1. Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome.
- Author
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Cheng, Jin M., Oemrawsingh, Rohit M., Akkerhuis, K. Martijn, Garcia-Garcia, Hector M., de Boer, Sanneke P. M., Battes, Linda C., Buljubasic, Nermina, Lenzen, Mattie J., de Jaegere, Peter P. T., van Geuns, Robert-Jan, Serruys, Patrick W., Kardys, Isabella, and Boersma, Eric
- Subjects
ATHEROSCLEROSIS ,BIOMARKERS ,CHEMOKINES ,INTRAVASCULAR ultrasonography ,PROGNOSIS - Abstract
Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome. Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma. Results: Higher MCP-1, MIP-1α and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1α and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events. Conclusions: RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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