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167 results on '"KAPRIO, JAAKKO"'

2. Nightmares share genetic risk factors with sleep and psychiatric traits

Author

Ollila, Hanna M., primary, Sinnott-Armstrong, Nasa, additional, Kantojärvi, Katri, additional, Broberg, Martin, additional, Palviainen, Teemu, additional, Jones, Samuel, additional, Ripatti, Vili, additional, Pandit, Anita, additional, Rong, Robin, additional, Kristiansson, Kati, additional, Sandman, Nils, additional, Valli, Katja, additional, Hublin, Christer, additional, Ripatti, Samuli, additional, Widen, Elisabeth, additional, Kaprio, Jaakko, additional, Saxena, Richa, additional, and Paunio, Tiina, additional

Published
2024
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4. Proteomic insights into mental health status: plasma markers in young adults

Author

Afonin, Alexey M., primary, Piironen, Aino-Kaisa, additional, de Sousa Maciel, Izaque, additional, Ivanova, Mariia, additional, Alatalo, Arto, additional, Whipp, Alyce M., additional, Pulkkinen, Lea, additional, Rose, Richard J., additional, van Kamp, Irene, additional, Kaprio, Jaakko, additional, and Kanninen, Katja M., additional

Published
2024
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7. Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use

Author

Fang, Fang, primary, Quach, Bryan, additional, Lawrence, Kaitlyn G., additional, van Dongen, Jenny, additional, Marks, Jesse A., additional, Lundgren, Sara, additional, Lin, Mingkuan, additional, Odintsova, Veronika V., additional, Costeira, Ricardo, additional, Xu, Zongli, additional, Zhou, Linran, additional, Mandal, Meisha, additional, Xia, Yujing, additional, Vink, Jacqueline M., additional, Bierut, Laura J., additional, Ollikainen, Miina, additional, Taylor, Jack A., additional, Bell, Jordana T., additional, Kaprio, Jaakko, additional, Boomsma, Dorret I., additional, Xu, Ke, additional, Sandler, Dale P., additional, Hancock, Dana B., additional, and Johnson, Eric O., additional

Published
2023
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10. Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes

Author

Garske, Kristina M., primary, Kar, Asha, additional, Comenho, Caroline, additional, Balliu, Brunilda, additional, Pan, David Z., additional, Bhagat, Yash V., additional, Rosenberg, Gregory, additional, Koka, Amogha, additional, Das, Sankha Subhra, additional, Miao, Zong, additional, Sinsheimer, Janet S., additional, Kaprio, Jaakko, additional, Pietiläinen, Kirsi H., additional, and Pajukanta, Päivi, additional

Published
2023
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11. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G, Chen, Jing, Packer, Richard, Hall, Robert J, Guyatt, Anna L, Batini, Chiara, Thompson, Rebecca J, Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D, Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A, John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y, Chen, Zhengming, Li, Liming, Wijnant, Sara RA, Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G, Manichaikul, Ani, Oelsner, Elizabeth C, Rich, Stephen S, Barr, R Graham, Kerr, Shona M, Vitart, Veronique, Brown, Michael R, Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M, Gharib, Sina A, Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E, Meyers, Deborah A, Bleecker, Eugene R, Gabriel, Stacey B, Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F, Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H, Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L, Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T, Thareja, Gaurav, Albagha, Omar ME, Ismail, Said I, Al-Muftah, Wadha, Badji, Radja, Mbarek, Hamdi, Darwish, Dima, Fadl, Tasnim, Yasin, Heba, Ennaifar, Maryem, Abdellatif, Rania, Alkuwari, Fatima, Alvi, Muhammad, Al-Sarraj, Yasser, Saad, Chadi, Althani, Asmaa, Fethnou, Eleni, Qafoud, Fatima, Alkhayat, Eiman, Afifi, Nahla, Tomei, Sara, Liu, Wei, Lorenz, Stephan, Syed, Najeeb, Almabrazi, Hakeem, Vempalli, Fazulur Rehaman, Temanni, Ramzi, Saqri, Tariq Abu, Khatib, Mohammedhusen, Hamza, Mehshad, Zaid, Tariq Abu, El Khouly, Ahmed, Pathare, Tushar, Poolat, Shafeeq, Al-Ali, Rashid, Al-Khodor, Souhaila, Alshafai, Mashael, Badii, Ramin, Chouchane, Lotfi, Estivill, Xavier, Fakhro, Khalid, Mokrab, Younes, Puthen, Jithesh V, Tatari, Zohreh, Suhre, Karsten, Granell, Raquel, Faquih, Tariq O, Hiemstra, Pieter S, Slats, Annelies M, Mullin, Benjamin H, Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T, Wyss, Annah B, Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A, Joshi, Peter K, Timmers, Paul RHJ, Williams, Alexander T, Free, Robert C, Wang, Xueyang, Morrison, John L, Gilliland, Frank D, Chen, Zhanghua, Wang, Carol A, Foong, Rachel E, Harris, Sarah E, Taylor, Adele, Redmond, Paul, Cook, James P, Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T, Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H, Cox, Simon R, Pennell, Craig E, Hall, Graham L, Gauderman, W James, Brightling, Chris, Wilson, James F, Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O, Timpson, Nicholas J, Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C, Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L, Dudbridge, Frank, Silverman, Edwin K, Strachan, David P, Walters, Robin G, Morris, Andrew P, London, Stephanie J, Cho, Michael H, Wain, Louise V, Hall, Ian P, Tobin, Martin D, Shrine, Nick [0000-0003-3641-4371], Chen, Jing [0000-0003-1287-1930], Guyatt, Anna L [0000-0003-1860-6337], Hobbs, Brian D [0000-0001-9564-0745], Kim, Wonji [0000-0002-1249-797X], Coley, Kayesha [0000-0003-4951-6799], Chen, Zhengming [0000-0001-6423-105X], Li, Liming [0000-0001-5873-7089], Lahousse, Lies [0000-0002-3494-4363], Uitterlinden, Andre G [0000-0002-7276-3387], Oelsner, Elizabeth C [0000-0002-7481-9671], Rich, Stephen S [0000-0003-3872-7793], Kerr, Shona M [0000-0002-4137-1495], Vitart, Veronique [0000-0002-4991-3797], Jeong, Ayoung [0000-0003-1542-0756], Gharib, Sina A [0000-0002-2480-4367], Gieger, Christian [0000-0001-6986-9554], Peters, Annette [0000-0001-6645-0985], Hu, Xiaowei [0000-0001-7804-7392], Smith, Albert Vernon [0000-0003-1942-5845], Luan, Jian’an [0000-0003-3137-6337], Langhammer, Arnulf [0000-0001-5296-6673], Willer, Cristen [0000-0001-5645-4966], Porteous, David [0000-0003-1249-6106], Smith, Blair H [0000-0002-5362-9430], Campbell, Archie [0000-0003-0198-5078], Sofer, Tamar [0000-0001-8520-8860], Lee, Jiwon [0000-0002-4079-7494], Lim, Elise [0000-0001-8967-8464], Thareja, Gaurav [0000-0003-2277-6400], Albagha, Omar ME [0000-0001-5916-5983], Suhre, Karsten [0000-0001-9638-3912], Granell, Raquel [0000-0002-4890-4012], Faquih, Tariq O [0000-0001-8026-2251], Hiemstra, Pieter S [0000-0002-0238-5982], Hysi, Pirro [0000-0001-5752-2510], Koskela, Jukka T [0000-0002-0154-7222], Jin, Jianping [0000-0002-3774-1609], Sikdar, Sinjini [0000-0003-1230-5162], Lee, Mikyeong [0000-0002-3036-3684], May-Wilson, Sebastian [0000-0003-2668-5717], Joshi, Peter K [0000-0002-6361-5059], Timmers, Paul RHJ [0000-0002-5197-1267], Gilliland, Frank D [0000-0002-9033-7269], Wang, Carol A [0000-0002-4301-3974], Harris, Sarah E [0000-0002-4941-5106], Mahajan, Anubha [0000-0001-5585-3420], Palviainen, Teemu [0000-0002-7847-8384], Kaprio, Jaakko [0000-0002-3716-2455], Pietiläinen, Kirsi H [0000-0002-8522-1288], Cox, Simon R [0000-0003-4036-3642], Pennell, Craig E [0000-0002-0937-6165], Wilson, James F [0000-0001-5751-9178], Vasankari, Tuula [0000-0002-1413-8970], Salomaa, Veikko [0000-0001-7563-5324], Timpson, Nicholas J [0000-0002-7141-9189], Dupuis, Josée [0000-0003-2871-3603], Brumpton, Ben [0000-0002-3058-1059], Langenberg, Claudia [0000-0002-5017-7344], Weiss, Stefan [0000-0002-3553-4315], Homuth, Georg [0000-0001-6839-0605], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Morrison, Alanna C [0000-0001-6381-4296], Rudan, Igor [0000-0001-6993-6884], Lee, Joo-Hyeon [0000-0002-7364-6422], Sayers, Ian [0000-0001-5601-5410], Rawlins, Emma L [0000-0001-7426-3792], Dudbridge, Frank [0000-0002-8817-8908], Strachan, David P [0000-0001-7854-1366], Walters, Robin G [0000-0002-9179-0321], Morris, Andrew P [0000-0002-6805-6014], London, Stephanie J [0000-0003-4911-5290], Cho, Michael H [0000-0002-4907-1657], Wain, Louise V [0000-0003-4951-1867], Hall, Ian P [0000-0001-9933-3216], Tobin, Martin D [0000-0002-3596-7874], and Apollo - University of Cambridge Repository

Subjects
hengityselimet, genome-wide association studies, perimä, 631/208/205/2138, 45/43, article, keuhkosairaudet, hengityselinten taudit, riskitekijät, 692/699/1785, keuhkot, perinnöllisyys, respiratory tract diseases
Abstract

Funder: British Lung Foundation (BLF); doi: https://doi.org/10.13039/501100000351, Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272, Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.

