17 results on '"Rimesh Pal"'
Search Results
2. Autonomous growth hormone secretion due to McCune Albright syndrome in paediatric age group: an ominous triad
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Satyam Singh Jayant, Rama Walia, Rahul Gupta, Rimesh Pal, Shakun Chaudhary, Kanhaiya Agrawal, Ashu Rastogi, Anish Bhattacharya, Pinaki Dutta, Sanjay Kumar Bhadada, and Anil Bhansali
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Endocrinology ,Endocrinology, Diabetes and Metabolism - Published
- 2023
3. Can SGLT2 inhibitors prevent incident gout? A systematic review and meta-analysis
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Mainak Banerjee, Rimesh Pal, and Satinath Mukhopadhyay
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Observational Studies as Topic ,Endocrinology ,Diabetes Mellitus, Type 2 ,Gout ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,Humans ,Hypoglycemic Agents ,Hyperuricemia ,General Medicine ,Sodium-Glucose Transporter 2 Inhibitors - Abstract
To collate the effect of SGLT2 inhibitors (SGLT2i) on adverse gout events in people with type 2 diabetes mellitus (T2DM).PubMed/MEDLINE, Embase, and Web of Science databases were systematically searched using appropriate keywords/MeSH/Emtree terms till January 25, 2022, to identify observational studies, randomized controlled trials (RCTs) or post hoc analysis reporting incident gout events and/or commencement of anti-gout drug in people with T2DM receiving SGLT2i versus those not receiving SGLT2i. Subgroup analyses were performed using comparators as placebo/other antidiabetic drugs and presence/absence of baseline hyperuricemia (uric acid ≥ 7 or 7 mg/dl). Hazard ratios (HR) with 95% confidence intervals (CI) were calculated.We identified 5 studies (3 observational, 2 post hoc analysis of RCTs) pooling data retrieved from 568,010 people with T2DM. Pooled analysis showed that SGLT2i use was associated with 30% reduction in incident gout events/gout flares (HR 0.70, 95% CI: 0.59, 0.84, p 0.001, ISGLT2i may potentially prevent gout-related adverse events in people with T2DM.
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- 2022
4. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis
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A J Shetty, Birgurman Singh, Sanjay Kumar Bhadada, A Vyas, Rimesh Pal, and Monisha Banerjee
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medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,MEDLINE ,030209 endocrinology & metabolism ,Subgroup analysis ,Comorbidity ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Randomized controlled trial ,law ,Internal medicine ,Odds Ratio ,Vitamin D and neurology ,medicine ,Humans ,Vitamin D ,Mortality ,ICU admission ,SARS-CoV-2 ,business.industry ,COVID-19 ,Odds ratio ,Vitamin D Deficiency ,Confidence interval ,COVID-19 Drug Treatment ,Intensive Care Units ,Treatment Outcome ,030220 oncology & carcinogenesis ,Meta-analysis ,Dietary Supplements ,Original Article ,Observational study ,business - Abstract
Purpose To provide a precise summary and collate the hitherto available clinical evidence on the effect of vitamin D supplementation on clinical outcomes in COVID-19 patients. Methods PubMed/MEDLINE, Scopus, and Web of Science databases were systematically searched using appropriate keywords till June 8, 2021, to identify observational studies and randomized controlled trials (RCTs) reporting adverse clinical outcomes (ICU admission and/or mortality) in COVID-19 patients receiving vitamin D supplementation vs. those not receiving the same. Both prior use and use of vitamin D after COVID-19 diagnosis were considered. Unadjusted/adjusted pooled odds ratio (OR) with 95% confidence intervals (CI) were calculated (PROSPERO registration number CRD42021248488). Results We identified 13 studies (10 observational, 3 RCTs) pooling data retrieved from 2933 COVID-19 patients. Pooled analysis of unadjusted data showed that vitamin D use in COVID-19 was significantly associated with reduced ICU admission/mortality (OR 0.41, 95% CI: 0.20, 0.81, p = 0.01, I2 = 66%, random-effects model). Similarly, on pooling adjusted risk estimates, vitamin D was also found to reduce the risk of adverse outcomes (pooled OR 0.27, 95% CI: 0.08, 0.91, p = 0.03, I2 = 80%, random-effects model). Subgroup analysis showed that vitamin D supplementation was associated with improved clinical outcomes only in patients receiving the drug post-COVID-19 diagnosis and not in those who had received vitamin D before diagnosis. Conclusions Vitamin D supplementation might be associated with improved clinical outcomes, especially when administered after the diagnosis of COVID-19. However, issues regarding the appropriate dose, duration, and mode of administration of vitamin D remain unanswered and need further research. Supplementary Information The online version contains supplementary material available at 10.1007/s40618-021-01614-4.
