Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2.

Authors :: Syniugin, Anatolii R.
Ostrynska, Olga V.
Chekanov, Maksym O.
Volynets, Galyna P.
Starosyla, Sergiy A.
Bdzhola, Volodymyr G.
Yarmoluk, Sergiy M.
Source :: Journal of Enzyme Inhibition & Medicinal Chemistry; 2016 Spplement4, Vol. 31, p160-169, 10p
Publication Year :: 2016
Abstract: In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives. [ABSTRACT FROM PUBLISHER]

Subjects :: AROMATIC compound synthesis
CHEMICAL inhibitors
PROTEIN kinases
CARBOXYLIC acids
ANTIOXIDANTS

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