1. Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance.
- Author
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Campos-Sousa RN, Quagliato EM, Almeida KJ, Castro IA, and Campelo V
- Subjects
- Aged, Aged, 80 and over, Cohort Studies, Disease Progression, Female, Humans, Middle Aged, Parkinson Disease physiopathology, Prognosis, Prospective Studies, Severity of Illness Index, Parkinson Disease complications, Psychomotor Performance, Urinary Bladder, Overactive complications, Urination Disorders etiology
- Abstract
Introduction: Detrusor hyperactivity is the leading cause of urinary dysfunction in Parkinson's disease (PD). There are few studies correlating PD clinical aspects with this autonomic feature., Methods: A cohort of 63 women with PD were prospectively examined for assessment of clinical aspects and disease severity using unified Parkinson's disease rating scale and Hoehn-Yahr scale, respectively. The urologic function was evaluated by the urodynamic study. Two groups were categorized at this time - groups with and without detrusor hyperactivity. After seven years, the same parameters were re-evaluated., Results: Progression of the disease on mental scores was found in the group with detrusor hyperactivity. On follow-up, clinical symptoms and severity did not show significant worsening between the groups., Conclusion: Detrusor hyperactivity is a frequent urodynamic finding in PD, and even though it is associated with dopaminergic dysfunction, it cannot be blamed as a factor of worsening motor performance, but is probably associated with poor cognitive and mental prognosis.
- Published
- 2013
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