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2. Sicherheit medizintechnischer Protokolle im Krankenhaus

Author

Saatjohann, Christoph, primary, Ising, Fabian, additional, Gierlings, Matthias, additional, Noss, Dominik, additional, Schimmler, Sascha, additional, Klemm, Alexander, additional, Grundmann, Leif, additional, Frosch, Tilman, additional, and Schinzel, Sebastian, additional

Published
2022
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5. Antithrombotische Therapie bei akutem Koronarsyndrom und Vorhofflimmern

Author

G. Görge, H Schinzel, Harald Darius, and Martin Spiecker

Subjects
Gynecology, medicine.medical_specialty, Acute coronary syndrome, business.industry, Atrial fibrillation, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, Antithrombotic treatment, 0302 clinical medicine, Stroke prevention, medicine, Platelet aggregation inhibitor, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Die Zahl der Patienten mit Vorhofflimmern (VHF) steigt mit zunehmender Alterung der Bevolkerung. Auch die Zahl der Patienten mit VHF und Indikation fur eine orale Antikoagulation (OAK) zur Schlaganfallpravention, die aufgrund eines akuten Koronarsyndroms (ACS) oder einer perkutanen Koronarintervention (PCI) eine duale antithrombozytare Therapie (DAPT) mit Acetylsalicylsaure (ASS) und einem P2Y12-Inhibitor benotigen, steigt. Diese Patienten erhielten dann fur 3 bis 12 Monate eine Triple-Therapie (TT). Diese TT ist nie hinsichtlich ihrer Wirksamkeit uberpruft worden, allerdings ist die Blutungskomplikationsrate gegenuber einer einfachen OAK bzw. einer DAPT signifikant erhoht. Register und kleinere Studien zeigen, dass eine Zweifachtherapie mit OAK und einem Thrombozyteninhibitor ausreichend sein kann, um Schlaganfalle und Stentthrombosen/Myokardinfarkte zu verhindern. Diese Fragestellung wurde in verschiedenen prospektiven und randomisierten Studien mit den 4 fur die Schlaganfallpravention bei VHF zugelassenen NOAK (Nicht-Vitamin-K-abhangige orale Antikoagulanzien) untersucht. Dabei wurden die NOAK gegenuber einer Therapie mit Vitamin-K-Antagonisten (VKA) verglichen, wobei auf eine DAPT verzichtet und eine singulare Thrombozytenhemmertherapie getestet wurde. Die Untersuchungen mit Rivaroxaban (PIONEER-AF-PCI) und Dabigatran (RE-DUAL-PCI) sind publiziert, die Ergebnisse mit Apixaban (AUGUSTUS) und Edoxaban (ENTRUST-AF-PCI) werden demnachst erwartet. Bisher konnte nachgewiesen werden, dass NOAK plus ein Thrombozytenhemmer, meistens Clopidogrel, einer TT mit VKA hinsichtlich der Blutungen uberlegen war, ohne beobachtete Zunahme der Schlaganfalle und/oder kardialen Ischamien. Die internationalen Leitlinien erlauben, bereits auf eine TT zu verzichten, wenn das Blutungsrisiko im Vordergrund steht. Dafur sollten ein NOAK und eine singulare Thrombozytenhemmertherapie eingesetzt werden. Daher scheint die TT fur die allermeisten Patienten mit VHF und nach ACS/perkutaner Koronarintervention (PCI) nicht mehr indiziert zu sein.

Published
2019

6. Correction to: Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-centre study

Author

Frank Tegtmeier, Reinhard Schinzel, Ronny Beer, Diederik Bulters, Jean-Yves LeFrant, Joan Sahuquillo, Andreas Unterberg, Peter Andrews, Antonio Belli, Javier Ibanez, Alfonso Lagares, Michael Mokry, Harald Willschke, Charlotte Flüh, Erich Schmutzhard, and on behalf of the NOSTRA Investigators

Subjects
Adult, Pediatrics, medicine.medical_specialty, Adolescent, Traumatic brain injury, Medicine (miscellaneous), Placebos, Double blind, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Brain Injuries, Traumatic, medicine, Humans, Glasgow Coma Scale, Pharmacology (medical), In patient, Prospective Studies, 030212 general & internal medicine, Multi centre, Infusions, Intravenous, Protocol (science), lcsh:R5-920, Trial study, business.industry, Correction, Middle Aged, medicine.disease, Biopterin, Europe, Treatment Outcome, Case-Control Studies, Quality of Life, Nitric Oxide Synthase, lcsh:Medicine (General), business, 030217 neurology & neurosurgery
Abstract

Traumatic brain injury is a leading cause of death and disability worldwide. The nitric oxide synthase inhibitor Ronopterin was shown to improve clinical outcome by enhancing neuroprotection in a phase IIa trial.The NOSTRA phase III trial (Ronopterin in traumatic brain injury) is a multi-centre, prospective, randomised, double-blinded, placebo-controlled, phase III trial in Europe. It aims at determining whether the administration of Ronopterin compared to placebo improves neurological outcome in patients with moderate or severe traumatic brain injury at 6 months after injury. The trial is designed to recruit patients between 18 and 60 years of age with moderate or severe traumatic brain injury (Glasgow Coma Scale score ≥ 3) and requiring insertion of an intracranial pressure probe. Trial patients will receive a 48-h intravenous infusion of either Ronopterin or placebo starting at the earliest 6 h and at the latest 18 h after injury. The primary outcome will be the extended Glasgow Outcome Score (eGOS) at 6 months. Secondary outcomes will include the Quality of Life Index (QOLIBRI) at 6 months after the injury and the eGOS at 3 months after the injury. Additionally, effects on mortality, intracranial pressure and cerebral perfusion pressure are evaluated.The trial aims to provide evidence on the efficacy and safety of Ronopterin in patients with traumatic brain injury.EudraCT, 2013-003368-29. Registered on 9 March 2016. ClinicalTrials.gov, NCT02794168. Registered on 8 June 2016. Protocol version 14.0 from 05 November 2018.

Published
2020

7. Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study

Author

Frank Tegtmeier, Reinhard Schinzel, Ronny Beer, Diederik Bulters, Jean-Yves LeFrant, Joan Sahuquillo, Andreas Unterberg, Peter Andrews, Antonio Belli, Javier Ibanez, Alfonso Lagares, Michael Mokry, Harald Willschke, Charlotte Flüh, Erich Schmutzhard, on behalf of the NOSTRA Investigators, Vasopharm GmbH (IGZ Würzburg), Innsbruck Medical University [Austria] (IMU), Wessex Neurological Centre, Southampton General Hospital, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Vall d'Hebron University Hospital [Barcelona], UniversitätsKlinikum Heidelberg, Western General Hospital, Edinburgh, Queens Elizabeth Hospital [Birmingham], Hospital Universitario Son Espases, Hospital Universitario 12 de Octubre [Madrid], University Hospital Graz, Medizinische Universität Wien = Medical University of Vienna, University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein (UKSH), and Kiel University

Subjects
humanos, adolescente, Medicine (miscellaneous), MESH: Biopterin, Placebos, Study Protocol, Traumatic brain injury, 0302 clinical medicine, estudios prospectivos, MESH: Double-Blind Method, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, mediana edad, MESH: Treatment Outcome, Outcome, lcsh:R5-920, MESH: Middle Aged, resultado del tratamiento, Middle Aged, adulto, MESH: Case-Control Studies, 3. Good health, adulto joven, Treatment Outcome, MESH: Young Adult, MESH: Nitric Oxide Synthase, lcsh:Medicine (General), escala del coma de Glasgow, óxido nítrico sintasa, Adult, Adolescent, estudios de casos y controles, traumatismos cerebrales, MESH: Placebos, MESH: Brain Injuries, Traumatic, Randomised controlled trials, Young Adult, 03 medical and health sciences, Double-Blind Method, MESH: Glasgow Coma Scale, Humans, Glasgow Coma Scale, método con doble ocultación, MESH: Infusions, Intravenous, MESH: Adolescent, MESH: Humans, [SCCO.NEUR]Cognitive science/Neuroscience, Nitric oxide synthase inhibition, MESH: Quality of Life, MESH: Adult, Biopterin, MESH: Prospective Studies, biopterina, Brain Injuries, Case-Control Studies, calidad de vida, Quality of Life, MESH: Europe, Nitric Oxide Synthase, 030217 neurology & neurosurgery
Abstract

Background Traumatic brain injury is a leading cause of death and disability worldwide. The nitric oxide synthase inhibitor Ronopterin was shown to improve clinical outcome by enhancing neuroprotection in a phase IIa trial. Methods/design The NOSTRA phase III trial (Ronopterin in traumatic brain injury) is a multi-centre, prospective, randomised, double-blinded, placebo-controlled, phase III trial in Europe. It aims at determining whether the administration of Ronopterin compared to placebo improves neurological outcome in patients with moderate or severe traumatic brain injury at 6 months after injury. The trial is designed to recruit patients between 18 and 60 years of age with moderate or severe traumatic brain injury (Glasgow Coma Scale score >= 3) and requiring insertion of an intracranial pressure probe. Trial patients will receive a 48-h intravenous infusion of either Ronopterin or placebo starting at the earliest 6 h and at the latest 18 h after injury. The primary outcome will be the extended Glasgow Outcome Score (eGOS) at 6 months. Secondary outcomes will include the Quality of Life Index (QOLIBRI) at 6 months after the injury and the eGOS at 3 months after the injury. Additionally, effects on mortality, intracranial pressure and cerebral perfusion pressure are evaluated. Discussion The trial aims to provide evidence on the efficacy and safety of Ronopterin in patients with traumatic brain injury., The study is completely funded by vasopharm GmbH. FT and RS as employees of vasopharm were involved in the design of the study.

Published
2020

10. Prevalence of juvenile idiopathic arthritis in schoolchildren from the city of São Paulo, the largest city in Latin America

Author

Vânia Schinzel, Claudio Arnaldo Len, Maria Teresa Terreri, and Simone Guerra Lopes da Silva

Subjects
lcsh:Immunologic diseases. Allergy, Questionnaires, medicine.medical_specialty, Pediatrics, lcsh:Diseases of the musculoskeletal system, Adolescent, Epidemiology, Population, Arthritis, Physical examination, Disease, Rheumatology, Internal medicine, Prevalence, medicine, Humans, Juvenile, Cities, Child, Students, education, Anamnesis, education.field_of_study, Schools, medicine.diagnostic_test, business.industry, Infant, Juvenile idiopathic arthritis, medicine.disease, Health Surveys, Arthritis, Juvenile, Cross-Sectional Studies, Child, Preschool, Sample Size, Private Sector, lcsh:RC925-935, lcsh:RC581-607, business, Brazil
Abstract

Background: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that affects children and adolescents. Its prevalence varies greatly from one study to another according to the population and methodology. Some tools may be helpful in screening for suspected cases. The aim of this study is determine the prevalence of JIA in children and adolescent students in the city of São Paulo, Brazil. Methods: This cross-sectional study was conducted from March 2016 to November 2017. It was based on a populational study envolving school children and adolescents from São Paulo, the largest city of Brazil. We randomly selected students under 16 years old from private schools with more than 1000 students who were evaluated through a specific questionnaire for screening suspected cases of chronic arthropathy (Early Diagnosis of Chronic Arthritis - 12 items - EDA-12) and subsequent anamnesis and rheumatologic physical examination for diagnostic confirmation. Results: We contacted all 79 schools in the universe, of which 12(15, 18%) agreed to participate in the study. A total of 21,119 questionnaires were handed out to the parents. We obtained a response of 5,710 (27%). In 108 cases the EDA-12 score was considered positive (≥ 5). We examined all these 108 suspicious” children. In 10 cases, the rheumatologic evaluation confirmed the diagnosis of arthritis, since the subjects presented a history and physical examination compatible with JIA. The prevalence of JIA in children and adolescents was 0.196% (95% CI = 0.1040.371%). Conclusion: In this first Brazilian population study to evaluate the prevalence of JIA, we observed that the disease is relatively prevalent in our country (196 / 100.000 children), which is similar to that observed in other studies involving children from urban centers.

