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Your search keyword '"Lehtimäki, Terho"' showing total 172 results
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172 results on '"Lehtimäki, Terho"'

1. Gene expression networks regulated by human personality

Author

del Val, Coral, primary, Díaz de la Guardia-Bolívar, Elisa, additional, Zwir, Igor, additional, Mishra, Pashupati P., additional, Mesa, Alberto, additional, Salas, Ramiro, additional, Poblete, Guillermo F., additional, de Erausquin, Gabriel, additional, Raitoharju, Emma, additional, Kähönen, Mika, additional, Raitakari, Olli, additional, Keltikangas-Järvinen, Liisa, additional, Lehtimäki, Terho, additional, and Cloninger, Claude Robert, additional

Published
2024
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2. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

Author

Scholz, Markus, primary, Horn, Katrin, additional, Pott, Janne, additional, Wuttke, Matthias, additional, Kühnapfel, Andreas, additional, Nasr, M. Kamal, additional, Kirsten, Holger, additional, Li, Yong, additional, Hoppmann, Anselm, additional, Gorski, Mathias, additional, Ghasemi, Sahar, additional, Li, Man, additional, Tin, Adrienne, additional, Chai, Jin-Fang, additional, Cocca, Massimiliano, additional, Wang, Judy, additional, Nutile, Teresa, additional, Akiyama, Masato, additional, Åsvold, Bjørn Olav, additional, Bansal, Nisha, additional, Biggs, Mary L., additional, Boutin, Thibaud, additional, Brenner, Hermann, additional, Brumpton, Ben, additional, Burkhardt, Ralph, additional, Cai, Jianwen, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chalmers, John, additional, Chasman, Daniel I., additional, Chee, Miao Ling, additional, Chee, Miao Li, additional, Chen, Xu, additional, Cheng, Ching-Yu, additional, Cifkova, Renata, additional, Daviglus, Martha, additional, Delgado, Graciela, additional, Dittrich, Katalin, additional, Edwards, Todd L., additional, Endlich, Karlhans, additional, Michael Gaziano, J., additional, Giri, Ayush, additional, Giulianini, Franco, additional, Gordon, Scott D., additional, Gudbjartsson, Daniel F., additional, Hallan, Stein, additional, Hamet, Pavel, additional, Hartman, Catharina A., additional, Hayward, Caroline, additional, Heid, Iris M., additional, Hellwege, Jacklyn N., additional, Holleczek, Bernd, additional, Holm, Hilma, additional, Hutri-Kähönen, Nina, additional, Hveem, Kristian, additional, Isermann, Berend, additional, Jonas, Jost B., additional, Joshi, Peter K., additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kastarinen, Mika, additional, Khor, Chiea Chuen, additional, Kiess, Wieland, additional, Kleber, Marcus E., additional, Körner, Antje, additional, Kovacs, Peter, additional, Krajcoviechova, Alena, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kuokkanen, Mikko, additional, Kähönen, Mika, additional, Lange, Leslie A., additional, Lash, James P., additional, Lehtimäki, Terho, additional, Li, Hengtong, additional, Lin, Bridget M., additional, Liu, Jianjun, additional, Loeffler, Markus, additional, Lyytikäinen, Leo-Pekka, additional, Magnusson, Patrik K. E., additional, Martin, Nicholas G., additional, Matsuda, Koichi, additional, Milaneschi, Yuri, additional, Mishra, Pashupati P., additional, Mononen, Nina, additional, Montgomery, Grant W., additional, Mook-Kanamori, Dennis O., additional, Mychaleckyj, Josyf C., additional, März, Winfried, additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Nolte, Ilja M., additional, Noordam, Raymond, additional, Okada, Yukinori, additional, Olafsson, Isleifur, additional, Oldehinkel, Albertine J., additional, Penninx, Brenda W. J. H., additional, Perola, Markus, additional, Pirastu, Nicola, additional, Polasek, Ozren, additional, Porteous, David J., additional, Poulain, Tanja, additional, Psaty, Bruce M., additional, Rabelink, Ton J., additional, Raffield, Laura M., additional, Raitakari, Olli T., additional, Rasheed, Humaira, additional, Reilly, Dermot F., additional, Rice, Kenneth M., additional, Richmond, Anne, additional, Ridker, Paul M., additional, Rotter, Jerome I., additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Salomaa, Veikko, additional, Schneiderman, Neil, additional, Schöttker, Ben, additional, Sims, Mario, additional, Snieder, Harold, additional, Stark, Klaus J., additional, Stefansson, Kari, additional, Stocker, Hannah, additional, Stumvoll, Michael, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Svensson, Per O., additional, Tai, E-Shyong, additional, Taylor, Kent D., additional, Tayo, Bamidele O., additional, Teren, Andrej, additional, Tham, Yih-Chung, additional, Thiery, Joachim, additional, Thio, Chris H. L., additional, Thomas, Laurent F., additional, Tremblay, Johanne, additional, Tönjes, Anke, additional, van der Most, Peter J., additional, Vitart, Veronique, additional, Völker, Uwe, additional, Wang, Ya Xing, additional, Wang, Chaolong, additional, Wei, Wen Bin, additional, Whitfield, John B., additional, Wild, Sarah H., additional, Wilson, James F., additional, Winkler, Thomas W., additional, Wong, Tien-Yin, additional, Woodward, Mark, additional, Sim, Xueling, additional, Chu, Audrey Y., additional, Feitosa, Mary F., additional, Thorsteinsdottir, Unnur, additional, Hung, Adriana M., additional, Teumer, Alexander, additional, Franceschini, Nora, additional, Parsa, Afshin, additional, Köttgen, Anna, additional, Schlosser, Pascal, additional, and Pattaro, Cristian, additional

Published
2024
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3. Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Author

Kavousi, Maryam, primary, Bos, Maxime M., additional, Barnes, Hanna J., additional, Cardenas, Christian L. Lino, additional, Wong, Doris, additional, Lu, Haojie, additional, Hodonsky, Chani J., additional, Landsmeer, Lennart P. L., additional, Turner, Adam W., additional, Kho, Minjung, additional, Hasbani, Natalie R., additional, de Vries, Paul S., additional, Bowden, Donald W., additional, Chopade, Sandesh, additional, Deelen, Joris, additional, Benavente, Ernest Diez, additional, Guo, Xiuqing, additional, Hofer, Edith, additional, Hwang, Shih-Jen, additional, Lutz, Sharon M., additional, Lyytikäinen, Leo-Pekka, additional, Slenders, Lotte, additional, Smith, Albert V., additional, Stanislawski, Maggie A., additional, van Setten, Jessica, additional, Wong, Quenna, additional, Yanek, Lisa R., additional, Becker, Diane M., additional, Beekman, Marian, additional, Budoff, Matthew J., additional, Feitosa, Mary F., additional, Finan, Chris, additional, Hilliard, Austin T., additional, Kardia, Sharon L. R., additional, Kovacic, Jason C., additional, Kral, Brian G., additional, Langefeld, Carl D., additional, Launer, Lenore J., additional, Malik, Shaista, additional, Hoesein, Firdaus A. A. Mohamed, additional, Mokry, Michal, additional, Schmidt, Reinhold, additional, Smith, Jennifer A., additional, Taylor, Kent D., additional, Terry, James G., additional, van der Grond, Jeroen, additional, van Meurs, Joyce, additional, Vliegenthart, Rozemarijn, additional, Xu, Jianzhao, additional, Young, Kendra A., additional, Zilhão, Nuno R., additional, Zweiker, Robert, additional, Assimes, Themistocles L., additional, Becker, Lewis C., additional, Bos, Daniel, additional, Carr, J. Jeffrey, additional, Cupples, L. Adrienne, additional, de Kleijn, Dominique P. v., additional, de Winther, Menno, additional, den Ruijter, Hester M., additional, Fornage, Myriam, additional, Freedman, Barry I., additional, Gudnason, Vilmundur, additional, Hingorani, Aroon D., additional, Hokanson, John E., additional, Ikram, M. Arfan, additional, Išgum, Ivana, additional, Jacobs, David R., additional, Kähönen, Mika, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Pasterkamp, Gerard, additional, Raitakari, Olli T., additional, Schmidt, Helena, additional, Slagboom, P. Eline, additional, Uitterlinden, André G., additional, Vernooij, Meike W., additional, Bis, Joshua C., additional, Franceschini, Nora, additional, Psaty, Bruce M., additional, Post, Wendy S., additional, Rotter, Jerome I., additional, Björkegren, Johan L. M., additional, O’Donnell, Christopher J., additional, Bielak, Lawrence F., additional, Peyser, Patricia A., additional, Malhotra, Rajeev, additional, van der Laan, Sander W., additional, and Miller, Clint L., additional

Published
2023
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4. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author

Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Søren Karl, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, Swertz, Morris, Wijmenga, Tjitske Nienke, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Wolffenbuttel, Bruce H. R., Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., Hoed, Marcel den, Epidemiology, Internal Medicine, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J, Moore, Tim, Hyppönen, Elina, den Hoed, Marcel, Lifelines Cohort Study, Alizadeh, B.Z., Boezen, H.M., Franke, L., Swertz, M., Wijmenga, C., van der Harst, P., Navis, G., Rots, M., Wolffenbuttel, BHR, Wang, Zhe [0000-0002-8046-4969], Emmerich, Andrew [0000-0002-0908-9924], Pillon, Nicolas J [0000-0003-1107-9490], Moore, Tim [0000-0003-4250-3370], Ameur, Adam [0000-0001-6085-6749], Bis, Joshua C [0000-0002-3409-1110], Boehnke, Michael [0000-0002-6442-7754], Bouchard, Claude [0000-0002-0048-491X], Chasman, Daniel I [0000-0003-3357-0862], Smith, George Davey [0000-0002-1407-8314], de Geus, Eco JC [0000-0001-6022-2666], Dörr, Marcus [0000-0001-7471-475X], Ferrucci, Luigi [0000-0002-6273-1613], Fornage, Myriam [0000-0003-0677-8158], Garland, Theodore [0000-0002-7916-3552], Gyllensten, Ulf [0000-0002-6316-3355], Hansen, Torben [0000-0001-8748-3831], Horta, Bernardo L [0000-0001-9843-412X], Hyppönen, Elina [0000-0003-3670-9399], Johnson, W Craig [0000-0002-3161-3753], Kiemeney, Lambertus A [0000-0002-2368-1326], Laakso, Markku [0000-0002-3394-7749], Langenberg, Claudia [0000-0002-5017-7344], Lehtimäki, Terho [0000-0002-2555-4427], Magnusson, Patrik KE [0000-0002-7315-7899], Martin, Nicholas G [0000-0003-4069-8020], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Meyre, David [0000-0003-4850-7444], North, Kari E [0000-0002-8903-0366], Ohlsson, Claes [0000-0002-9633-2805], Oldehinkel, Albertine J [0000-0003-3925-3913], Orho-Melander, Marju [0000-0002-3578-2503], Pare, Guillaume [0000-0002-6795-4760], Park, Taesung [0000-0002-8294-590X], Pedersen, Oluf [0000-0002-3321-3972], Pers, Tune H [0000-0003-0207-4831], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Rotimi, Charles N [0000-0001-5759-053X], Sim, Xueling [0000-0002-1233-7642], Snieder, Harold [0000-0003-1949-2298], Sørensen, Thorkild IA [0000-0003-4821-430X], Spector, Tim D [0000-0002-9795-0365], Timpson, Nicholas J [0000-0002-7141-9189], Voortman, Trudy [0000-0003-2830-6813], Waeber, Gérard [0000-0003-4193-788X], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Wilson, James F [0000-0001-5751-9178], Krook, Anna [0000-0002-0891-0258], Zierath, Juleen R [0000-0001-6891-7497], Thomis, Martine AI [0000-0001-9093-2191], Loos, Ruth JF [0000-0002-8532-5087], Hoed, Marcel den [0000-0001-8081-428X], Apollo - University of Cambridge Repository, Center for Liver, Digestive and Metabolic Diseases (CLDM), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, and AMS - Sports

Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 631/208/205/2138, 610 Medicine & health, heritability, Actinin/genetics, Cross-Sectional Studies, Exercise/physiology, Genome-Wide Association Study, Humans, Leisure Activities, Sedentary Behavior, apolipoprotein-e genotype, Lifelines Cohort Study, 360 Social problems & social services, 692/308/575, Genetics, Actinin, Exercise, Medicinsk genetik, exercise, APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS, 360 Soziale Probleme, Sozialdienste, 692/308/2056, article, gwas, gene-expression, mortality, 3142 Public health care science, environmental and occupational health, fitness, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], LD score regression, 3111 Biomedicine, 610 Medizin und Gesundheit, Medical Genetics, complex, performance
Abstract

Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353, Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.