Published
2023

13. FinnGen provides genetic insights from a well-phenotyped isolated population

Author

Kurki, Mitja I, Karjalainen, Juha, Palta, Priit, Sipilä, Timo P, Kristiansson, Kati, Donner, Kati M, Reeve, Mary P, Laivuori, Hannele, Aavikko, Mervi, Kaunisto, Mari A, Loukola, Anu, Lahtela, Elisa, Mattsson, Hannele, Laiho, Päivi, Della Briotta Parolo, Pietro, Lehisto, Arto A, Kanai, Masahiro, Mars, Nina, Rämö, Joel, Kiiskinen, Tuomo, Heyne, Henrike O, Veerapen, Kumar, Rüeger, Sina, Lemmelä, Susanna, Zhou, Wei, Ruotsalainen, Sanni, Pärn, Kalle, Hiekkalinna, Tero, Koskelainen, Sami, Paajanen, Teemu, Llorens, Vincent, Gracia-Tabuenca, Javier, Siirtola, Harri, Reis, Kadri, Elnahas, Abdelrahman G, Sun, Benjamin, Foley, Christopher N, Aalto-Setälä, Katriina, Alasoo, Kaur, Arvas, Mikko, Auro, Kirsi, Biswas, Shameek, Bizaki-Vallaskangas, Argyro, Carpen, Olli, Chen, Chia-Yen, Dada, Oluwaseun A, Ding, Zhihao, Ehm, Margaret G, Eklund, Kari, Färkkilä, Martti, Finucane, Hilary, Ganna, Andrea, Ghazal, Awaisa, Graham, Robert R, Green, Eric M, Hakanen, Antti, Hautalahti, Marco, Hedman, Åsa K, Hiltunen, Mikko, Hinttala, Reetta, Hovatta, Iiris, Hu, Xinli, Huertas-Vazquez, Adriana, Huilaja, Laura, Hunkapiller, Julie, Jacob, Howard, Jensen, Jan-Nygaard, Joensuu, Heikki, John, Sally, Julkunen, Valtteri, Jung, Marc, Junttila, Juhani, Kaarniranta, Kai, Kähönen, Mika, Kajanne, Risto, Kallio, Lila, Kälviäinen, Reetta, Kaprio, Jaakko, FinnGen, Kerimov, Nurlan, Kettunen, Johannes, Kilpeläinen, Elina, Kilpi, Terhi, Klinger, Katherine, Kosma, Veli-Matti, Kuopio, Teijo, Kurra, Venla, Laisk, Triin, Laukkanen, Jari, Lawless, Nathan, Liu, Aoxing, Longerich, Simonne, Mägi, Reedik, Mäkelä, Johanna, Mäkitie, Antti, Malarstig, Anders, Mannermaa, Arto, Maranville, Joseph, Matakidou, Athena, Meretoja, Tuomo, Mozaffari, Sahar V, Niemi, Mari EK, Niemi, Marianna, Niiranen, Teemu, O Donnell, Christopher J, Obeidat, Ma En, Okafo, George, Ollila, Hanna M, Palomäki, Antti, Palotie, Tuula, Partanen, Jukka, Paul, Dirk S, Pelkonen, Margit, Pendergrass, Rion K, Petrovski, Slavé, Pitkäranta, Anne, Platt, Adam, Pulford, David, Punkka, Eero, Pussinen, Pirkko, Raghavan, Neha, Rahimov, Fedik, Rajpal, Deepak, Renaud, Nicole A, Riley-Gillis, Bridget, Rodosthenous, Rodosthenis, Saarentaus, Elmo, Salminen, Aino, Salminen, Eveliina, Salomaa, Veikko, Schleutker, Johanna, Serpi, Raisa, Shen, Huei-Yi, Siegel, Richard, Silander, Kaisa, Siltanen, Sanna, Soini, Sirpa, Soininen, Hilkka, Sul, Jae Hoon, Tachmazidou, Ioanna, Tasanen, Kaisa, Tienari, Pentti, Toppila-Salmi, Sanna, Tukiainen, Taru, Tuomi, Tiinamaija, Turunen, Joni A, Ulirsch, Jacob C, Vaura, Felix, Virolainen, Petri, Waring, Jeffrey, Waterworth, Dawn, Yang, Robert, Nelis, Mari, Reigo, Anu, Metspalu, Andres, Milani, Lili, Esko, Tõnu, Fox, Caroline, Havulinna, Aki S, Perola, Markus, Ripatti, Samuli, Jalanko, Anu, Laitinen, Tarja, Mäkelä, Tomi P, Plenge, Robert, McCarthy, Mark, Runz, Heiko, Daly, Mark J, Palotie, Aarno, Palotie, Aarno [0000-0002-2527-5874], and Apollo - University of Cambridge Repository

Subjects
Estonia, 631/208/205/2138, 692/308/2056, 45/43, article, Middle Aged, United Kingdom, White People, 631/208/457/649/2219, Phenotype, Gene Frequency, Meta-Analysis as Topic, 631/208/727/2000, Humans, Disease, Genetic Predisposition to Disease, Finland, Genome-Wide Association Study
Abstract

Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding bottleneck rather than being distributed over a large number of ultrarare variants. Although this effect is well established in Mendelian genetics, its value in common disease genetics is less explored1,2. FinnGen aims to study the genome and national health register data of 500,000 Finnish individuals. Given the relatively high median age of participants (63 years) and the substantial fraction of hospital-based recruitment, FinnGen is enriched for disease end points. Here we analyse data from 224,737 participants from FinnGen and study 15 diseases that have previously been investigated in large genome-wide association studies (GWASs). We also include meta-analyses of biobank data from Estonia and the United Kingdom. We identified 30 new associations, primarily low-frequency variants, enriched in the Finnish population. A GWAS of 1,932 diseases also identified 2,733 genome-wide significant associations (893 phenome-wide significant (PWS), P < 2.6 × 10-11) at 2,496 (771 PWS) independent loci with 807 (247 PWS) end points. Among these, fine-mapping implicated 148 (73 PWS) coding variants associated with 83 (42 PWS) end points. Moreover, 91 (47 PWS) had an allele frequency of

Published
2023
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14. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Author