Published
2019

11. Antikoagulation und antithrombozytäre Therapie

Author

Helmut Schinzel

Subjects
Gynecology, medicine.medical_specialty, business.industry, Medicine, Family Practice, business
Abstract

Blutverdunnende Medikamente werden eingesetzt zur peri- und postoperativen Thromboseprophylaxe, zur Thromboseprophylaxe bei konservativen, nichtchirurgischen Patienten, zur Akut- und Folgetherapie thromboembolischer Ereignisse, wie z.B. tiefen Bein-Beckenvenenthrombosen, Lungenembolien und auch Thrombosen atypischer Lokalisation, nach Stentimplantationen, Bypassoperationen, bei technischen Herzklappen, zur Schlaganfallprophylaxe bei Vorhofflimmern, beim akuten Koronarsyndrom (ACS), bei extrakorporalen Verfahren, wie Herz-Lungenmaschine, extrakorporaler Membranoxygenierung (ECMO), Hamodialyse, Hamofiltration und kombinierten Eliminationsverfahren.

Published
2016

12. Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling

Author

Beatrice Oneda, Albert Schinzel, Arif B. Ekici, Michael Papik, Orly Elpeleg, Paranchai Boonsawat, Pascal Joset, Michael Nothnagel, Justin E Strauss, Tim M. Strom, Deborah Bartholdi, Martin Zenker, Oliver Beuing, Reza Asadollahi, Katharina Steindl, Esther T. Stoeckli, Eugen Boltshauser, Dunja Niedrist, Alessandra Baumer, Anita Rauch, Markus Zweier, Cordula Haas, Simon Edvardson, Christine Otte, Silvia Azzarello-Burri, University of Zurich, and Rauch, Anita

Subjects
Male, 0301 basic medicine, Acrocallosal Syndrome, 10039 Institute of Medical Genetics, Kinesins, 340 Law, Chick Embryo, Bioinformatics, Ciliopathies, Holoprosencephaly, Cerebellum, Eye Abnormalities, Hypertelorism, 10064 Neuroscience Center Zurich, Child, 610 Medicine & health, Cells, Cultured, Genetics (clinical), Kidney Diseases, Cystic, 10218 Institute of Legal Medicine, 10124 Institute of Molecular Life Sciences, ddc, 10076 Center for Integrative Human Physiology, Female, medicine.symptom, Signal Transduction, Adult, 2716 Genetics (clinical), Retina, Joubert syndrome, 03 medical and health sciences, 1311 Genetics, Genetics, medicine, Animals, Humans, Abnormalities, Multiple, Hedgehog Proteins, Craniofacial, QH426, business.industry, Macrocephaly, Membrane Proteins, medicine.disease, Acrocallosal syndrome, Ciliopathy, 030104 developmental biology, 10036 Medical Clinic, Mutation, business
Abstract

Acrocallosal syndrome (ACLS) is an autosomal recessive neurodevelopmental disorder caused by KIF7 defects and belongs to the heterogeneous group of ciliopathies related to Joubert syndrome (JBTS). While ACLS is characterized by macrocephaly, prominent forehead, depressed nasal bridge, and hypertelorism, facial dysmorphism has not been emphasized in JBTS cohorts with molecular diagnosis. To evaluate the specificity and etiology of ACLS craniofacial features, we performed whole exome or targeted Sanger sequencing in patients with the aforementioned overlapping craniofacial appearance but variable additional ciliopathy features followed by functional studies. We found (likely) pathogenic variants of KIF7 in 5 out of 9 families, including the original ACLS patients, and delineated 1000 to 4000-year-old Swiss founder alleles. Three of the remaining families had (likely) pathogenic variants in the JBTS gene C5orf42, and one patient had a novel de novo frameshift variant in SHH known to cause autosomal dominant holoprosencephaly. In accordance with the patients' craniofacial anomalies, we showed facial midline widening after silencing of C5orf42 in chicken embryos. We further supported the link between KIF7, SHH, and C5orf42 by demonstrating abnormal primary cilia and diminished response to a SHH agonist in fibroblasts of C5orf42-mutated patients, as well as axonal pathfinding errors in C5orf42-silenced chicken embryos similar to those observed after perturbation of Shh signaling. Our findings, therefore, suggest that beside the neurodevelopmental features, macrocephaly and facial widening are likely more general signs of disturbed SHH signaling. Nevertheless, long-term follow-up revealed that C5orf42-mutated patients showed catch-up development and fainting of facial features contrary to KIF7-mutated patients.

Published
2018

14. Bridging bei Patienten mit Vorhofflimmern

Author

H. Schinzel and S. Nitschmann

Subjects
Nephrology, medicine.medical_specialty, Bridging (networking), business.industry, MEDLINE, Atrial fibrillation, Heparin, Hepatology, medicine.disease, Surgery, Internal medicine, Internal Medicine, Medicine, In patient, business, Elective Surgical Procedure, medicine.drug
Published
2015

15. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two

Author

David Kern, Masato Yashiro, Gerd Horneff, Ana P. Sakamoto, Berent J. Prakken, Paula Vähäsalo, Juergen Brunner, Ezgi H. Baris, Helen McCarthy, Janet E. McDonagh, A. Grom, Adriana Albu, Lenka Linkova, I. Nikishina, Daniel Álvarez de la Sierra, Bruno Papia, Peggy Lee, Luisa Giannone, Tobias Schwarz, Mekibib Altaye, Margarita Onoufriou, Tatiana Sleptsova, N. Ruperto, O Thana, A. Baheti, Ilonka Orbán, Kai Lehmberg, F. Zulian, Helga Sanner, Karin Palmblad, Kousuke Shabana, Sebastiaan Vastert, Marta Rusmini, Olga Vougiouka, Dirk Holzinger, D. Shaikhani, Shouichi Ohga, Ismail Dursun Dursun, Claire T Deakin, Ingrid Herta Rotstein Grein, Maria Trachana, Ariane Klein, Eugenia Enriquez, Angelo Ravelli, Paul A. Brogan, L.S. Nazarova, Laila Al Shaqshi, Paulina Vele, Liana Guerra, Antonia Pascarella, Jelena Vojinovic, Juliana Molina, Kjell Tullus, S. Rodionovskaya, Chris Scott, A. N. Olivieri, Cliff Taggart, Clare Heard, Ricardo Pujol Borrell, Jens Klotsche, Grendel Burrell, Oriany L. Pereira, Silvia Giliani, Sandra Pereira, Jennifer Horonjeff, Beth A. Mueller, Lyudmyla M. Byelyaeva, Sergio Tufik, Carlo Agostoni, Valentina Muratore, Rostislav M. Filonovich, Fiona Hawke, Virginia Messia, Bo Magnusson, Kerry West, Sara Murias, Mustafa Doğan, Hafize Emine Sönmez, Annet van Royen-Kerkhof, K. Minden, Raquel Campanilho-Marques, Reem Abdawani, Maria Ceci, Maria Ekelund, Seza Ozen, Ratna Puri, Girolamo Luppino, Shannon Carr, Rita A. Amorim, K Kobrová, Rachael D. Wright, Chantal Job-Deslandre, Daniel J. Lovell, Jorge Kalil, Yi-jin Gao, Kubra Ozturk, Fulvio Parentin, Ursula Fearon, Frank Weller-Heinemann, Elizabeth Ang, Charles A Mebus, Andrea Superti-Furga, Alina Ferster, Rikard Wicksell, Mohammadreza Modaressi, F La Torre, Ela Tarakci, Wendy Thomson, Giorgia Malighetti, Antonio Eleuteri, Helena K. Khrustaleva, Alan Easton, Alexander Mushkin, Sara Marsal Barril, Erkan Demirkaya, Florence Kanakoudi-Tsakalidou, Diana Ekdawy, Lana Tambić Bukovac, Suvi Peltoniemi, Nur Arslan, Hermine I. Brunner, Tim Rapley, Donatella Vairo, Kirill Savostyanov, Fumiko Okazaki, Rachel Corkhill, Tufan Kutlu, MG Alpigiani, Fabio Fernandes Morato Castro, Juliana Farhat, Butsabong Lerkvaleekul, Scolozzi Paolo, Akihiko Saitoh, Jason Dare, Gustavo Rocha, Tatiana V. Viktorova, Riva Brik, Jason Palman, Fabrizia Corona, Susan Nielsen, Johannes Roth, Ma. Theresa M. Collante, Leonardo Oliveira Mendonça, D. Alexeev, Randy Q. Cron, Sriharsha Grevich, Andrea L. Jorgensen, Lúcia Maria de Arruda Campos, Kiran Nistala, Fernando Martins, R. Cimaz, Angela C. Mosquera, Ruy Carrasco, Reyhan Dedeoglu, Giovanni Filocamo, J. Dare, Paula Keskitalo, Ana J. D. F. C. Lichtenfels, Florence Uettwiller, Umberto Conte, Gecilmara Salviato Pileggi, Michal Uher, Mercedes Chan, Sarka Fingerhutova, Anne M. Stevens, Peter Bale, Mikel Alberdi-Saugstrup, Olga L Kopchak, Thomas A. Griffin, Constantin Ailioaie, Clifton Bingham, Ekaterina Alexeeva, Loshinidevi D Bathi, Jane Hurst, AnnaCarin Horne, Laura Muntean, Nermin Uncu, Mara Carraro, C Vargas, Lorenzo Quartulli, Ayşenur Paç Kısaarslan, Angela Mauro, F. Corona, Donato Rigante, Helen J. Lachmann, Ana Cordeiro, Ivan Foeldvari, Faysal Gok, Tatiana Gonzalez, S. S. M. Kamphuis, Hasret Ayyildiz-Civan, Claudia Pastorino, Gleice C. S. Russo, J. B. Kuemmerle-Deschner, Serena Pastore, Nigel Klein, M. Jorini, Tatjana Freye, Maria Tsolia, Philippe Jacqmin, Suzanne M M Verstappen, Syuji Takei, Khalid Hussain, Renzo Marcolongo, Yuichi Yamasaki, Sharmila Jandial, K. Leon, Maria Pia Sormani, T. A. Simon, Mohammed Muzaffer, Catalina Mosquera, Clovis Aa Silva, Zelal Ekinci, Zübeyde Gündüz, Bernd Denecke, Felicitas Bellutti Enders, Despina Eleftheriou, Ishbel MacGregor, Andrew Cant, Luisa Bonafé, Valda Staņēviča, Helen E. Foster, Alberto Tommasini, Nora Bartholomä, Nural Kiper, A. Kardolus, Eloisa Bonfa, Alessandro Consolaro, Lillemor Berntson, Umberto Garagiola, Richard K. Vehe, Vanessa Bugni Miotto e Silva, Chihaya Imai, Kathleen G. Lomax, Brian Best, Barbara Bonafini, M. Toth, D. Rigante, Eiman Abdalla, Leona Prochazkova, Lucy Wedderburn, Lovro Lamot, S. Verazza, Raffaella Carlomagno, Gillian I. Rice, Norm Ilowite, K. de Leeuw, Havva Evrengül, Jerold Jeyaratnam, Andrew Zeft, Andrea Taddio, R. Podda, Samuel Cassidy, Grant S. Schulert, Silvia Rosina, Marija Jelušić, Olivier Gilliaux, Rubén Burgos-Vargas, Mao Mizuta, Akihiro Yachie, Angel Phuti, Antonio Zea Mendoza, Emily Boulter, Zane Dāvidsone, Sofia Torreggiani, Marco Cattalini, Natali W. Gormezano, Fatma Dedeoglu, Hercília Guimarães, A. Insalaco, Andrea Coda, Viktor A. Malievsky, Thomas Zumbrunn, Agostino Nocerino, Ronald Pederson, Katarzyna Kobusinska, Anasuya Hazra, Ananadreia S. Lopes, Elena Campione, Toshiyuki Kitoh, Elena Tsitsami, Henny G. Hotten, Radka Kaneva, R. J. E. M. Dolhain, Ndate Fall, Francesco Licciardi, Deepti Suri, G. D’Angelo, Valentina Seraya, Elżbieta Smolewska, Anastasia Dropol, Ezgi Deniz Batu, Andreas Woerner, Christine Arango, Nadia E. Aikawa, Zoilo Morel, Megan Yuasa, Sandra Ammann, Erbil Unsal, Tomohiro Kubota, Toshitaka Kizawa, Fabrizio De Benedetti, Catherine Laing, Liudmila Rakovska, Yonatan Butbul Aviel, J-Peter Haas, Marta Minute, Christine Alvey, Vasiliko Dermentzoglou, Vania Schinzel, Isree Leelayuwattanakul, Ekim Taskiran, Gabriele Simonini, N. Martin, Nathalie Canham, Nicky Brice, Beatrice Vergara, Ika Birkić, Cengizhan Acikel, Johannes-Peter Haas, Ruth Fritsch, Alisa Vitebskaya, Fatih Yazici, Iva Brito, Nataša Toplak, Veronica Moshe, Gordon J Hendry, Nadia Luca, Deniz Doğru-Ersöz, Marco Matucci-Cerinic, Claudia Toppino, Zoë Johnson, Beatrice Goilav, Siyaram Didel, K. Marzan, Tamar B. Rubinstein, Angela Barnicoat, Peter Nourse, Thita Pacharapakornpong, Adele Civino, Inmaculada Calvo Penades, H. I. Brunner, Massimo Imazio, V. Gerloni, Ayla Kacar, Heinrike Schmeling, Marija Perica, Silvestre García de la Puente, Tadej Avcin, Filipa Oliveira-Ramos, S. Arsenyeva, Phillip J Hashkes, Sabrina Schuller, Adriana Rodriguez Vidal, Kathy de Graaf, Giedre Januskeviciute, M. Kaleda, Lee Dossetter, Jelena Basic, Elena Kaschenko, Erik Sundberg, Gizem Pamuk, Marek Zak, I. Foeldvari, Rachael Quarmby, Marc D. Natter, Antonarakis Gregory, P. A. Brogan, João Eurico Fonseca, Andrea Jorgensen, Ana F. Mourão, Gaurav Gulati, Yelda Bilginer, Banu Acar Celikel, Utako Kaneko, Karen L. Durrant, Alice Grossi, Maurizio Aricò, Ibrahim Al Zakwani, Yildirim Karslioglu, Takuji Murata, Monika Stoll, Maria Teresa Terreri, Ariana Kariminejad, Teresa A. Simon, Laura B Lewandowski, Marina Garcia Prat, Walter G. Ferlin, Albena Telcharova, Giovanni Maria Severini, Judith Wienke, Panagiota Nalbanti, Hakan Poyrazoglu, Athimalaipet V. Ramanan, Manisha Lamba, Z. Guo, J. Bohnsack, Norberto Guelbert, John F. Bohnsack, Lucy R. Wedderburn, Elvira Cannizzaro Schneider, Raul Gutiérrez Suárez, Debra Grech, Yonit Reis, Chris Pruunsild, Amit Rawat, Nienke M. ter Haar, Hiroshi Tamai, Alexander Pushkov, A. De Fanti, Valentina Marzetti, Sheila Weitzman, I. E. M. Bultink, Dilek Keskin, Sania Valieva, Klaus Tenbrock, Ana Luisa Rodriguez-Lozano, Lianne Kearsley-Fleet, Luca Messina, Chiara Gorio, Amra Adrovic, Stephanie J. W. Shoop, Davide Cumetti, Sana Al Zuhbi, Helena Khrustaleva, E. Zirkzee, Elio Castagnola, Clarissa Pilkington, Jingyao Leong, Vitor A. Teixeira, Reinhard Würzner, Sonia Melo Gomes, Orla Killeen, Antony C. Fisher, Sevket Erbil Unsal, Edward M. Behrens, Kristiina Aalto, Rebecca Nicolai, Thomas C. Stock, Luiz Cláudio Danzmann, Y. K. O. Teng, Stephen D. Marks, Fotios Papachristou, Valda Stanevicha, Richard Saffrey, Elizabeth Ralph, Johannes Peter Haas, Mary Slatter, Maria Tsinti, Mehmet Alikasifoglu, Mónica Martínez Gallo, Rayfel Schneider, Rosa Maria Rodrigues Pereira, Maria F. D. A. Giacomin, Alfésio Luís Ferreira Braga, Giulia Camilla Varnier, James McElnay, Jessica Foster, Ingrida Rumba-Rozenfelde, Francesca Minoia, Laurence Goffin, Roger C. Allen, Zehra S. Arıcı, Mette Nørgaard, Alberto Martini, Hofer Michaël, Andreas Eikelberg, Junko Yasumura, Maria José Santos, Tom Wolfs, Ada B. Sinoplu, Natalia Balera Ferreira Pinto, Michael Lang, Umberto Corpora, Hidenobu Kaneyasu, Fiorenzo Gaita, Olga Lomakina, Dimitrina Mihaylova, Gian Luca Erre, Fugen Cullu-Cokugras, Mesut Topdemir, Sriram Krishnaswami, Irina Nikishina, Noortje Groot, S. Pastore, Joke Dehoorne, Paula Estanqueiro, Shafe Fahoum, Francisca Aguiar, Mabel Ladino, Nico M Wulffraat, Jana Franova, Helena Erlandsson-Harris, Denise Pires Marafon, Adrian Liston, Edward H. Schuchman, Jaime C. Branco, Maria Teresa R. Terreri, Radoslava Saraeva, Ulrika Järpemo Nykvist, Maria Cristina Maggio, Kazuko Yamazaki, Lídia Teixeira, Hanquinet Sylviane, Ricardo Yepez, Susan Maillard, Tommy Gerschman, G. Horneff, Anne-Louise Ponsonby, Meredith Riebschleger, Alessandra Alongi, José Melo-Gomes, Iris Haug, Maria De Iorio, Ekaterina Alekseeva, Jan-Inge Henter, Elisa Pisaneschi, H. Kupper, Martina Niewerth, Berta López Montesinos, Shunji Hasegawa, Zahra Hadipour, R. M. Kuester, Silvia Maestroni, Pilar Guarnizo, Antonio Brucato, Tamaki Nakamura, Gustavo Antonio Moreira, Chaim Putterman, A. Hospach, Joost Frenkel, Svetlana O Salugina, A. Ravelli, Pavla Dolezalova, Gunnar L. Olsson, Eva González-Roca, Ellen Dalen Arnstad, Mohammad Alhemairi, Tina Hinnershitz, P. Quartier, Yildirim Karsioglu, Davinder Singh Grewal, Sergio Davì, Gökçen D. Tuğcu, Tomo Nozawa, Emily Robinson, M. C. Maggio, Maria Ballabio, Eleonora Bellucci, Alexei A. Grom, Rosa M. Pereira, Federica Vanoni, Shumpei Yokota, Justine A. Ellis, Helen Bristow, Mohammad-Hassan Moradinejad, Ricardo Russo, Harun Evrengül, Mario Abinun, Laura Carenini, Francesca Santarelli, C. Wallace, Maria Beatriz Fonseca, Timothy Beukelman, Saša Sršen, Véronique Hentgen, Sezgin Sahin, Silvia Zaffarano, Salvatore Albani, Valentin Brodszky, Clovis A. Silva, Graciela Espada, Jana Pachlopnik Schmid, Margaux Gerbaux, Stefano Stagi, Valentina Leone, Brian Leroux, Isabelle Koné-Paut, Gabriella Giancane, Soley Omarsdottir, Benedetta Schiappapietra, Alessandra Carobbio, Ricardo Menendez-Castro, Yoshifumi Kawano, Ozge Erdemli, Monia Lorini, Arjan Boltjes, Ellen Nordal, Carol A. Wallace, Mustafa Çakan, Reni Tzveova, Stefano Lanni, Salah Shokry, Kirsty McLellan, Qiong Wu, Nilay Arman, Adelina Tsakova, Michael W. Beresford, A. Consolaro, Francesca Bovis, Margarita Ganeva, Christoph Kessel, A. Martini, Taichi Kanetaka, Andre Schultz, Flora McErlane, Ronnie Wang, Mojca Zajc Avramovič, Thaschawee Arkachaisri, Boris Huegle, Funda Öztunç, Jane E Munro, Yanick J. Crow, Hiroyuki Wakiguchi, Rita Fonseca, Kim E. Nichols, Mia Glerup, Nils Venhoff, R. Filonovich, Erika Van Nieuwenhove, Nadia Rafiq, Elena Kamenets, Yasuo Nakagishi, Giampietro Farronato, Consuelo Modesto Caballero, Tulay Erkan, Jan Bonhoeffer, Jack Bukowski, Myrthes Toledo Barros, Gladys C. C. Esteves, Mirta Lamot, Rosa Alcobendas, Cláudia Moura, Florencia María Barbé-Tuana, Joo Guan Yeo, Mark Friswell, Yuko Sugita, Ari Shapiro, Nagla Abdelrahman, Phu-Quoc Lê, Kevin Murray, Susanne M Benseler, Anna Monica Bianco, J. Kalabic, Ana Catarina Duarte, Ivan Caiello, Joyce Davidson, Maria Isabel Gonzalez Fernandez, Larisa Zajtseva, Ebun Omoyinmi, Jaime de Inocencio, Dragana Lazarevic, Ritambhra Nada, Claudia Saad-Magalhães C, G. Conti, Andrew Gennery, Caroline Jones, Christophe Lelubre, Brian Rusted, Geneviève Lapeyre, Giulia Zani, Alina Boteanu, Maria T. Terreri, Nataliya Panko, Julia Albrecht, Federica Mongini, Lucio Giordano, Daniela Kaiser, Robert Nelson, Hans-Iko Huppertz, Gonca Keskindemirci, Karla Ištuk, Raffaele Strippoli, Dorota Rowczenio, Emma MacDermott, Roberta Caorsi, Emiliano Marasco, Sandra Sousa, Fatoş Yalçınkaya, Jaanika Ilisson, Yuki Kimura, Marco Turco, Nami Okamoto, Parveen Bhatti, Ekaterina M. Kuchinskaya, Stefano Volpi, Min Wang, Jeffrey M. Craig, M. Bijl, Giusi Prencipe, Fatemeh Tahghighi, W. van Dijk, Christiaan Scott, Masaki Shimizu, Alexey Maletin, Braydon Meyer, Joost F Swart, Sylvia Costa Lima Farhat, Anna Taparkou, R. Fritsch-Stork, Paolo Cressoni, Reiji Hirano, I. Chyzheuskaya, Stefania Simou, Kseniya Isayeva, Mariluz Gámir Gámir, Paivi Miettunen, Francesca Ricci, Ruta Šantere, George Lazaros, Madeleine Rooney, Stefan Stefanov, Huseyin Ozkan, Céline La, Boris Hügle, Vita Dolžan, P. Barone, R. Gallizzi, Aline L. de Oliveira, Silvia Federici, Lauren J. Lahey, Kimme L. Hyrich, Claudia Saad-Magalhães, Selçuk Yüksel, Valda Stanevica, Silvia De Pauli, Seid-Reza Raeeskarami, Calin Lazar, Sema Akman, Laurence Chatel, Kirsten Minden, Ismaiel A. Tekko, Philipp Henneke, E. Cortis, Elena Košková, Gil Amarilyo, Ana M. Marín Sánchez, Antonella Insalaco, Z. Birsin Ozcakar, Melissa Mariti Fraga, Lena Klevenvall, Luis Lira, Phoi-Ngoc Duong, Tatiana Bzarova, Neus Quilis, Wilco de Jager, Gary Sterba, Rina Denisova, Miroslav Harjacek, Eve M D Smith, N Ruperto, Gemma Lepri, Evgeniya Chistyakova, Rachel Kaufmann, Liliana Lourenço Jorge, Violeta Panaviene, Helena Canhão, Riccardo Belli, Grigoris Pardalos, Larisa I. Zajtseva, Nicolino Ruperto, Ezgi Batu, Paola Montesano, Alexander Solyom, Nicola Smith, Ales Janda, Sagar Bhattad, Liora Harel, Philip N. Hawkins, Gozde Yucel, François Willermain, Paolo Picco, Alessandro Rimini, Gordana Susic, Esi M. Morgan, Jessica Beckmann, Arina Lazareva, Agustin Remesal, Özge Altuğ Gücenmez, Troels Herlin, Andreas Groll, T. Yuraga, Ekaterina Zaharova, Adriana E. M. Sallum, Zeynep Birsin Özçakar, D. Milojevic, Can Kosukcu, Isabella Ceccherini, Sandrine Lacassagne, Tania M. Castro, R. Consolini, Klaus Müller, Dogan Simsek, Frank Rühle, Katia Kozu, Femke van Wijk, Yasin Sahin, Jonathan S. Hausmann, Gokalp Basbozkurt, M. Cattalini, Mª José Santos, Norman T. Ilowite, Adriana M. E. Sallum, Simona Rednic, Sirisucha Soponkanaporn, Giancarla Di Landro, Semanur Özdel, Timothy R. Radstake, Anastasia Wiener, Betül Sözeri, Estefania Quesada-Masachs, E. Zholobova, Joshua Newson, Ozgur Kasapcopur, Davide Montin, Terence Flood, Amir Mendelson, Manuela Pardeo, Flávia Heloísa dos Santos, Jamie Eaton, Vignesh Pandiarajan, Lyudmila Belyaeva, Edson Amaro Junior, Claudio Arnaldo Len, Tamás Constantin, Livia de Freitas Keppeke, Cristina Ferrari, Margarita Soloshenko, C. Rabinovich, David Popp, Jeremy Sokolove, Jaymi Taiani, Chiara Passarelli, de Min Cristina, José Costa, Stefanie Herresthal, Thomas Giner, Laure Caspers, Dilek Konukbay, Ulrich Salzer, Jorre S. Mertens, Marijan Frković, Yosef Uziel, Sabrina Chiesa, Luisa Bracci-Laudiero, Anders Fasth, Raul A. Chavez Valencia, Jordan T. Jones, Francesca Lancini, Alessandra Ferrari, Dana Nemcova, Mark Difrancesco, Ricardo Figueira, John Mitchell, Zohreh Nademi, E. Fedorov, Thomas Vogl, Carine Wouters, Mónica Eusébio, Hannah Leahey, Alessandra Pontillo, Marco Gattorno, Mandica Vidović, Lucas L. van den Hoogen, Mikhail Kostik, Giovanni Corsello, Gian Marco Moneta, Richard Mouy, Mariana Rodrigues, Veronica Medeghini, Gökçe Gür, Lucas Kich Grun, Stephan Ehl, Edi Paleka Bosak, Walter Ferlin, Hanna Lythgoe, Tsuyoshi Yamatou, Navdha R. Ramchurn, Carolina Furtado, Estefania Barral, Cecilia Lazea, Nikolay Tzaribachev, Vahid Ziaee, Fatemeh Hadipour, Alberto Sifuentes Giraldo, Kimberly Gilmour, Marite Rygg, Anna Valenti, María M Katsicas, Raju Khubchandani, Despoina Maritsi, Alessandra Tesser, R. M. Laxer, Clotilde Alizzi, Francisco Rivas-Larrauri, Aysen Tezcaner, Anne Dennos, Vasiliki Tzimouli, Vibeke Strand, Banu Acar, Fabio Candotti, Kseniia V. Danilko, Joachim Schultze, María Luz Gámir Gámir, Alessia Omenetti, Berit Flatø, Ruth Eraso, Bernard Lauwerys, Angela Pistorio, Andressa G. F. Alves, Gerd Ganser, Sara Signa, Ana Lopes, Emese Kiss, Charlene Foley, Sylvia Kamphuis, Maja Di Rocco, Kenan Barut, Ilaria Parissenti, Aida Koka, Nicholas Ng, Francis Corazza, Vinícius L. Braga, Laura E. Schanberg, Karin Beutel, Camila Hirotsu, Jonathan D Akikusa, Mihaela Sparchez, Karoline Ehlert, Jordi Anton, Adriana M. Sallum, Maria Cristina Castiglione, Surjit Singh, Julie Jones, Katya Temelkova, Tania S. Amin, Jasmin B Kuemmerle-Deschner, Samantha Bell, Sakda A.-O. Vallipakorn, Manuel Salgado, Filipa Ramos, Balahan Makay, Nadezhda Tsurikova, Gianmaria Viglizzo, Rosalba Ferraro, Sandra Hansmann, Nilgün Çakar, Ismail Dursun, Maria Stavrakidou, T. Bzarova, Sally Pino, Dhouib Amira, Salla Kangas, Antonella Meini, Dirk Foell, Dolunay Gürses, Dace Bērziņa, A. Speziale, Juan I. Arostegui Gorospe, Kelly L. Mieszkalski, Dawn M. Wahezi, S. Davì, Radoslav Srp, Daniel J. Kingsbury, Alexei A Grom, Falcini Fernanda, Peng Yin, Claire T. Deakin, Eva Hlavackova, Pavla Doležalová, Maria Mercedes Picarelli, Ezgi D. Batu, Alessandra Tricarico, Soamarat Vilaiyuk, Ivan Costa-Filho, A. Civino, Lukas Hackl, Pilar Gomez, Michael Hofer, M Manuela Costa, Zbigniew Zuber, Elena Ligostaeva, Carlos D. Rose, Jozef Hoza, Pranoot Tanpaiboon, Bonnie Vlahos, Sandra Garrote Corral, Martina Finetti, Giedre Grigelioniene, Susanne M. Benseler, X Wei, Pieter Van Dijkhuizen, Lee Nelson, Elettra Santori, David Martino, Anju Gupta, Nuray Aktay Ayaz, Noa Rabinowicz, Susan Shenoi, Rachel Chiaroni-Clarke, Claudia Bracaglia, Ruhan Düşünsel, M. Hofer, Rolando Cimaz, Juan I. Aróstegui, Ana Filipa Mourão, Ivonne Arroyo, Laura Damian, Marco F. C. D. Silva, D. J. Lovell, Marta Torcoletti, Clara Malagón, Luisa Klotz, Krisztina Sevcic, Douglas Veale, Belen Serrano Benavente, N. Groot, Polyxeni Pratsidou, Nicole Johnson, Karen Wynne, SR Rodionovskaya, Melania Saifridova, Kaara Tiewsoh, Ryan F. Donnelly, Fernanda Falcini, Valérie Badot, M. G. Alpigiani, L. Breda, Farida Abduragimova, Veronika Gjertsen Rypdal, Sophie Hambleton, E. Chalom, Anna Horne, Antonio Novelli, O. Kostareva, Panagiotis Tziavas, Yara Barrense-Dias, Cecilia Bava, Sarah Ringold, William H. Robinson, Sirirat Charuvanij, D. Kingsbury, Shuichi Ito, Luiz A. A. Pereira, Marcus Herbert Jones, S. I. Valieva, Flavio Sztajnbok, Florence Guilhot, Cristina de Min, Adriana Diaz-Maldonado, Simone A. Lotufo, Beril Talim, M. Heinrich, Paul Newland, and Laura Pagani

