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Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2.
- Source :
- Journal of Enzyme Inhibition & Medicinal Chemistry; 2016 Spplement4, Vol. 31, p160-169, 10p
- Publication Year :
- 2016
-
Abstract
- In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 14756366
- Volume :
- 31
- Database :
- Complementary Index
- Journal :
- Journal of Enzyme Inhibition & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 120264848
- Full Text :
- https://doi.org/10.1080/14756366.2016.1222584