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- 2021
5. Fracture risk in hypoparathyroidism: a systematic review and meta-analysis
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M Banerjee, Sanjay Kumar Bhadada, Rimesh Pal, Akash Kumar, and Soham Mukherjee
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0301 basic medicine ,medicine.medical_specialty ,Hypoparathyroidism ,business.industry ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Odds ratio ,medicine.disease ,Lower risk ,Confidence interval ,Rheumatology ,Fractures, Bone ,Observational Studies as Topic ,03 medical and health sciences ,0302 clinical medicine ,Bone Density ,Meta-analysis ,Internal medicine ,Orthopedic surgery ,medicine ,Humans ,Observational study ,030101 anatomy & morphology ,business - Abstract
In this meta-analysis, we analyzed 7 observational studies for assessing the fracture risk in patients with hypoparathyroidism (hypoPT). We found that the risk of vertebral fractures is increased by almost 2-fold, especially those with nonsurgical hypoPT. Patients with hypoPT have higher bone mineral density than age- and sex-matched controls. This would theoretically translate into a lower risk of fractures, although available clinical evidence is contradictory. Hence, the present systematic review and meta-analysis was undertaken to collate and provide a precise summary of fracture risk in hypoPT. PubMed, Scopus, and Web of Science databases were systematically searched using appropriate keywords till March 8, 2021, to identify observational studies reporting the rate of occurrence of fractures among hypoPT patients (nonsurgical and/or postsurgical) compared to non-hypoPT subjects (controls). Study quality was assessed using Newcastle-Ottawa Scale. Pooled odds ratio (OR) with 95% confidence intervals (CI) was calculated. Subgroup analyses of nonsurgical and postsurgical hypoPT patients were also conducted. We identified 7 observational studies of high-quality pooling data retrieved from 1470 patients with hypoPT. When stratified based on the skeletal site, pooled analyses showed that hypoPT patients were at an increased risk of vertebral fractures compared to non-hypoPT controls (OR 2.22, 95% CI: 1.23, 4.03, p = 0.009, I2 = 49%, random-effects model). The increased risk of vertebral fractures was seen only in patients with nonsurgical hypoPT (OR 2.31, 95% CI: 1.32, 4.03, p = 0.003, I2 = 3%, random-effects model) but not in those with postsurgical hypoPT. hypoPT patients were not at an increased or decreased risk of any, humerus, or proximal femur/hip fractures than controls. Nonsurgical hypoPT patients are at an almost 2-fold increased risk of vertebral fractures and thus need to be actively screened irrespective of the underlying BMD.
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- 2021
6. Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry
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Gurwinder Kaur, S M Arvindbhai, Rama Walia, Arun Kumar Aggarwal, Sanjay Kumar Bhadada, Uma Nahar Saikia, Rimesh Pal, Neelam Aggarwal, Nishkarsh Gupta, A Behera, and K V Raviteja
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Pediatrics ,medicine.medical_specialty ,Pregnancy ,Cinacalcet ,Eclampsia ,endocrine system diseases ,business.industry ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,medicine.disease ,Asymptomatic ,Preeclampsia ,Miscarriage ,03 medical and health sciences ,Low birth weight ,0302 clinical medicine ,Endocrinology ,030220 oncology & carcinogenesis ,Medicine ,medicine.symptom ,business ,Primary hyperparathyroidism ,medicine.drug - Abstract