Subjects
030203 arthritis & rheumatology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, Rheumatology, business.industry, 030220 oncology & carcinogenesis, Family medicine, Pediatrics, Perinatology and Child Health, medicine, Immunology and Allergy, business, Paediatric rheumatology
Published
2017

16. Science beyond fiction? Ansprüche und Wirkungen von EU-Flagship-Projekten

Author

Britta Schinzel

Subjects
Political science, Humanities
Abstract

Zur Eroffnung der Konferenz FET09 in Prag verkundete die EU-Kommissarin fur Informationsgesellschaft und Medien, Viviane Reding, 2009, dass die EU-Kommission sehr viel mehr in den Bereich der Future and Emerging Technologies (FET), in „Science beyond Fiction“, investieren wolle, damit Europa gegenuber den USA, China und Japan aufholen und weltweit die fuhrende Rolle in der Grundlagenforschung zu Informations- und Kommunikationstechnik (ICT) einnehmen solle [1]. Im Folgenden sollen die Projekte, die personlichkeitsrechtlich von hoher Relevanz sind und neue Dimensionen von Big Data aufzeigen, naher betrachtet werden.

Published
2014

17. An unexpected finding: younger fathers have a higher risk for offspring with chromosomal aneuploidies

Author

Albert Schinzel, Oliver Kundert, Dunja Niedrist, Kaspar Rufibach, Mariluce Riegel, Rahim Masood, Bernhard Steiner, University of Zurich, and Steiner, Bernhard

Subjects
Adult, Male, 2716 Genetics (clinical), Down syndrome, medicine.risk_factor, Adolescent, Trisomy 13 Syndrome, 10039 Institute of Medical Genetics, Offspring, Population, Mothers, 610 Medicine & health, Chromosome Disorders, Trisomy, Biology, Logistic regression, Article, Paternal Age, Odds, Fathers, Young Adult, 1311 Genetics, Risk Factors, Genetics, medicine, Humans, Young adult, Paternal age effect, education, Genetics (clinical), Demography, Retrospective Studies, education.field_of_study, Chromosomes, Human, Pair 13, Middle Aged, Aneuploidy, medicine.disease, Logistic Models, 570 Life sciences, biology, Female, Down Syndrome, Chromosomes, Human, Pair 18, Switzerland, Trisomy 18 Syndrome, Maternal Age
Abstract

The past decades have seen a remarkable shift in the demographics of childbearing in Western countries. The risk for offspring with chromosomal aneuploidies with advancing maternal age is well known, but most studies failed to demonstrate a paternal age effect. Retrospectively, we analyzed two case data sets containing parental ages from pre- and postnatal cases with trisomies 21, 13 and 18. The reference data set contains the parental ages of the general Swiss population. We dichotomized all couples into two distinct groups. In the first group, the mothers' integral age was as least as the father's age or older. We compared the frequency of cases in nine 5-year intervals of maternal age. In addition, we computed logistic regression models for the binary endpoint aneuploidy yes/no where paternal ages were incorporated as linear or quadratic, as well as smooth functions within a generalized additive model framework. We demonstrated that the proportion of younger fathers is uniformly different between cases and controls of live-born trisomy 21 as well, although not reaching significance, for fetuses over all mother's ages. Logistic regression models with different strategies to incorporate paternal ages confirmed our findings. The negative paternal age effect was also found in pre- and postnatal cases taken together with trisomies 13 and 18. The couples with younger fathers face almost twofold odds for a child with Down syndrome (DS). We estimated odds curves for parental ages. If confirmation of these findings can be achieved, the management of couples at risk needs a major correction of the risk stratification.

Published
2014

18. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling

Author

Matthew R. Strickland, Anna C. Schinzel, William C. Hahn, Shambhavi Singh, Susan Moody, Zhigang C. Wang, Sapana R. Thomas, L. Luo, Jesse S. Boehm, So Young Kim, and Francesca Izzo

Subjects
Cancer Research, Receptor, ErbB-2, medicine.medical_treatment, bcl-X Protein, PIM1, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Biology, Antibodies, Monoclonal, Humanized, Lapatinib, Article, Targeted therapy, Open Reading Frames, Phosphatidylinositol 3-Kinases, breast cancer, Breast cancer, Proto-Oncogene Proteins c-pim-1, HER2, Genetics, medicine, Humans, Phosphorylation, skin and connective tissue diseases, Protein Kinase Inhibitors, neoplasms, Molecular Biology, PI3K/AKT/mTOR pathway, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits, drug resistance, Kinase, Gene Expression Profiling, Cancer, Trastuzumab, medicine.disease, 3. Good health, PRKACA, HEK293 Cells, Drug Resistance, Neoplasm, Quinazolines, Cancer research, Female, bcl-Associated Death Protein, Mitogen-Activated Protein Kinases, medicine.drug
Abstract

Targeting HER2 with antibodies or small molecule inhibitors in HER2-positive breast cancer leads to improved survival, but resistance is a common clinical problem. To uncover novel mechanisms of resistance to anti-HER2 therapy in breast cancer, we performed a kinase open reading frame screen to identify genes that rescue HER2-amplified breast cancer cells from HER2 inhibition or suppression. In addition to multiple members of the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) signaling pathways, we discovered that expression of the survival kinases PRKACA and PIM1 rescued cells from anti-HER2 therapy. Furthermore, we observed elevated PRKACA expression in trastuzumab-resistant breast cancer samples, indicating that this pathway is activated in breast cancers that are clinically resistant to trastuzumab-containing therapy. We found that neither PRKACA nor PIM1 restored MAPK or PI3K activation after lapatinib or trastuzumab treatment, but rather inactivated the pro-apoptotic protein BAD, the BCl-2-associated death promoter, thereby permitting survival signaling through BCL-XL. Pharmacological blockade of BCL-XL/BCL-2 partially abrogated the rescue effects conferred by PRKACA and PIM1, and sensitized cells to lapatinib treatment. These observations suggest that combined targeting of HER2 and the BCL-XL/BCL-2 anti-apoptotic pathway may increase responses to anti-HER2 therapy in breast cancer and decrease the emergence of resistant disease.

