Back to Search
Start Over
Dopaminomimetic action of diphenylhydantoin in rat striatum: effect on homovanillic acid and cyclic AMP levels.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 1985; Vol. 86 (1-2), pp. 27-30. - Publication Year :
- 1985
-
Abstract
- Diphenylhydantoin (DPH) is known to induce reversible paroxysmal dyskinesias and paranoid psychosis in humans, but its interactions with dopamine (DA) metabolism are not clear. Single doses of DPH (60-100 mg kg-1), with serum levels over 10 micrograms ml-1, reduced homovanillic acid (HVA) levels in rat striatum. The DPH-induced HVA decrease was enhanced by supersensitivity of postsynaptic DA receptors following chronic haloperidol (Hal) administration. DPH 60 mg kg-1 given acutely enhanced the HVA decrease induced by apomorphine (Apo) and partially counteracted the HVA increase following acute Hal (0.1-0.5-2 mg kg-1). After chronic DPH treatment, Apo was ineffective in reducing striatal HVA levels. Concomitant chronic treatment with DPH and Hal counteracted the development of supersensitivity of postsynaptic DA receptors to Apo. Single doses of DPH (30-60-100 mg kg-1) increased cyclic AMP striatal content; this effect was blocked by Hal. A dopaminomimetic DPH action and a subsensitivity of postsynaptic DA receptors after chronic DPH seem to be suggested. These effects could be related to the dyskinetic and psychotic syndromes produced by the drug.
- Subjects :
- Animals
Apomorphine antagonists & inhibitors
Corpus Striatum analysis
Dyskinesia, Drug-Induced etiology
Haloperidol antagonists & inhibitors
Humans
Male
Psychoses, Substance-Induced etiology
Rats
Rats, Inbred Strains
Corpus Striatum drug effects
Cyclic AMP analysis
Homovanillic Acid analysis
Phenylacetates analysis
Phenytoin pharmacology
Receptors, Dopamine drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 86
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2991966
- Full Text :
- https://doi.org/10.1007/BF00431679