Howe, Laurence J, Nivard, Michel G, Morris, Tim T, Hansen, Ailin F, Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A, Palviainen, Teemu, Van Der Zee, Matthijs D, Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M, Bielak, Lawrence F, Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A, Reynolds, Chandra A, Balbona, Jared V, Andreassen, Ole A, Ask, Helga, Baras, Aris, Bauer, Christopher R, Boomsma, Dorret I, Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C, Dokuru, Deepika R, Evans, Luke M, De Geus, Eco JC, Giddaluru, Sudheer, Gordon, Scott D, Harden, K Paige, Hill, W David, Hughes, Amanda, Kerr, Shona M, Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A, Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik KE, Mallard, Travis T, Martikainen, Pekka, Mills, Melinda C, Njølstad, Pål Rasmus, Overton, John D, Pedersen, Nancy L, Porteous, David J, Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C, Stoltenberg, Camilla, Tucker-Drob, Elliot M, Wright, Margaret J, Social Science Genetic Association Consortium, Within Family Consortium, Hewitt, John K, Keller, Matthew C, Stallings, Michael C, Lee, James J, Christensen, Kaare, Kardia, Sharon LR, Peyser, Patricia A, Smith, Jennifer A, Wilson, James F, Hopper, John L, Hägg, Sara, Spector, Tim D, Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G, Oskarsson, Sven, Justice, Anne E, Millwood, Iona Y, Hveem, Kristian, Naess, Øyvind, Willer, Cristen J, Åsvold, Bjørn Olav, Koellinger, Philipp D, Kaprio, Jaakko, Medland, Sarah E, Walters, Robin G, Benjamin, Daniel J, Turley, Patrick, Evans, David M, Davey Smith, George, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, Davies, Neil M, Howe, Laurence J [0000-0002-2819-9686], Nivard, Michel G [0000-0003-2015-1888], Morris, Tim T [0000-0001-8178-6815], Rasheed, Humaira [0000-0002-3331-5864], Cho, Yoonsu [0000-0001-6118-6652], Lind, Penelope A [0000-0002-3887-2598], Palviainen, Teemu [0000-0002-7847-8384], van der Zee, Matthijs D [0000-0003-4076-9167], Mangino, Massimo [0000-0002-2167-7470], Wang, Yunzhang [0000-0003-1165-3595], Klaric, Lucija [0000-0003-3105-8929], Bielak, Lawrence F [0000-0002-3443-8030], Nygaard, Marianne [0000-0003-0703-2665], Giannelis, Alexandros [0000-0003-4587-0336], Willoughby, Emily A [0000-0001-7559-1544], Reynolds, Chandra A [0000-0001-6502-7173], Balbona, Jared V [0000-0003-4466-248X], Andreassen, Ole A [0000-0002-4461-3568], Ask, Helga [0000-0003-0149-5319], Baras, Aris [0000-0002-6830-3396], Boomsma, Dorret I [0000-0002-7099-7972], Campbell, Archie [0000-0003-0198-5078], Chen, Zhengming [0000-0001-6423-105X], Corfield, Elizabeth [0000-0002-0119-157X], Evans, Luke M [0000-0002-7458-1720], Gordon, Scott D [0000-0001-7623-328X], Harden, K Paige [0000-0002-1557-6737], Hughes, Amanda [0000-0001-5896-7650], Kerr, Shona M [0000-0002-4137-1495], Kweon, Hyeokmoon [0000-0002-3649-0457], Lawlor, Deborah A [0000-0002-6793-2262], Magnusson, Patrik KE [0000-0002-7315-7899], Mallard, Travis T [0000-0002-3265-3001], Martikainen, Pekka [0000-0001-9374-1438], Njølstad, Pål Rasmus [0000-0003-0304-6728], Porteous, David J [0000-0003-1249-6106], Reid, Jeffrey [0000-0001-8645-4713], Southey, Melissa C [0000-0002-6313-9005], Stoltenberg, Camilla [0000-0002-8747-1985], Tucker-Drob, Elliot M [0000-0001-5599-6237], Wright, Margaret J [0000-0001-7133-4970], Keller, Matthew C [0000-0002-6075-9882], Lee, James J [0000-0001-6547-5128], Christensen, Kaare [0000-0002-5429-5292], Peyser, Patricia A [0000-0002-9717-8459], Smith, Jennifer A [0000-0002-3575-5468], Wilson, James F [0000-0001-5751-9178], Hägg, Sara [0000-0002-2452-1500], Spector, Tim D [0000-0002-9795-0365], Plomin, Robert [0000-0002-0756-3629], Havdahl, Alexandra [0000-0002-9268-0423], Bartels, Meike [0000-0002-9667-7555], Oskarsson, Sven [0000-0001-8698-2866], Willer, Cristen J [0000-0001-5645-4966], Åsvold, Bjørn Olav [0000-0003-3837-2101], Koellinger, Philipp D [0000-0001-7413-0412], Kaprio, Jaakko [0000-0002-3716-2455], Walters, Robin G [0000-0002-9179-0321], Benjamin, Daniel J [0000-0002-2642-5416], Evans, David M [0000-0003-0663-4621], Davey Smith, George [0000-0002-1407-8314], Hayward, Caroline [0000-0002-9405-9550], Brumpton, Ben [0000-0002-3058-1059], Hemani, Gibran [0000-0003-0920-1055], Davies, Neil M [0000-0002-2460-0508], and Apollo - University of Cambridge Repository

Subjects
Multifactorial Inheritance, Phenotype, 631/208/205/2138, article, Humans, 631/208/457, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Genome-Wide Association Study
Abstract

Funder: Jacobs Foundation; doi: https://doi.org/10.13039/501100003986, Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.

Published
2022
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15. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Author

Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional

Published
2022
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16. Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts

Author

Barr, Peter B., primary, Driver, Morgan N., additional, Kuo, Sally I-Chun, additional, Stephenson, Mallory, additional, Aliev, Fazil, additional, Linnér, Richard Karlsson, additional, Marks, Jesse, additional, Anokhin, Andrey P., additional, Bucholz, Kathleen, additional, Chan, Grace, additional, Edenberg, Howard J., additional, Edwards, Alexis C., additional, Francis, Meredith W., additional, Hancock, Dana B., additional, Harden, K. Paige, additional, Kamarajan, Chella, additional, Kaprio, Jaakko, additional, Kinreich, Sivan, additional, Kramer, John R., additional, Kuperman, Samuel, additional, Latvala, Antti, additional, Meyers, Jacquelyn L., additional, Palmer, Abraham A., additional, Plawecki, Martin H., additional, Porjesz, Bernice, additional, Rose, Richard J., additional, Schuckit, Marc A., additional, Salvatore, Jessica E., additional, and Dick, Danielle M., additional

Published
2022
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17. Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Author

Lahti, Jari, primary, Tuominen, Samuli, additional, Yang, Qiong, additional, Pergola, Giulio, additional, Ahmad, Shahzad, additional, Amin, Najaf, additional, Armstrong, Nicola J., additional, Beiser, Alexa, additional, Bey, Katharina, additional, Bis, Joshua C., additional, Boerwinkle, Eric, additional, Bressler, Jan, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chen, Qiang, additional, Corley, Janie, additional, Cox, Simon R., additional, Davies, Gail, additional, De Jager, Philip L., additional, Derks, Eske M., additional, Faul, Jessica D., additional, Fitzpatrick, Annette L., additional, Fohner, Alison E., additional, Ford, Ian, additional, Fornage, Myriam, additional, Gerring, Zachary, additional, Grabe, Hans J., additional, Grodstein, Francine, additional, Gudnason, Vilmundur, additional, Simonsick, Eleanor, additional, Holliday, Elizabeth G., additional, Joshi, Peter K., additional, Kajantie, Eero, additional, Kaprio, Jaakko, additional, Karell, Pauliina, additional, Kleineidam, Luca, additional, Knol, Maria J., additional, Kochan, Nicole A., additional, Kwok, John B., additional, Leber, Markus, additional, Lam, Max, additional, Lee, Teresa, additional, Li, Shuo, additional, Loukola, Anu, additional, Luck, Tobias, additional, Marioni, Riccardo E., additional, Mather, Karen A., additional, Medland, Sarah, additional, Mirza, Saira S., additional, Nalls, Mike A., additional, Nho, Kwangsik, additional, O’Donnell, Adrienne, additional, Oldmeadow, Christopher, additional, Painter, Jodie, additional, Pattie, Alison, additional, Reppermund, Simone, additional, Risacher, Shannon L., additional, Rose, Richard J., additional, Sadashivaiah, Vijay, additional, Scholz, Markus, additional, Satizabal, Claudia L., additional, Schofield, Peter W., additional, Schraut, Katharina E., additional, Scott, Rodney J., additional, Simino, Jeannette, additional, Smith, Albert V., additional, Smith, Jennifer A., additional, Stott, David J., additional, Surakka, Ida, additional, Teumer, Alexander, additional, Thalamuthu, Anbupalam, additional, Trompet, Stella, additional, Turner, Stephen T., additional, van der Lee, Sven J., additional, Villringer, Arno, additional, Völker, Uwe, additional, Wilson, Robert S., additional, Wittfeld, Katharina, additional, Vuoksimaa, Eero, additional, Xia, Rui, additional, Yaffe, Kristine, additional, Yu, Lei, additional, Zare, Habil, additional, Zhao, Wei, additional, Ames, David, additional, Attia, John, additional, Bennett, David A., additional, Brodaty, Henry, additional, Chasman, Daniel I., additional, Goldman, Aaron L., additional, Hayward, Caroline, additional, Ikram, M. Arfan, additional, Jukema, J. Wouter, additional, Kardia, Sharon L. R., additional, Lencz, Todd, additional, Loeffler, Markus, additional, Mattay, Venkata S., additional, Palotie, Aarno, additional, Psaty, Bruce M., additional, Ramirez, Alfredo, additional, Ridker, Paul M., additional, Riedel-Heller, Steffi G., additional, Sachdev, Perminder S., additional, Saykin, Andrew J., additional, Scherer, Martin, additional, Schofield, Peter R., additional, Sidney, Stephen, additional, Starr, John M., additional, Trollor, Julian, additional, Ulrich, William, additional, Wagner, Michael, additional, Weir, David R., additional, Wilson, James F., additional, Wright, Margaret J., additional, Weinberger, Daniel R., additional, Debette, Stephanie, additional, Eriksson, Johan G., additional, Mosley, Thomas H., additional, Launer, Lenore J., additional, van Duijn, Cornelia M., additional, Deary, Ian J., additional, Seshadri, Sudha, additional, and Räikkönen, Katri, additional