Published
2014

19. Results of the first performance tests * of the CMS electromagnetic calorimeter

Author

N. Zamiatin, Anna Elliott-Peisert, I. Yaselli, G. Dewhirst, Tiziano Camporesi, P. Chang, R. Gomez-Reino, Jordan Nash, N. G. Redaelli, Zeljko Antunovic, Frixos A Triantis, C. Gargiulo, P. Miné, Dieter Renker, Petar Adzic, A. M. Gaillac, S. Shevchenko, M. E. Zeller, A. Nardulli, Michael Dittmar, Bernard Ille, O. Ravat, Viktor Matveev, Konrad Deiters, Alessio Ghezzi, J. D. Swain, Y. Geerebaert, H. Mathez, D. Holmes, I. Semeniouk, P. Bordalo, S. Udriot, David Ja Cockerill, Florian Beaudette, A. Asimidis, Marcella Diemoz, S. K. Dhawan, Wolfgang Funk, Roger Rusack, Nikola Godinovic, J. M. Reymond, Ren-Yuan Zhu, J. A. Hill, Paolo Meridiani, George Wei-Shu Hou, Patrick Jarry, T. Sakhelashvili, P. S. Flower, Jean-Louis Faure, Luciano Barone, K. Ueno, Nadia Pastrone, Alison Lister, Riccardo Paramatti, B. W. Kennedy, M. Hansen, J. Grahl, Federico Ferri, H. El Mamouni, Marco Paganoni, M. Haguenauer, J. Gilly, F. Rondeaux, I. Mandjavidze, Christopher Seez, Claire Shepherd-Themistocleous, Michel Raymond, Elizabeth Locci, P. Vichoudis, P. Negri, Patrick Janot, M. J. Bercher, Remi Chipaux, M. Bonesini, J. Ehlers, A. De Min, M. C. Lemaire, S. Drndarevic, A. Tcheremoukhine, Ioannis Papadopoulos, R. Beuselinck, Isabel C. Teixeira, A. Singovski, K. W. Bell, J. Puzović, Pierre Lecomte, Georgios Anagnostou, G. Sidiropoulos, S. Gascon Shotkin, E. A. Chen, D. Schinzel, J. P. Guillaud, Cristina Biino, B. Fabbro, Harvey B Newman, Egidio Longo, J. Greenhalgh, Ivica Puljak, R. Alemany-Fernandez, H. Rykaczewski, S. Ramos, L. Djambazov, Giovanni Organtini, B. Smith, Carlos Almeida, G. Franzoni, Werner Lustermann, R. Bruneliere, André Holzner, A. B. Lodge, P. Gras, T. Tabarelli de Fatis, Demetrios Loukas, D. Krpic, S. Blyth, R. J. Tapper, R. Salerno, Jean Fay, G. Viertel, Y. H. Chang, A. Pullia, Sergey Troshin, Meng Wang, C. Combaret, S. Baccaro, N. Krasnikov, A. Markou, M. Mur, Ivan Anicin, M. Lebeau, N. Regnault, P. Sharp, W. T. Lin, A.L. Lintern, S. Costantini, P. Sempere Roldan, R. Della Negra, Francesca Nessi-Tedaldi, M. Dupanloup, C. Rovelli, Q. Ingram, P. Busson, Adolf Bornheim, S. K. Kataria, Ioannis Evangelou, J. C. da Silva, S. N. Gninenko, David Barney, Stephanie Beauceron, Nikolay Tyurin, E. Menichetti, Alain Givernaud, Stefano Ragazzi, M. Sproston, G. Hamel de Montechenault, B. L. Betev, H. Suter, André Rosowsky, Morgan Lethuillier, M. Montecchi, Alexander Nikitenko, T. Romanteau, M. J. Ryan, O. Teller, M. Reynaud, N. Almeida, S. Reynaud, O. Sharif, Predrag Milenovic, Peter R Hobson, J. Bourotte, R. M. Brown, Pietro Govoni, Pascal Paganini, L. Dobrzynski, Marc Dejardin, Yves Sirois, I. van Vulpen, Paul Lecoq, Panos A Razis, N. Vaz Cardoso, D. Chamont, Albert M. Sirunyan, M. Santos, Aristotelis Kyriakis, A. S. Giolo-Nicollerat, R. Benetta, Francesca Cavallari, Kostas Kloukinas, P. Bloch, G. Milleret, S. Bimbot, A. Bartoloni, João Paulo Teixeira, Joao Varela, M. Dzelalija, D. Sillou, Pierre Depasse, Andrey Uzunian, H. A. Neal, Yuri Musienko, G. Davatz, F. X. Gentit, Catherine Kirsty Mackay, S. Reucroft, Günther Dissertori, M. Anfreville, A. Go, John Rander, J. H. Williams, A. Jain, Felicitas Pauss, Maiko Takahashi, P. Barrillon, P. Verrecchia, Dave Britton, K. Zhu, Panagiotis Kokkas, C. Lynch, M. Korjik, V. Katchanov, Vincent J Smith, Nikolaos Manthos, Nicolo Cartiglia, Claude Charlot, Ashutosh Bhardwaj, R. K. Shivpuri, L. Y. Zhang, Georgios Daskalakis, D. Maletic, S. V. Rusakov, M. A. Karar, B. Koblitz, G. Maurelli, N. Golubev, P. Nedelec, Helen F Heath, I. Dafinei, J. Descamp, Tejinder Virdee, S. Zelepoukine, Etiennette Auffray, R. Ofierzynski, C. Collard, P. Poilleux, M. M. Obertino, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), (ukupan broj autora: 246), Adzic, P, Alemany Fernandez, R, Almeida, C, Almeida, N, Anagnostou, G, Anfreville, M, Anicin, I, Antunovic, Z, Asimidis, A, Auffray, E, Baccaro, S, Barney, D, Barone, L, Barrillon, P, Bartoloni, A, Beauceron, S, Beaudette, F, Bell, K, Benetta, R, Bercher, M, Betev, B, Beuselinck, R, Bhardwaj, A, Biino, C, Bimbot, S, Bloch, P, Blyth, S, Bonesini, M, Bordalo, P, Bornheim, A, Bourotte, J, Britton, D, Brown, R, Bruneliere, R, Busson, P, Camporesi, T, Cartiglia, N, Cavallari, F, Chamont, D, Chang, P, Chang, Y, Charlot, C, Chen, E, Chipaux, R, Cockerill, D, Collard, C, Combaret, C, Costantini, S, Da Silva, J, Dafinei, I, Daskalakis, G, Davatz, G, De Min, A, Deiters, K, Dejardin, M, Della Negra, R, Depasse, P, Descamp, J, Dewhirst, G, Dhawan, S, Diemoz, M, Dissertori, G, Dittmar, M, Djambazov, L, Dobrzynski, L, Drndarevic, S, Dupanloup, M, Dzelalija, M, Ehlers, J, El Mamouni, H, Elliott Peisert, A, Evangelou, I, Fabbro, B, Faure, J, Fay, J, Ferri, F, Flower, P, Franzoni, G, Funk, W, Gaillac, A, Gargiulo, C, Gascon Shotkin, S, Geerebaert, Y, Gentit, F, Ghezzi, A, Gilly, J, Giolo Nicollerat, A, Givernaud, A, Gninenko, S, Go, A, Godinovic, N, Golubev, N, Gomez Reino, R, Govoni, P, Grahl, J, Gras, P, Greenhalgh, J, Guillaud, J, Haguenauer, M, Hamel De Monchenault, G, Hansen, M, Heath, H, Hill, J, Hobson, P, Holmes, D, Holzner, A, Hou, G, Ille, B, Ingram, Q, Jain, A, Janot, P, Jarry, P, Karar, A, Kataria, S, Kachanov, V, Kennedy, B, Kloukinas, K, Koblitz, B, Kokkas, P, Korzhik, M, Krasnikov, N, Krpic, D, Kyriakis, A, Lebeau, M, Lecomte, P, Lecoq, P, Lemaire, M, Lethuillier, M, Lin, W, Lintern, A, Lister, A, Locci, E, Lodge, A, Longo, E, Loukas, D, Lustermann, W, Lynch, C, Mackay, C, Maletic, D, Mandzhavidze, I, Manthos, N, Markou, A, Mathez, H, Matveev, V, Maurelli, G, Menichetti, E, Meridiani, P, Milenovic, P, Milleret, G, Mine, P, Montecchi, M, Mur, M, Musienko, Y, Nardulli, A, Nash, J, Neal, H, Nedelec, P, Negri, P, Nessi Tedaldi, F, Newman, H, Nikitenko, A, Obertino, M, Ofierzynski, R, Organtini, G, Paganini, P, Paganoni, M, Papadopoulos, I, Paramatti, R, Pastrone, N, Pauss, F, Poilleux, P, Puljak, I, Pullia, A, Puzovic, J, Ragazzi, S, Ramos, S, Rander, J, Ravat, O, Raymond, M, Razis, P, Redaelli, N, Regnault, N, Renker, D, Reucroft, S, Reymond, J, Reynaud, M, Reynaud, S, Romanteau, T, Rondeaux, F, Rosowsky, A, Rovelli, C, Rusack, R, Rusakov, S, Ryan, M, Rykaczewski, H, Sakhelashvili, T, Salerno, R, Santos, M, Schinzel, D, Seez, C, Semenyuk, I, Sempere Roldan, P, Sharif, O, Sharp, P, Shepherd Themistocleous, C, Shevchenko, S, Shivpuri, R, Sidiropoulos, G, Sillou, D, Singovski, A, Sirois, Y, Sirunian, A, Smith, B, Smith, V, Sproston, M, Suter, H, Swain, J, TABARELLI DE FATIS, T, Takahashi, M, Tapper, R, Cheremukhin, A, Teixeira, I, Teixeira, J, Teller, O, Triantis, F, Troshin, S, Tyurin, N, Udriot, S, Ueno, K, Uzunian, A, Van Vulpen, I, Varela, J, Vaz Cardoso, N, Verrecchia, P, Vichoudis, P, Viertel, G, Virdee, T, Wang, M, Williams, J, Yaselli, I, Zamyatin, N, Zelepukin, S, Zeller, M, Zhang, L, Zhu, K, Zhu, R, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Laboratoire d'Annecy de Physique des Particules (LAPP)

Subjects
Physics, Photomultiplier, Large Hadron Collider, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Nuclear engineering, 01 natural sciences, 7. Clean energy, Particle detector, calorimetry, lead tungstate, scintillator, Background noise, Nuclear physics, Noise, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Measuring instrument, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Engineering (miscellaneous), Low voltage, Energy (signal processing)
Abstract

Performance tests of some aspects of the CMS ECAL were carried out on modules of the "barrel" sub-system in 2002 and 2003. A brief test with high energy electron beams was made in late 2003 to validate prototypes of the new Very Front End electronics. The final versions of the monitoring and cooling systems, and of the high and low voltage regulation were used in these tests. The results are consistent with the performance targets including those for noise and overall energy resolution, required to fulfil the physics programme of CMS at the LHC. ISSN:1434-6044 ISSN:1434-6052

Published
2006

20. Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling

Author

Asadollahi, Reza, primary, Strauss, Justin E, additional, Zenker, Martin, additional, Beuing, Oliver, additional, Edvardson, Simon, additional, Elpeleg, Orly, additional, Strom, Tim M, additional, Joset, Pascal, additional, Niedrist, Dunja, additional, Otte, Christine, additional, Oneda, Beatrice, additional, Boonsawat, Paranchai, additional, Azzarello-Burri, Silvia, additional, Bartholdi, Deborah, additional, Papik, Michael, additional, Zweier, Markus, additional, Haas, Cordula, additional, Ekici, Arif B, additional, Baumer, Alessandra, additional, Boltshauser, Eugen, additional, Steindl, Katharina, additional, Nothnagel, Michael, additional, Schinzel, Albert, additional, Stoeckli, Esther T, additional, and Rauch, Anita, additional

Published
2018
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21. On certain biquadratic equations

Author

Mariusz Skałba and Andrzej Schinzel

Subjects
Algebra, Mathematics(all), Mathematics::Number Theory, General Mathematics, Condensed Matter::Statistical Mechanics, Mathematics::Metric Geometry, Condensed Matter::Strongly Correlated Electrons, Prime (order theory), Mathematics
Abstract

It is proved that if certain biquadratic equations with a prime parameter and four unknowns have a non-trivial solution in the integers, then they have infinitely many such solutions.

