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Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products
- Source :
- Journal of Human Hypertension. 17:265-270
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Enhanced oxidative stress is involved in the progression of renal disease. Since angiotensin converting enzyme inhibitors (ACEI) have been shown to improve the antioxidative defence, we investigated, in patients with nondiabetic nephropathy, the short-term effect of the ACEI ramipril on parameters of oxidative stress, such as advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), homocysteine (Hcy), and lipid peroxidation products. Ramipril (2.5-5.0 mg/day) was administered to 12 newly diagnosed patients for 2 months and data compared with a patient group under conventional therapy (diuretic/beta-blockers) and with age- and sex-matched healthy subjects (CTRL). Patients had mild to moderate renal insufficiency and showed, in the plasma, higher fluorescent AGE and carboxymethyllysine (CML) levels, as well as elevated concentrations of AOPPs, lipofuscin and Hcy when compared with CTRL. Basal data of the patients on conventional therapy did not differ significantly from the ramipril group, except for higher Hcy levels in the latter. Administration of ramipril resulted in a drop in blood pressure and proteinuria, while creatinine clearance remained the same. The fluorescent AGEs exhibited a mild but significant decline, yet CML concentration was unchanged. The AOPP and malondialdehyde concentrations decreased, while a small rise in neopterin levels was evident after treatment. The mentioned parameters were not affected significantly in the conventionally treated patients. Evidence that ramipril administration results in a mild decline of fluorescent AGEs is herein presented for the first time. The underlying mechanism may be decreased oxidative stress, as indicated by a decline in AOPPs and malondialdehyde.
- Subjects :
- Blood Glucose
Glycation End Products, Advanced
Male
Ramipril
medicine.medical_specialty
Statistics as Topic
Renal function
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure
Severity of Illness Index
Lipofuscin
Nephropathy
Lipid peroxidation
chemistry.chemical_compound
Glomerulonephritis
Glycation
Malondialdehyde
Internal medicine
Internal Medicine
medicine
Humans
Diabetic Nephropathies
Cystatin C
Homocysteine
Aged
Polycystic Kidney Diseases
biology
business.industry
Lysine
Neopterin
Angiotensin-converting enzyme
Middle Aged
medicine.disease
Cystatins
Oxidative Stress
Treatment Outcome
Endocrinology
chemistry
Creatinine
biology.protein
Nephritis, Interstitial
Female
business
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 14765527 and 09509240
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Human Hypertension
- Accession number :
- edsair.doi.dedup.....2917fd9936235d21726ef52d98a75b32