Published
2022
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9. Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Author

Elhakeem, Ahmed, primary, Ronkainen, Justiina, additional, Mansell, Toby, additional, Lange, Katherine, additional, Mikkola, Tuija M., additional, Mishra, Binisha H., additional, Wahab, Rama J., additional, Cadman, Tim, additional, Yang, Tiffany, additional, Burgner, David, additional, Eriksson, Johan G., additional, Järvelin, Marjo-Riitta, additional, Gaillard, Romy, additional, Jaddoe, Vincent W. V., additional, Lehtimäki, Terho, additional, Raitakari, Olli T., additional, Saffery, Richard, additional, Wake, Melissa, additional, Wright, John, additional, Sebert, Sylvain, additional, and Lawlor, Deborah A., additional

Published
2023
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10. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G, Chen, Jing, Packer, Richard, Hall, Robert J, Guyatt, Anna L, Batini, Chiara, Thompson, Rebecca J, Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D, Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A, John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y, Chen, Zhengming, Li, Liming, Wijnant, Sara RA, Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G, Manichaikul, Ani, Oelsner, Elizabeth C, Rich, Stephen S, Barr, R Graham, Kerr, Shona M, Vitart, Veronique, Brown, Michael R, Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M, Gharib, Sina A, Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E, Meyers, Deborah A, Bleecker, Eugene R, Gabriel, Stacey B, Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F, Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H, Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L, Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T, Thareja, Gaurav, Albagha, Omar ME, Ismail, Said I, Al-Muftah, Wadha, Badji, Radja, Mbarek, Hamdi, Darwish, Dima, Fadl, Tasnim, Yasin, Heba, Ennaifar, Maryem, Abdellatif, Rania, Alkuwari, Fatima, Alvi, Muhammad, Al-Sarraj, Yasser, Saad, Chadi, Althani, Asmaa, Fethnou, Eleni, Qafoud, Fatima, Alkhayat, Eiman, Afifi, Nahla, Tomei, Sara, Liu, Wei, Lorenz, Stephan, Syed, Najeeb, Almabrazi, Hakeem, Vempalli, Fazulur Rehaman, Temanni, Ramzi, Saqri, Tariq Abu, Khatib, Mohammedhusen, Hamza, Mehshad, Zaid, Tariq Abu, El Khouly, Ahmed, Pathare, Tushar, Poolat, Shafeeq, Al-Ali, Rashid, Al-Khodor, Souhaila, Alshafai, Mashael, Badii, Ramin, Chouchane, Lotfi, Estivill, Xavier, Fakhro, Khalid, Mokrab, Younes, Puthen, Jithesh V, Tatari, Zohreh, Suhre, Karsten, Granell, Raquel, Faquih, Tariq O, Hiemstra, Pieter S, Slats, Annelies M, Mullin, Benjamin H, Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T, Wyss, Annah B, Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A, Joshi, Peter K, Timmers, Paul RHJ, Williams, Alexander T, Free, Robert C, Wang, Xueyang, Morrison, John L, Gilliland, Frank D, Chen, Zhanghua, Wang, Carol A, Foong, Rachel E, Harris, Sarah E, Taylor, Adele, Redmond, Paul, Cook, James P, Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T, Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H, Cox, Simon R, Pennell, Craig E, Hall, Graham L, Gauderman, W James, Brightling, Chris, Wilson, James F, Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O, Timpson, Nicholas J, Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C, Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L, Dudbridge, Frank, Silverman, Edwin K, Strachan, David P, Walters, Robin G, Morris, Andrew P, London, Stephanie J, Cho, Michael H, Wain, Louise V, Hall, Ian P, Tobin, Martin D, Shrine, Nick [0000-0003-3641-4371], Chen, Jing [0000-0003-1287-1930], Guyatt, Anna L [0000-0003-1860-6337], Hobbs, Brian D [0000-0001-9564-0745], Kim, Wonji [0000-0002-1249-797X], Coley, Kayesha [0000-0003-4951-6799], Chen, Zhengming [0000-0001-6423-105X], Li, Liming [0000-0001-5873-7089], Lahousse, Lies [0000-0002-3494-4363], Uitterlinden, Andre G [0000-0002-7276-3387], Oelsner, Elizabeth C [0000-0002-7481-9671], Rich, Stephen S [0000-0003-3872-7793], Kerr, Shona M [0000-0002-4137-1495], Vitart, Veronique [0000-0002-4991-3797], Jeong, Ayoung [0000-0003-1542-0756], Gharib, Sina A [0000-0002-2480-4367], Gieger, Christian [0000-0001-6986-9554], Peters, Annette [0000-0001-6645-0985], Hu, Xiaowei [0000-0001-7804-7392], Smith, Albert Vernon [0000-0003-1942-5845], Luan, Jian’an [0000-0003-3137-6337], Langhammer, Arnulf [0000-0001-5296-6673], Willer, Cristen [0000-0001-5645-4966], Porteous, David [0000-0003-1249-6106], Smith, Blair H [0000-0002-5362-9430], Campbell, Archie [0000-0003-0198-5078], Sofer, Tamar [0000-0001-8520-8860], Lee, Jiwon [0000-0002-4079-7494], Lim, Elise [0000-0001-8967-8464], Thareja, Gaurav [0000-0003-2277-6400], Albagha, Omar ME [0000-0001-5916-5983], Suhre, Karsten [0000-0001-9638-3912], Granell, Raquel [0000-0002-4890-4012], Faquih, Tariq O [0000-0001-8026-2251], Hiemstra, Pieter S [0000-0002-0238-5982], Hysi, Pirro [0000-0001-5752-2510], Koskela, Jukka T [0000-0002-0154-7222], Jin, Jianping [0000-0002-3774-1609], Sikdar, Sinjini [0000-0003-1230-5162], Lee, Mikyeong [0000-0002-3036-3684], May-Wilson, Sebastian [0000-0003-2668-5717], Joshi, Peter K [0000-0002-6361-5059], Timmers, Paul RHJ [0000-0002-5197-1267], Gilliland, Frank D [0000-0002-9033-7269], Wang, Carol A [0000-0002-4301-3974], Harris, Sarah E [0000-0002-4941-5106], Mahajan, Anubha [0000-0001-5585-3420], Palviainen, Teemu [0000-0002-7847-8384], Kaprio, Jaakko [0000-0002-3716-2455], Pietiläinen, Kirsi H [0000-0002-8522-1288], Cox, Simon R [0000-0003-4036-3642], Pennell, Craig E [0000-0002-0937-6165], Wilson, James F [0000-0001-5751-9178], Vasankari, Tuula [0000-0002-1413-8970], Salomaa, Veikko [0000-0001-7563-5324], Timpson, Nicholas J [0000-0002-7141-9189], Dupuis, Josée [0000-0003-2871-3603], Brumpton, Ben [0000-0002-3058-1059], Langenberg, Claudia [0000-0002-5017-7344], Weiss, Stefan [0000-0002-3553-4315], Homuth, Georg [0000-0001-6839-0605], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Morrison, Alanna C [0000-0001-6381-4296], Rudan, Igor [0000-0001-6993-6884], Lee, Joo-Hyeon [0000-0002-7364-6422], Sayers, Ian [0000-0001-5601-5410], Rawlins, Emma L [0000-0001-7426-3792], Dudbridge, Frank [0000-0002-8817-8908], Strachan, David P [0000-0001-7854-1366], Walters, Robin G [0000-0002-9179-0321], Morris, Andrew P [0000-0002-6805-6014], London, Stephanie J [0000-0003-4911-5290], Cho, Michael H [0000-0002-4907-1657], Wain, Louise V [0000-0003-4951-1867], Hall, Ian P [0000-0001-9933-3216], Tobin, Martin D [0000-0002-3596-7874], and Apollo - University of Cambridge Repository

Subjects
hengityselimet, genome-wide association studies, perimä, 631/208/205/2138, 45/43, article, keuhkosairaudet, hengityselinten taudit, riskitekijät, 692/699/1785, keuhkot, perinnöllisyys, respiratory tract diseases
Abstract

Funder: British Lung Foundation (BLF); doi: https://doi.org/10.13039/501100000351, Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272, Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.

Published
2023

11. Genetic analyses implicate complex links between adult testosterone levels and health and disease

Author

FinnGen Consortium, Leinonen, Jaakko T., Mars, Nina, Lehtonen, Leevi E., Ahola-Olli, Ari, Ruotsalainen, Sanni, Lehtimäki, Terho, Kähönen, Mika, Raitakari, Olli, Piltonen, Terhi, Tuomi, Tiinamaija, Daly, Mark, Ripatti, Samuli, Tukiainen, Taru, Pirinen, Matti, Genomics of Sex Differences, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Faculty Common Matters (Faculty of Medicine), Genomics of Neurological and Neuropsychiatric Disorders, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Clinicum, Centre of Excellence in Complex Disease Genetics, Tiinamaija Tuomi Research Group, HUS Abdominal Center, Department of Public Health, Faculty Common Matters (Faculty of Social Sciences), Molecular and Integrative Biosciences Research Programme, Helsinki Institute for Information Technology, Statistical and population genetics, and Department of Mathematics and Statistics

Subjects
Risk, Pleiotropy, Resource, Genome-wide association, Sex steroids, Polycystic-ovary-syndrome, Mendelian randomization, Men, Women, Hormone-binding globulin, 3142 Public health care science, environmental and occupational health
Abstract

BackgroundTestosterone levels are linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of genetically determined testosterone on complex diseases in both sexes.MethodsLeveraging genetic and health registry data from the UK Biobank and FinnGen (total N = 625,650), we constructed polygenic scores (PGS) for total testosterone, sex-hormone binding globulin (SHBG) and free testosterone, associating these with 36 endpoints across different disease categories in the FinnGen. These analyses were combined with Mendelian Randomization (MR) and cross-sex PGS analyses to address causality.ResultsWe show testosterone and SHBG levels are intricately tied to metabolic health, but report lack of causality behind most associations, including type 2 diabetes (T2D). Across other disease domains, including 13 behavioral and neurological diseases, we similarly find little evidence for a substantial contribution from normal variation in testosterone levels. We nonetheless find genetically predicted testosterone affects many sex-specific traits, with a pronounced impact on female reproductive health, including causal contribution to PCOS-related traits like hirsutism and post-menopausal bleeding (PMB). We also illustrate how testosterone levels associate with antagonistic effects on stroke risk and reproductive endpoints between the sexes.ConclusionsOverall, these findings provide insight into how genetically determined testosterone correlates with several health parameters in both sexes. Yet the lack of evidence for a causal contribution to most traits beyond sex-specific health underscores the complexity of the mechanisms linking testosterone levels to disease risk and sex differences.Plain language summaryHormones, such as testosterone, travel around the body communicating between the different parts. Testosterone is present at higher levels in men, but also present in women. Variable testosterone levels explain some differences in human traits and disease prevalence. Here, we study how adult testosterone levels relate to health and disease. Genetic, i.e. inherited, differences in testosterone levels contribute to many traits specific to men or women, such as women's reproductive health, hormonal cancers, and hair growth typical in males. However, testosterone levels do not appear as a major cause of most traits studied, including psychiatric diseases and metabolic health. Normal variation in baseline testosterone levels thus seems to have a relatively minor impact on health and disease.Leinonen et al. investigate correlations between testosterone levels and disease using genetic and health registry data from the UK Biobank and FinnGen. There is a lack of evidence for normal variation in testosterone levels having a causal contribution to most non-sex-specific traits.