Published
2022
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18. Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

Author

Silventoinen, Karri, primary, Li, Weilong, additional, Jelenkovic, Aline, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Aaltonen, Sari, additional, Piirtola, Maarit, additional, Sugawara, Masumi, additional, Tanaka, Mami, additional, Matsumoto, Satoko, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik K. E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, and Kaprio, Jaakko, additional

Published
2022
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19. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

Author

Silventoinen, Karri, primary, Piirtola, Maarit, additional, Jelenkovic, Aline, additional, Sund, Reijo, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Honda, Chika, additional, Inui, Fujio, additional, Tomizawa, Rie, additional, Watanabe, Mikio, additional, Sakai, Norio, additional, Gatz, Margaret, additional, Butler, David A., additional, Lee, Jooyeon, additional, Lee, Soo Ji, additional, Sung, Joohon, additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harris, Jennifer R., additional, Tyler, Jessica, additional, Hopper, John L., additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Dahl Aslan, Anna K., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Rebato, Esther, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Tan, Qihua, additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Korhonen, Tellervo, additional, and Kaprio, Jaakko, additional

Published
2022
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22. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, de Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, van Duijn, Cornelia M, van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, Medland, Sarah E, Cuellar-Partida, Gabriel [0000-0001-7648-4097], Aliev, Fazil [0000-0001-8357-4699], Andreassen, Ole A [0000-0002-4461-3568], Barroso, Inês [0000-0001-5800-4520], Beckmann, Jacques S [0000-0002-9741-1900], Boks, Marco P [0000-0001-6163-7484], Boomsma, Dorret I [0000-0002-7099-7972], Boyd, Heather A [0000-0001-6849-9985], Breteler, Monique MB [0000-0002-0626-9305], Chasman, Daniel I [0000-0003-3357-0862], de Geus, Eco JC [0000-0001-6022-2666], Deary, Ian J [0000-0002-1733-263X], Deloukas, Panos [0000-0001-9251-070X], Dick, Danielle M [0000-0002-1636-893X], Feenstra, Bjarke [0000-0003-1478-649X], Geller, Frank [0000-0002-9238-3269], Gordon, Scott D [0000-0001-7623-328X], Hansen, Thomas F [0000-0001-6703-7762], Hayward, Caroline [0000-0002-9405-9550], Hicks, Andrew A [0000-0001-6320-0411], Hirschhorn, Joel N [0000-0002-1650-7901], Hottenga, Jouke-Jan [0000-0002-5668-2368], Huffman, Jennifer E [0000-0002-9672-2491], Hwang, Liang-Dar [0000-0002-5535-2199], Ikram, M Arfan [0000-0003-0372-8585], Kaprio, Jaakko [0000-0002-3716-2455], Kemp, John P [0000-0002-9105-2249], Konte, Bettina [0000-0001-5287-308X], Kutalik, Zoltan [0000-0001-8285-7523], Lahti, Jari [0000-0002-4310-5297], Li, Xin [0000-0002-0135-8800], Loos, Ruth JF [0000-0002-8532-5087], Luciano, Michelle [0000-0002-7306-3008], Magnusson, Sigurdur H [0000-0001-6669-3071], Mangino, Massimo [0000-0002-2167-7470], Marques-Vidal, Pedro [0000-0002-4548-8500], Martin, Nicholas G [0000-0003-4069-8020], McArdle, Wendy L [0000-0002-0605-5403], McCarthy, Mark I [0000-0002-4393-0510], Medina-Gomez, Carolina [0000-0001-7999-5538], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Milani, Lili [0000-0002-5323-3102], Nelis, Mari [0000-0001-9748-1020], Nyholt, Dale R [0000-0001-7159-3040], O'Connell, Kevin S [0000-0002-6865-8795], Ophoff, Roel A [0000-0002-8287-6457], Palviainen, Teemu [0000-0002-7847-8384], Pare, Guillaume [0000-0002-6795-4760], Paternoster, Lavinia [0000-0003-2514-0889], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Ripatti, Samuli [0000-0002-0504-1202], Rivadeneira, Fernando [0000-0001-9435-9441], Rudan, Igor [0000-0001-6993-6884], Smit, Johannes H [0000-0002-2062-8378], Smith, George Davey [0000-0002-1407-8314], Smoller, Jordan W [0000-0002-0381-6334], Spector, Tim D [0000-0002-9795-0365], Pourcain, Beate St [0000-0002-4680-3517], Stefánsson, Hreinn [0000-0002-9331-6666], Steinberg, Stacy [0000-0001-7726-5152], Teder-Laving, Maris [0000-0002-5872-1850], Stefánsson, Kári [0000-0003-1676-864X], Timpson, Nicholas J [0000-0002-7141-9189], Uitterlinden, André G [0000-0002-7276-3387], van Rooij, Frank JA [0000-0002-8600-9852], Vink, Jaqueline M [0000-0003-3910-3528], Waeber, Gérard [0000-0003-4193-788X], Warrington, Nicole [0000-0003-4195-775X], Werge, Thomas [0000-0003-1829-0766], Wright, Margaret J [0000-0001-7133-4970], Zhao, Jing Hua [0000-0002-1463-5870], Kraft, Peter [0000-0002-4472-8103], Hinds, David A [0000-0002-4911-803X], Lindgren, Cecilia M [0000-0002-4903-9374], Neale, Benjamin M [0000-0003-1513-6077], Evans, David M [0000-0003-0663-4621], Medland, Sarah E [0000-0003-1382-380X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide, Functional Laterality, Linkage Disequilibrium, Quantitative Trait, Heritable, Sex Factors, Gene Frequency, Genetic Loci, Humans, Female, Aged, Genome-Wide Association Study
Abstract

