1. Brain-derived neurotrophic factor gene variation influences cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol concentrations in healthy volunteers.
- Author
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Jönsson EG, Saetre P, Edman-Ahlbom B, Sillén A, Gunnar A, Andreou D, Agartz I, Sedvall G, Hall H, and Terenius L
- Subjects
- Adult, Brain Chemistry genetics, DNA Mutational Analysis, Female, Gene Frequency genetics, Genetic Predisposition to Disease genetics, Genetic Testing, Genotype, Homovanillic Acid analysis, Homovanillic Acid cerebrospinal fluid, Humans, Hydroxyindoleacetic Acid analysis, Hydroxyindoleacetic Acid cerebrospinal fluid, Male, Methoxyhydroxyphenylglycol analysis, Neurocognitive Disorders genetics, Neurocognitive Disorders metabolism, Neurocognitive Disorders physiopathology, Predictive Value of Tests, Serotonin metabolism, Young Adult, Brain metabolism, Brain-Derived Neurotrophic Factor genetics, Methoxyhydroxyphenylglycol cerebrospinal fluid, Norepinephrine metabolism, Polymorphism, Genetic genetics
- Abstract
Brain-derived neurotrophic factor (BDNF) has been shown to influence monoamine transmitter synthesis, metabolism and release. We investigated possible relationships between four BDNF gene polymorphisms and cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 132). All BDNF polymorphisms (270 C/T, -633 T/A, Val66Met, and 11757 G/C) were associated with MHPG (P < 0.02), but not with 5-HIAA and HVA concentrations. At a second clinical investigation 8-20 years after CSF sampling 30% of the subjects had experienced various psychiatric disorders. Development of a psychiatric disorder was predicted by low 5-HIAA concentrations (P = 0.01). The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects.
- Published
- 2008
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