Published
2023

12. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Author

Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional

Published
2022
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13. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Author

Young, William J., primary, Lahrouchi, Najim, additional, Isaacs, Aaron, additional, Duong, ThuyVy, additional, Foco, Luisa, additional, Ahmed, Farah, additional, Brody, Jennifer A., additional, Salman, Reem, additional, Noordam, Raymond, additional, Benjamins, Jan-Walter, additional, Haessler, Jeffrey, additional, Lyytikäinen, Leo-Pekka, additional, Repetto, Linda, additional, Concas, Maria Pina, additional, van den Berg, Marten E., additional, Weiss, Stefan, additional, Baldassari, Antoine R., additional, Bartz, Traci M., additional, Cook, James P., additional, Evans, Daniel S., additional, Freudling, Rebecca, additional, Hines, Oliver, additional, Isaksen, Jonas L., additional, Lin, Honghuang, additional, Mei, Hao, additional, Moscati, Arden, additional, Müller-Nurasyid, Martina, additional, Nursyifa, Casia, additional, Qian, Yong, additional, Richmond, Anne, additional, Roselli, Carolina, additional, Ryan, Kathleen A., additional, Tarazona-Santos, Eduardo, additional, Thériault, Sébastien, additional, van Duijvenboden, Stefan, additional, Warren, Helen R., additional, Yao, Jie, additional, Raza, Dania, additional, Aeschbacher, Stefanie, additional, Ahlberg, Gustav, additional, Alonso, Alvaro, additional, Andreasen, Laura, additional, Bis, Joshua C., additional, Boerwinkle, Eric, additional, Campbell, Archie, additional, Catamo, Eulalia, additional, Cocca, Massimiliano, additional, Cutler, Michael J., additional, Darbar, Dawood, additional, De Grandi, Alessandro, additional, De Luca, Antonio, additional, Ding, Jun, additional, Ellervik, Christina, additional, Ellinor, Patrick T., additional, Felix, Stephan B., additional, Froguel, Philippe, additional, Fuchsberger, Christian, additional, Gögele, Martin, additional, Graff, Claus, additional, Graff, Mariaelisa, additional, Guo, Xiuqing, additional, Hansen, Torben, additional, Heckbert, Susan R., additional, Huang, Paul L., additional, Huikuri, Heikki V., additional, Hutri-Kähönen, Nina, additional, Ikram, M. Arfan, additional, Jackson, Rebecca D., additional, Junttila, Juhani, additional, Kavousi, Maryam, additional, Kors, Jan A., additional, Leal, Thiago P., additional, Lemaitre, Rozenn N., additional, Lin, Henry J., additional, Lind, Lars, additional, Linneberg, Allan, additional, Liu, Simin, additional, MacFarlane, Peter W., additional, Mangino, Massimo, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Mishra, Pashupati P., additional, Mitchell, Rebecca N., additional, Mononen, Nina, additional, Montasser, May E., additional, Morrison, Alanna C., additional, Nauck, Matthias, additional, Nauffal, Victor, additional, Navarro, Pau, additional, Nikus, Kjell, additional, Pare, Guillaume, additional, Patton, Kristen K., additional, Pelliccione, Giulia, additional, Pittman, Alan, additional, Porteous, David J., additional, Pramstaller, Peter P., additional, Preuss, Michael H., additional, Raitakari, Olli T., additional, Reiner, Alexander P., additional, Ribeiro, Antonio Luiz P., additional, Rice, Kenneth M., additional, Risch, Lorenz, additional, Schlessinger, David, additional, Schotten, Ulrich, additional, Schurmann, Claudia, additional, Shen, Xia, additional, Shoemaker, M. Benjamin, additional, Sinagra, Gianfranco, additional, Sinner, Moritz F., additional, Soliman, Elsayed Z., additional, Stoll, Monika, additional, Strauch, Konstantin, additional, Tarasov, Kirill, additional, Taylor, Kent D., additional, Tinker, Andrew, additional, Trompet, Stella, additional, Uitterlinden, André, additional, Völker, Uwe, additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Weng, Lu-Chen, additional, Whitsel, Eric A., additional, Wilson, James G., additional, Avery, Christy L., additional, Conen, David, additional, Correa, Adolfo, additional, Cucca, Francesco, additional, Dörr, Marcus, additional, Gharib, Sina A., additional, Girotto, Giorgia, additional, Grarup, Niels, additional, Hayward, Caroline, additional, Jamshidi, Yalda, additional, Järvelin, Marjo-Riitta, additional, Jukema, J. Wouter, additional, Kääb, Stefan, additional, Kähönen, Mika, additional, Kanters, Jørgen K., additional, Kooperberg, Charles, additional, Lehtimäki, Terho, additional, Lima-Costa, Maria Fernanda, additional, Liu, Yongmei, additional, Loos, Ruth J. F., additional, Lubitz, Steven A., additional, Mook-Kanamori, Dennis O., additional, Morris, Andrew P., additional, O’Connell, Jeffrey R., additional, Olesen, Morten Salling, additional, Orini, Michele, additional, Padmanabhan, Sandosh, additional, Pattaro, Cristian, additional, Peters, Annette, additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Stricker, Bruno, additional, van der Harst, Pim, additional, van Duijn, Cornelia M., additional, Verweij, Niek, additional, Wilson, James F., additional, Arking, Dan E., additional, Ramirez, Julia, additional, Lambiase, Pier D., additional, Sotoodehnia, Nona, additional, Mifsud, Borbala, additional, Newton-Cheh, Christopher, additional, and Munroe, Patricia B., additional

Published
2022
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14. Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics

Author

Kananen, Laura, primary, Hurme, Mikko, additional, Bürkle, Alexander, additional, Moreno-Villanueva, Maria, additional, Bernhardt, Jürgen, additional, Debacq-Chainiaux, Florence, additional, Grubeck-Loebenstein, Beatrix, additional, Malavolta, Marco, additional, Basso, Andrea, additional, Piacenza, Francesco, additional, Collino, Sebastiano, additional, Gonos, Efstathios S., additional, Sikora, Ewa, additional, Gradinaru, Daniela, additional, Jansen, Eugene H. J. M., additional, Dollé, Martijn E. T., additional, Salmon, Michel, additional, Stuetz, Wolfgang, additional, Weber, Daniela, additional, Grune, Tilman, additional, Breusing, Nicolle, additional, Simm, Andreas, additional, Capri, Miriam, additional, Franceschi, Claudio, additional, Slagboom, Eline, additional, Talbot, Duncan, additional, Libert, Claude, additional, Raitanen, Jani, additional, Koskinen, Seppo, additional, Härkänen, Tommi, additional, Stenholm, Sari, additional, Ala-Korpela, Mika, additional, Lehtimäki, Terho, additional, Raitakari, Olli T., additional, Ukkola, Olavi, additional, Kähönen, Mika, additional, Jylhä, Marja, additional, and Jylhävä, Juulia, additional

Published
2022
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15. Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses—a general population study

Author

Saarinen, Aino, primary, Lyytikäinen, Leo-Pekka, additional, Hietala, Jarmo, additional, Dobewall, Henrik, additional, Lavonius, Veikka, additional, Raitakari, Olli, additional, Kähönen, Mika, additional, Sormunen, Elina, additional, Lehtimäki, Terho, additional, and Keltikangas-Järvinen, Liisa, additional

Published
2022
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16. Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis

Author

Scholz, Markus, primary, Horn, Katrin, additional, Pott, Janne, additional, Gross, Arnd, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Mishra, Pashupati Prasad, additional, Kirsten, Holger, additional, Gieger, Christian, additional, Müller-Nurasyid, Martina, additional, Tönjes, Anke, additional, Kovacs, Peter, additional, Lehtimäki, Terho, additional, Raitakari, Olli, additional, Kähönen, Mika, additional, Gylling, Helena, additional, Baber, Ronny, additional, Isermann, Berend, additional, Stumvoll, Michael, additional, Loeffler, Markus, additional, März, Winfried, additional, Meitinger, Thomas, additional, Peters, Annette, additional, Thiery, Joachim, additional, Teupser, Daniel, additional, and Ceglarek, Uta, additional

Published
2022
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18. Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis

Author

Scholz, Markus, primary, Horn, Katrin, additional, Pott, Janne, additional, Gross, Arnd, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Mishra, Pashupati Prasad, additional, Kirsten, Holger, additional, Gieger, Christian, additional, Müller-Nurasyid, Martina, additional, Tönjes, Anke, additional, Kovacs, Peter, additional, Lehtimäki, Terho, additional, Raitakari, Olli, additional, Kähönen, Mika, additional, Gylling, Helena, additional, Baber, Ronny, additional, Isermann, Berend, additional, Stumvoll, Michael, additional, Loeffler, Markus, additional, März, Winfried, additional, Meitinger, Thomas, additional, Peters, Annette, additional, Thiery, Joachim, additional, Teupser, Daniel, additional, and Ceglarek, Uta, additional

Published
2022
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20. RSPO3 is important for trabecular bone and fracture risk in mice and humans

Author

Nilsson, Karin H., primary, Henning, Petra, additional, El Shahawy, Maha, additional, Nethander, Maria, additional, Andersen, Thomas Levin, additional, Ejersted, Charlotte, additional, Wu, Jianyao, additional, Gustafsson, Karin L., additional, Koskela, Antti, additional, Tuukkanen, Juha, additional, Souza, Pedro P. C., additional, Tuckermann, Jan, additional, Lorentzon, Mattias, additional, Ruud, Linda Engström, additional, Lehtimäki, Terho, additional, Tobias, Jon H., additional, Zhou, Sirui, additional, Lerner, Ulf H., additional, Richards, J. Brent, additional, Movérare-Skrtic, Sofia, additional, and Ohlsson, Claes, additional

Published
2021
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21. Genetic association study of childhood aggression across raters, instruments, and age