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P

Published
2021

24. Genetic association study of childhood aggression across raters, instruments, and age

Author

Ip, Hill F., primary, van der Laan, Camiel M., additional, Krapohl, Eva M. L., additional, Brikell, Isabell, additional, Sánchez-Mora, Cristina, additional, Nolte, Ilja M., additional, St Pourcain, Beate, additional, Bolhuis, Koen, additional, Palviainen, Teemu, additional, Zafarmand, Hadi, additional, Colodro-Conde, Lucía, additional, Gordon, Scott, additional, Zayats, Tetyana, additional, Aliev, Fazil, additional, Jiang, Chang, additional, Wang, Carol A., additional, Saunders, Gretchen, additional, Karhunen, Ville, additional, Hammerschlag, Anke R., additional, Adkins, Daniel E., additional, Border, Richard, additional, Peterson, Roseann E., additional, Prinz, Joseph A., additional, Thiering, Elisabeth, additional, Seppälä, Ilkka, additional, Vilor-Tejedor, Natàlia, additional, Ahluwalia, Tarunveer S., additional, Day, Felix R., additional, Hottenga, Jouke-Jan, additional, Allegrini, Andrea G., additional, Rimfeld, Kaili, additional, Chen, Qi, additional, Lu, Yi, additional, Martin, Joanna, additional, Soler Artigas, María, additional, Rovira, Paula, additional, Bosch, Rosa, additional, Español, Gemma, additional, Ramos Quiroga, Josep Antoni, additional, Neumann, Alexander, additional, Ensink, Judith, additional, Grasby, Katrina, additional, Morosoli, José J., additional, Tong, Xiaoran, additional, Marrington, Shelby, additional, Middeldorp, Christel, additional, Scott, James G., additional, Vinkhuyzen, Anna, additional, Shabalin, Andrey A., additional, Corley, Robin, additional, Evans, Luke M., additional, Sugden, Karen, additional, Alemany, Silvia, additional, Sass, Lærke, additional, Vinding, Rebecca, additional, Ruth, Kate, additional, Tyrrell, Jess, additional, Davies, Gareth E., additional, Ehli, Erik A., additional, Hagenbeek, Fiona A., additional, De Zeeuw, Eveline, additional, Van Beijsterveldt, Toos C.E.M., additional, Larsson, Henrik, additional, Snieder, Harold, additional, Verhulst, Frank C., additional, Amin, Najaf, additional, Whipp, Alyce M., additional, Korhonen, Tellervo, additional, Vuoksimaa, Eero, additional, Rose, Richard J., additional, Uitterlinden, André G., additional, Heath, Andrew C., additional, Madden, Pamela, additional, Haavik, Jan, additional, Harris, Jennifer R., additional, Helgeland, Øyvind, additional, Johansson, Stefan, additional, Knudsen, Gun Peggy S., additional, Njolstad, Pal Rasmus, additional, Lu, Qing, additional, Rodriguez, Alina, additional, Henders, Anjali K., additional, Mamun, Abdullah, additional, Najman, Jackob M., additional, Brown, Sandy, additional, Hopfer, Christian, additional, Krauter, Kenneth, additional, Reynolds, Chandra, additional, Smolen, Andrew, additional, Stallings, Michael, additional, Wadsworth, Sally, additional, Wall, Tamara L., additional, Silberg, Judy L., additional, Miller, Allison, additional, Keltikangas-Järvinen, Liisa, additional, Hakulinen, Christian, additional, Pulkki-Råback, Laura, additional, Havdahl, Alexandra, additional, Magnus, Per, additional, Raitakari, Olli T., additional, Perry, John R. B., additional, Llop, Sabrina, additional, Lopez-Espinosa, Maria-Jose, additional, Bønnelykke, Klaus, additional, Bisgaard, Hans, additional, Sunyer, Jordi, additional, Lehtimäki, Terho, additional, Arseneault, Louise, additional, Standl, Marie, additional, Heinrich, Joachim, additional, Boden, Joseph, additional, Pearson, John, additional, Horwood, L. John, additional, Kennedy, Martin, additional, Poulton, Richie, additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Hewitt, John, additional, Copeland, William E., additional, Costello, Elizabeth J., additional, Williams, Gail M., additional, Wray, Naomi, additional, Järvelin, Marjo-Riitta, additional, McGue, Matt, additional, Iacono, William, additional, Caspi, Avshalom, additional, Moffitt, Terrie E., additional, Whitehouse, Andrew, additional, Pennell, Craig E., additional, Klump, Kelly L., additional, Burt, S. Alexandra, additional, Dick, Danielle M., additional, Reichborn-Kjennerud, Ted, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Vrijkotte, Tanja, additional, Kaprio, Jaakko, additional, Tiemeier, Henning, additional, Davey Smith, George, additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, Casas, Miquel, additional, Ribasés, Marta, additional, Lichtenstein, Paul, additional, Lundström, Sebastian, additional, Plomin, Robert, additional, Bartels, Meike, additional, Nivard, Michel G., additional, and Boomsma, Dorret I., additional

Published
2021
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28. Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

Author

Sillanpää, Elina, primary, Heikkinen, Aino, additional, Kankaanpää, Anna, additional, Paavilainen, Aini, additional, Kujala, Urho M., additional, Tammelin, Tuija H., additional, Kovanen, Vuokko, additional, Sipilä, Sarianna, additional, Pietiläinen, Kirsi H., additional, Kaprio, Jaakko, additional, Ollikainen, Miina, additional, and Laakkonen, Eija K., additional

Published
2021
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30. Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents

Author

Hüls, Anke, primary, Wright, Marvin N., additional, Bogl, Leonie H., additional, Kaprio, Jaakko, additional, Lissner, Lauren, additional, Molnár, Dénes, additional, Moreno, Luis A., additional, De Henauw, Stefaan, additional, Siani, Alfonso, additional, Veidebaum, Toomas, additional, Ahrens, Wolfgang, additional, Pigeot, Iris, additional, and Foraita, Ronja, additional

Published
2021
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31. Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Author

Heiskanen, Marja A., primary, Honkala, Sanna M., additional, Hentilä, Jaakko, additional, Ojala, Ronja, additional, Lautamäki, Riikka, additional, Koskensalo, Kalle, additional, Lietzén, Martin S., additional, Saunavaara, Virva, additional, Saunavaara, Jani, additional, Helmiö, Mika, additional, Löyttyniemi, Eliisa, additional, Nummenmaa, Lauri, additional, Collado, Maria C., additional, Malm, Tarja, additional, Lahti, Leo, additional, Pietiläinen, Kirsi H., additional, Kaprio, Jaakko, additional, Rinne, Juha O., additional, and Hannukainen, Jarna C., additional

Published
2021
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32. Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants

Author

Saarentaus, Elmo Christian, primary, Havulinna, Aki Samuli, additional, Mars, Nina, additional, Ahola-Olli, Ari, additional, Kiiskinen, Tuomo Tapio Johannes, additional, Partanen, Juulia, additional, Ruotsalainen, Sanni, additional, Kurki, Mitja, additional, Urpa, Lea Martta, additional, Chen, Lei, additional, Perola, Markus, additional, Salomaa, Veikko, additional, Veijola, Juha, additional, Männikkö, Minna, additional, Hall, Ira M., additional, Pietiläinen, Olli, additional, Kaprio, Jaakko, additional, Ripatti, Samuli, additional, Daly, Mark, additional, and Palotie, Aarno, additional

Published
2021
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33. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, De Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, Van Duijn, Cornelia M, Van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, and Medland, Sarah E

Subjects
Adult, Male, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide, Functional Laterality, Linkage Disequilibrium, Quantitative Trait, Heritable, Sex Factors, Gene Frequency, Genetic Loci, Humans, Female, Aged, Genome-Wide Association Study
Abstract

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

Published
2020
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34. A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

Author

Guo, Yanjun, Rist, Pamela M., Daghlas, Iyas, Giulianini, Franco, Gormley, Padhraig, Anttila, Verneri, Winsvold, Bendik S., Palta, Priit, Esko, Tonu, Pers, Tune H., Farh, Kai How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A., Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M., Kallela, Mikko, Freilinger, Tobias M., Ran, Caroline, Gordon, Scott G., Stam, Anine H., Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H.H., Lehtimäki, Terho, Sarin, Antti Pekka, Wedenoja, Juho, Hinds, David A., Buring, Julie E., Schürks, Markus, Ridker, Paul M., Hrafnsdottir, Maria Gudlaug, Stefansson, Hreinn, Ring, Susan M., Hottenga, Jouke Jan, Penninx, Brenda W.J.H., Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C., Madden, Pamela A.F., Martin, Nicholas G., Montgomery, Grant W., Kurki, Mitja, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E., Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H., Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G., Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G., Hofman, Albert, Duijn, Cornelia M.van, Cherkas, Lynn, Pedersen, Linda M., Stubhaug, Audun, Nielsen, Christopher S., Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann Louise, Christensen, Anne Francke, Hansen, Thomas Folkmann, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J., Raitakari, Olli, Ikram, M. Arfan, Spector, Tim, Järvelin, Marjo Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P., Ferrari, Michel D., Belin, Andrea C., Dichgans, Martin, Wessman, Maija, Maagdenberg, Arn M.J.M.van den, Zwart, John Anker, Boomsma, Dorret I., Smith, George Davey, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J., Neale, Benjamin M., Olesen, Jes, Chasman, Daniel I., Nyholt, Dale R., Palotie, Aarno, Agee, Michelle, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Psychiatry, APH - Digital Health, Radiology & Nuclear Medicine, Epidemiology, Neurology, Internal Medicine, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Clinicum, Neurologian yksikkö, HUS Neurocenter, HUS Helsinki and Uusimaa Hospital District, Department of Neurosciences, Research Programs Unit, Institute for Molecular Medicine Finland, Neuroscience Center, STEMM - Stem Cells and Metabolism Research Program, Genomics of Neurological and Neuropsychiatric Disorders, Department of Public Health, Biosciences, Centre of Excellence in Complex Disease Genetics, Research Programme of Molecular Medicine, Aarno Palotie / Principal Investigator, Helsinki University Hospital Area, University of Helsinki, Johan Eriksson / Principal Investigator, and Department of General Practice and Primary Health Care

Subjects
0301 basic medicine, Netherlands Twin Register (NTR), Integrin beta Chains, LOCI, Medizin, General Physics and Astronomy, Blood Pressure, Genome-wide association study, Genome-wide association studies, DISEASE, 3124 Neurology and psychiatry, 0302 clinical medicine, HEADACHE, Risk Factors, Polymorphism (computer science), Genome-wide, lcsh:Science, Telomerase, Multidisciplinary, Mendelian Randomization Analysis, Blóðþrýstingur, 3. Good health, Pulse pressure, Mígreni, Hypertension, Blood pressure, Cross-phenotype, Erfðarannsóknir, medicine.medical_specialty, Migraine Disorders, Science, Diastole, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Meta-Analysis as Topic, SDG 3 - Good Health and Well-being, Receptors, Adrenergic, alpha-2, Internal medicine, Mendelian randomization, medicine, Humans, Genetic Predisposition to Disease, Migraine, business.industry, Proteins, General Chemistry, medicine.disease, Meta-analysis, 030104 developmental biology, Endocrinology, RISK-FACTORS, lcsh:Q, business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Publisher's version (útgefin grein), Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P, This research has been conducted using the UK Biobank Resource under Application Number 29273. We would like to thank the participants and researchers from the UK Biobank, 23andMe, Inc., International Headache Genetics Consortium (IHGC), MEGASTROKE, CARDIoGRAM, and International Consortium of Blood Pressure-Genome Wide Association Studies (ICBP) who contributed or collected data. Daniel I. Chasman is funded by US National Institutes of Health and US National Institute of Neurological Disorders and Stroke (R21NS09296 and R21NS104398). Pamela M. Rist is funded by K01 HL128791. The MEGASTROKE project received funding from sources specified at http://www.megastroke.org/acknowledgments.html.

