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A randomized trial of normothermic preservation in liver transplantation
- Publisher :
- Springer Science and Business Media LLC
-
Abstract
- Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.
- Subjects :
- Adult
Aged, 80 and over
Male
Adolescent
Waiting Lists
Graft Survival
Temperature
Organ Preservation
Length of Stay
Middle Aged
Allografts
Survival Analysis
Tissue Donors
3. Good health
Liver Transplantation
Perfusion
Young Adult
Treatment Outcome
Liver
Tissue and Organ Harvesting
Humans
Female
Bile Ducts
Aged
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........359b0a1d8cd00477139634f4e0edbf4a