To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and other characteristics with age-matched non-pregnant women with PHPT. Out of 386 women, eight had gestational PHPT (2.1%). The common presenting manifestations were acute pancreatitis (50%) and renal stone disease (50%); two were asymptomatic. Five women (62.5%) had a history of prior miscarriages. Seven patients (88%) had preeclampsia during the present gestation. Serum calcium and intact parathyroid hormone (iPTH) were not statistically different from the age-matched non-pregnant PHPT group. Six patients with mild-to-moderate hypercalcemia were medically managed with hydration with/without cinacalcet while one patient underwent percutaneous ethanol ablation of the parathyroid adenoma; none underwent surgery during pregnancy. Mean serum calcium maintained from treatment initiation till delivery was 10.5 ± 0.4 mg/dl. One patient had spontaneous preterm delivery at 36 weeks; the remaining patients had normal vaginal delivery at term. None had severe preeclampsia/eclampsia. Fetal outcomes included low birth weight in three newborns (37.5%); two of them had hypocalcemic seizures. The prevalence of gestational PHPT was 2.1% in this largest Indian PHPT cohort, which is higher than that reported from the West (
- Published
- 2020
7. COVID-19 Associated Hemophagocytic Lymphohistiocytosis and Coagulopathy: Targeting the Duumvirate
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Mainak Banerjee, Rimesh Pal, and Sukrita Bhattacharjee
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Secondary Hemophagocytic Lymphohistiocytosis ,Pediatrics ,medicine.medical_specialty ,medicine.drug_class ,Pneumonia, Viral ,Population ,Low molecular weight heparin ,Review Article ,Disseminated intravascular coagulation ,Cytokine storm ,Lymphohistiocytosis, Hemophagocytic ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,medicine ,Coagulopathy ,Humans ,Pediatrics, Perinatology, and Child Health ,030212 general & internal medicine ,education ,Chilblains ,Pandemics ,Hemophagocytic lymphohistiocytosis ,education.field_of_study ,SARS-CoV-2 ,business.industry ,COVID-19 ,Blood Coagulation Disorders ,medicine.disease ,Management ,Pediatrics, Perinatology and Child Health ,Coronavirus Infections ,business ,Immunosuppression - Abstract
Context Preliminary data on coexistence of secondary hemophagocytic lymphohistiocytosis syndrome (HLH) and disseminated intravascular coagulation (DIC) in critically ill children with novel coronavirus disease (COVID-19) are emerging. Herein, we summarize the available literature and fill-in the gaps in this regard. Evidence Acquisition We have performed a literature search for articles in PubMed, EMBASE and Google Scholar databases till May 12, 2020, with following keywords: “COVID-19”, “SARS-CoV-2”, “HLH”, “HScore”, “coagulopathy”, “D-dimer”, “cytokine storm”, “children” and “pediatrics” with interposition of Boolean operator “AND”. Results Children presenting with moderate-severe COVID-19 and Kawasaki disease shock-like syndrome exhibit peripheral blood picture analogous to HLH. HScore, a validated tool to diagnose HLH, has been suggested to screen severe COVID-19 patients for cytokine storm. However, HScore faces certain limitations in this scenario. It may be more pragmatic to use ‘high D-dimer’ (> 3 µg/mL) instead of ‘low fibrinogen’ to facilitate early detection of cytokine storm. COVID-19 associated coagulopathy resembles hypercoagulable form of DIC with bleeding being rarely reported. Although the International Society on Thrombosis and Haemostasis (ISTH) interim guidance recommends low molecular weight heparin in all hospitalized patients, data is lacking in population below 14 years of age. However, in the presence of life-threatening thromboembolic event or symptomatic acro-ischemia, unfractionated heparin (UFH) should be used with caution. Conclusions HScore can be used as a complement to clinical decision for initiating immunosuppression. Children with moderate-to-severe COVID-19, especially those with documented thrombocytopenia or chilblains, should be regularly monitored for coagulopathy.
