9 results on '"Ayse Kubat Uzum"'
Search Results
2. The Metabolic Effects of Pre-probiotic Supplementation After Roux-en-Y Gastric Bypass (RYGB) Surgery: a Prospective, Randomized Controlled Study
- Author
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Ilhan Satman, Ayse Kubat Uzum, Fulya Calikoglu, Umut Barbaros, and Yildiz Tutuncu
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Blood Glucose ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,media_common.quotation_subject ,Gastric Bypass ,Incretin ,030209 endocrinology & metabolism ,medicine.disease_cause ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Glucagon-Like Peptide 1 ,law ,Weight loss ,medicine ,Humans ,Insulin ,Prospective Studies ,media_common ,Nutrition and Dietetics ,Gastric bypass surgery ,business.industry ,Probiotics ,Area under the curve ,Appetite ,Glucagon-like peptide-1 ,Obesity, Morbid ,Surgery ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Following Roux-en-Y gastric bypass (RYGB), positive alterations are observed in gut microbiota and intestinal peptides. Previous studies demonstrated similar alterations observed in cases when pre-probiotics are used without surgery. The aim of this trial was to evaluate the effectiveness of early use of pre-probiotics after RYGB. The operation and follow-up of the patients were performed at Istanbul University Medical Faculty. Thirty-two patients who had undergone RYGB were randomized to pre-probiotic group (PreProBG, n = 16; 200 g/day yogurt plus 10 g/day inulin+oligofructose) and probiotic group (ProBG, n = 16; 200 g/day yogurt only) for 6 months. Blood samples (glucose, insulin, A1c, GLP-1, PYY), anthropometric measurements, and appetite ratings have been evaluated at baseline and 3 (m3) and 6 (m6) months after RYGB. Initial anthropometric measurements and appetite ratings decreased significantly after surgery and there were no significant differences between the groups. The decrease of area under the curve(insulin) was less and has a positive correlation with the changes in anthropometric measurements in PreProBG. GLP-1 and PYY which increased dramatically after surgery in all patients were higher in PreProBG. But this increase had a negative correlation with the changes in anthropometric measurements during the study. Increased insulin, GLP-1, and PYY secretion was more enhanced by pre-probiotic use in early postoperative period. But this increase not only in anthropometric measurements but also in appetite ratings affects negatively, contrary to expectations. In summary, it should be investigated with new studies that use of pre-probiotics in the late postoperative period may be more effective in patients with weak insulin and incretin response and therefore insufficient weight loss. Trial Registration clinicaltrials.gov Identifier: NCT03517345.
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- 2020
3. Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
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Gulsah Yenidunya Yalin, Ayse Kubat Uzum, Ferihan Aral, Refik Tanakol, Seher Tanrikulu, and Nurdan Gul
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Logistic regression ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Acromegaly ,medicine ,Humans ,Initial treatment ,In patient ,Insulin-Like Growth Factor I ,Oral glucose tolerance ,Retrospective Studies ,Human Growth Hormone ,business.industry ,Remission Induction ,Phosphorus ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Pituitary adenoma size ,Female ,Serum phosphorus ,business ,Biomarkers ,030217 neurology & neurosurgery ,After treatment - Abstract
High GH and IGF I levels increase tubular phosphate reabsorption in patients with acromegaly. We aimed to investigate the utility of serum phosphorus levels as an indicator for predicting chance of remission in acromegaly patients. Fifty-one patients (n: 51; F: 24, M: 27) with diagnosis of acromegaly were included in the study. Plasma IGF-1, Phosphorus (P) and nadir GH levels on oral glucose tolerance test (OGTT) at the time of diagnosis were analysed retrospectively. Patients were classified into two groups according to their plasma P levels; P ≤ 4.5 mg/dl (Group-1, n: 23, 45.1%), P > 4.5 mg/dl (Group-2, n: 28, 54.9%). Two groups were compared according to remission status; remission (n: 27) and non-remission (n: 24). Remission was defined with absence of clinical symptoms, normal plasma IGF-1 (adjusted for age and gender) and GH levels (
- Published
- 2017
4. HDL-C levels in newly diagnosed type 2 diabetes in Turkey
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Ilhan Satman, Ayse Kubat Uzum, Ahmet Ekmekçi, Nevin Dinccag, Kubilay Karsidag, Gonca Tamer, Murat Mertoglu, and Meral Mert
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congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Traditional medicine ,Turkish ,business.industry ,Endocrinology, Diabetes and Metabolism ,social sciences ,Newly diagnosed ,Type 2 diabetes ,medicine.disease ,eye diseases ,language.human_language ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,language ,population characteristics ,Risk factor ,business ,geographic locations - Abstract
In this study, we aimed to investigate whether HDL-C levels of non-diabetic and type 2 diabetic Turks are as low as those of non-diabetic Turks reported in Turkish Heart Study (THS) and Turkish Adult Risk Factor Sudy (TEKHARF).