Author

Ip, Hill F., primary, van der Laan, Camiel M., additional, Krapohl, Eva M. L., additional, Brikell, Isabell, additional, Sánchez-Mora, Cristina, additional, Nolte, Ilja M., additional, St Pourcain, Beate, additional, Bolhuis, Koen, additional, Palviainen, Teemu, additional, Zafarmand, Hadi, additional, Colodro-Conde, Lucía, additional, Gordon, Scott, additional, Zayats, Tetyana, additional, Aliev, Fazil, additional, Jiang, Chang, additional, Wang, Carol A., additional, Saunders, Gretchen, additional, Karhunen, Ville, additional, Hammerschlag, Anke R., additional, Adkins, Daniel E., additional, Border, Richard, additional, Peterson, Roseann E., additional, Prinz, Joseph A., additional, Thiering, Elisabeth, additional, Seppälä, Ilkka, additional, Vilor-Tejedor, Natàlia, additional, Ahluwalia, Tarunveer S., additional, Day, Felix R., additional, Hottenga, Jouke-Jan, additional, Allegrini, Andrea G., additional, Rimfeld, Kaili, additional, Chen, Qi, additional, Lu, Yi, additional, Martin, Joanna, additional, Soler Artigas, María, additional, Rovira, Paula, additional, Bosch, Rosa, additional, Español, Gemma, additional, Ramos Quiroga, Josep Antoni, additional, Neumann, Alexander, additional, Ensink, Judith, additional, Grasby, Katrina, additional, Morosoli, José J., additional, Tong, Xiaoran, additional, Marrington, Shelby, additional, Middeldorp, Christel, additional, Scott, James G., additional, Vinkhuyzen, Anna, additional, Shabalin, Andrey A., additional, Corley, Robin, additional, Evans, Luke M., additional, Sugden, Karen, additional, Alemany, Silvia, additional, Sass, Lærke, additional, Vinding, Rebecca, additional, Ruth, Kate, additional, Tyrrell, Jess, additional, Davies, Gareth E., additional, Ehli, Erik A., additional, Hagenbeek, Fiona A., additional, De Zeeuw, Eveline, additional, Van Beijsterveldt, Toos C.E.M., additional, Larsson, Henrik, additional, Snieder, Harold, additional, Verhulst, Frank C., additional, Amin, Najaf, additional, Whipp, Alyce M., additional, Korhonen, Tellervo, additional, Vuoksimaa, Eero, additional, Rose, Richard J., additional, Uitterlinden, André G., additional, Heath, Andrew C., additional, Madden, Pamela, additional, Haavik, Jan, additional, Harris, Jennifer R., additional, Helgeland, Øyvind, additional, Johansson, Stefan, additional, Knudsen, Gun Peggy S., additional, Njolstad, Pal Rasmus, additional, Lu, Qing, additional, Rodriguez, Alina, additional, Henders, Anjali K., additional, Mamun, Abdullah, additional, Najman, Jackob M., additional, Brown, Sandy, additional, Hopfer, Christian, additional, Krauter, Kenneth, additional, Reynolds, Chandra, additional, Smolen, Andrew, additional, Stallings, Michael, additional, Wadsworth, Sally, additional, Wall, Tamara L., additional, Silberg, Judy L., additional, Miller, Allison, additional, Keltikangas-Järvinen, Liisa, additional, Hakulinen, Christian, additional, Pulkki-Råback, Laura, additional, Havdahl, Alexandra, additional, Magnus, Per, additional, Raitakari, Olli T., additional, Perry, John R. B., additional, Llop, Sabrina, additional, Lopez-Espinosa, Maria-Jose, additional, Bønnelykke, Klaus, additional, Bisgaard, Hans, additional, Sunyer, Jordi, additional, Lehtimäki, Terho, additional, Arseneault, Louise, additional, Standl, Marie, additional, Heinrich, Joachim, additional, Boden, Joseph, additional, Pearson, John, additional, Horwood, L. John, additional, Kennedy, Martin, additional, Poulton, Richie, additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Hewitt, John, additional, Copeland, William E., additional, Costello, Elizabeth J., additional, Williams, Gail M., additional, Wray, Naomi, additional, Järvelin, Marjo-Riitta, additional, McGue, Matt, additional, Iacono, William, additional, Caspi, Avshalom, additional, Moffitt, Terrie E., additional, Whitehouse, Andrew, additional, Pennell, Craig E., additional, Klump, Kelly L., additional, Burt, S. Alexandra, additional, Dick, Danielle M., additional, Reichborn-Kjennerud, Ted, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Vrijkotte, Tanja, additional, Kaprio, Jaakko, additional, Tiemeier, Henning, additional, Davey Smith, George, additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, Casas, Miquel, additional, Ribasés, Marta, additional, Lichtenstein, Paul, additional, Lundström, Sebastian, additional, Plomin, Robert, additional, Bartels, Meike, additional, Nivard, Michel G., additional, and Boomsma, Dorret I., additional

Published
2021
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22. Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs

Author

Marttila, Saara, primary, Viiri, Leena E., additional, Mishra, Pashupati P., additional, Kühnel, Brigitte, additional, Matias-Garcia, Pamela R., additional, Lyytikäinen, Leo-Pekka, additional, Ceder, Tiina, additional, Mononen, Nina, additional, Rathmann, Wolfgang, additional, Winkelmann, Juliane, additional, Peters, Annette, additional, Kähönen, Mika, additional, Hutri-Kähönen, Nina, additional, Juonala, Markus, additional, Aalto-Setälä, Katriina, additional, Raitakari, Olli, additional, Lehtimäki, Terho, additional, Waldenberger, Melanie, additional, and Raitoharju, Emma, additional

Published
2021
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24. Meta-analysis of epigenome-wide association studies of carotid intima-media thickness

Author

Portilla-Fernández, Eliana, primary, Hwang, Shih-Jen, additional, Wilson, Rory, additional, Maddock, Jane, additional, Hill, W. David, additional, Teumer, Alexander, additional, Mishra, Pashupati P., additional, Brody, Jennifer A., additional, Joehanes, Roby, additional, Ligthart, Symen, additional, Ghanbari, Mohsen, additional, Kavousi, Maryam, additional, Roks, Anton J. M., additional, Danser, A. H. Jan, additional, Levy, Daniel, additional, Peters, Annette, additional, Ghasemi, Sahar, additional, Schminke, Ulf, additional, Dörr, Marcus, additional, Grabe, Hans J., additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Hurme, Mikko A., additional, Bartz, Traci M., additional, Sotoodehnia, Nona, additional, Bis, Joshua C., additional, Thiery, Joachim, additional, Koenig, Wolfgang, additional, Ong, Ken K., additional, Bell, Jordana T., additional, Meisinger, Christine, additional, Wardlaw, Joanna M., additional, Starr, John M., additional, Seissler, Jochen, additional, Then, Cornelia, additional, Rathmann, Wolfgang, additional, Ikram, M. Arfan, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Völzke, Henry, additional, Deary, Ian J., additional, Wong, Andrew, additional, Waldenberger, Melanie, additional, O’Donnell, Christopher J., additional, and Dehghan, Abbas, additional

Published
2021
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25. Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health

Author

Marttila, Saara, primary, Rovio, Suvi, additional, Mishra, Pashupati P., additional, Seppälä, Ilkka, additional, Lyytikäinen, Leo-Pekka, additional, Juonala, Markus, additional, Waldenberger, Melanie, additional, Oksala, Niku, additional, Ala-Korpela, Mika, additional, Harville, Emily, additional, Hutri-Kähönen, Nina, additional, Kähönen, Mika, additional, Raitakari, Olli, additional, Lehtimäki, Terho, additional, and Raitoharju, Emma, additional

Published
2021
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26. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Author

Deelen, Joris, primary, Evans, Daniel S., additional, Arking, Dan E., additional, Tesi, Niccolò, additional, Nygaard, Marianne, additional, Liu, Xiaomin, additional, Wojczynski, Mary K., additional, Biggs, Mary L., additional, van der Spek, Ashley, additional, Atzmon, Gil, additional, Ware, Erin B., additional, Sarnowski, Chloé, additional, Smith, Albert V., additional, Seppälä, Ilkka, additional, Cordell, Heather J., additional, Dose, Janina, additional, Amin, Najaf, additional, Arnold, Alice M., additional, Ayers, Kristin L., additional, Barzilai, Nir, additional, Becker, Elizabeth J., additional, Beekman, Marian, additional, Blanché, Hélène, additional, Christensen, Kaare, additional, Christiansen, Lene, additional, Collerton, Joanna C., additional, Cubaynes, Sarah, additional, Cummings, Steven R., additional, Davies, Karen, additional, Debrabant, Birgit, additional, Deleuze, Jean-François, additional, Duncan, Rachel, additional, Faul, Jessica D., additional, Franceschi, Claudio, additional, Galan, Pilar, additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Huisman, Martijn, additional, Hurme, Mikko A., additional, Jagger, Carol, additional, Jansen, Iris, additional, Jylhä, Marja, additional, Kähönen, Mika, additional, Karasik, David, additional, Kardia, Sharon L. R., additional, Kingston, Andrew, additional, Kirkwood, Thomas B. L., additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lyytikäinen, Leo-Pekka, additional, Martin-Ruiz, Carmen, additional, Min, Junxia, additional, Nebel, Almut, additional, Newman, Anne B., additional, Nie, Chao, additional, Nohr, Ellen A., additional, Orwoll, Eric S., additional, Perls, Thomas T., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Reinders, Marcel J. T., additional, Robine, Jean-Marie, additional, Rotter, Jerome I., additional, Sebastiani, Paola, additional, Smith, Jennifer, additional, Sørensen, Thorkild I. A., additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van der Flier, Wiesje, additional, van der Lee, Sven J., additional, van Duijn, Cornelia M., additional, van Heemst, Diana, additional, Vaupel, James W., additional, Weir, David, additional, Ye, Kenny, additional, Zeng, Yi, additional, Zheng, Wanlin, additional, Holstege, Henne, additional, Kiel, Douglas P., additional, Lunetta, Kathryn L., additional, Slagboom, P. Eline, additional, and Murabito, Joanne M., additional

Published
2021
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27. Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