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- 2020
8. Diagnostic cut-offs, prevalence, and biochemical predictors of sarcopenia in healthy Indian adults: The Sarcopenia-Chandigarh Urban Bone Epidemiological Study (Sarco-CUBES)
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Priyanka Singh, Anil Bhansali, Abhilasha Garg, Sanjay Kumar Bhadada, Pinaki Dutta, Urmila Yadav, Tulika Singh, Anshita Aggarwal, Sadhna Sharma, Niranjan Khandelwal, Rimesh Pal, Ashok Kumar, and Vandana Dhiman
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medicine.medical_specialty ,030214 geriatrics ,business.industry ,Skeletal muscle ,musculoskeletal system ,medicine.disease ,Muscle mass ,Gait speed ,03 medical and health sciences ,Low muscle mass ,0302 clinical medicine ,medicine.anatomical_structure ,Internal medicine ,Sarcopenia ,Epidemiology ,Muscle strength ,Medicine ,030212 general & internal medicine ,business ,human activities ,Blood sampling - Abstract
To determine the diagnostic cut-offs and the prevalence of sarcopenia in India. Indians have lower muscle strength and muscle mass than Caucasians. The prevalence of ‘probable sarcopenia’, ‘sarcopenia’, and ‘severe sarcopenia’ is 14.6%, 3.2%, and 2.3%, respectively; corresponding values are higher using well-established Western cut-offs. Indigenous and not Western cut-offs should be used to define sarcopenia in Indians. Comprehensive data on diagnosis and prevalence of sarcopenia in India are lacking. The present study was undertaken to determine cut-offs for low muscle strength (MS) and low muscle mass (MM), and find out the prevalence of sarcopenia in Indians. Apparently healthy individuals aged ≥ 20 years with no prior history of any co-morbidities were recruited from community by door-to-door survey. Participants eligible for study underwent blood sampling. Individuals identified as having biochemical abnormalities that could potentially affect MS and MM were excluded. Enrolled participants underwent DEXA. Muscle mass, MS, and physical performance were expressed as appendicular skeletal muscle index (ASMI), dominant handgrip strength (HGS), and usual gait speed (GS), respectively. Cut-offs for low MS and MM were defined as HGS and ASMI 2SD
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- 2020
9. COVID-19 and the endocrine system: exploring the unexplored
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Rimesh Pal and Monisha Banerjee
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2019-20 coronavirus outbreak ,Pituitary diseases ,Coronavirus disease 2019 (COVID-19) ,Endocrinology, Diabetes and Metabolism ,Pneumonia, Viral ,Endocrine System Diseases ,Betacoronavirus ,Diabetes mellitus ,Endocrinology ,Endocrine Glands ,Pandemic ,Animals ,Humans ,Medicine ,Endocrine system ,Hormone metabolism ,Adrenal ,Pandemics ,biology ,SARS-CoV-2 ,business.industry ,Comment ,COVID-19 ,biology.organism_classification ,Virology ,Hormones ,Thyroid diseases ,Coronavirus Infections ,business ,Endocrine gland - Published
- 2020
10. Prevalence and predictors of osteopenia and osteoporosis in patients with type 2 diabetes mellitus: a cross-sectional study from a tertiary care institute in North India
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Deba Prasad Dhibar, Niranjan Khandelwal, Rimesh Pal, Vandana Dhiman, Mahesh Prakash, Sarath Aleti, Sanjay Kumar Bhadada, and Pinaki Dutta
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musculoskeletal diseases ,Bone mineral ,medicine.medical_specialty ,business.industry ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Type 2 Diabetes Mellitus ,030209 endocrinology & metabolism ,musculoskeletal system ,medicine.disease ,Osteopenia ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Cohort ,Internal Medicine ,Medicine ,030212 general & internal medicine ,business ,Pioglitazone ,medicine.drug - Abstract
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of hip and vertebral fractures. The increased fracture risk has largely been attributed to poor bone quality and microarchitecture. The contribution of bone quantity, measured as areal bone mineral density (BMD), to the risk of fracture is variable with most studies showing an increase in BMD in T2DM. The present study was undertaken to find out the prevalence of osteoporosis and osteopenia (based on BMD) in a cohort of patients with T2DM and delineate the possible modifiable and non-modifiable risk factors. In this cross-sectional observational study, 252 otherwise ostensibly healthy patients with T2DM underwent dual energy X-ray absorptiometry (DEXA) scan. Osteoporosis and osteopenia were defined based on T-scores. The effect of modifiable and non-modifiable risk factors on BMD and osteoporosis were assessed. The mean age of the cohort was 59.9 years with a M:F ratio 2.9:3.4. The mean BMD at the lumbar spine and hip were 0.892 g/cm2 and 0.715 g/cm2, respectively. Males had significantly higher BMD at both the sites compared to females. The prevalence of osteoporosis and osteopenia was 33% and 40%, respectively. Female gender, increasing age, normal body mass index (BMI), low serum 25-hydroxyvitamin D, and use of pioglitazone were significantly associated with the risk of osteoporosis. The prevalence of osteoporosis and osteopenia in patients with T2DM is high. Female gender, increasing age, normal BMI, low serum 25-hydroxyvitamin D, and pioglitazone use further increase the risk of osteoporosis.
