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Your search keyword '"Yarmoluk, Sergiy"' showing total 2 results
Start Over Author "Yarmoluk, Sergiy" Topic protein kinases Publisher taylor & francis ltd
2 results on '"Yarmoluk, Sergiy"'

1. Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2.

Author

Syniugin, Anatolii R., Ostrynska, Olga V., Chekanov, Maksym O., Volynets, Galyna P., Starosyla, Sergiy A., Bdzhola, Volodymyr G., and Yarmoluk, Sergiy M.

Subjects
AROMATIC compound synthesis, CHEMICAL inhibitors, PROTEIN kinases, CARBOXYLIC acids, ANTIOXIDANTS
Abstract

In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives. [ABSTRACT FROM PUBLISHER]

Published
2016
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2. Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors.

Author

Gryshchenko, Andrii Anatoliyovych, Levchenko, Kostiantyn Vasyliovych, Bdzhola, Volodymyr Grygorovich, Ruban, Tatiana Panasivna, Lukash, Lyubov Leonidovna, and Yarmoluk, Sergiy Mikolayovych

Subjects
CHEMICAL derivatives, PROTEIN kinases, FIBROBLAST growth factor receptors, SULFONAMIDES, CANCER cell proliferation, IN vitro studies
Abstract

New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1-sulfonamide inhibited FGFR1 with IC50 of 2 µM. In our preliminary studies, N-phenylnaphthostyril-1-sulfonamides demonstrated selectivity of FGFR1 inhibition and antiproliferative activity on cancer cell line. N-phenylnaphthostyril-1-sulfonamides have a good potential for further development as anticancer agents. [ABSTRACT FROM AUTHOR]

Published
2015
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