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181 results on '"Deubiquitinating enzyme"'

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1. The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3

2. TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination

3. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

4. Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2

5. Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases

6. Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence

7. USP15: a review of its implication in immune and inflammatory processes and tumor progression

8. Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma

9. The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer

10. The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2

11. The Ubiquitin Proteasome System and Skin Fibrosis

12. Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond

13. Ubiquitin–proteasome system (UPS) as a target for anticancer treatment

14. Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A

15. USP13 controls the stability of Aurora B impacting progression through the cell cycle

16. USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer

17. Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer

18. The role of deubiquitinating enzymes in cancer drug resistance

19. The putative deubiquitinating enzyme MoUbp4 is required for infection-related morphogenesis and pathogenicity in the rice blast fungus Magnaporthe oryzae

20. Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop

21. Inhibition of UCHL1 by LDN-57444 attenuates Ang II–Induced atrial fibrillation in mice

22. Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

23. Selective degradation of AR-V7 to overcome castration resistance of prostate cancer

24. The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

25. MINDY1 promotes bladder cancer progression by stabilizing YAP

26. USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells

27. Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis

28. Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36

29. The role of proteases in epithelial-to-mesenchymal cell transitions in cancer

30. Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells

31. Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis

32. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

33. A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

34. Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization

35. The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining

36. PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis

37. Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress

38. Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA

39. Backbone 1H, 13C, and 15N resonance assignments of deubiquitinase A in non-phosphorylated and phosphorylated forms

40. BAP1 links metabolic regulation of ferroptosis to tumour suppression

41. Requirement for POH1 in differentiation and maintenance of regulatory T cells

42. The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation

43. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

44. Proteasome-associated deubiquitinases and cancer

45. USP7 small-molecule inhibitors interfere with ubiquitin binding

46. Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents

47. Inhibition of USP10 induces degradation of oncogenic FLT3

48. Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

49. Targeting the Ubiquitin-Dependent Transcriptional and Epigenetic Landscape in Cancer

50. Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling

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