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15 results on '"human hepatocyte"'

3. Hepatic Tissue Engineering

Author

Shan, Jing, Stevens, Kelly R., Trehan, Kartik, Underhill, Gregory H., Chen, Alice A., Bhatia, Sangeeta N., and Monga, Satdarshan P. S., editor

Published
2011
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6. Human Epoxide Hydrolase is the Target of Germander Autoantibodies on the Surface of Human Hepatocytes: Enzymatic Implications

Author

Loeper, Jacqueline, De Berardinis, Veronique, Moulis, Claude, Beaune, Philippe, Pessayre, Dominique, Pompon, Denis, Dansette, Patrick M., editor, Snyder, Robert, editor, Delaforge, Marcel, editor, Gibson, G. Gordon, editor, Greim, Helmut, editor, Jollow, David J., editor, Monks, Terrence J., editor, and Sipes, I. Glenn, editor

Published
2001
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8. Studies on the Formation of Hepatic DNA Adducts by the Antiandrogenic and Gestagenic Drug, Cyproterone Acetate : 1. Adduct Levels in Various Species Including Man and 2. Persistence and Accumulation in the Rat

Author

Werner, S., Topinka, J., Kunz, S., Beckurts, T., Heidecke, C.-D., Schwarz, L. R., Wolff, T., Snyder, Robert, editor, Sipes, I. Glenn, editor, Jollow, David J., editor, Monks, Terrence J., editor, Kocsis, James J., editor, Kalf, George F., editor, Greim, Helmut, editor, and Witmer, Charlotte M., editor

Published
1996
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10. Inhibition of Cytochrome P450 Enzymes by Nitric Oxide

Author

Stadler, J., Schmalix, W. A., Doehmer, J., Snyder, Robert, editor, Sipes, I. Glenn, editor, Jollow, David J., editor, Monks, Terrence J., editor, Kocsis, James J., editor, Kalf, George F., editor, Greim, Helmut, editor, and Witmer, Charlotte M., editor

Published
1996
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12. Engraftment of Human Hepatocytes in the PiZ-NSG Mouse Model

Author

Yangfun Cheng, Gwladys Gernoux, Qiushi Tang, Terence R. Flotte, and Christian Mueller

Subjects
Genetically modified mouse, 0303 health sciences, Xenotransplantation, medicine.medical_treatment, Strain (biology), Biology, Molecular biology, Liver regeneration, 03 medical and health sciences, Human hepatocyte, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, NSG mouse, Allele, Gene, 030304 developmental biology
Abstract

We recently described the generation of a novel mouse strain that efficiently and readily engrafts human primary hepatocytes to create liver xenografts (Borel et al., Mol Ther, 25: 2477-89, 2017). A transgenic mouse strain expressing a human PiZ allele for the SerpinA1 gene was crossed with the NOD-SCID-gamma chain knockout (NSG) strain to create a recipient strain (PiZ-NSG) for human hepatocyte xenotransplantation. In this chapter we provide a description of the methods to achieve these liver xenografts in the PiZ-NSG mouse.

Published
2020

14. Engineering Quasi-Vivo® in Vitro Organ Models

Author

Arti Ahluwalia and Tommaso Sbrana

Subjects
Human hepatocyte, Cell type, Computer science, Cell culture, Interconnectivity, Drug toxicity, Organ Model, Neuroscience
Abstract

Cell culture is the workhorse of biologists, toxicologists, tissue engineers and a whole host of research fields in both academia and industry. Having explored individual molecular mechanisms inside cells for decades using traditional cell culture techniques, researchers have only just begun to appreciate that the intricate interconnectivity between cells and cellular networks as well as with the external environment is far more important to cellular orchestration than are single molecular events inside the cell. For example many questions regarding cell, tissue, organ and system response to drugs, environmental toxins, stress and nutrients cannot possibly be answered by concentrating on the minutiae of what goes on in the deepest recesses of single cells. New models are required to investigate cellular cross-talk between different cell types and to construct complex in-vitro models to properly study tissue, organ and system interaction without resorting to animal experiments. This chapter describes how tissue and organ models can be developed using the Quasi-Vivo® system and discusses how they may be used in drug toxicity studies.

Published
2012

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