- Published
- 2014
5. Therapeutic apheresis for severe hypertriglyceridemia in pregnancy
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Ferihan Aral, Sema Ciftci Dogansen, Bülent Canbaz, Rafet Basar, Nese Ozbey, Senem Altay-Dadin, Ayse Kubat Uzum, and Sevgi Kalayoglu-Besisik
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Gestational Age ,chemistry.chemical_compound ,Pregnancy ,Internal medicine ,Fatty Acids, Omega-3 ,medicine ,Humans ,Hypertriglyceridemia ,Triglyceride ,Cesarean Section ,Cholesterol ,business.industry ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Plasmapheresis ,General Medicine ,medicine.disease ,Pregnancy Complications ,Endocrinology ,Pancreatitis ,chemistry ,Acute Disease ,Blood Component Removal ,Acute pancreatitis ,Female ,business ,Filtration - Abstract
During pregnancy, a progressive increase in serum triglyceride (TG) and cholesterol levels is observed whereas TG levels mostly remain300 mg/dl. In women with genetic forms of hypertriglyceridemia, pregnancy may cause extremely elevated TG levels leading to potentially life-threatening pancreatitis attacks and chylomicronemia syndrome. The only safe medical treatment option during pregnancy is ω-3 fatty acids, which have moderate TG lowering effects. Therapeutic apheresis could be used as primary treatment approach during pregnancy.We reported the effect of double filtration apheresis in one pregnant women with severe hypertriglyceridemia, therapeutic plasmapheresis and double filtration methods in the other severe hypertriglyceridemic pregnant woman; a 32-year-old pregnant woman (patient 1) with a history of hypertriglyceridemia-induced acute pancreatitis during pregnancy and a 30-year-old pregnant woman with extremely high TG levels (12,000 mg/dl) leading to chylomicronemia syndrome (patient 2). Medical nutrition therapy and ω-3 fatty acids were also provided. Double filtration apheresis (patient 1) and plasmapheresis + double filtration apheresis (patient 2) were used.When we calculated the TG levels before and after therapeutic apheresis, maximum decrease achieved with double filtration apheresis was 46.3 % for patient 1 and 37.3 % for patient 2. However, with plasmapheresis TG level declined by 72 % in patient 2. Plasmapheresis seemed to be more efficient to decrease TG levels. Iron deficiency anemia was the main complication apart from technical difficulties by lipemic obstruction of tubing system. Healthy babies were born. Delivery led to decreases in TG levels. It is concluded that during pregnancy therapeutic apheresis is an effective method to decrease extremely high TG levels and risks of its potentially life-threatening complications.
- Published
- 2013
6. Prevalence of pituitary adenomas in macroprolactinemic patients may be higher than it is presumed
- Author
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Faruk Alagol, Meral Mert, Gonca Tamer, Ferihan Aral, Aysegul Telci, Nese Colak, Ayse Kubat Uzum, Refik Tanakol, Sema Yarman, and Harika Boztepe
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Pituitary gland ,education.field_of_study ,medicine.medical_specialty ,Galactorrhea ,Adenoma ,business.industry ,Endocrinology, Diabetes and Metabolism ,Population ,Pituitary neoplasm ,Macroprolactin ,medicine.disease ,Gastroenterology ,Endocrinology ,medicine.anatomical_structure ,Pituitary adenoma ,Internal medicine ,medicine ,medicine.symptom ,education ,business ,Prolactinoma - Abstract
One form of prolactin (PRL) is macroprolactin with high molecular mass. Many macroprolactinemic patients have no pituitary adenomas and no clinical symptoms of hyperprolactinemia, it is controversial whether macroprolactinemia is a benign condition that does not need further investigation and treatment. In this study, we aimed to compare macroprolactinemic patients (group I) with the true hyperprolactinemic patients (group II) for the presence of pituitary adenoma. We investigated 161 patients with hyperprolactinemia, whose magnetic resonance imaging records of the pituitary were taken. All patients were questioned for irregular menses, infertility and examined for galactorrhea. Patients were screened for macroprolactinemia by polyethylene glycol precipitation, and a recovery of ≤40% and normal monomeric PRL level was taken as an indication of significant macroprolactinemia. Of 161 patients with hyperprolactinemia, 60 (37.26%) had macroprolactinemia. PRL levels of group II were lower than those of group I (P = 0.011), although monomeric PRL levels of group II were higher than those of group I (P = 0.0005). Of 60 macroprolactinemic patients, 16 (26.7%) had pituitary adenomas. The prevalence of pituitary adenomas was lower in group I, compared with group II (P = 0.0005). No significant differences were found between the prevalences of irregular menses and infertility of group I and II (P = 0.084, P = 0.361). Prevalence of galactorrhea in group I was lower than that in group II (P = 0.048). Prevalence of pituitary adenomas in macroprolactinemic patients is lower compared with the true hyperprolactinemic patients, but may be higher than that found in other recent studies and in the general population.