Author

Wang, Heming, primary, Noordam, Raymond, additional, Cade, Brian E., additional, Schwander, Karen, additional, Winkler, Thomas W., additional, Lee, Jiwon, additional, Sung, Yun Ju, additional, Bentley, Amy R., additional, Manning, Alisa K., additional, Aschard, Hugues, additional, Kilpeläinen, Tuomas O., additional, Ilkov, Marjan, additional, Brown, Michael R., additional, Horimoto, Andrea R., additional, Richard, Melissa, additional, Bartz, Traci M., additional, Vojinovic, Dina, additional, Lim, Elise, additional, Nierenberg, Jovia L., additional, Liu, Yongmei, additional, Chitrala, Kumaraswamynaidu, additional, Rankinen, Tuomo, additional, Musani, Solomon K., additional, Franceschini, Nora, additional, Rauramaa, Rainer, additional, Alver, Maris, additional, Zee, Phyllis C., additional, Harris, Sarah E., additional, van der Most, Peter J., additional, Nolte, Ilja M., additional, Munroe, Patricia B., additional, Palmer, Nicholette D., additional, Kühnel, Brigitte, additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Hall, Kelly A., additional, Lyytikäinen, Leo-Pekka, additional, O’Connell, Jeff, additional, Eiriksdottir, Gudny, additional, Launer, Lenore J., additional, de Vries, Paul S., additional, Arking, Dan E., additional, Chen, Han, additional, Boerwinkle, Eric, additional, Krieger, Jose E., additional, Schreiner, Pamela J., additional, Sidney, Stephen, additional, Shikany, James M., additional, Rice, Kenneth, additional, Chen, Yii-Der Ida, additional, Gharib, Sina A., additional, Bis, Joshua C., additional, Luik, Annemarie I., additional, Ikram, M. Arfan, additional, Uitterlinden, André G., additional, Amin, Najaf, additional, Xu, Hanfei, additional, Levy, Daniel, additional, He, Jiang, additional, Lohman, Kurt K., additional, Zonderman, Alan B., additional, Rice, Treva K., additional, Sims, Mario, additional, Wilson, Gregory, additional, Sofer, Tamar, additional, Rich, Stephen S., additional, Palmas, Walter, additional, Yao, Jie, additional, Guo, Xiuqing, additional, Rotter, Jerome I., additional, Biermasz, Nienke R., additional, Mook-Kanamori, Dennis O., additional, Martin, Lisa W., additional, Barac, Ana, additional, Wallace, Robert B., additional, Gottlieb, Daniel J., additional, Komulainen, Pirjo, additional, Heikkinen, Sami, additional, Mägi, Reedik, additional, Milani, Lili, additional, Metspalu, Andres, additional, Starr, John M., additional, Milaneschi, Yuri, additional, Waken, R. J., additional, Gao, Chuan, additional, Waldenberger, Melanie, additional, Peters, Annette, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Roenneberg, Till, additional, Völker, Uwe, additional, Dörr, Marcus, additional, Shu, Xiao-Ou, additional, Mukherjee, Sutapa, additional, Hillman, David R., additional, Kähönen, Mika, additional, Wagenknecht, Lynne E., additional, Gieger, Christian, additional, Grabe, Hans J., additional, Zheng, Wei, additional, Palmer, Lyle J., additional, Lehtimäki, Terho, additional, Gudnason, Vilmundur, additional, Morrison, Alanna C., additional, Pereira, Alexandre C., additional, Fornage, Myriam, additional, Psaty, Bruce M., additional, van Duijn, Cornelia M., additional, Liu, Ching-Ti, additional, Kelly, Tanika N., additional, Evans, Michele K., additional, Bouchard, Claude, additional, Fox, Ervin R., additional, Kooperberg, Charles, additional, Zhu, Xiaofeng, additional, Lakka, Timo A., additional, Esko, Tõnu, additional, North, Kari E., additional, Deary, Ian J., additional, Snieder, Harold, additional, Penninx, Brenda W. J. H., additional, Gauderman, W. James, additional, Rao, Dabeeru C., additional, Redline, Susan, additional, and van Heemst, Diana, additional

Published
2021
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29. Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs

Author

Marttila, Saara, Viiri, Leena E., Mishra, Pashupati P., Kühnel, Brigitte, Matias-Garcia, Pamela R., Lyytikäinen, Leo-Pekka, Ceder, Tiina, Mononen, Nina, Rathmann, Wolfgang, Winkelmann, Juliane, Peters, Annette, Kähönen, Mika, Hutri-Kähönen, Nina, Juonala, Markus, Aalto-Setälä, Katriina, Raitakari, Olli, Lehtimäki, Terho, Waldenberger, Melanie, and Raitoharju, Emma

Subjects
ddc
Published
2020

30. Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study

Author

Mishra, Binisha H., primary, Mishra, Pashupati P., additional, Raitoharju, Emma, additional, Marttila, Saara, additional, Mononen, Nina, additional, Sievänen, Harri, additional, Viikari, Jorma, additional, Juonala, Markus, additional, Laaksonen, Marika, additional, Hutri-Kähönen, Nina, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, and Lehtimäki, Terho, additional

Published
2021
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31. Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

Author

Carmeli, Cristian, primary, Kutalik, Zoltán, additional, Mishra, Pashupati P., additional, Porcu, Eleonora, additional, Delpierre, Cyrille, additional, Delaneau, Olivier, additional, Kelly-Irving, Michelle, additional, Bochud, Murielle, additional, Dhayat, Nasser A., additional, Ponte, Belen, additional, Pruijm, Menno, additional, Ehret, Georg, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Raitakari, Olli T., additional, Vineis, Paolo, additional, Kivimäki, Mika, additional, Chadeau-Hyam, Marc, additional, Dermitzakis, Emmanouil, additional, Vuilleumier, Nicolas, additional, and Stringhini, Silvia, additional

Published
2021
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32. Examining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts

Author

Laaksonen, Jaakko, primary, Mishra, Pashupati P., additional, Seppälä, Ilkka, additional, Lyytikäinen, Leo-Pekka, additional, Raitoharju, Emma, additional, Mononen, Nina, additional, Lepistö, Maija, additional, Almusa, Henrikki, additional, Ellonen, Pekka, additional, Hutri-Kähönen, Nina, additional, Juonala, Markus, additional, Raitakari, Olli, additional, Kähönen, Mika, additional, Salonen, Jukka T., additional, and Lehtimäki, Terho, additional

Published
2021
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33. DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

Author

Gomez-Alonso, Monica del C., primary, Kretschmer, Anja, additional, Wilson, Rory, additional, Pfeiffer, Liliane, additional, Karhunen, Ville, additional, Seppälä, Ilkka, additional, Zhang, Weihua, additional, Mittelstraß, Kirstin, additional, Wahl, Simone, additional, Matias-Garcia, Pamela R., additional, Prokisch, Holger, additional, Horn, Sacha, additional, Meitinger, Thomas, additional, Serrano-Garcia, Luis R., additional, Sebert, Sylvain, additional, Raitakari, Olli, additional, Loh, Marie, additional, Rathmann, Wolfgang, additional, Müller-Nurasyid, Martina, additional, Herder, Christian, additional, Roden, Michael, additional, Hurme, Mikko, additional, Jarvelin, Marjo-Riitta, additional, Ala-Korpela, Mika, additional, Kooner, Jaspal S., additional, Peters, Annette, additional, Lehtimäki, Terho, additional, Chambers, John C., additional, Gieger, Christian, additional, Kettunen, Johannes, additional, and Waldenberger, Melanie, additional

Published
2021
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34. A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

Author

Guo, Yanjun, Rist, Pamela M., Daghlas, Iyas, Giulianini, Franco, Gormley, Padhraig, Anttila, Verneri, Winsvold, Bendik S., Palta, Priit, Esko, Tonu, Pers, Tune H., Farh, Kai How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A., Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M., Kallela, Mikko, Freilinger, Tobias M., Ran, Caroline, Gordon, Scott G., Stam, Anine H., Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H.H., Lehtimäki, Terho, Sarin, Antti Pekka, Wedenoja, Juho, Hinds, David A., Buring, Julie E., Schürks, Markus, Ridker, Paul M., Hrafnsdottir, Maria Gudlaug, Stefansson, Hreinn, Ring, Susan M., Hottenga, Jouke Jan, Penninx, Brenda W.J.H., Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C., Madden, Pamela A.F., Martin, Nicholas G., Montgomery, Grant W., Kurki, Mitja, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E., Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H., Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G., Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G., Hofman, Albert, Duijn, Cornelia M.van, Cherkas, Lynn, Pedersen, Linda M., Stubhaug, Audun, Nielsen, Christopher S., Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann Louise, Christensen, Anne Francke, Hansen, Thomas Folkmann, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J., Raitakari, Olli, Ikram, M. Arfan, Spector, Tim, Järvelin, Marjo Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P., Ferrari, Michel D., Belin, Andrea C., Dichgans, Martin, Wessman, Maija, Maagdenberg, Arn M.J.M.van den, Zwart, John Anker, Boomsma, Dorret I., Smith, George Davey, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J., Neale, Benjamin M., Olesen, Jes, Chasman, Daniel I., Nyholt, Dale R., Palotie, Aarno, Agee, Michelle, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Psychiatry, APH - Digital Health, Radiology & Nuclear Medicine, Epidemiology, Neurology, Internal Medicine, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Clinicum, Neurologian yksikkö, HUS Neurocenter, HUS Helsinki and Uusimaa Hospital District, Department of Neurosciences, Research Programs Unit, Institute for Molecular Medicine Finland, Neuroscience Center, STEMM - Stem Cells and Metabolism Research Program, Genomics of Neurological and Neuropsychiatric Disorders, Department of Public Health, Biosciences, Centre of Excellence in Complex Disease Genetics, Research Programme of Molecular Medicine, Aarno Palotie / Principal Investigator, Helsinki University Hospital Area, University of Helsinki, Johan Eriksson / Principal Investigator, and Department of General Practice and Primary Health Care

Subjects
0301 basic medicine, Netherlands Twin Register (NTR), Integrin beta Chains, LOCI, Medizin, General Physics and Astronomy, Blood Pressure, Genome-wide association study, Genome-wide association studies, DISEASE, 3124 Neurology and psychiatry, 0302 clinical medicine, HEADACHE, Risk Factors, Polymorphism (computer science), Genome-wide, lcsh:Science, Telomerase, Multidisciplinary, Mendelian Randomization Analysis, Blóðþrýstingur, 3. Good health, Pulse pressure, Mígreni, Hypertension, Blood pressure, Cross-phenotype, Erfðarannsóknir, medicine.medical_specialty, Migraine Disorders, Science, Diastole, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Meta-Analysis as Topic, SDG 3 - Good Health and Well-being, Receptors, Adrenergic, alpha-2, Internal medicine, Mendelian randomization, medicine, Humans, Genetic Predisposition to Disease, Migraine, business.industry, Proteins, General Chemistry, medicine.disease, Meta-analysis, 030104 developmental biology, Endocrinology, RISK-FACTORS, lcsh:Q, business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Publisher's version (útgefin grein), Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P, This research has been conducted using the UK Biobank Resource under Application Number 29273. We would like to thank the participants and researchers from the UK Biobank, 23andMe, Inc., International Headache Genetics Consortium (IHGC), MEGASTROKE, CARDIoGRAM, and International Consortium of Blood Pressure-Genome Wide Association Studies (ICBP) who contributed or collected data. Daniel I. Chasman is funded by US National Institutes of Health and US National Institute of Neurological Disorders and Stroke (R21NS09296 and R21NS104398). Pamela M. Rist is funded by K01 HL128791. The MEGASTROKE project received funding from sources specified at http://www.megastroke.org/acknowledgments.html.

