4 results on '"Carmen Ribes-Koninckx"'
Search Results
2. Bone mineral density in spanish children at the diagnosis of inflammatory bowel disease
- Author
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Carmen Ribes-Koninckx, Begoña Polo Miquel, Etna Masip, and Ester Donat
- Subjects
musculoskeletal diseases ,0301 basic medicine ,Bone mineral ,medicine.medical_specialty ,Bone density ,Bone disease ,business.industry ,Osteoporosis ,030209 endocrinology & metabolism ,medicine.disease ,Inflammatory bowel disease ,digestive system diseases ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,Cohort ,medicine ,Orthopedics and Sports Medicine ,030101 anatomy & morphology ,Risk factor ,business - Abstract
The association between low bone mineral density (BMD) and inflammatory bowel disease (IBD) is already known. Our study, performed in Spanish pediatric IBD patients at diagnosis onset, shows that low BMD already existed at the beginning of the disease. Low weight and height are also associated with low BMD and have to be considered as risk factors. Introduction Inflammatory bowel disease (IBD) has been reported to be associated, even at disease onset, with low bone mass. The aim of this study was to know the bone mineral density (BMD) status in the IBD pediatric population of group of Spanish children, at the time of diagnosis. Material and methods Retrospective review of patients' records from pediatric IBD patients diagnosed in our unit in the last 10 years. BMD was measured at the time of diagnosis and was expressed by Z-score. Results Fifty-seven patients were included. Sixty-one percent were male and 47.4% had Crohn's disease (CD). Average age was 11.18 (SD 2.24) years old. Median BMD Z-score was - 0.30 (interquartile range: - 1.10 to + 0.10). Low BMD, defined as Z-score ≤ - 2SD, was present in 5% of patients, but there was no single patient with osteoporosis. There were no differences in BMD between Ulcerative Colitis (UC) and CD. Statistical differences appeared between healthy Spanish pediatric population and our IBD cohort, these having lower BMD for the same age and gender. A linear regression analysis showed a significant association between BMD Z-score and patient´s weight and height Z-score with a p values of 0.001 and 0.048, respectively. Conclusions Suboptimal bone density is present at diagnosis in Spanish pediatric patients with IBD. There is no difference in BMD between patients with CD and UC. Lower weight and height are associated with a lower BMD; thus these data at IBD diagnosis should be considered as a risk factor for bone disease in the pediatric population.
- Published
- 2021
3. Anti-gliadin antibodies in breast milk from celiac mothers on a gluten-free diet
- Author
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Isabel Polanco, María Carmen Mena, Riccardo Troncone, Renata Auricchio, Paula Crespo-Escobar, María Roca, Carmen Ribes-Koninckx, David Hervás, M.L. Mearin, Sabine L. Vriezinga, Gemma Castillejo, Roca, María, Vriezinga, Sabine Lisa, Crespo Escobar, Paula, Auricchio, Renata, Hervás, David, Castillejo, Gemma, Mena, Maria Carmen, Polanco, Isabel, Troncone, Riccardo, Mearin, Maria Luisa, and Ribes Koninckx, Carmen
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Adult ,Immunoglobulin A ,medicine.medical_specialty ,Breast milk ,Globulin ,Mothers ,Medicine (miscellaneous) ,Physiology ,Antibodies ,Gliadin ,Diet, Gluten-Free ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Lactation ,Internal medicine ,Gliadin antibodie ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Netherlands ,chemistry.chemical_classification ,Nutrition and Dietetics ,Milk, Human ,biology ,business.industry ,Gluten ,Europe ,Celiac Disease ,Endocrinology ,medicine.anatomical_structure ,Italy ,chemistry ,Spain ,Immunoglobulin G ,Anti-gliadin antibodies ,biology.protein ,Female ,030211 gastroenterology & hepatology ,Gluten free ,business - Abstract
