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Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
- Source :
- Archives of Pharmacal Research
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics.
- Subjects :
- 0301 basic medicine
Proteasome Endopeptidase Complex
Small molecule inhibitors
Deubiquitinating enzymes (DUBs)
Ubiquitin–proteasome system (UPS)
Antineoplastic Agents
Review
medicine.disease_cause
Deubiquitinating enzyme
03 medical and health sciences
0302 clinical medicine
Neoplasms
Drug Discovery
medicine
Animals
Humans
Molecular Targeted Therapy
E3 ligase
Multiple myeloma
Cancer
Proteasome
biology
business.industry
Bortezomib
Organic Chemistry
Ubiquitination
medicine.disease
Ubiquitin ligase
030104 developmental biology
030220 oncology & carcinogenesis
Proteolysis
biology.protein
Cancer research
Proteasome inhibitor
Molecular Medicine
business
Carcinogenesis
Proteasome Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 19763786 and 02536269
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Archives of Pharmacal Research
- Accession number :
- edsair.doi.dedup.....cbfaff361c6f5ba4e7c82db29f28fc02