Published
2020

35. Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

Author

Quach, Bryan C., primary, Bray, Michael J., additional, Gaddis, Nathan C., additional, Liu, Mengzhen, additional, Palviainen, Teemu, additional, Minica, Camelia C., additional, Zellers, Stephanie, additional, Sherva, Richard, additional, Aliev, Fazil, additional, Nothnagel, Michael, additional, Young, Kendra A., additional, Marks, Jesse A., additional, Young, Hannah, additional, Carnes, Megan U., additional, Guo, Yuelong, additional, Waldrop, Alex, additional, Sey, Nancy Y. A., additional, Landi, Maria T., additional, McNeil, Daniel W., additional, Drichel, Dmitriy, additional, Farrer, Lindsay A., additional, Markunas, Christina A., additional, Vink, Jacqueline M., additional, Hottenga, Jouke-Jan, additional, Iacono, William G., additional, Kranzler, Henry R., additional, Saccone, Nancy L., additional, Neale, Michael C., additional, Madden, Pamela, additional, Rietschel, Marcella, additional, Marazita, Mary L., additional, McGue, Matthew, additional, Won, Hyejung, additional, Winterer, Georg, additional, Grucza, Richard, additional, Dick, Danielle M., additional, Gelernter, Joel, additional, Caporaso, Neil E., additional, Baker, Timothy B., additional, Boomsma, Dorret I., additional, Kaprio, Jaakko, additional, Hokanson, John E., additional, Vrieze, Scott, additional, Bierut, Laura J., additional, Johnson, Eric O., additional, and Hancock, Dana B., additional

Published
2020
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36. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, primary, Tung, Joyce Y., additional, Eriksson, Nicholas, additional, Albrecht, Eva, additional, Aliev, Fazil, additional, Andreassen, Ole A., additional, Barroso, Inês, additional, Beckmann, Jacques S., additional, Boks, Marco P., additional, Boomsma, Dorret I., additional, Boyd, Heather A., additional, Breteler, Monique M. B., additional, Campbell, Harry, additional, Chasman, Daniel I., additional, Cherkas, Lynn F., additional, Davies, Gail, additional, de Geus, Eco J. C., additional, Deary, Ian J., additional, Deloukas, Panos, additional, Dick, Danielle M., additional, Duffy, David L., additional, Eriksson, Johan G., additional, Esko, Tõnu, additional, Feenstra, Bjarke, additional, Geller, Frank, additional, Gieger, Christian, additional, Giegling, Ina, additional, Gordon, Scott D., additional, Han, Jiali, additional, Hansen, Thomas F., additional, Hartmann, Annette M., additional, Hayward, Caroline, additional, Heikkilä, Kauko, additional, Hicks, Andrew A., additional, Hirschhorn, Joel N., additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E., additional, Hwang, Liang-Dar, additional, Ikram, M. Arfan, additional, Kaprio, Jaakko, additional, Kemp, John P., additional, Khaw, Kay-Tee, additional, Klopp, Norman, additional, Konte, Bettina, additional, Kutalik, Zoltan, additional, Lahti, Jari, additional, Li, Xin, additional, Loos, Ruth J. F., additional, Luciano, Michelle, additional, Magnusson, Sigurdur H., additional, Mangino, Massimo, additional, Marques-Vidal, Pedro, additional, Martin, Nicholas G., additional, McArdle, Wendy L., additional, McCarthy, Mark I., additional, Medina-Gomez, Carolina, additional, Melbye, Mads, additional, Melville, Scott A., additional, Metspalu, Andres, additional, Milani, Lili, additional, Mooser, Vincent, additional, Nelis, Mari, additional, Nyholt, Dale R., additional, O’Connell, Kevin S., additional, Ophoff, Roel A., additional, Palmer, Cameron, additional, Palotie, Aarno, additional, Palviainen, Teemu, additional, Pare, Guillaume, additional, Paternoster, Lavinia, additional, Peltonen, Leena, additional, Penninx, Brenda W. J. H., additional, Polasek, Ozren, additional, Pramstaller, Peter P., additional, Prokopenko, Inga, additional, Raikkonen, Katri, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Rujescu, Dan, additional, Smit, Johannes H., additional, Smith, George Davey, additional, Smoller, Jordan W., additional, Soranzo, Nicole, additional, Spector, Tim D., additional, Pourcain, Beate St, additional, Starr, John M., additional, Stefánsson, Hreinn, additional, Steinberg, Stacy, additional, Teder-Laving, Maris, additional, Thorleifsson, Gudmar, additional, Stefánsson, Kári, additional, Timpson, Nicholas J., additional, Uitterlinden, André G., additional, van Duijn, Cornelia M., additional, van Rooij, Frank J. A., additional, Vink, Jaqueline M., additional, Vollenweider, Peter, additional, Vuoksimaa, Eero, additional, Waeber, Gérard, additional, Wareham, Nicholas J., additional, Warrington, Nicole, additional, Waterworth, Dawn, additional, Werge, Thomas, additional, Wichmann, H.-Erich, additional, Widen, Elisabeth, additional, Willemsen, Gonneke, additional, Wright, Alan F., additional, Wright, Margaret J., additional, Xu, Mousheng, additional, Zhao, Jing Hua, additional, Kraft, Peter, additional, Hinds, David A., additional, Lindgren, Cecilia M., additional, Mägi, Reedik, additional, Neale, Benjamin M., additional, Evans, David M., additional, and Medland, Sarah E., additional

Published
2020
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38. Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Latvala, Antti, additional, Honda, Chika, additional, Inui, Fujio, additional, Tomizawa, Rie, additional, Watanabe, Mikio, additional, Sakai, Norio, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Tyler, Jessica, additional, Hopper, John L., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Calais-Ferreira, Lucas, additional, Oliveira, Vinicius C., additional, Ferreira, Paulo H., additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Dahl Aslan, Anna K., additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harris, Jennifer R., additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Kandler, Christian, additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Gatz, Margaret, additional, Butler, David A., additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Park, Hang A., additional, Lee, Jooyeon, additional, Lee, Soo Ji, additional, Sung, Joohon, additional, Yokoyama, Yoshie, additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, and Kaprio, Jaakko, additional

Published
2020
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39. Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples

Author

Barr, Peter B., primary, Ksinan, Albert, additional, Su, Jinni, additional, Johnson, Emma C., additional, Meyers, Jacquelyn L., additional, Wetherill, Leah, additional, Latvala, Antti, additional, Aliev, Fazil, additional, Chan, Grace, additional, Kuperman, Samuel, additional, Nurnberger, John, additional, Kamarajan, Chella, additional, Anokhin, Andrey, additional, Agrawal, Arpana, additional, Rose, Richard J., additional, Edenberg, Howard J., additional, Schuckit, Marc, additional, Kaprio, Jaakko, additional, and Dick, Danielle M., additional

Published
2020
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40. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Latvala, Antti, additional, Sugawara, Masumi, additional, Tanaka, Mami, additional, Matsumoto, Satoko, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Saudino, Kimberly J., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik K. E., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Sung, Joohon, additional, Kim, Jina, additional, Lee, Jooyeon, additional, Lee, Sooji, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A., additional, Harris, Jennifer R., additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Lichtenstein, Paul, additional, Bartels, Meike, additional, Beijsterveldt, Catharina E. M. van, additional, Willemsen, Gonneke, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Jeong, Hoe-Uk, additional, Hur, Yoon-Mi, additional, Turkheimer, Eric, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2020
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41. Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent

Author

Buchwald, Jadwiga, primary, Chenoweth, Meghan J., additional, Palviainen, Teemu, additional, Zhu, Gu, additional, Benner, Christian, additional, Gordon, Scott, additional, Korhonen, Tellervo, additional, Ripatti, Samuli, additional, Madden, Pamela A. F., additional, Lehtimäki, Terho, additional, Raitakari, Olli T., additional, Salomaa, Veikko, additional, Rose, Richard J., additional, George, Tony P., additional, Lerman, Caryn, additional, Pirinen, Matti, additional, Martin, Nicholas G., additional, Kaprio, Jaakko, additional, Loukola, Anu, additional, and Tyndale, Rachel F., additional

