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Your search keyword '"Mergental, Hynek"' showing total 7 results
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7 results on '"Mergental, Hynek"'

1. N-acetylcysteine: a novel approach to methaemoglobinaemia in normothermic liver machine perfusion

Author

Clarke, George, primary, Mao, Jingwen, additional, Fan, Yiyu, additional, Hann, Angus, additional, Gupta, Amita, additional, Nutu, Anisa, additional, Buckel, Erwin, additional, Kayani, Kayani, additional, Murphy, Nicholas, additional, Bangash, Mansoor N., additional, Casey, Anna L., additional, Wootton, Isla, additional, Lawson, Alexander J., additional, Dasari, Bobby V. M., additional, Perera, M. Thamara P. R., additional, Mergental, Hynek, additional, and Afford, Simon C., additional

Published
2023
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4. Transplantation of discarded livers following viability testing with normothermic machine perfusion

Author

Mergental, Hynek, primary, Laing, Richard W., additional, Kirkham, Amanda J., additional, Perera, M. Thamara P. R., additional, Boteon, Yuri L., additional, Attard, Joseph, additional, Barton, Darren, additional, Curbishley, Stuart, additional, Wilkhu, Manpreet, additional, Neil, Desley A. H., additional, Hübscher, Stefan G., additional, Muiesan, Paolo, additional, Isaac, John R., additional, Roberts, Keith J., additional, Abradelo, Manuel, additional, Schlegel, Andrea, additional, Ferguson, James, additional, Cilliers, Hentie, additional, Bion, Julian, additional, Adams, David H., additional, Morris, Chris, additional, Friend, Peter J., additional, Yap, Christina, additional, Afford, Simon C., additional, and Mirza, Darius F., additional

Published
2020
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5. A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation

Author

Nasralla, David, primary, Nasralla, David, additional, Akhtar, Mohammed Zeeshan, additional, Bradley, Ally, additional, Butler, Andrew, additional, Chiocchia, Virginia, additional, Dutton, Susan, additional, García-Valdecasas, Juan Carlos, additional, Imber, Charles, additional, Jassem, Wayel, additional, Knight, Simon, additional, Mergental, Hynek, additional, Paul, Andreas, additional, Pirenne, Jacques, additional, Ploeg, Rutger, additional, Coussios, Constantin C, additional, and Friend, Peter J, additional

Published
2018
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7. A randomized trial of normothermic preservation in liver transplantation

Author

Nasralla, David, Coussios, Constantin C, Mergental, Hynek, Akhtar, M Zeeshan, Butler, Andrew J, Ceresa, Carlo DL, Chiocchia, Virginia, Dutton, Susan J, García-Valdecasas, Juan Carlos, Heaton, Nigel, Imber, Charles, Jassem, Wayel, Jochmans, Ina, Karani, John, Knight, Simon R, Kocabayoglu, Peri, Malagò, Massimo, Mirza, Darius, Morris, Peter J, Pallan, Arvind, Paul, Andreas, Pavel, Mihai, Perera, M Thamara PR, Pirenne, Jacques, Ravikumar, Reena, Russell, Leslie, Upponi, Sara, Watson, Chris JE, Weissenbacher, Annemarie, Ploeg, Rutger J, Friend, Peter J, and Consortium For Organ Preservation In Europe

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Waiting Lists, Graft Survival, Temperature, Organ Preservation, Length of Stay, Middle Aged, Allografts, Survival Analysis, Tissue Donors, 3. Good health, Liver Transplantation, Perfusion, Young Adult, Treatment Outcome, Liver, Tissue and Organ Harvesting, Humans, Female, Bile Ducts, Aged
Abstract

Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.

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