Published
2013

22. Weltbilder und Bilder der Informatik

Author

Britta Schinzel

Subjects
media_common.quotation_subject, Art, Humanities, Computer Science Applications, Information Systems, media_common
Abstract

In der Einleitung wurde der Weltbildbegriff ganz allgemein beschrieben, hier nun wird er fur die genannten Ziele der Untersuchung operationalisiert. Es erscheint plausibel, dass Technik- und Menschenbilder dafur relevant sind, auch das Bild der Informatik selbst. Erklarungsbedurftig konnte sein, dass wir auch die Wirklichkeitsauffassung der Studierenden fur wichtig erachtet haben, und zwar deshalb, weil die Informatik Ausschnitte der Realitat erfasst, um sie mit einer erwunschten Problemlosung zu verandern. Die Antworten der Studierenden zu all diesen Fragestellungen sind aufschlussreich, auch weil sie in nicht unmittelbar erwartbarer Weise mit den Fragen der spater behandelten Sekundarevaluation, wie Diversity, Geschlecht und Ethik zusammenhangen.

Published
2013

23. Diskussion der Ergebnisse und Resümee

Author

Britta Schinzel

Subjects
Computer science, Operating system, computer.software_genre, computer, Computer Science Applications, Information Systems
Published
2013

24. Wie lässt sich eine venöse Thromboembolie effektiv verhindern?

Author

H. Schinzel

Subjects
Drug, medicine.medical_specialty, business.industry, Guideline adherence, media_common.quotation_subject, MEDLINE, Cancer, General Medicine, Heparin, medicine.disease, X ray computed, Internal medicine, medicine, In patient, business, Venous thromboembolism, media_common, medicine.drug
Published
2012

25. Programming human pluripotent stem cells into white and brown adipocytes

Author

Tony Shen, Rahul C. Deo, Robert E. Gerszten, Clary B. Clish, Jennifer Shay, Greg Mowrer, Heba Al-Siddiqi, John L. Rinn, Kiran Musunuru, Chad A. Cowan, Fang Xia, Tim Ahfeldt, Youn-Kyoung Lee, Raymond Camahort, Matthias Nahrendorf, Robert T. Schinzel, Adam Kaplan, Alicia Cowley, David H. Lum, David G. Hendrickson, Eugene P. Rhee, and Frank H. Lau

Subjects
Pluripotent Stem Cells, Adipose Tissue, White, Cellular differentiation, Adipocytes, White, Transplantation, Heterologous, Adipose tissue, Biology, Mesenchymal Stem Cell Transplantation, Mice, Adipose Tissue, Brown, Brown adipose tissue, medicine, Animals, Cluster Analysis, Humans, Transgenes, Progenitor cell, Induced pluripotent stem cell, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, CCAAT-Enhancer-Binding Protein-beta, Gene Expression Profiling, Mesenchymal stem cell, Cell Differentiation, Mesenchymal Stem Cells, 3T3 Cells, Cell Biology, Immunohistochemistry, Cell biology, DNA-Binding Proteins, PPAR gamma, Endothelial stem cell, Adipocytes, Brown, HEK293 Cells, medicine.anatomical_structure, Stem cell, Transcription Factors
Abstract

The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human pluripotent stem cells into white or brown adipocytes. We found that inducible expression of PPARG2 alone or combined with CEBPB and/or PRDM16 in mesenchymal progenitor cells derived from pluripotent stem cells programmed their development towards a white or brown adipocyte cell fate with efficiencies of 85%-90%. These adipocytes retained their identity independent of transgene expression, could be maintained in culture for several weeks, expressed mature markers and had mature functional properties such as lipid catabolism and insulin-responsiveness. When transplanted into mice, the programmed cells gave rise to ectopic fat pads with the morphological and functional characteristics of white or brown adipose tissue. These results indicate that the cells could be used to faithfully model human disease.

Published
2012

26. Paternal meiotic origin of der(21;21)(q10;q10) mosaicism [46,XX/46,XX,der(21;21)(q10;q10),+21] in a girl with mild Down syndrome

Author

Albert Schinzel, Dieter Kotzot, University of Zurich, and Schinzel, Albert

Subjects
Genetic Markers, Male, 2716 Genetics (clinical), Down syndrome, 10039 Institute of Medical Genetics, isochromosome, translocation, 610 Medicine & health, Chromosome Disorders, Biology, 1311 Genetics, Meiosis, Pregnancy, Age Determination by Skeleton, Genetics, medicine, Humans, Child, Mitosis, In Situ Hybridization, Fluorescence, Genetics (clinical), Chromosome Aberrations, Zygote, Mosaicism, Infant, Newborn, Infant, Chromosome, Karyotype, medicine.disease, Pedigree, trisomy 21, Karyotyping, 570 Life sciences, biology, Female, Down Syndrome, Trisomy, Chromosome 21
Abstract

Mosaicism for a derivative 21, der(21;21)(q10;q10), is a rare chromosomal abnormality. Since a normal cell line is present, mitotic origin is considered. Chromosome examination of a female with developmental delay and dysmorphic features compatible with mosaic trisomy 21 revealed a normal cell line and a second cell line with a der(21;21)(q10;q10) [46,XX/46,XX,der(21;21)(q10;q10),+21]. Molecular investigation with a panel of highly polymorphic microsatellites mapping to chromosome 21 demonstrated three different alleles, two of paternal and one of maternal origin. Therefore, either formation of the der(21;21)(q10;q10) during paternal meiosis with subsequent loss of the der(21;21)(q10;q10) and mitotic reduplication of the maternal homologue in the normal cell line, or more likely a zygote with paternally derived trisomy 21 and subsequent mitotic formation of the der(21;21)(q10;q10) have to be considered. This case again shows that mammalian chromosome aberrations may have a more complex mechanism of formation than was previously thought.

Published
2000

28. Control system design and test for cryogenic ground support equipment

Author

Xiang-bao Li, Liang Gong, Rui Ji, Dietrich Schinzel, and Yupu Yang

Subjects
Engineering, Multidisciplinary, Ground support equipment, Physics::Instrumentation and Detectors, business.industry, Nuclear engineering, Electrical engineering, chemistry.chemical_element, Superconducting magnet, chemistry, Operating temperature, Magnet, Control system, Control system design, business, Superfluid helium-4, Helium
Abstract

The cryogenic ground support equipment (CGSE) is an important part of Alpha Magnetic Spectrometer-02 (AMS-02) experiment which is a particle physics experiment. CGSE is used to cool down the superconducting magnet of AMS-02 to its operating temperature of 1.8K and to fill the magnet helium tank with superfluid helium. This paper introduces the control system of CGSE and presents the performance of the system.

Published
2011

29. Pericentric inversion of chromosome 18 in parents leading to a phenotypically normal child with segmental uniparental disomy 18

Author

Azadeh Moshtagh, Eva Wey, Albert Schinzel, Roxana Kariminejad, Stefan Neuenschwander, Ariana Kariminejad, Mohammad Hassan Kariminejad, Maryam Zanganeh, Alessandra Baumer, Michal J. Okoniewski, University of Zurich, and Kariminejad, A

Subjects
Male, 2716 Genetics (clinical), congenital, hereditary, and neonatal diseases and abnormalities, Derivative chromosome, 10039 Institute of Medical Genetics, 610 Medicine & health, 10071 Functional Genomics Center Zurich, Consanguinity, Biology, Article, 1311 Genetics, Chromosome 18, Genetics, medicine, Humans, Child, In Situ Hybridization, Fluorescence, Genetics (clinical), Chromosomal inversion, Pregnancy, Chromosome, Uniparental Disomy, medicine.disease, Uniparental disomy, Pedigree, Child, Preschool, Chromosome Inversion, dup, 570 Life sciences, biology, Female, Chromosomes, Human, Pair 18
Abstract

In this study, we report a familial inversion of chromosome 18, inv(18)(p11.31q21.33), in both members of a consanguineous couple. Their first child had inherited one balanced pericentric inversion along with a recombinant chromosome 18 resulting in dup(18q)/del(18p), and had mild dysmorphic features in the absence of mental and developmental retardation. The second child had received two recombinant chromosomes 18, from the mother a derivative chromosome 18 with dup(18p)/del(18q) and from the father a derivative chromosome 18 with dup(18q)/del(18p). The aberration was prenatally detected; however, as the two opposite aneuploidies were thought to compensate each other, the family decided to carry on with the pregnancy, knowing that uniparental disomy for the segments outside the inversion could have an adverse influence on the development of the child. Uniparental disomy was confirmed by SNP arrays. The child, who has been followed up until the age of 20 months, is healthy and normal. It seems to be the first reported case with two opposite recombinant chromosomes that compensate each other and lead to segmental uniparental disomy for two segments on the chromosome, one maternal and the other paternal.

Published
2011

30. Multiplicative properties of sets of positive integers

Author

Andrzej Schinzel, Lajos Hajdu, and Mariusz Skałba

Subjects
Discrete mathematics, General Mathematics, Multiplicative function, Dirichlet density, Square (algebra), Set (abstract data type), symbols.namesake, Természettudományok, Product (mathematics), symbols, Dirichlet's theorem on arithmetic progressions, Matematika- és számítástudományok, Well-ordering principle, Mathematics
Abstract

It is proved that every set of positive integers with upper Dirichlet density greater than 1/2 contains three distinct elements whose product is a square. Several similar problems are considered.

Published
2009

31. BCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects

Author

Florence Dastot-Le-Moal, Pierre Bitoun, Kathreen Johnston, François-Guillaume Debray, Nobuhiko Okamoto, Beverly N. Hay, Jennifer J. Johnston, Leslie G. Biesecker, Chiharu Torii, Odile Boute, Marion Gérard, Josiane Martin, Sylvie Manouvrier, Rahat Perveen, Michel Goossens, Hiroshi Kohara, Emma Hilton, Kenjiro Kosaki, Anthony T. Moore, Graeme C.M. Black, Michael Lyons, Yoshikazu Hatsukawa, David R. FitzPatrick, Irina Giurgea, Johannes Lemke, Juntaro Nishio, John W. Belmont, Deborah Bartholdi, Sandra Whalen, Kim Jenny, Caroline J Law, Albert Schinzel, Seiji Mizuno, Tanya Bardakjian, Alain Verloes, Florence Fellmann, and Yoshiko Hirano

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Heart Diseases, BCL-6 Corepressor, medicine.disease_cause, Microphthalmia, Article, Cohort Studies, Intellectual Disability, Proto-Oncogene Proteins, Genetics, medicine, Animals, Humans, Microphthalmos, Genetics(clinical), Eye Abnormalities, Allele, Child, Alleles, Genetics (clinical), Aged, Mutation, business.industry, Infant, Newborn, Genetic Diseases, X-Linked, Syndrome, Middle Aged, medicine.disease, Phenotype, eye diseases, Repressor Proteins, Developmental disorder, Lenz microphthalmia syndrome, Child, Preschool, Female, Oculofaciocardiodental syndrome, business
Abstract

Oculofaciocardiodental (OFCD) and Lenz microphthalmia syndromes form part of a spectrum of X-linked microphthalmia disorders characterized by ocular, dental, cardiac and skeletal anomalies and mental retardation. The two syndromes are allelic, caused by mutations in the BCL-6 corepressor gene (BCOR). To extend the series of phenotypes associated with pathogenic mutations in BCOR, we sequenced the BCOR gene in patients with (1) OFCD syndrome, (2) putative X-linked (‘Lenz') microphthalmia syndrome, (3) isolated ocular defects and (4) laterality phenotypes. We present a new cohort of females with OFCD syndrome and null mutations in BCOR, supporting the hypothesis that BCOR is the sole molecular cause of this syndrome. We identify for the first time mosaic BCOR mutations in two females with OFCD syndrome and one apparently asymptomatic female. We present a female diagnosed with isolated ocular defects and identify minor features of OFCD syndrome, suggesting that OFCD syndrome may be mild and underdiagnosed. We have sequenced a cohort of males diagnosed with putative X-linked microphthalmia and found a mutation, p.P85L, in a single case, suggesting that BCOR mutations are not a major cause of X-linked microphthalmia in males. The absence of BCOR mutations in a panel of patients with non-specific laterality defects suggests that mutations in BCOR are not a major cause of isolated heart and laterality defects. Phenotypic analysis of OFCD and Lenz microphthalmia syndromes shows that in addition to the standard diagnostic criteria of congenital cataract, microphthalmia and radiculomegaly, patients should be examined for skeletal defects, particularly radioulnar synostosis, and cardiac/laterality defects.