Published
2020

35. HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study

Author

Hunjadi, Monika, primary, Lamina, Claudia, additional, Kahler, Patrick, additional, Bernscherer, Tamara, additional, Viikari, Jorma, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Hurme, Mikko, additional, Juonala, Markus, additional, Taittonen, Leena, additional, Laitinen, Tomi, additional, Jokinen, Eero, additional, Tossavainen, Päivi, additional, Hutri-Kähönen, Nina, additional, Raitakari, Olli, additional, and Ritsch, Andreas, additional

Published
2020
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38. Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study

Author

Buscot, Marie-Jeanne, primary, Wu, Feitong, additional, Juonala, Markus, additional, Lehtimäki, Terho, additional, Pitkänen, Niina, additional, Sabin, Matthew A., additional, Viikari, Jorma S. A., additional, Raitakari, Olli T., additional, and Magnussen, Costan G., additional

Published
2020
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39. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Author

Ntalla, Ioanna, primary, Weng, Lu-Chen, additional, Cartwright, James H., additional, Hall, Amelia Weber, additional, Sveinbjornsson, Gardar, additional, Tucker, Nathan R., additional, Choi, Seung Hoan, additional, Chaffin, Mark D., additional, Roselli, Carolina, additional, Barnes, Michael R., additional, Mifsud, Borbala, additional, Warren, Helen R., additional, Hayward, Caroline, additional, Marten, Jonathan, additional, Cranley, James J., additional, Concas, Maria Pina, additional, Gasparini, Paolo, additional, Boutin, Thibaud, additional, Kolcic, Ivana, additional, Polasek, Ozren, additional, Rudan, Igor, additional, Araujo, Nathalia M., additional, Lima-Costa, Maria Fernanda, additional, Ribeiro, Antonio Luiz P., additional, Souza, Renan P., additional, Tarazona-Santos, Eduardo, additional, Giedraitis, Vilmantas, additional, Ingelsson, Erik, additional, Mahajan, Anubha, additional, Morris, Andrew P., additional, Del Greco M, Fabiola, additional, Foco, Luisa, additional, Gögele, Martin, additional, Hicks, Andrew A., additional, Cook, James P., additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Sundström, Johan, additional, Nelson, Christopher P., additional, Riaz, Muhammad B., additional, Samani, Nilesh J., additional, Sinagra, Gianfranco, additional, Ulivi, Sheila, additional, Kähönen, Mika, additional, Mishra, Pashupati P., additional, Mononen, Nina, additional, Nikus, Kjell, additional, Caulfield, Mark J., additional, Dominiczak, Anna, additional, Padmanabhan, Sandosh, additional, Montasser, May E., additional, O’Connell, Jeff R., additional, Ryan, Kathleen, additional, Shuldiner, Alan R., additional, Aeschbacher, Stefanie, additional, Conen, David, additional, Risch, Lorenz, additional, Thériault, Sébastien, additional, Hutri-Kähönen, Nina, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo-Pekka, additional, Raitakari, Olli T., additional, Barnes, Catriona L. K., additional, Campbell, Harry, additional, Joshi, Peter K., additional, Wilson, James F., additional, Isaacs, Aaron, additional, Kors, Jan A., additional, van Duijn, Cornelia M., additional, Huang, Paul L., additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Launer, Lenore J., additional, Smith, Albert V., additional, Bottinger, Erwin P., additional, Loos, Ruth J. F., additional, Nadkarni, Girish N., additional, Preuss, Michael H., additional, Correa, Adolfo, additional, Mei, Hao, additional, Wilson, James, additional, Meitinger, Thomas, additional, Müller-Nurasyid, Martina, additional, Peters, Annette, additional, Waldenberger, Melanie, additional, Mangino, Massimo, additional, Spector, Timothy D., additional, Rienstra, Michiel, additional, van de Vegte, Yordi J., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Kääb, Stefan, additional, Schramm, Katharina, additional, Sinner, Moritz F., additional, Strauch, Konstantin, additional, Cutler, Michael J., additional, Fatkin, Diane, additional, London, Barry, additional, Olesen, Morten, additional, Roden, Dan M., additional, Benjamin Shoemaker, M., additional, Gustav Smith, J., additional, Biggs, Mary L., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Psaty, Bruce M., additional, Rice, Kenneth, additional, Sotoodehnia, Nona, additional, De Grandi, Alessandro, additional, Fuchsberger, Christian, additional, Pattaro, Cristian, additional, Pramstaller, Peter P., additional, Ford, Ian, additional, Wouter Jukema, J., additional, Macfarlane, Peter W., additional, Trompet, Stella, additional, Dörr, Marcus, additional, Felix, Stephan B., additional, Völker, Uwe, additional, Weiss, Stefan, additional, Havulinna, Aki S., additional, Jula, Antti, additional, Sääksjärvi, Katri, additional, Salomaa, Veikko, additional, Guo, Xiuqing, additional, Heckbert, Susan R., additional, Lin, Henry J., additional, Rotter, Jerome I., additional, Taylor, Kent D., additional, Yao, Jie, additional, de Mutsert, Renée, additional, Maan, Arie C., additional, Mook-Kanamori, Dennis O., additional, Noordam, Raymond, additional, Cucca, Francesco, additional, Ding, Jun, additional, Lakatta, Edward G., additional, Qian, Yong, additional, Tarasov, Kirill V., additional, Levy, Daniel, additional, Lin, Honghuang, additional, Newton-Cheh, Christopher H., additional, Lunetta, Kathryn L., additional, Murray, Alison D., additional, Porteous, David J., additional, Smith, Blair H., additional, Stricker, Bruno H., additional, Uitterlinden, André, additional, van den Berg, Marten E., additional, Haessler, Jeffrey, additional, Jackson, Rebecca D., additional, Kooperberg, Charles, additional, Peters, Ulrike, additional, Reiner, Alexander P., additional, Whitsel, Eric A., additional, Alonso, Alvaro, additional, Arking, Dan E., additional, Boerwinkle, Eric, additional, Ehret, Georg B., additional, Soliman, Elsayed Z., additional, Avery, Christy L., additional, Gogarten, Stephanie M., additional, Kerr, Kathleen F., additional, Laurie, Cathy C., additional, Seyerle, Amanda A., additional, Stilp, Adrienne, additional, Assa, Solmaz, additional, Abdullah Said, M., additional, Yldau van der Ende, M., additional, Lambiase, Pier D., additional, Orini, Michele, additional, Ramirez, Julia, additional, Van Duijvenboden, Stefan, additional, Arnar, David O., additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Sulem, Patrick, additional, Thorleifsson, Gudmar, additional, Thorolfsdottir, Rosa B., additional, Thorsteinsdottir, Unnur, additional, Benjamin, Emelia J., additional, Tinker, Andrew, additional, Stefansson, Kari, additional, Ellinor, Patrick T., additional, Jamshidi, Yalda, additional, Lubitz, Steven A., additional, and Munroe, Patricia B., additional

Published
2020
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40. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Author

Zheng, Yan, primary, Huang, Tao, additional, Wang, Tiange, additional, Mei, Zhendong, additional, Sun, Zhonghan, additional, Zhang, Tao, additional, Ellervik, Christina, additional, Chai, Jin-Fang, additional, Sim, Xueling, additional, van Dam, Rob M., additional, Tai, E-Shyong, additional, Koh, Woon-Puay, additional, Dorajoo, Rajkumar, additional, Saw, Seang-Mei, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, Gupta, Preeti, additional, Rossing, Peter, additional, Ahluwalia, Tarunveer S., additional, Vinding, Rebecca K., additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Wang, Yujie, additional, Graff, Mariaelisa, additional, Voortman, Trudy, additional, van Rooij, Frank J. A., additional, Hofman, Albert, additional, van Heemst, Diana, additional, Noordam, Raymond, additional, Estampador, Angela C., additional, Varga, Tibor V., additional, Enzenbach, Cornelia, additional, Scholz, Markus, additional, Thiery, Joachim, additional, Burkhardt, Ralph, additional, Orho-Melander, Marju, additional, Schulz, Christina-Alexandra, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Kubo, Michiaki, additional, Akiyama, Masato, additional, Zhou, Ang, additional, Kilpeläinen, Tuomas O., additional, Hansen, Torben, additional, Kleber, Marcus E., additional, Delgado, Graciela, additional, McCarthy, Mark, additional, Lemaitre, Rozenn N., additional, Felix, Janine F., additional, Jaddoe, Vincent W. V., additional, Wu, Ying, additional, Mohlke, Karen L., additional, Lehtimäki, Terho, additional, Wang, Carol A., additional, Pennell, Craig E., additional, Schunkert, Heribert, additional, Kessler, Thorsten, additional, Zeng, Lingyao, additional, Willenborg, Christina, additional, Peters, Annette, additional, Lieb, Wolfgang, additional, Grote, Veit, additional, Rzehak, Peter, additional, Koletzko, Berthold, additional, Erdmann, Jeanette, additional, Munz, Matthias, additional, Wu, Tangchun, additional, He, Meian, additional, Yu, Caizheng, additional, Lecoeur, Cécile, additional, Froguel, Philippe, additional, Corella, Dolores, additional, Moreno, Luis A., additional, Lai, Chao-Qiang, additional, Pitkänen, Niina, additional, Boreham, Colin A., additional, Ridker, Paul M., additional, Rosendaal, Frits R., additional, de Mutsert, Renée, additional, Power, Chris, additional, Paternoster, Lavinia, additional, Sørensen, Thorkild I. A., additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Djousse, Luc, additional, Rivadeneira, Fernando, additional, Lee, Nanette R., additional, Raitakari, Olli T., additional, Kähönen, Mika, additional, Viikari, Jorma, additional, Langhendries, Jean-Paul, additional, Escribano, Joaquin, additional, Verduci, Elvira, additional, Dedoussis, George, additional, König, Inke, additional, Balkau, Beverley, additional, Coltell, Oscar, additional, Dallongeville, Jean, additional, Meirhaeghe, Aline, additional, Amouyel, Philippe, additional, Gottrand, Frédéric, additional, Pahkala, Katja, additional, Niinikoski, Harri, additional, Hyppönen, Elina, additional, März, Winfried, additional, Mackey, David A., additional, Gruszfeld, Dariusz, additional, Tucker, Katherine L., additional, Fumeron, Frédéric, additional, Estruch, Ramon, additional, Ordovas, Jose M., additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Mozaffarian, Dariush, additional, Psaty, Bruce M., additional, North, Kari E., additional, Chasman, Daniel I., additional, and Qi, Lu, additional

Published
2020
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42. Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent

Author

Buchwald, Jadwiga, primary, Chenoweth, Meghan J., additional, Palviainen, Teemu, additional, Zhu, Gu, additional, Benner, Christian, additional, Gordon, Scott, additional, Korhonen, Tellervo, additional, Ripatti, Samuli, additional, Madden, Pamela A. F., additional, Lehtimäki, Terho, additional, Raitakari, Olli T., additional, Salomaa, Veikko, additional, Rose, Richard J., additional, George, Tony P., additional, Lerman, Caryn, additional, Pirinen, Matti, additional, Martin, Nicholas G., additional, Kaprio, Jaakko, additional, Loukola, Anu, additional, and Tyndale, Rachel F., additional

Published
2020
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43. Three genetic–environmental networks for human personality

Author

Zwir, Igor, primary, Del-Val, Coral, additional, Arnedo, Javier, additional, Pulkki-Råback, Laura, additional, Konte, Bettina, additional, Yang, Sarah S., additional, Romero-Zaliz, Rocio, additional, Hintsanen, Mirka, additional, Cloninger, Kevin M., additional, Garcia, Danilo, additional, Svrakic, Dragan M., additional, Lester, Nigel, additional, Rozsa, Sandor, additional, Mesa, Alberto, additional, Lyytikäinen, Leo-Pekka, additional, Giegling, Ina, additional, Kähönen, Mika, additional, Martinez, Maribel, additional, Seppälä, Ilkka, additional, Raitoharju, Emma, additional, de Erausquin, Gabriel A., additional, Mamah, Daniel, additional, Raitakari, Olli, additional, Rujescu, Dan, additional, Postolache, Teodor T., additional, Gu, C. Charles, additional, Sung, Joohon, additional, Lehtimäki, Terho, additional, Keltikangas-Järvinen, Liisa, additional, and Cloninger, C. Robert, additional

