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Anti-gliadin antibodies in breast milk from celiac mothers on a gluten-free diet
- Source :
- European Journal of Nutrition. 57:1947-1955
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- To analyze the presence of total IgA and anti-gliadin antibodies (AGA) in BM from CD mothers who follow a gluten-free diet (GFD) and from mothers on a normal gluten-containing diet (ND). 218 samples of mature milk were obtained at different months of lactation (1–6) from 83 mothers (2 or more samples per mother) from Italy (Naples), The Netherlands (Leiden) and Spain (Madrid, Valencia and Reus): 42 CD mothers on GFD for more than 2 years and 41 non-CD mothers on a ND. Whey samples were analyzed for AGA-IgA by an indirect homemade ELISA and for total IgA (g/L) by a commercial ELISA kit. AGA-IgA was detected in BM, both in mothers on a GFD and mothers on a ND. AGA-IgA levels in both groups of mothers, CD and non-CD, show the same trend towards decreasing slightly along the months of lactation (p = 0.91). A different trend is observed for total IgA levels, decreasing markedly in CD mothers from the first month of lactation onwards but remaining stable in non-CD mothers (p = 0.048). A statistically significant association was found between the means of total IgA and AGA-IgA (p
- Subjects :
- Adult
Immunoglobulin A
medicine.medical_specialty
Breast milk
Globulin
Mothers
Medicine (miscellaneous)
Physiology
Antibodies
Gliadin
Diet, Gluten-Free
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Lactation
Internal medicine
Gliadin antibodie
medicine
Humans
Prospective Studies
030212 general & internal medicine
Netherlands
chemistry.chemical_classification
Nutrition and Dietetics
Milk, Human
biology
business.industry
Gluten
Europe
Celiac Disease
Endocrinology
medicine.anatomical_structure
Italy
chemistry
Spain
Immunoglobulin G
Anti-gliadin antibodies
biology.protein
Female
030211 gastroenterology & hepatology
Gluten free
business
Subjects
Details
- ISSN :
- 14366215 and 14366207
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- European Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....ade447faef1a96948a6526f23232650f