Published
2009

32. Isochromosomes 12p and 9p: parental origin and possible mechanisms of formation

Author

Alessandra Baumer, Albert Schinzel, Franz Binkert, Fabrizio Dutly, Damina Balmer, University of Zurich, and Schinzel, Albert

Subjects
Adult, Male, Proband, 2716 Genetics (clinical), 10039 Institute of Medical Genetics, tetrasomy, Isochromosome, 610 Medicine & health, Biology, Loss of heterozygosity, Fetus, 1311 Genetics, isochromosome 9p, Gene duplication, Genetics, medicine, Humans, Allele, Genetics (clinical), Chromosomes, Human, Pair 12, Meiosis II, medicine.disease, Pedigree, Isochromosomes, Nondisjunction, Child, Preschool, isochromosome 12p, 570 Life sciences, biology, Tetrasomy 9p, Chromosomes, Human, Pair 9
Abstract

In a recent study Bugge et al and Kotzot et al reported that isochromosomes 18p originate mainly from maternal meiosis II nondisjunction, followed by misdivision. In order to determine if there is a common mechanism for isochromosome formation, three cases with mosaicism for an additional isochromosome 12p and three cases with tetrasomy 9p were studied. Two probands with isochromosomes 12p and the three cases with isochromosome 9p showed 3 alleles (two different maternal alleles and one paternal allele) at several loci mapping to distal 12p and 9p, respectively. Maternal heterozygosity for distal markers was reduced to homozygosity for markers closer to the centromere in both i(12p) cases and in one i(9p) case. For one patient with isochromosome 12p, the maternal band was clearly stronger than the paternal one at some loci, but two distinct maternal alleles were never seen. For one foetus and the patient with tetrasomy 9p, distal markers showed maternal heterozygosity. All proximal markers were not informative in these two i(9p) cases. Our findings indicate common features in different autosomal isochromosomes: the origin of the isochromosomes analysed in predominantly maternal; and a common mechanism appears to underlie their formation, namely due to meiosis II nondisjunction followed by a rearrangements leading to duplication of the short and loss of the long arm.

Published
1998

33. Structure and electron paramagnetic resonance parameters of the manganese site of concanavalin A studied by density functional methods

Author

Robert Müller, Martin Kaupp, and Sandra Schinzel

Subjects
Proton, Ligand, chemistry.chemical_element, Manganese, Hybrid functional, law.invention, Bond length, Nuclear magnetic resonance, chemistry, law, Physical chemistry, Density functional theory, Physical and Theoretical Chemistry, Electron paramagnetic resonance, Hyperfine structure
Abstract

The EPR parameters of the manganese site in the saccharide-binding protein concanavalin A have been studied by density functional methods, with an emphasis on metal (55Mn) and ligand (1H and 17O) hyperfine couplings, in comparison with high-field EPR and ENDOR data. Results for gradient-corrected and hybrid functionals with different exact-exchange admixture have been compared with experiment for the 55Mn and the 1H ligand hyperfine coupling and have been predicted for 17O hyperfine coupling based on comparison with experiment for the related [Mn(H2O)6]2+. Appreciable exact-exchange admixture in the hybrid functional is needed to obtain an adequate spin-density distribution and thus near-quantitative agreement with experimental EPR parameters. The common use of experimental proton hyperfine coupling tensors together with the point-dipole approximation for determination of bond lengths is evaluated by explicit calculations.

Published
2008

34. Correction: Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Author

Day, Tovah A., primary, Layer, Jacob V., additional, Cleary, J. Patrick, additional, Guha, Srijoy, additional, Stevenson, Kristen E., additional, Tivey, Trevor, additional, Kim, Sunhee, additional, Schinzel, Anna C, additional, Izzo, Francesca, additional, Doench, John, additional, Root, David E., additional, Hahn, William C., additional, Price, Brendan D., additional, and Weinstock, David M., additional

Published
2017
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35. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Author

Day, Tovah A., primary, Layer, Jacob V., additional, Cleary, J. Patrick, additional, Guha, Srijoy, additional, Stevenson, Kristen E., additional, Tivey, Trevor, additional, Kim, Sunhee, additional, Schinzel, Anna C., additional, Izzo, Francesca, additional, Doench, John, additional, Root, David E., additional, Hahn, William C., additional, Price, Brendan D., additional, and Weinstock, David M., additional

Published
2017
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36. Who is a ‘healthy subject’?—consensus results on pivotal eligibility criteria for clinical trials

Author

Breithaupt-Groegler, Kerstin, primary, Coch, Christoph, additional, Coenen, Martin, additional, Donath, Frank, additional, Erb-Zohar, Katharina, additional, Francke, Klaus, additional, Goehler, Karin, additional, Iovino, Mario, additional, Kammerer, Klaus Peter, additional, Mikus, Gerd, additional, Rengelshausen, Jens, additional, Sourgens, Hildegard, additional, Schinzel, Reinhard, additional, Sudhop, Thomas, additional, and Wensing, Georg, additional

Published
2017
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38. Self-inversive polynomials of odd degree

Author

László Losonczi and Andrzej Schinzel

Subjects
Combinatorics, Discrete mathematics, Polynomial, Algebra and Number Theory, Number theory, Unit circle, Degree (graph theory), Inversive, Mathematics
Abstract

If the coefficients of a self-inversive polynomial P(z)=∑ k=0 m A k z k ∈ℂ[z] of odd degree m≥3 satisfy the inequality $$|A_{m}|\ge \cos \frac{\pi }{2(m+1)}\inf_{\scriptstyle{c,d\in\mathbb{C}}\atop\scriptstyle{|d|=1}}\sum _{k=0}^{m}|cA_{k}-d^{m-k}A_{m}|,$$ then all zeros of P are on the unit circle and they are simple.

Published
2007

39. The body in medical imaging between reality and construction

Author

Britta Schinzel

Subjects
Cognitive systems, Computer science, business.industry, General Engineering, Medical imaging, General Social Sciences, Artificial intelligence, Medical diagnosis, business, Constructive, Living body, Wonder, Cognitive psychology
Abstract

Medical imaging has provided insight into the living body that were not possible beforehand. With these methods a revolution in medical diagnosis and biomedical research has begun. Problematic aspects on the other hand are arising from the highly constructive properties of image production, which use complicated physical and physiological effects. Images are established via highly complicated combinations of technology and contingently chosen mathematical and algorithmic solutions. In addition, image construction follows properties of the human visual and cognitive system to allow for the discrimination of the desired categories. It is no wonder that the visualizations referring to the body also show effects which have no physiological correlation within the body. Still such images are often used as if they were one-to-one correlates of the body. This has impacts, e.g. for their use as standardizing instances, resulting in new definitions of the normed healthy body, sickness or pathologies, maleness and femaleness and in determinisms as opposed to the brain’s plasticity and variability, both in time and space, inter- as well as intra-individually.

Published
2006

40. Die akute heparininduzierte Thrombozytopenie Typ II während der Schwangerschaft

Author

M. A. von Mach, H. Schinzel, J. Wiechelt, D. Macciella, and D. Peetz

Subjects
Gynecology, medicine.medical_specialty, business.industry, Emergency Medicine, medicine, Emergency Nursing, Critical Care and Intensive Care Medicine, business
Abstract

Bei der heparininduzierten Thrombozytopenie Typ II (HIT II) handelt es sich um eine antikorpervermittelte unerwunschte Heparinnebenwirkung. Sie ist charakterisiert durch einen Abfall der Thrombozyten bei gleichzeitig stark erhohtem Risiko fur arterielle und v. a. venose Thromboembolien. Abhangig von der Grose und Lokalisation der Thromboembolie, den Grund- und Begleiterkrankungen kann rasch eine vital bedrohliche Situation entstehen. In der Schwangerschaft und im Wochenbett stellt die HIT Typ II ein seltenes Ereignis dar, da Heparin in der Graviditat nur bei akuten Thromboembolien bzw. bei Patientinnen mit deutlich erhohtem Thromboembolierisiko appliziert wird. Auch durch die in den letzten Jahren zunehmende Verwendung von niedermolekularen Heparinen (NMH), anstelle unfraktionierter Heparine (UFH), ist die HIT-II-Inzidenz insgesamt rucklaufig. Das Auftreten einer heparininduzierten Thrombozytopenie Typ II stellt in der Schwangerschaft eine interdiziplinare Herausforderung dar. In der Graviditat und im Puerperium besteht physiologischerweise schon ein hyperkoagulabiler Zustand, der durch die mit der HIT-II-assoziierten vermehrten Thrombingenerierung die Entstehung von Thromboembolien zusatzlich begunstigt. Bereits bei Verdacht HIT Typ II muss das Heparin sofort abgesetzt und unverzuglich eine alternative Antikoagulation eingeleitet werden. Die Diagnosestellung der HIT Typ II ist in der Graviditat erschwert. So kann durch andere Ursachen ein Thrombozytenabfall induziert werden, wie beispielsweise durch ein sich entwickelndes HELLP-Syndrom, durch einen schwangerschaftsassozierten Progress einer idiopathischen thrombozytopenischen Purpura oder auch durch einen medikamententoxischen Effekt. Ferner ist die Objektivierung bei klinischem Thromboembolieverdacht durch die eingeschrankten diagnostischen Moglichkeiten in der Schwangerschaft begrenzt. Der Nachweis von HIT-Antikorpern alleine sichert nicht die Diagnose einer HIT II. In ca. 20% der Falle unter Therapie mit unfraktionierten Heparinen lassen sich positive HIT-Antkorper nachweisen ohne dass sich eine manifeste HIT Typ II entwickelt. Ein weiteres Problem bei diesem Kollektiv stellen die begrenzten Moglichkeiten und Erfahrungen mit der alternativen Antikoagulation wahrend der Graviditat dar. Die Erfahrungen bezuglich des unmittelbar peripartalen Antikoagulations- und Geburtsmanagements sind rudimentar. Die Gabe von Vitamin-K-Antagonisten (Kumarinderivate) ist v. a. in der Phase der Organogenese wegen der Gefahr von Fetopathien und in der 2. Halfte des dritten Trimenons wegen des erhohten maternalen und kindlichen intra- und peripartalen Blutungsrisikos nicht unproblematisch und nur unter strengsten Kautelen vertretbar. Auch sind Vitamin-K-Antagonisten nicht zur Akuttherapie geeignet, da ihr Wirkungseintritt zu langsam und damit in der Initialphase der akuten HIT II keine ausreichende Antikoagulation zu erzielen ist, wodurch das Risiko von Thromboembolien bzw. deren Progress erhoht wird. Das Heparinoid Danaparoid-Natrium und das rekombinante Hirudin (Lepirudin) stellen eine Alternativen dar, wobei wegen der besseren Datenlage und der intravenosen und insbesondere auch der subkutanen Applikationsform dem Danaparoid der Vorzug bei der Therapie HIT II in der Graviditat zu geben ist. Beide Substanzen sind zwar fur die akute Therapie der HIT II zugelassen, jedoch besteht fur keines der Praparate eine Zulassung zur HIT-II-Behandlung in der Schwangerschaft. Nach der Entbindung stellen die Vitamin-K-Antagonisten Warfarin oder Phenprocoumon die Therapie der Wahl dar. Die Umstellung sollte hierbei uberlappend erfolgen bis ein INR-Wert groser 2,0 erreicht ist. Stillen ist unter Vitamin K-Antagonisten moglich. Berichtet wird uber eine Patientin mit akuter Sinusvenenthrombose in der Fruhschwangerschaft und der Entwicklung einer HIT Typ II unter der darauf erfolgenden Heparintherapie. Das Management der Langzeit- und peripartalen Antikoagulation mit Danaparoid-Natrium wird dargestellt.