Published
2019
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44. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Author

Noordam, Raymond, primary, Bos, Maxime M., additional, Wang, Heming, additional, Winkler, Thomas W., additional, Bentley, Amy R., additional, Kilpeläinen, Tuomas O., additional, de Vries, Paul S., additional, Sung, Yun Ju, additional, Schwander, Karen, additional, Cade, Brian E., additional, Manning, Alisa, additional, Aschard, Hugues, additional, Brown, Michael R., additional, Chen, Han, additional, Franceschini, Nora, additional, Musani, Solomon K., additional, Richard, Melissa, additional, Vojinovic, Dina, additional, Aslibekyan, Stella, additional, Bartz, Traci M., additional, de las Fuentes, Lisa, additional, Feitosa, Mary, additional, Horimoto, Andrea R., additional, Ilkov, Marjan, additional, Kho, Minjung, additional, Kraja, Aldi, additional, Li, Changwei, additional, Lim, Elise, additional, Liu, Yongmei, additional, Mook-Kanamori, Dennis O., additional, Rankinen, Tuomo, additional, Tajuddin, Salman M., additional, van der Spek, Ashley, additional, Wang, Zhe, additional, Marten, Jonathan, additional, Laville, Vincent, additional, Alver, Maris, additional, Evangelou, Evangelos, additional, Graff, Maria E., additional, He, Meian, additional, Kühnel, Brigitte, additional, Lyytikäinen, Leo-Pekka, additional, Marques-Vidal, Pedro, additional, Nolte, Ilja M., additional, Palmer, Nicholette D., additional, Rauramaa, Rainer, additional, Shu, Xiao-Ou, additional, Snieder, Harold, additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Yanek, Lisa R., additional, Adolfo, Correa, additional, Ballantyne, Christie, additional, Bielak, Larry, additional, Biermasz, Nienke R., additional, Boerwinkle, Eric, additional, Dimou, Niki, additional, Eiriksdottir, Gudny, additional, Gao, Chuan, additional, Gharib, Sina A., additional, Gottlieb, Daniel J., additional, Haba-Rubio, José, additional, Harris, Tamara B., additional, Heikkinen, Sami, additional, Heinzer, Raphaël, additional, Hixson, James E., additional, Homuth, Georg, additional, Ikram, M. Arfan, additional, Komulainen, Pirjo, additional, Krieger, Jose E., additional, Lee, Jiwon, additional, Liu, Jingmin, additional, Lohman, Kurt K., additional, Luik, Annemarie I., additional, Mägi, Reedik, additional, Martin, Lisa W., additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Milaneschi, Yuri, additional, Nalls, Mike A., additional, O’Connell, Jeff, additional, Peters, Annette, additional, Peyser, Patricia, additional, Raitakari, Olli T., additional, Reiner, Alex P., additional, Rensen, Patrick C. N., additional, Rice, Treva K., additional, Rich, Stephen S., additional, Roenneberg, Till, additional, Rotter, Jerome I., additional, Schreiner, Pamela J., additional, Shikany, James, additional, Sidney, Stephen S., additional, Sims, Mario, additional, Sitlani, Colleen M., additional, Sofer, Tamar, additional, Strauch, Konstantin, additional, Swertz, Morris A., additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van Duijn, Cornelia M., additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Wallance, Robert B., additional, van Dijk, Ko Willems, additional, Yu, Caizheng, additional, Zonderman, Alan B., additional, Becker, Diane M., additional, Elliott, Paul, additional, Esko, Tõnu, additional, Gieger, Christian, additional, Grabe, Hans J., additional, Lakka, Timo A., additional, Lehtimäki, Terho, additional, North, Kari E., additional, Penninx, Brenda W. J. H., additional, Vollenweider, Peter, additional, Wagenknecht, Lynne E., additional, Wu, Tangchun, additional, Xiang, Yong-Bing, additional, Zheng, Wei, additional, Arnett, Donna K., additional, Bouchard, Claude, additional, Evans, Michele K., additional, Gudnason, Vilmundur, additional, Kardia, Sharon, additional, Kelly, Tanika N., additional, Kritchevsky, Stephen B., additional, Loos, Ruth J. F., additional, Pereira, Alexandre C., additional, Province, Mike, additional, Psaty, Bruce M., additional, Rotimi, Charles, additional, Zhu, Xiaofeng, additional, Amin, Najaf, additional, Cupples, L. Adrienne, additional, Fornage, Myriam, additional, Fox, Ervin F., additional, Guo, Xiuqing, additional, Gauderman, W. James, additional, Rice, Kenneth, additional, Kooperberg, Charles, additional, Munroe, Patricia B., additional, Liu, Ching-Ti, additional, Morrison, Alanna C., additional, Rao, Dabeeru C., additional, van Heemst, Diana, additional, and Redline, Susan, additional

Published
2019
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45. Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

Author

Ahola-Olli, Ari V., primary, Mustelin, Linda, additional, Kalimeri, Maria, additional, Kettunen, Johannes, additional, Jokelainen, Jari, additional, Auvinen, Juha, additional, Puukka, Katri, additional, Havulinna, Aki S., additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Juonala, Markus, additional, Keinänen-Kiukaanniemi, Sirkka, additional, Salomaa, Veikko, additional, Perola, Markus, additional, Järvelin, Marjo-Riitta, additional, Ala-Korpela, Mika, additional, Raitakari, Olli, additional, and Würtz, Peter, additional

Published
2019
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46. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Author

Jiang, Xia, O'Reilly, Paul F, Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J Brent, Dupuis, Josée, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A, Albanes, Demetrius, Lutsey, Pamela L, Yao, Lu, Tang, Weihong, Econs, Michael J, Wallaschofski, Henri, Völzke, Henry, Zhou, Ang, Power, Chris, McCarthy, Mark I, Michos, Erin D, Boerwinkle, Eric, Weinstein, Stephanie J, Freedman, Neal D, Huang, Wen-Yi, Van Schoor, Natasja M, Van Der Velde, Nathalie, Groot, Lisette CPGM De, Enneman, Anke, Cupples, L Adrienne, Booth, Sarah L, Vasan, Ramachandran S, Liu, Ching-Ti, Zhou, Yanhua, Ripatti, Samuli, Ohlsson, Claes, Vandenput, Liesbeth, Lorentzon, Mattias, Eriksson, Johan G, Shea, M Kyla, Houston, Denise K, Kritchevsky, Stephen B, Liu, Yongmei, Lohman, Kurt K, Ferrucci, Luigi, Peacock, Munro, Gieger, Christian, Beekman, Marian, Slagboom, Eline, Deelen, Joris, Heemst, Diana Van, Kleber, Marcus E, März, Winfried, De Boer, Ian H, Wood, Alexis C, Rotter, Jerome I, Rich, Stephen S, Robinson-Cohen, Cassianne, Den Heijer, Martin, Jarvelin, Marjo-Riitta, Cavadino, Alana, Joshi, Peter K, Wilson, James F, Hayward, Caroline, Lind, Lars, Michaëlsson, Karl, Trompet, Stella, Zillikens, M Carola, Uitterlinden, Andre G, Rivadeneira, Fernando, Broer, Linda, Zgaga, Lina, Campbell, Harry, Theodoratou, Evropi, Farrington, Susan M, Timofeeva, Maria, Dunlop, Malcolm G, Valdes, Ana M, Tikkanen, Emmi, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Raitakari, Olli T, Mikkilä, Vera, Ikram, M Arfan, Sattar, Naveed, Jukema, J Wouter, Wareham, Nicholas J, Langenberg, Claudia, Forouhi, Nita G, Gundersen, Thomas E, Khaw, Kay-Tee, Butterworth, Adam S, Danesh, John, Spector, Timothy, Wang, Thomas J, Hyppönen, Elina, Kraft, Peter, and Kiel, Douglas P

Subjects
Cohort Studies, Male, Vesicular Transport Proteins, Humans, Female, Vitamin D, Polymorphism, Single Nucleotide, White People, Amidohydrolases, Autoimmune Diseases, Genome-Wide Association Study
Abstract

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC23A, and P = 1.9×10-14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.

Published
2018
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47. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author

Wain, Louise V, Verwoert, Germaine C, O'Reilly, Paul F, Shi, Gang, Johnson, Toby, Johnson, Andrew D, Bochud, Murielle, Rice, Kenneth M, Henneman, Peter, Smith, Albert V, Ehret, Georg B, Amin, Najaf, Larson, Martin G, Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile JW, Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'an, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U, Webster, Rebecca J, Zhang, Feng, Peden, John F, Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I, Trompet, Stella, Bragg-Gresham, Jennifer L, Alizadeh, Behrooz Z, Chambers, John C, Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M, Polašek, Ozren, Boban, Mladen, Nelson, Christopher P, Morrison, Alanna C, Pihur, Vasyl, Ganesh, Santhi K, Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco US, Rivadeneira, Fernando, Sijbrands, Eric JG, Uitterlinden, Andre G, Hwang, Shih-Jen, Vasan, Ramachandran S, Wang, Thomas J, Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L, Kroemer, Heyo K, Völker, Uwe, Völzke, Henry, Glazer, Nicole L, Taylor, Kent D, Harris, Tamara B, Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, Inês, Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M, Penninx, Brenda W, Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco, Fabiola M, Facheris, Maurizio, Collins, Francis S, Bergman, Richard N, Beilby, John P, Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S, Navarro, Pau, Wild, Sarah H, Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco JC, Willemsen, Gonneke, Parker, Alex N, Rose, Lynda M, Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, LifeLines Cohort Study, Van Der Klauw, Melanie M, Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M, Emilsson, Valur, Plump, Andrew, Lindeman, Jan H, Hoen, Peter AC 'T, König, Inke R, EchoGen Consortium, Felix, Janine F, Clarke, Robert, Hopewell, Jemma C, Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L, Fornage, Myriam, AortaGen Consortium, Mitchell, Gary F, CHARGE Consortium Heart Failure Working Group, Smith, Nicholas L, KidneyGen Consortium, Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, CKDGen Consortium, Cardiogenics Consortium, CardioGram, Samani, Nilesh J, Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J, Wichmann, H-Erich, Raitakari, Olli T, Palmas, Walter, Kooner, Jaspal S, Stolk, Ronald P, Jukema, J Wouter, Wright, Alan F, Boomsma, Dorret I, Bandinelli, Stefania, Gyllensten, Ulf B, Wilson, James F, Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D, Palmer, Lyle J, Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth JF, Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J, Oostra, Ben A, Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P, Beckmann, Jacques S, Witteman, Jacqueline CM, Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M, Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R, Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B, Psaty, Bruce M, Caulfield, Mark J, Rao, Dabeeru C, Tobin, Martin D, Elliott, Paul, and Van Duijn, Cornelia M

Subjects
Genetic Loci, Case-Control Studies, Hypertension, Humans, Blood Pressure, cardiovascular diseases, Arteries, Polymorphism, Single Nucleotide, Linkage Disequilibrium, circulatory and respiratory physiology, Follow-Up Studies, Genome-Wide Association Study
Abstract

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

Published
2018
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48. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Author