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- 2020
11. Metabolic Bone Profile of Healthy Adult North Indian Population from Chandigarh Urban Bone Epidemiological Study (CUBES)
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Anshita Aggarwal, Priyanka Singh, Anil Bhansali, Naresh Sachdeva, Sanjay Kumar Bhadada, Sant Ram, Jarnail Singh Thakur, Rimesh Pal, Abhilasha Garg, and Sadhna Sharma
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0301 basic medicine ,medicine.medical_specialty ,education.field_of_study ,North indian population ,business.industry ,Clinical Biochemistry ,Population ,Albumin ,chemistry.chemical_element ,Physiology ,Calcium ,medicine.disease ,vitamin D deficiency ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,chemistry ,030220 oncology & carcinogenesis ,Epidemiology ,Vitamin D and neurology ,Medicine ,Alkaline phosphatase ,Original Research Article ,business ,education - Abstract
We aimed to estimate metabolic bone profile in a large cohort of healthy, adult Indian population to generate reference standards of serum calcium, phosphate and alkaline phosphatase (ALP), 25 (OH) Vitamin D and iPTH, and also to find out the prevalence of Vitamin D deficiency in healthy population. Apparently healthy people in the age group of 20–80 years, residing in the union territory of Chandigarh were chosen. Fasting samples for serum calcium, phosphate, albumin, alkaline phosphatase (ALP), 25 (OH) D and iPTH were collected and were processed on the same day. We recruited 930 healthy subjects from different subsectors of Chandigarh. Final analysis was done for 915 subjects. Out of this, 530 (58%) were women and 385 (42%) were men. The study participants were divided into two groups, less than and more than 50 years for the men and pre and post-menopausal for the women. The serum calcium, phosphate, ALP and iPTH were significantly higher in the post-menopausal women compared to the pre-menopausal women. The median plasma 25 (OH) D in men and women was 12.5 ng/mL and 14.3 ng/mL, respectively. 25 (OH) D deficiency was seen in 65.4% of individuals. 25 (OH) D levels co-related negatively with iPTH levels (r = − 0.4, p
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- 2019
12. Comment on 'Rebound hypercalcemia post-denosumab cessation in metastatic breast cancer': Waxing-Waning Serum Calcium following Denosumab use in a patient with Polyostotic Paget’s Disease of Bone
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Rimesh Pal and Sanjay Kumar Bhadada
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Endocrinology, Diabetes and Metabolism ,Hypercalcemia ,Humans ,Breast Neoplasms ,Calcium ,Female ,Denosumab ,Osteitis Deformans - Published
- 2022
13. The Indian Society for Bone and Mineral Research (ISBMR) position statement for the diagnosis and treatment of osteoporosis in adults
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Shriraam Mahadevan, Sanjay Kumar Bhadada, Nikhil Tandon, Narendra Kotwal, Thomas V Paul, Usha Sriram, Satinath Mukhopadhyay, Ameya Joshi, Soham Mukherjee, Rajesh Khadgawat, Beena Bansal, Sushil Gupta, Anshita Aggarwal, Ambrish Mithal, Mahendra Kumar Garg, Nitin Kapoor, Manoj Chadha, Subhash C. Kukreja, Sudhaker D Rao, and Rimesh Pal
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Adult ,0301 basic medicine ,medicine.medical_specialty ,FRAX ,Osteoporosis ,Population ,030209 endocrinology & metabolism ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Pharmacotherapy ,Bone Density ,Risk Factors ,medicine ,Humans ,Orthopedics and Sports Medicine ,Intensive care medicine ,education ,Bone mineral ,Estimation ,Minerals ,education.field_of_study ,business.industry ,Public health ,medicine.disease ,Orthopedic surgery ,030101 anatomy & morphology ,business ,Osteoporotic Fractures - Abstract
The Indian Society for Bone and Mineral Research (ISBMR) has herein drafted clinical practice guidelines for the diagnosis and management of osteoporosis for the people of India. Implementation of the position statement in clinical practice is expected to improve the overall care of patients with osteoporosis in India. In India, osteoporosis is a major public health problem. However, in the absence of any robust regional guidelines, the screening, treatment, and follow-up of patients with osteoporosis are lagging behind in the country. The Indian Society for Bone and Mineral Research (ISBMR), which is a multidisciplinary group of physicians, researchers, dietitians, and epidemiologists and who study bone and related tissues, in their annual meeting, drafted the guidelines for the diagnosis and management of osteoporosis that would be appropriate in a resource constraint setting like India. Diagnosis of osteoporosis can be made in a patient with minimal trauma fracture without the aid of any other diagnostic tools. In others, bone mineral density measured by dual-energy X-ray absorptiometry remains the modality of choice. Data indicates that osteoporotic fractures occur at an earlier age in Indians than in the West; hence, screening for osteoporosis should begin at an earlier age. FRAX can be used for fracture risk estimation; however, it may underestimate the risk of future fractures in our population and still needs validation. Maintaining optimum serum 25-hydroxyvitamin D levels is essential, which, in most cases, would require regular vitamin D supplementation. Pharmacotherapy should be guided by the presence/absence of vertebral/hip fractures or the severity of risk based on clinical factors, although bisphosphonates remain the first choice in most cases. Regular follow-up is essential to ensure adherence and response to therapy. Implementation of the position statement in clinical practice is expected to improve the overall care of patients with osteoporosis in India.