Published
2006

41. Self-Inversive Polynomials with All Zeros on the Unit Circle

Author

Andrzej Schinzel

Subjects
Polynomial, Pure mathematics, Algebra and Number Theory, Inversive, Gauss circle problem, Algebra, Generalised circle, symbols.namesake, Unit circle, Number theory, Fourier analysis, symbols, Minimum phase, Mathematics
Abstract

Conditions are given in the coefficients of a self-inversive polynomial under which all its zeros are on the unit circle.

Published
2005

42. On Vectors whose Span Contains a Given Linear Subspace

Author

Iskander Aliev, Wolfgang M. Schmidt, and Andrzej Schinzel

Subjects
Discrete mathematics, Combinatorics, General Mathematics, Product (mathematics), Span (engineering), Linear subspace, Orthogonalization, Mathematics, Integer (computer science)
Abstract

Estimates are given for the product of the lengths of integer vectors spanning a given linear subspace.

Published
2004

43. Softwareentwicklung als Profession?

Author

Esther Ruiz Ben and Britta Schinzel

Subjects
Political science, Humanities, Computer Science Applications, Information Systems
Abstract

Im Rahmen unserer DFG-Studie „Professionalisierung der Informatik in Deutschland. Chance oder Hindernis fur die Beteiligung von Frauen“ DFG Projekt Num. SPP 1042 SCHI 316-6 sind wir der Frage nachgegangen, wie sich die Informatik als Profession entwickelt (Zustandigkeitsabgrenzungen, Monopolisierung von Wissen) und welche Auswirkungen dies fur die Inklusion/Exklusion von Frauen hat.

Published
2004

44. Investigation of $K_\mathrm{L,S} \rightarrow \pi^+ \pi^{-} e^+ e^{-}$ decays

Author

Benedetto Gorini, J.P. Matheys, Manfred Jeitler, Victoria Jane Martin, M. De Beer, J. Duclos, G. Anzivino, Michael Ziolkowski, T. Cuhadar-Dönszelmann, G. Kalmus, H.G. Becker, Mayda Velasco, Cristina Biino, Ivan Mikulec, M. Wittgen, I. Augustin, Vladimir Kekelidze, G. Neuhofer, E. Iacopini, M. Pernicka, M. Veltri, M. Contalbrigo, A. Winhart, P. Grafström, M. Cirilli, O. Vossnack, Wolfgang Funk, Mauro Piccini, R. Carosi, T.J. Gershon, D.C. Cundy, A. Gaponenko, A. Hirstius, Paolo Calafiura, A. Norton, A. I. Zinchenko, S. Luitz, A. Lai, Nadia Pastrone, M. Sozzi, Augusto Ceccucci, A. Gianoli, K. Holtz, I. Mannelli, J.B. Cheze, R. Granier de Cassagnac, Michal Szleper, Roberto Guida, Y. Schué, R. Casali, R. Fantechi, B. Hay, L. Köpke, Frederic Derue, D. Coward, D. Marras, M. Savrie, Cristina Lazzeroni, G. Fischer, A. Peters, Milene Calvetti, H. D. Wahl, E. Menichetti, D. Schinzel, C. Cheshkov, G.D. Barr, G. Unal, Michael Bender, A. Kalter, M. Martini, J. Nassalski, U. Koch, A. Nappi, Anton Taurok, H. Bluemer, Louis Fayard, F. Marchetto, S. A. Wotton, R.S. Dosanjh, Roberta Arcidiacono, P. Lopes da Silva, H. Taureg, Lydia Iconomidou-Fayard, A L Tkachev, P. Marouelli, H. Dibon, L. Bertanza, R. Turlay, L. Widhalm, G. Tatishvili, M. Markytan, Niels Doble, Adrian John Bevan, M. Lenti, E. Rondio, A. Bigi, B. Peyaud, Lau Gatignon, G. Graziani, R. Sacco, J.-C. Chollet, Andrea Bizzeti, I. Wingerter-Seez, G. Pierazzini, V. Falaleev, P Z Khristov, I.G. Knowles, W. Wislicki, E. Mazzucato, G. Govi, P. Cenci, S. Giudici, W. Kubischta, S. Wronka, P. Lubrano, P. Debu, S.A. Schmidt, M. Scarpa, D. J. Munday, E. Imbergamo, Alexi Mestvirishvili, J. Ocariz, J. G. Cogan, F. Martelli, M. Holder, M. Pepe, G. D'Agostini, D. Madigojine, Konrad Kleinknecht, I. Pellmann, F. Costantini, G. Bocquet, Yu. Potrebenikov, A. Gonidec, G. Collazuol, A. Maier, Matthew Needham, M. Eppard, Nicolo Cartiglia, Michael Andrew Parker, Rainer Wanke, P. F. Dalpiaz, V. Schönharting, B. Vallage, Jacqueline Batley, C. Cerri, E. Olaiya, H. Fox, A. Lacourt, B. Panzer-Steindel, Fabrizio Petrucci, P.L. Frabetti, T. O. White, H. Parsons, Alan W. Walker, Sandro Palestini, A. Formica, and N. A. Molokanova

Subjects
Nuclear physics, Physics, Particle physics, Angular distribution, Large Hadron Collider, Physics and Astronomy (miscellaneous), Angular correlation, Charge radius, Pi, NA48 experiment, Engineering (miscellaneous)
Published
2003

45. Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products

Author

Rastislav Dzúrik, Spustová, August Heidland, Blazicek P, Katarína Šebeková, Reinhard Schinzel, Gazdíková K, and Syrová D

Subjects
Blood Glucose, Glycation End Products, Advanced, Male, Ramipril, medicine.medical_specialty, Statistics as Topic, Renal function, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Severity of Illness Index, Lipofuscin, Nephropathy, Lipid peroxidation, chemistry.chemical_compound, Glomerulonephritis, Glycation, Malondialdehyde, Internal medicine, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Cystatin C, Homocysteine, Aged, Polycystic Kidney Diseases, biology, business.industry, Lysine, Neopterin, Angiotensin-converting enzyme, Middle Aged, medicine.disease, Cystatins, Oxidative Stress, Treatment Outcome, Endocrinology, chemistry, Creatinine, biology.protein, Nephritis, Interstitial, Female, business, Biomarkers, medicine.drug
Abstract

Enhanced oxidative stress is involved in the progression of renal disease. Since angiotensin converting enzyme inhibitors (ACEI) have been shown to improve the antioxidative defence, we investigated, in patients with nondiabetic nephropathy, the short-term effect of the ACEI ramipril on parameters of oxidative stress, such as advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), homocysteine (Hcy), and lipid peroxidation products. Ramipril (2.5-5.0 mg/day) was administered to 12 newly diagnosed patients for 2 months and data compared with a patient group under conventional therapy (diuretic/beta-blockers) and with age- and sex-matched healthy subjects (CTRL). Patients had mild to moderate renal insufficiency and showed, in the plasma, higher fluorescent AGE and carboxymethyllysine (CML) levels, as well as elevated concentrations of AOPPs, lipofuscin and Hcy when compared with CTRL. Basal data of the patients on conventional therapy did not differ significantly from the ramipril group, except for higher Hcy levels in the latter. Administration of ramipril resulted in a drop in blood pressure and proteinuria, while creatinine clearance remained the same. The fluorescent AGEs exhibited a mild but significant decline, yet CML concentration was unchanged. The AOPP and malondialdehyde concentrations decreased, while a small rise in neopterin levels was evident after treatment. The mentioned parameters were not affected significantly in the conventionally treated patients. Evidence that ramipril administration results in a mild decline of fluorescent AGEs is herein presented for the first time. The underlying mechanism may be decreased oxidative stress, as indicated by a decline in AOPPs and malondialdehyde.

Published
2003

46. [Untitled]

Author

Burkhard Bechinger, Susan Schinzel, and Titus C. B. Vogt

Subjects
chemistry.chemical_compound, Chromatography, Solid-state nuclear magnetic resonance, chemistry, Isotopes of carbon, Tyrocidine, Labelling, Gramicidin, Nuclear magnetic resonance spectroscopy, Mass spectrometry, Biochemistry, Spectroscopy, Isotopes of nitrogen
Abstract

The three-dimensional structure of bilayer-associated gramicidin A is available from a structural data base. This and related peptides are, therefore, ideal model compounds to use during the implementation and development of new NMR techniques for the structural investigations of membrane proteins. As these methods rely on the isotopic labelling of single, selected or all sites, we have, investigated and optimised biochemical protocols using different strains of the Gram-positive bacterium Bacillus brevis. With newly developed schemes for isotopic labelling large amounts of gramicidin and tyrocidin enriched with stable isotopes such as 15N or 15N/13C have been obtained at low cost. A variety of analytical and spectroscopic techniques, including HPLC, mass spectrometry and NMR spectroscopy are used to characterise the resulting products.

Published
2003

47. Ciclopiroxolamine Cream for Treating Seborrheic Dermatitis: A Double-Blind Parallel Group Comparison

Author

Hans Christian Korting, H. Ulbricht, G. Varigos, S. Schinzel, D. Nicholls, K. H. Nietsch, and Angela Unholzer

Subjects
Adult, Male, Microbiology (medical), Sebaceous gland, medicine.medical_specialty, Antifungal Agents, Pyridones, medicine.medical_treatment, law.invention, Ointments, Double-Blind Method, Randomized controlled trial, law, Seborrheic dermatitis, medicine, Humans, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Chemotherapy, Ciclopirox, business.industry, General Medicine, Middle Aged, medicine.disease, Dermatology, Dermatitis, Seborrheic, Clinical trial, Infectious Diseases, medicine.anatomical_structure, Tolerability, Patient Compliance, Female, business, medicine.drug
Abstract

Background: The aim of this study was to compare the efficacy and tolerability of topically applied ciclopiroxolamine cream with that of the corresponding vehicle in patients with seborrheic dermatitis of the face. Patients and Methods: The study was conducted as a multicenter prospective, randomized, double-blind parallel group comparison at 14 centers in Australia and New Zealand. 189 patients with clinically diagnosed seborrheic dermatitis participated in the study. Each patient applied ciclopiroxolamine 1% cream or the corresponding vehicle twice daily as a thin film to the affected skin areas and to clinically unaffected skin areas surrounding the lesions for 29 days. Results: The rate of treatment success was significantly higher with ciclopiroxolamine than with vehicle (73.9 vs 53.6%; p = 0.003). Treatment with ciclopiroxolamine reduced the sum score of the clinical signs of seborrheic dermatitis to a greater extent than the vehicle (p ≤ 0.001). Conclusion: This study confirms that topical treatment with ciclopiroxolamine is effective and well tolerated in patients with seborrheic dermatitis.

Published
2002

48. A Property of Polynomials with an Applicationto Siegel's Lemma

Author

Andrzej Schinzel

Subjects
Discrete mathematics, Pure mathematics, Lemma (mathematics), Coprime integers, General Mathematics, Multivariate polynomials, Siegel's lemma, Mathematics
Abstract

It is proved that natural necessary conditions imply the existence of infinitely many integer points at which given multivariate polynomials with integer coefficients take coprime values. As a consequence the best constant in the simplest case of Siegel’s lemma is expressed in terms of critical determinants of suitable star bodies.

Published
2002

49. [Untitled]

Author

A. Schinzel

Subjects
Genetics, Chromosome (genetic algorithm), Biology, Human genetics
Published
2002

50. Ciclopiroxolamine Cream 1% in the Treatment of Seborrhoeic Dermatitis

Author

K. H. Nietsch, Angela Unholzer, Hans Christian Korting, G. E. Jung, and S. Schinzel

Subjects
medicine.medical_specialty, Ciclopiroxolamine, business.industry, digestive, oral, and skin physiology, food and beverages, Seborrhoeic dermatitis, General Medicine, Group comparison, Dermatology, Confirmatory trial, Double blind, Tolerability, medicine, Pharmacology (medical), Ketoconazole, In patient, skin and connective tissue diseases, business, medicine.drug
Abstract

Objective: To compare the efficacy and tolerability of topically applied ciclopiroxolamine cream with that of ketoconazole cream and the corresponding vehicle in patients with seborrhoeic dermatitis.

Published
2002

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