Published
2020
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42. A cross-sectional study of obesogenic behaviours and family rules according to family structure in European children

Author

Stahlmann, Katharina, primary, Hebestreit, Antje, additional, DeHenauw, Stefaan, additional, Hunsberger, Monica, additional, Kaprio, Jaakko, additional, Lissner, Lauren, additional, Molnár, Dénes, additional, Ayala-Marín, Alelí M., additional, Reisch, Lucia A., additional, Russo, Paola, additional, Tornaritis, Michael, additional, Veidebaum, Toomas, additional, Pohlabeln, Hermann, additional, and Bogl, Leonie H., additional

Published
2020
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44. Associations of autozygosity with a broad range of human phenotypes

Author

Clark, David W, primary, Okada, Yukinori, additional, Moore, Kristjan H S, additional, Mason, Dan, additional, Pirastu, Nicola, additional, Gandin, Ilaria, additional, Mattsson, Hannele, additional, Barnes, Catriona L K, additional, Lin, Kuang, additional, Zhao, Jing Hua, additional, Deelen, Patrick, additional, Rohde, Rebecca, additional, Schurmann, Claudia, additional, Guo, Xiuqing, additional, Giulianini, Franco, additional, Zhang, Weihua, additional, Medina-Gomez, Carolina, additional, Karlsson, Robert, additional, Bao, Yanchun, additional, Bartz, Traci M, additional, Baumbach, Clemens, additional, Biino, Ginevra, additional, Bixley, Matthew J, additional, Brumat, Marco, additional, Chai, Jin-Fang, additional, Corre, Tanguy, additional, Cousminer, Diana L, additional, Dekker, Annelot M, additional, Eccles, David A, additional, van Eijk, Kristel R, additional, Fuchsberger, Christian, additional, Gao, He, additional, Germain, Marine, additional, Gordon, Scott D, additional, de Haan, Hugoline G, additional, Harris, Sarah E, additional, Hofer, Edith, additional, Huerta-Chagoya, Alicia, additional, Igartua, Catherine, additional, Jansen, Iris E, additional, Jia, Yucheng, additional, Kacprowski, Tim, additional, Karlsson, Torgny, additional, Kleber, Marcus E, additional, Li, Shengchao Alfred, additional, Li-Gao, Ruifang, additional, Mahajan, Anubha, additional, Matsuda, Koichi, additional, Meidtner, Karina, additional, Meng, Weihua, additional, Montasser, May E, additional, van der Most, Peter J, additional, Munz, Matthias, additional, Nutile, Teresa, additional, Palviainen, Teemu, additional, Prasad, Gauri, additional, Prasad, Rashmi B, additional, Priyanka, Tallapragada Divya Sri, additional, Rizzi, Federica, additional, Salvi, Erika, additional, Sapkota, Bishwa R, additional, Shriner, Daniel, additional, Skotte, Line, additional, Smart, Melissa C, additional, Smith, Albert Vernon, additional, van der Spek, Ashley, additional, Spracklen, Cassandra N, additional, Strawbridge, Rona J, additional, Tajuddin, Salman M, additional, Trompet, Stella, additional, Turman, Constance, additional, Verweij, Niek, additional, Viberti, Clara, additional, Wang, Lihua, additional, Warren, Helen R, additional, Wootton, Robyn E, additional, Yanek, Lisa R, additional, Yao, Jie, additional, Yousri, Noha A, additional, Zhao, Wei, additional, Adeyemo, Adebowale A, additional, Afaq, Saima, additional, Aguilar-Salinas, Carlos Alberto, additional, Akiyama, Masato, additional, Albert, Matthew L, additional, Allison, Matthew A, additional, Alver, Maris, additional, Aung, Tin, additional, Azizi, Fereidoun, additional, Bentley, Amy R, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Borja, Judith B, additional, de Borst, Gert J, additional, Bottinger, Erwin P, additional, Broer, Linda, additional, Campbell, Harry, additional, Chanock, Stephen, additional, Chee, Miao-Li, additional, Chen, Guanjie, additional, Chen, Yii-Der I, additional, Chen, Zhengming, additional, Chiu, Yen-Feng, additional, Cocca, Massimiliano, additional, Collins, Francis S, additional, Concas, Maria Pina, additional, Corley, Janie, additional, Cugliari, Giovanni, additional, van Dam, Rob M, additional, Damulina, Anna, additional, Daneshpour, Maryam S, additional, Day, Felix R, additional, Delgado, Graciela E, additional, Dhana, Klodian, additional, Doney, Alexander S F, additional, Dörr, Marcus, additional, Doumatey, Ayo P, additional, Dzimiri, Nduna, additional, Ebenesersdóttir, S Sunna, additional, Elliott, Joshua, additional, Elliott, Paul, additional, Ewert, Ralf, additional, Felix, Janine F, additional, Fischer, Krista, additional, Freedman, Barry I, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gögele, Martin, additional, Goodarzi, Mark O, additional, Graff, Mariaelisa, additional, Granot-Hershkovitz, Einat, additional, Grodstein, Francine, additional, Guarrera, Simonetta, additional, Gudbjartsson, Daniel F, additional, Guity, Kamran, additional, Gunnarsson, Bjarni, additional, Guo, Yu, additional, Hagenaars, Saskia P, additional, Haiman, Christopher A, additional, Halevy, Avner, additional, Harris, Tamara B, additional, Hedayati, Mehdi, additional, van Heel, David A, additional, Hirata, Makoto, additional, Höfer, Imo, additional, Hsiung, Chao Agnes, additional, Huang, Jinyan, additional, Hung, Yi-Jen, additional, Ikram, M Arfan, additional, Jagadeesan, Anuradha, additional, Jousilahti, Pekka, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kerrison, Nicola D, additional, Kessler, Thorsten, additional, Khaw, Kay-Tee, additional, Khor, Chiea Chuen, additional, de Kleijn, Dominique P V, additional, Koh, Woon-Puay, additional, Kolcic, Ivana, additional, Kraft, Peter, additional, Krämer, Bernhard K, additional, Kutalik, Zoltán, additional, Kuusisto, Johanna, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lawlor, Deborah A, additional, Lee, I-Te, additional, Lee, Wen-Jane, additional, Lerch, Markus M, additional, Li, Liming, additional, Liu, Jianjun, additional, Loh, Marie, additional, London, Stephanie J, additional, Loomis, Stephanie, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Mägi, Reedik, additional, Manichaikul, Ani W, additional, Manunta, Paolo, additional, Másson, Gísli, additional, Matoba, Nana, additional, Mei, Xue W, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Milani, Lili, additional, Millwood, Iona Y, additional, Momozawa, Yukihide, additional, Moore, Amy, additional, Morange, Pierre-Emmanuel, additional, Moreno-Macías, Hortensia, additional, Mori, Trevor A, additional, Morrison, Alanna C, additional, Muka, Taulant, additional, Murakami, Yoshinori, additional, Murray, Alison D, additional, de Mutsert, Renée, additional, Mychaleckyj, Josyf C, additional, Nalls, Mike A, additional, Nauck, Matthias, additional, Neville, Matt J, additional, Nolte, Ilja M, additional, Ong, Ken K, additional, Orozco, Lorena, additional, Padmanabhan, Sandosh, additional, Pálsson, Gunnar, additional, Pankow, James S, additional, Pattaro, Cristian, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poulter, Neil, additional, Pramstaller, Peter P, additional, Quintana-Murci, Lluis, additional, Räikkönen, Katri, additional, Ralhan, Sarju, additional, Rao, Dabeeru C, additional, van Rheenen, Wouter, additional, Rich, Stephen S, additional, Ridker, Paul M, additional, Rietveld, Cornelius A, additional, Robino, Antonietta, additional, van Rooij, Frank J A, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sabanayagam, Charumathi, additional, Sabater-Lleal, Maria, additional, Sala, Cinzia Felicita, additional, Salomaa, Veikko, additional, Sandow, Kevin, additional, Schmidt, Helena, additional, Scott, Laura J, additional, Scott, William R, additional, Sedaghati-Khayat, Bahareh, additional, Sennblad, Bengt, additional, van Setten, Jessica, additional, Sever, Peter J, additional, Sheu, Wayne H-H, additional, Shi, Yuan, additional, Shrestha, Smeeta, additional, Shukla, Sharvari Rahul, additional, Sigurdsson, Jon K, additional, Sikka, Timo Tonis, additional, Singh, Jai Rup, additional, Smith, Blair H, additional, Stančáková, Alena, additional, Stanton, Alice, additional, Starr, John M, additional, Stefansdottir, Lilja, additional, Straker, Leon, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Swertz, Morris A, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Terzikhan, Natalie, additional, Tham, Yih-Chung, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tillander, Annika, additional, Tracy, Russell P, additional, Tusié-Luna, Teresa, additional, Tzoulaki, Ioanna, additional, Vaccargiu, Simona, additional, Vangipurapu, Jagadish, additional, Veldink, Jan H, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vuoksimaa, Eero, additional, Wakil, Salma M, additional, Waldenberger, Melanie, additional, Wander, Gurpreet S, additional, Wang, Ya Xing, additional, Wareham, Nicholas J, additional, Wild, Sarah, additional, Yajnik, Chittaranjan S, additional, Yuan, Jian-Min, additional, Zeng, Lingyao, additional, Zhang, Liang, additional, Zhou, Jie, additional, Amin, Najaf, additional, Asselbergs, Folkert W, additional, Bakker, Stephan J L, additional, Becker, Diane M, additional, Lehne, Benjamin, additional, Bennett, David A, additional, van den Berg, Leonard H, additional, Berndt, Sonja I, additional, Bharadwaj, Dwaipayan, additional, Bielak, Lawrence F, additional, Bochud, Murielle, additional, Boehnke, Mike, additional, Bouchard, Claude, additional, Bradfield, Jonathan P, additional, Brody, Jennifer A, additional, Campbell, Archie, additional, Carmi, Shai, additional, Caulfield, Mark J, additional, Cesarini, David, additional, Chambers, John C, additional, Chandak, Giriraj Ratan, additional, Cheng, Ching-Yu, additional, Ciullo, Marina, additional, Cornelis, Marilyn, additional, Cusi, Daniele, additional, Smith, George Davey, additional, Deary, Ian J, additional, Dorajoo, Rajkumar, additional, van Duijn, Cornelia M, additional, Ellinghaus, David, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Evans, Michele K, additional, Faul, Jessica D, additional, Feenstra, Bjarke, additional, Feitosa, Mary, additional, Foisy, Sylvain, additional, Franke, Andre, additional, Friedlander, Yechiel, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Gonzalez, Clicerio, additional, Goyette, Philippe, additional, Grant, Struan F A, additional, Griffiths, Lyn R, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hakonarson, Hakon, additional, Hamsten, Anders, additional, van der Harst, Pim, additional, Heng, Chew-Kiat, additional, Hicks, Andrew A, additional, Hochner, Hagit, additional, Huikuri, Heikki, additional, Hunt, Steven C, additional, Jaddoe, Vincent W V, additional, De Jager, Philip L, additional, Johannesson, Magnus, additional, Johansson, Åsa, additional, Jonas, Jost B, additional, Jukema, J Wouter, additional, Junttila, Juhani, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Karpe, Fredrik, additional, Kumari, Meena, additional, Laakso, Markku, additional, van der Laan, Sander W, additional, Lahti, Jari, additional, Laudes, Matthias, additional, Lea, Rodney A, additional, Lieb, Wolfgang, additional, Lumley, Thomas, additional, Martin, Nicholas G, additional, März, Winfried, additional, Matullo, Giuseppe, additional, McCarthy, Mark I, additional, Medland, Sarah E, additional, Merriman, Tony R, additional, Metspalu, Andres, additional, Meyer, Brian F, additional, Mohlke, Karen L, additional, Montgomery, Grant W, additional, Mook-Kanamori, Dennis, additional, Munroe, Patricia B, additional, North, Kari E, additional, Nyholt, Dale R, additional, O’connell, Jeffery R, additional, Ober, Carole, additional, Oldehinkel, Albertine J, additional, Palmas, Walter, additional, Palmer, Colin, additional, Pasterkamp, Gerard G, additional, Patin, Etienne, additional, Pennell, Craig E, additional, Perusse, Louis, additional, Peyser, Patricia A, additional, Pirastu, Mario, additional, Polderman, Tinca J. C., additional, Porteous, David J, additional, Posthuma, Danielle, additional, Psaty, Bruce M, additional, Rioux, John D, additional, Rivadeneira, Fernando, additional, Rotimi, Charles, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Den Ruijter, Hester M, additional, Sanghera, Dharambir K, additional, Sattar, Naveed, additional, Schmidt, Reinhold, additional, Schulze, Matthias B, additional, Schunkert, Heribert, additional, Scott, Robert A, additional, Shuldiner, Alan R, additional, Sim, Xueling, additional, Small, Neil, additional, Smith, Jennifer A, additional, Sotoodehnia, Nona, additional, Tai, E-Shyong, additional, Teumer, Alexander, additional, Timpson, Nicholas J, additional, Toniolo, Daniela, additional, Tregouet, David-Alexandre, additional, Tuomi, Tiinamaija, additional, Vollenweider, Peter, additional, Wang, Carol A, additional, Weir, David R, additional, Whitfield, John B, additional, Wijmenga, Cisca, additional, Wong, Tien-Yin, additional, Wright, John, additional, Yang, Jingyun, additional, Yu, Lei, additional, Zemel, Babette S, additional, Zonderman, Alan B, additional, Perola, Markus, additional, Magnusson, Patrik K. E., additional, Uitterlinden, André G, additional, Kooner, Jaspal S, additional, Chasman, Daniel I, additional, Loos, Ruth J. F., additional, Franceschini, Nora, additional, Franke, Lude, additional, Haley, Chris S, additional, Hayward, Caroline, additional, Walters, Robin G, additional, Perry, John R. B., additional, Esko, Tōnu, additional, Helgason, Agnar, additional, Stefansson, Kari, additional, Joshi, Peter K, additional, Kubo, Michiaki, additional, and Wilson, James F, additional