- Published
- 2021
14. Post-liver transplantation diabetes mellitus — a clinical challenge for diabetologists?
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Rimesh Pal and Sanjay Kumar Bhadada
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medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,medicine.medical_treatment ,Diabetes mellitus ,Internal Medicine ,medicine ,Liver transplantation ,business ,medicine.disease ,Health administration - Published
- 2021
15. Bone fragility in type 2 diabetes mellitus: a lot left to explore
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Rimesh Pal, Trupti N. Prasad, and Sanjay K. Bhadada
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Endocrinology ,Endocrinology, Diabetes and Metabolism - Published
- 2022
16. Age- and sex-specific concentrations of bone remodeling markers in healthy Indian adults with and without vitamin D deficiency
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Sanjay Kumar Bhadada, Abhilasha Garg, Anshita Aggarwal, Anil Bhansali, Rimesh Pal, Naresh Sachdeva, and Sant Ram
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Adult ,Male ,0301 basic medicine ,Physiology ,030209 endocrinology & metabolism ,Age and sex ,Procollagen Type I ,Collagen Type I ,vitamin D deficiency ,Bone remodeling ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Child ,Aged ,business.industry ,Significant difference ,Healthy subjects ,Middle Aged ,Vitamin D Deficiency ,medicine.disease ,Peptide Fragments ,Menopause ,Female ,Bone Remodeling ,030101 anatomy & morphology ,Peptides ,business ,Biomarkers ,Procollagen ,Blood sampling - Abstract
Bone remodeling markers exhibit marked inter-ethnic variation; hence, population-specific data are required. Herein, we have established age- and sex-specific concentrations of serum PINP and CTX in healthy Indian adults with and without vitamin D deficiency that can be used in clinical practice for monitoring response to anti-osteoporotic therapy. The present study was undertaken to generate data on age- and sex-specific concentrations of serum procollagen type I N-propeptide (PINP) and type I collagen C-telopeptide (CTX) in healthy Indian adults with and without vitamin D deficiency. Apparently, healthy subjects aged ≥ 20 years with no prior co-morbidities were recruited from the community by door-to-door surveys. Provisionally eligible participants underwent blood sampling after overnight fast. Individuals with biochemical abnormalities that could potentially affect bone remodeling were excluded. However, subjects with vitamin D deficiency were not excluded. Serum total PINP and β-CrossLaps (CTX) were measured using electro-chemiluminescence immunoassay. After exclusion, 677 subjects were enrolled (M:F = 2.5:4.2, mean age = 45.0 years). Median serum PINP and CTX were 55.78 ng/ml (40.27–71.70) and 0.356 ng/ml (0.238–0.499), respectively. There was no difference in PINP/CTX between men and women or between premenopausal and postmenopausal women. Decade-wise distribution of PINP/CTX showed that maximum values were attained in 3rd decade; subsequently, in men, levels declined with age while in women, there was a peak in the 6th decade coinciding with the early years of menopause. Vitamin D deficiency and severe vitamin D deficiency were seen in 417 (61.5%) and 259 subjects (38.2%), respectively. There was no significant difference in PINP/CTX in subjects with and without vitamin D deficiency. The present study has allowed us to generate data on serum concentrations of PINP/CTX in a diverse group of healthy community-dwelling Indian adults with varying serum vitamin D levels. It might aid in monitoring response to anti-osteoporotic therapy amongst native Indians.
- Published
- 2021
17. Cherubism
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Rimesh Pal and Pinaki Dutta
- Subjects
Pediatrics, Perinatology and Child Health - Published
- 2020
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