Teumer, Alexander, primary, Li, Yong, additional, Ghasemi, Sahar, additional, Prins, Bram P., additional, Wuttke, Matthias, additional, Hermle, Tobias, additional, Giri, Ayush, additional, Sieber, Karsten B., additional, Qiu, Chengxiang, additional, Kirsten, Holger, additional, Tin, Adrienne, additional, Chu, Audrey Y., additional, Bansal, Nisha, additional, Feitosa, Mary F., additional, Wang, Lihua, additional, Chai, Jin-Fang, additional, Cocca, Massimiliano, additional, Fuchsberger, Christian, additional, Gorski, Mathias, additional, Hoppmann, Anselm, additional, Horn, Katrin, additional, Li, Man, additional, Marten, Jonathan, additional, Noce, Damia, additional, Nutile, Teresa, additional, Sedaghat, Sanaz, additional, Sveinbjornsson, Gardar, additional, Tayo, Bamidele O., additional, van der Most, Peter J., additional, Xu, Yizhe, additional, Yu, Zhi, additional, Gerstner, Lea, additional, Ärnlöv, Johan, additional, Bakker, Stephan J. L., additional, Baptista, Daniela, additional, Biggs, Mary L., additional, Boerwinkle, Eric, additional, Brenner, Hermann, additional, Burkhardt, Ralph, additional, Carroll, Robert J., additional, Chee, Miao-Li, additional, Chee, Miao-Ling, additional, Chen, Mengmeng, additional, Cheng, Ching-Yu, additional, Cook, James P., additional, Coresh, Josef, additional, Corre, Tanguy, additional, Danesh, John, additional, de Borst, Martin H., additional, De Grandi, Alessandro, additional, de Mutsert, Renée, additional, de Vries, Aiko P. J., additional, Degenhardt, Frauke, additional, Dittrich, Katalin, additional, Divers, Jasmin, additional, Eckardt, Kai-Uwe, additional, Ehret, Georg, additional, Endlich, Karlhans, additional, Felix, Janine F., additional, Franco, Oscar H., additional, Franke, Andre, additional, Freedman, Barry I., additional, Freitag-Wolf, Sandra, additional, Gansevoort, Ron T., additional, Giedraitis, Vilmantas, additional, Gögele, Martin, additional, Grundner-Culemann, Franziska, additional, Gudbjartsson, Daniel F., additional, Gudnason, Vilmundur, additional, Hamet, Pavel, additional, Harris, Tamara B., additional, Hicks, Andrew A., additional, Holm, Hilma, additional, Foo, Valencia Hui Xian, additional, Hwang, Shih-Jen, additional, Ikram, M. Arfan, additional, Ingelsson, Erik, additional, Jaddoe, Vincent W. V., additional, Jakobsdottir, Johanna, additional, Josyula, Navya Shilpa, additional, Jung, Bettina, additional, Kähönen, Mika, additional, Khor, Chiea-Chuen, additional, Kiess, Wieland, additional, Koenig, Wolfgang, additional, Körner, Antje, additional, Kovacs, Peter, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kronenberg, Florian, additional, Lange, Leslie A., additional, Langefeld, Carl D., additional, Lee, Jeannette Jen-Mai, additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lim, Su-Chi, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Liu, Jianjun, additional, Loeffler, Markus, additional, Lyytikäinen, Leo-Pekka, additional, Mahajan, Anubha, additional, Maranville, Joseph C., additional, Mascalzoni, Deborah, additional, McMullen, Barbara, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Miliku, Kozeta, additional, Mook-Kanamori, Dennis O., additional, Müller-Nurasyid, Martina, additional, Mychaleckyj, Josyf C., additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Ning, Boting, additional, Noordam, Raymond, additional, Connell, Jeffrey O’, additional, Olafsson, Isleifur, additional, Palmer, Nicholette D., additional, Peters, Annette, additional, Podgornaia, Anna I., additional, Ponte, Belen, additional, Poulain, Tanja, additional, Pramstaller, Peter P., additional, Rabelink, Ton J., additional, Raffield, Laura M., additional, Reilly, Dermot F., additional, Rettig, Rainer, additional, Rheinberger, Myriam, additional, Rice, Kenneth M., additional, Rivadeneira, Fernando, additional, Runz, Heiko, additional, Ryan, Kathleen A., additional, Sabanayagam, Charumathi, additional, Saum, Kai-Uwe, additional, Schöttker, Ben, additional, Shaffer, Christian M., additional, Shi, Yuan, additional, Smith, Albert V., additional, Strauch, Konstantin, additional, Stumvoll, Michael, additional, Sun, Benjamin B., additional, Szymczak, Silke, additional, Tai, E-Shyong, additional, Tan, Nicholas Y. Q., additional, Taylor, Kent D., additional, Teren, Andrej, additional, Tham, Yih-Chung, additional, Thiery, Joachim, additional, Thio, Chris H. L., additional, Thomsen, Hauke, additional, Thorsteinsdottir, Unnur, additional, Tönjes, Anke, additional, Tremblay, Johanne, additional, Uitterlinden, André G., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Vogelezang, Suzanne, additional, Völker, Uwe, additional, Waldenberger, Melanie, additional, Wang, Chaolong, additional, Wilson, Otis D., additional, Wong, Charlene, additional, Wong, Tien-Yin, additional, Yang, Qiong, additional, Yasuda, Masayuki, additional, Akilesh, Shreeram, additional, Bochud, Murielle, additional, Böger, Carsten A., additional, Devuyst, Olivier, additional, Edwards, Todd L., additional, Ho, Kevin, additional, Morris, Andrew P., additional, Parsa, Afshin, additional, Pendergrass, Sarah A., additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Stefansson, Kari, additional, Wilson, James G., additional, Susztak, Katalin, additional, Snieder, Harold, additional, Heid, Iris M., additional, Scholz, Markus, additional, Butterworth, Adam S., additional, Hung, Adriana M., additional, Pattaro, Cristian, additional, and Köttgen, Anna, additional

Published
2019
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49. A meta-analysis of genome-wide association studies identifies multiple longevity genes

Author

Deelen, Joris, primary, Evans, Daniel S., additional, Arking, Dan E., additional, Tesi, Niccolò, additional, Nygaard, Marianne, additional, Liu, Xiaomin, additional, Wojczynski, Mary K., additional, Biggs, Mary L., additional, van der Spek, Ashley, additional, Atzmon, Gil, additional, Ware, Erin B., additional, Sarnowski, Chloé, additional, Smith, Albert V., additional, Seppälä, Ilkka, additional, Cordell, Heather J., additional, Dose, Janina, additional, Amin, Najaf, additional, Arnold, Alice M., additional, Ayers, Kristin L., additional, Barzilai, Nir, additional, Becker, Elizabeth J., additional, Beekman, Marian, additional, Blanché, Hélène, additional, Christensen, Kaare, additional, Christiansen, Lene, additional, Collerton, Joanna C., additional, Cubaynes, Sarah, additional, Cummings, Steven R., additional, Davies, Karen, additional, Debrabant, Birgit, additional, Deleuze, Jean-François, additional, Duncan, Rachel, additional, Faul, Jessica D., additional, Franceschi, Claudio, additional, Galan, Pilar, additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Huisman, Martijn, additional, Hurme, Mikko A., additional, Jagger, Carol, additional, Jansen, Iris, additional, Jylhä, Marja, additional, Kähönen, Mika, additional, Karasik, David, additional, Kardia, Sharon L. R., additional, Kingston, Andrew, additional, Kirkwood, Thomas B. L., additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lyytikäinen, Leo-Pekka, additional, Martin-Ruiz, Carmen, additional, Min, Junxia, additional, Nebel, Almut, additional, Newman, Anne B., additional, Nie, Chao, additional, Nohr, Ellen A., additional, Orwoll, Eric S., additional, Perls, Thomas T., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Reinders, Marcel J. T., additional, Robine, Jean-Marie, additional, Rotter, Jerome I., additional, Sebastiani, Paola, additional, Smith, Jennifer, additional, Sørensen, Thorkild I. A., additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van der Flier, Wiesje, additional, van der Lee, Sven J., additional, van Duijn, Cornelia M., additional, van Heemst, Diana, additional, Vaupel, James W., additional, Weir, David, additional, Ye, Kenny, additional, Zeng, Yi, additional, Zheng, Wanlin, additional, Holstege, Henne, additional, Kiel, Douglas P., additional, Lunetta, Kathryn L., additional, Slagboom, P. Eline, additional, and Murabito, Joanne M., additional

Published
2019
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50. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Author

Evangelou, Evangelos, primary, Gao, He, additional, Chu, Congying, additional, Ntritsos, Georgios, additional, Blakeley, Paul, additional, Butts, Andrew R., additional, Pazoki, Raha, additional, Suzuki, Hideaki, additional, Koskeridis, Fotios, additional, Yiorkas, Andrianos M., additional, Karaman, Ibrahim, additional, Elliott, Joshua, additional, Luo, Qiang, additional, Aeschbacher, Stefanie, additional, Bartz, Traci M., additional, Baumeister, Sebastian E., additional, Braund, Peter S., additional, Brown, Michael R., additional, Brody, Jennifer A., additional, Clarke, Toni-Kim, additional, Dimou, Niki, additional, Faul, Jessica D., additional, Homuth, Georg, additional, Jackson, Anne U., additional, Kentistou, Katherine A., additional, Joshi, Peter K., additional, Lemaitre, Rozenn N., additional, Lind, Penelope A., additional, Lyytikäinen, Leo-Pekka, additional, Mangino, Massimo, additional, Milaneschi, Yuri, additional, Nelson, Christopher P., additional, Nolte, Ilja M., additional, Perälä, Mia-Maria, additional, Polasek, Ozren, additional, Porteous, David, additional, Ratliff, Scott M., additional, Smith, Jennifer A., additional, Stančáková, Alena, additional, Teumer, Alexander, additional, Tuominen, Samuli, additional, Thériault, Sébastien, additional, Vangipurapu, Jagadish, additional, Whitfield, John B., additional, Wood, Alexis, additional, Yao, Jie, additional, Yu, Bing, additional, Zhao, Wei, additional, Arking, Dan E., additional, Auvinen, Juha, additional, Liu, Chunyu, additional, Männikkö, Minna, additional, Risch, Lorenz, additional, Rotter, Jerome I., additional, Snieder, Harold, additional, Veijola, Juha, additional, Blakemore, Alexandra I., additional, Boehnke, Michael, additional, Campbell, Harry, additional, Conen, David, additional, Eriksson, Johan G., additional, Grabe, Hans J., additional, Guo, Xiuqing, additional, van der Harst, Pim, additional, Hartman, Catharina A., additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Jarvelin, Marjo-Riitta, additional, Kähönen, Mika, additional, Kardia, Sharon L. R., additional, Kühne, Michael, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lehtimäki, Terho, additional, McIntosh, Andrew M., additional, Mohlke, Karen L., additional, Morrison, Alanna C., additional, Martin, Nicholas G., additional, Oldehinkel, Albertine J., additional, Penninx, Brenda W. J. H., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Rudan, Igor, additional, Samani, Nilesh J., additional, Scott, Laura J., additional, Spector, Tim D., additional, Verweij, Niek, additional, Weir, David R., additional, Wilson, James F., additional, Levy, Daniel, additional, Tzoulaki, Ioanna, additional, Bell, Jimmy D., additional, Matthews, Paul M., additional, Rothenfluh, Adrian, additional, Desrivières, Sylvane, additional, Schumann, Gunter, additional, and Elliott, Paul, additional

Published
2019
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