- Published
- 2011
7. Serum adipokines and low density lipoprotein subfraction profile in hypopituitary patients with growth hormone deficiency
- Author
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Ayse Kubat Uzum, Nese Ozbey, Faruk Alagol, Aysegul Telci, and Serpil Salman
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Adipokine ,Hypopituitarism ,Growth hormone deficiency ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Adipokines ,Internal medicine ,medicine ,Homeostasis ,Humans ,Triglycerides ,Aged ,Triglyceride ,Adiponectin ,medicine.diagnostic_test ,Waist-Hip Ratio ,business.industry ,Leptin ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Lipoproteins, LDL ,chemistry ,Growth Hormone ,Female ,Resistin ,Insulin Resistance ,business ,Lipid profile - Abstract
The aim was to evaluate the concentrations of lipid subfractions in relation to adipokines and metabolic parameters in adult growth hormone (GH)-deficient hypopituitary patients on conventional replacement therapy. The study included 21 GH deficient-hypopituitary patients (age: 36.0 ± 15.1 years, male/female: 7/14) on conventional replacement therapy other than GH and 20 comparable controls (age: 37.3 ± 14.0 years, male/female: 6/14). Lipid subfractions (Lipoprint system), serum adipokine (leptin, adiponectin, resistin) concentrations, body composition, a surrogate marker for insulin resistance (HOMA) and conventional lipid profile were evaluated. No statistically significant difference was found with respect to HOMA, adipokine concentrations and anthropometric parameters between patients and controls except for significantly increased waist-to-hip ratio in hypopituitary group. Total and LDL cholesterol concentrations were significantly higher in the patients. LDL particle size (268.88 ± 3.16 vs. 271.31 ± 3.11 A, P = 0.151) and small-dense LDL subfraction did not differ significantly. According to logistic regression analysis, triglyceride concentrations ≥1.69 mmol/L was the sole parameter significantly and independently predicted small (
- Published
- 2011
8. Evaluation of the effect of l-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism
- Author
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Fatma Alibaz Öner, Mecdi Ergüney, Ayse Kubat Uzum, Ender Oner, and Selen Yurdakul
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Adult ,Male ,endocrine system ,medicine.medical_specialty ,Brachial Artery ,Turkey ,Endothelium ,Hormone Replacement Therapy ,Vasodilator Agents ,Endocrinology, Diabetes and Metabolism ,Vasodilation ,Severity of Illness Index ,Nitroglycerin ,Young Adult ,Endocrinology ,Hypothyroidism ,Risk Factors ,medicine.artery ,Internal medicine ,Diabetes mellitus ,medicine ,Hormone replacement therapy (male-to-female) ,Humans ,Longitudinal Studies ,Endothelial dysfunction ,Brachial artery ,Subclinical infection ,business.industry ,Ultrasonography, Doppler ,Middle Aged ,Atherosclerosis ,medicine.disease ,Thyroxine ,medicine.anatomical_structure ,Regional Blood Flow ,Female ,Endothelium, Vascular ,business ,Blood Flow Velocity ,Hormone - Abstract
Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (FT4), free T3 (FT3) levels and increased serum thyroid-stimulating hormone (TSH) levels. Endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. The aim of this study is to evaluate endothelial functions and the effect of L-thyroxin (L-T4) therapy on endothelial functions in SH. Twenty-seven patients with SH and 22 healthy controls were evaluated in terms of endothelial functions, using brachial artery Doppler ultrasonography. After restorating euthyroidism, measurements were repeated. Baseline and nitroglycerin induced diameter (NID) of brachial artery were similar in patients with SH and the control group. Compared to the control group, the patients with SH showed significantly reduced flow-mediated diameter (FMD). Baseline and NID values were significantly higher after LT4 therapy in SH group. FMD also significantly increased after LT4 therapy. Hypothyroidism accelerates atherogenesis through modification of atherosclerotic risk factors and direct effects on the blood vessels. In this study, we observed marked improvement in endothelial functions after L-T4 therapy in SH patients. We suggest that thyroid hormone replacement therapy may help to prevent atherosclerosis in this group of patients.
- Published
- 2011
9. Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery
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Alkan Yildirim, Ayse Kubat Uzum, Recep Has, Tülay Özkan, Ibrahim Kalelioglu, and Funda Gungor
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Adult ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,urologic and male genital diseases ,Preeclampsia ,Acute fatty liver of pregnancy ,Endocrinology ,Polyuria ,Pregnancy ,medicine ,Humans ,Deamino Arginine Vasopressin ,Cesarean Section, Repeat ,Desmopressin ,Fetus ,business.industry ,Obstetrics ,medicine.disease ,Magnetic Resonance Imaging ,female genital diseases and pregnancy complications ,Diabetes, Gestational ,Diabetes insipidus ,Etiology ,Female ,medicine.symptom ,business ,Diabetes Insipidus ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-D: -arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.
- Published
- 2007
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