Published
2019
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46. Sex-specific transcriptional and proteomic signatures in schizophrenia

Author

Tiihonen, Jari, primary, Koskuvi, Marja, additional, Storvik, Markus, additional, Hyötyläinen, Ida, additional, Gao, Yanyan, additional, Puttonen, Katja A., additional, Giniatullina, Raisa, additional, Poguzhelskaya, Ekaterina, additional, Ojansuu, Ilkka, additional, Vaurio, Olli, additional, Cannon, Tyrone D., additional, Lönnqvist, Jouko, additional, Therman, Sebastian, additional, Suvisaari, Jaana, additional, Kaprio, Jaakko, additional, Cheng, Lesley, additional, Hill, Andrew F., additional, Lähteenvuo, Markku, additional, Tohka, Jussi, additional, Giniatullin, Rashid, additional, Lehtonen, Šárka, additional, and Koistinaho, Jari, additional

Published
2019
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47. Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

Author

Konki, Mikko, primary, Malonzo, Maia, additional, Karlsson, Ida K., additional, Lindgren, Noora, additional, Ghimire, Bishwa, additional, Smolander, Johannes, additional, Scheinin, Noora M., additional, Ollikainen, Miina, additional, Laiho, Asta, additional, Elo, Laura L., additional, Lönnberg, Tapio, additional, Röyttä, Matias, additional, Pedersen, Nancy L., additional, Kaprio, Jaakko, additional, Lähdesmäki, Harri, additional, Rinne, Juha O., additional, and Lund, Riikka J., additional

Published
2019
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48. Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Author

Wang, Heming, primary, Lane, Jacqueline M., additional, Jones, Samuel E., additional, Dashti, Hassan S., additional, Ollila, Hanna M., additional, Wood, Andrew R., additional, van Hees, Vincent T., additional, Brumpton, Ben, additional, Winsvold, Bendik S., additional, Kantojärvi, Katri, additional, Palviainen, Teemu, additional, Cade, Brian E., additional, Sofer, Tamar, additional, Song, Yanwei, additional, Patel, Krunal, additional, Anderson, Simon G., additional, Bechtold, David A., additional, Bowden, Jack, additional, Emsley, Richard, additional, Kyle, Simon D., additional, Little, Max A., additional, Loudon, Andrew S., additional, Scheer, Frank A. J. L., additional, Purcell, Shaun M., additional, Richmond, Rebecca C., additional, Spiegelhalder, Kai, additional, Tyrrell, Jessica, additional, Zhu, Xiaofeng, additional, Hublin, Christer, additional, Kaprio, Jaakko A., additional, Kristiansson, Kati, additional, Sulkava, Sonja, additional, Paunio, Tiina, additional, Hveem, Kristian, additional, Nielsen, Jonas B., additional, Willer, Cristen J., additional, Zwart, John-Anker, additional, Strand, Linn B., additional, Frayling, Timothy M., additional, Ray, David, additional, Lawlor, Deborah A., additional, Rutter, Martin K., additional, Weedon, Michael N., additional, Redline, Susan, additional, and Saxena, Richa, additional

Published
2019
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