To analyze the presence of total IgA and anti-gliadin antibodies (AGA) in BM from CD mothers who follow a gluten-free diet (GFD) and from mothers on a normal gluten-containing diet (ND). 218 samples of mature milk were obtained at different months of lactation (1–6) from 83 mothers (2 or more samples per mother) from Italy (Naples), The Netherlands (Leiden) and Spain (Madrid, Valencia and Reus): 42 CD mothers on GFD for more than 2 years and 41 non-CD mothers on a ND. Whey samples were analyzed for AGA-IgA by an indirect homemade ELISA and for total IgA (g/L) by a commercial ELISA kit. AGA-IgA was detected in BM, both in mothers on a GFD and mothers on a ND. AGA-IgA levels in both groups of mothers, CD and non-CD, show the same trend towards decreasing slightly along the months of lactation (p = 0.91). A different trend is observed for total IgA levels, decreasing markedly in CD mothers from the first month of lactation onwards but remaining stable in non-CD mothers (p = 0.048). A statistically significant association was found between the means of total IgA and AGA-IgA (p
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- 2017
4. Autoimmunity as a prognostic factor in sporadic adult onset cerebellar ataxia
- Author
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Rafael Sivera, Carmen Ribes-Koninckx, I Azorín, M. Bolonio, Juan J. Vílchez, T. Sevilla, I. Boscá, N. Muelas, N. Martín, E. Donat, and L. Bataller
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Male ,Pathology ,medicine.medical_specialty ,Cerebellum ,Ataxia ,Cerebellar Ataxia ,medicine.medical_treatment ,Autoimmunity ,Nerve Tissue Proteins ,medicine.disease_cause ,Gliadin ,Statistics, Nonparametric ,GTP-Binding Proteins ,Thyroid peroxidase ,medicine ,Humans ,Protein Glutamine gamma Glutamyltransferase 2 ,Longitudinal Studies ,Aged ,Autoantibodies ,Retrospective Studies ,Transglutaminases ,biology ,Cerebellar ataxia ,Glutamate Decarboxylase ,business.industry ,Autoantibody ,Middle Aged ,Magnetic Resonance Imaging ,Anti-thyroid autoantibodies ,medicine.anatomical_structure ,Neurology ,Disease Progression ,biology.protein ,Female ,Thyroglobulin ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Cerebellar adult onset ataxia is a heterogeneous condition. The aim of this study was to ascertain if there is a heightened autoimmune background in patients with sporadic cerebellar ataxia of unknown origin, and if autoimmunity correlates with a more rapid evolution of the ataxia. We selected patients with sporadic progressive adult onset cerebellar ataxia with a follow-up of >5 years. As controls we included 43 patients with genetically demonstrated hereditary ataxia. All patients were tested for a panel of neuronal (onconeuronal, glutamate-decarboxylase [GAD], IgG/IgA transglutaminase 6 antibodies) and systemic non-neuronal antibodies (including IgG/IgA gliadin and transglutaminase 2, thyroperoxidase, thyroglobulin, antinuclear, striational, smooth muscle, mitochondrial, liver kidney microsomal, and parietal gastric cells antibodies). Correlation between the antibodies and disease progression was studied with Cox regression models and Kaplan-Meier plots. Forty-four patients were included. All patients were negative for onconeuronal or GAD antibodies. There were no significant differences between patients and controls in the prevalence of transglutaminase 6, 2, gliadin, or thyroid antibodies. However, when we studied the panel of systemic non-neuronal autoantibodies as a group, antibodies were more frequent in patients with sporadic ataxia (p = 0.018). The presence of one or more systemic non-neuronal antibodies correlated with a faster evolution to stage 2 (loss of independent gait) (p = 0.03) and shorter survival (p = 0.03) in patients with sporadic ataxia. We conclude that there is probably a heightened autoimmune background in some patients with sporadic cerebellar ataxia of unknown origin. The presence of systemic non-neuronal autoantibodies is a prognostic marker.
- Published
- 2011
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