ,Treatment Outcome ,Vardenafil ,Predictive value of tests ,Cardiology ,Drug Monitoring ,business ,medicine.drug - Abstract
Background/aim: To evaluate the predictability of vardenafil success in patients with erectile dysfunction (ED) by using cardiological tests. Materials and methods: Patients diagnosed with ED who did not benefit from lifestyle changes (n = 68) were evaluated with an abridged 5-item version of the International Index of Erectile Function (IIEF-5). The pretreatment and posttreatment IIEF-5 scores were compared with pretreatment data obtained from cardiological examinations. Results: When pretreatment scores were compared with test parameters, mitral flow E/A ratio and tissue Doppler imaging (TDI) E?/A?, exercise test duration, exercise capacity in MET, and percentage of maximum heart rate were found to be statistically significant. Furthermore, there was a significant negative correlation between mitral flow E/A ratio, TDI E?/A?, exercise test duration, exercise capacity in MET, and the difference in post- and pretreatment IIEF-5 scores. Conclusion: As a diastolic function indicator, TDI E?/A? positively correlates with pretreatment IIEF-5 scores and negatively correlates with the beneficial effect of vardenafil treatment. As a result, the cardiological status of the patient correlates with individual IIEF-5 scores, and it seems to be useful in predicting vardenafil success.
- Published
- 2015