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A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine
- Source :
- Nat. Commun. 11:3368 (2020), Nature Communications, 11(1):3368. Nature Publishing Group UK, Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020), Guo, Y, Rist, P M, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, B S, Palta, P, Esko, T, Pers, T H, Farh, K H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Hrafnsdottir, M G, Stefansson, H, Ring, S M, Hottenga, J J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Christensen, A F, Hansen, T F, Werge, T, Olesen, J, The International Headache Genetics Consortium & the 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368 . https://doi.org/10.1038/s41467-020-17002-0, Guo, Y, Rist, P M, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, B S, Palta, P, Esko, T, Pers, T H, Farh, K H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Hrafnsdottir, M G, Stefansson, H, Ring, S M, Hottenga, J J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Heath, A C, Madden, P A F, Martin, N G, Montgomery, G W, Kurki, M, Kals, M, Mägi, R, Pärn, K, Hämäläinen, E, Huang, H, Byrnes, A E, Franke, L, Huang, J, Stergiakouli, E, Lee, P H, Sandor, C, Webber, C, Cader, Z, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Eriksson, J G, Salomaa, V, Heikkilä, K, Loehrer, E, Uitterlinden, A G, Hofman, A, Duijn, C M V, Cherkas, L, Pedersen, L M, Stubhaug, A, Nielsen, C S, Männikkö, M, Mihailov, E, Milani, L, Göbel, H, Esserlind, A L, Christensen, A F, Hansen, T F, Werge, T, Kaprio, J, Aromaa, A J, Raitakari, O, Ikram, M A, Spector, T, Järvelin, M R, Metspalu, A, Kubisch, C, Strachan, D P, Ferrari, M D, Belin, A C, Dichgans, M, Wessman, M, Maagdenberg, A M J M V D, Zwart, J A, Boomsma, D I, Smith, G D, Stefansson, K, Eriksson, N, Daly, M J, Neale, B M, Olesen, J, Chasman, D I, Nyholt, D R, Palotie, A, Agee, M, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Huber, K E, Kleinman, A, Litterman, N K, McCreight, J C, McIntyre, M H, Mountain, J L, Noblin, E S, Northover, C A M, Pitts, S J, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Kurth, T, Chasman, D I, The International Headache Genetics Consortium & the 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368 . https://doi.org/10.1038/s41467-020-17002-0, Nature Communications, 11(1):3368, 1-11. Nature Publishing Group, Nature communications, Guo, Y, Ligthart, L, Hottenga, J J, Penninx, B W J H, Boomsma, D I, Chasman, D I, The International Headache Genetics Consortium & The 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368, pp. 1-11 . https://doi.org/10.1038/s41467-020-17002-0, Nature Communications
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Publisher's version (útgefin grein)<br />Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P<br />This research has been conducted using the UK Biobank Resource under Application Number 29273. We would like to thank the participants and researchers from the UK Biobank, 23andMe, Inc., International Headache Genetics Consortium (IHGC), MEGASTROKE, CARDIoGRAM, and International Consortium of Blood Pressure-Genome Wide Association Studies (ICBP) who contributed or collected data. Daniel I. Chasman is funded by US National Institutes of Health and US National Institute of Neurological Disorders and Stroke (R21NS09296 and R21NS104398). Pamela M. Rist is funded by K01 HL128791. The MEGASTROKE project received funding from sources specified at http://www.megastroke.org/acknowledgments.html.
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
Integrin beta Chains
LOCI
Medizin
General Physics and Astronomy
Blood Pressure
Genome-wide association study
Genome-wide association studies
DISEASE
3124 Neurology and psychiatry
0302 clinical medicine
HEADACHE
Risk Factors
Polymorphism (computer science)
Genome-wide
lcsh:Science
Telomerase
Multidisciplinary
Mendelian Randomization Analysis
Blóðþrýstingur
3. Good health
Pulse pressure
Mígreni
Hypertension
Blood pressure
Cross-phenotype
Erfðarannsóknir
medicine.medical_specialty
Migraine Disorders
Science
Diastole
Polymorphism, Single Nucleotide
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Meta-Analysis as Topic
SDG 3 - Good Health and Well-being
Receptors, Adrenergic, alpha-2
Internal medicine
Mendelian randomization
medicine
Humans
Genetic Predisposition to Disease
Migraine
business.industry
Proteins
General Chemistry
medicine.disease
Meta-analysis
030104 developmental biology
Endocrinology
RISK-FACTORS
lcsh:Q
business
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nat. Commun. 11:3368 (2020), Nature Communications, 11(1):3368. Nature Publishing Group UK, Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020), Guo, Y, Rist, P M, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, B S, Palta, P, Esko, T, Pers, T H, Farh, K H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Hrafnsdottir, M G, Stefansson, H, Ring, S M, Hottenga, J J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Christensen, A F, Hansen, T F, Werge, T, Olesen, J, The International Headache Genetics Consortium & the 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368 . https://doi.org/10.1038/s41467-020-17002-0, Guo, Y, Rist, P M, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, B S, Palta, P, Esko, T, Pers, T H, Farh, K H, Cuenca-Leon, E, Muona, M, Furlotte, N A, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, G M, Kallela, M, Freilinger, T M, Ran, C, Gordon, S G, Stam, A H, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, H H H, Lehtimäki, T, Sarin, A P, Wedenoja, J, Hinds, D A, Buring, J E, Schürks, M, Ridker, P M, Hrafnsdottir, M G, Stefansson, H, Ring, S M, Hottenga, J J, Penninx, B W J H, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Heath, A C, Madden, P A F, Martin, N G, Montgomery, G W, Kurki, M, Kals, M, Mägi, R, Pärn, K, Hämäläinen, E, Huang, H, Byrnes, A E, Franke, L, Huang, J, Stergiakouli, E, Lee, P H, Sandor, C, Webber, C, Cader, Z, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Eriksson, J G, Salomaa, V, Heikkilä, K, Loehrer, E, Uitterlinden, A G, Hofman, A, Duijn, C M V, Cherkas, L, Pedersen, L M, Stubhaug, A, Nielsen, C S, Männikkö, M, Mihailov, E, Milani, L, Göbel, H, Esserlind, A L, Christensen, A F, Hansen, T F, Werge, T, Kaprio, J, Aromaa, A J, Raitakari, O, Ikram, M A, Spector, T, Järvelin, M R, Metspalu, A, Kubisch, C, Strachan, D P, Ferrari, M D, Belin, A C, Dichgans, M, Wessman, M, Maagdenberg, A M J M V D, Zwart, J A, Boomsma, D I, Smith, G D, Stefansson, K, Eriksson, N, Daly, M J, Neale, B M, Olesen, J, Chasman, D I, Nyholt, D R, Palotie, A, Agee, M, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Huber, K E, Kleinman, A, Litterman, N K, McCreight, J C, McIntyre, M H, Mountain, J L, Noblin, E S, Northover, C A M, Pitts, S J, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Kurth, T, Chasman, D I, The International Headache Genetics Consortium & the 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368 . https://doi.org/10.1038/s41467-020-17002-0, Nature Communications, 11(1):3368, 1-11. Nature Publishing Group, Nature communications, Guo, Y, Ligthart, L, Hottenga, J J, Penninx, B W J H, Boomsma, D I, Chasman, D I, The International Headache Genetics Consortium & The 23andMe Research Team 2020, ' A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine ', Nature Communications, vol. 11, no. 1, 3368, pp. 1-11 . https://doi.org/10.1038/s41467-020-17002-0, Nature Communications
- Accession number :
- edsair.doi.dedup.....64bdfe457fede013ed23e57873fc1ee4