1. Fabrication of a novel antibacterial TPU nanofiber membrane containing Cu-loaded zeolite and its antibacterial activity toward Escherichia coli.
- Author
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Lei, Jingjing, Yao, Guangyuan, Sun, Zhiming, Wang, Bin, Yu, Caihong, and Zheng, Shuilin
- Subjects
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ESCHERICHIA coli , *SCANNING electron microscopes , *ZEOLITES , *X-ray fluorescence , *BACTERIAL cell walls , *CRYSTAL structure , *CELL membranes - Abstract
A novel antibacterial thermoplastic polyurethane (TPU) nanofiber membrane was fabricated by electrospinning with the aid of Cu-loaded NaX zeolite (CuX), which showed excellent and long-lasting antibacterial activity against Escherichia coli (E. coli). The crystalline structure, morphology and composition of the obtained NaX zeolite, CuX and CuX/TPU nanofiber membrane were analyzed by X-ray diffraction (XRD), scanning electron microscope (SEM) and X-ray fluorescence (XRF), respectively. The antibacterial activity of CuX/TPU nanofiber membrane against E. coli was investigated by inhibition zone method and plate-counting method, and it is indicated that the inactivation efficiency was increased from 58.40 to 99.85% with increasing the addition of CuX from 5 to 30% in 4 h. The result of kinetics study indicated that the disinfection process accorded with the pseudo-first-order model. The possible antibacterial mechanism was also proposed that the released Cu2+ by CuX in nanofiber membrane destroyed the cell wall and penetrated plasma membrane of E. coli. It is expected that this CuX/TPU nanofiber membrane with excellent antibacterial activity would be a promising candidate for biomedical applications. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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